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  1. In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeling complex whose mutations are associat...

    Authors: Kexuan Li, Baocai Wang and Haolin Hu
    Citation: Epigenetics & Chromatin 2024 17:4
  2. Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-associated H3K27me3 histone modifications on opposite tails of the same nucleosome occur...

    Authors: Janith A. Seneviratne, William W. H. Ho, Eleanor Glancy and Melanie A. Eckersley-Maslin
    Citation: Epigenetics & Chromatin 2024 17:3
  3. Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal an...

    Authors: Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles and Gregory David
    Citation: Epigenetics & Chromatin 2024 17:2
  4. The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inacti...

    Authors: Sombodhi Bhattacharya, Debasmita Sadhukhan and Radha Saraswathy
    Citation: Epigenetics & Chromatin 2024 17:1
  5. Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tube to close during early embryogenesis. Maternal folate deficiency could impact the occu...

    Authors: Xue Li, Pei Pei, Jinying Shen, Juan Yu, Fang Wang, Lei Wang, Changyun Liu and Shan Wang
    Citation: Epigenetics & Chromatin 2023 16:50
  6. Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function witho...

    Authors: Thomas Dupas, Benjamin Lauzier and Serge McGraw
    Citation: Epigenetics & Chromatin 2023 16:49
  7. This study presents a novel approach for mapping global chromatin interactions using S1 nuclease, a sequence-agnostic enzyme. We develop and outline a protocol that leverages S1 nuclease's ability to effective...

    Authors: Gridina Maria, Popov Andrey, Shadskiy Artem, Torgunakov Nikita, Kechin Andrey, Khrapov Evgeny, Ryzhkova Oxana, Filipenko Maxim and Fishman Veniamin
    Citation: Epigenetics & Chromatin 2023 16:48
  8. Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) is known to be involved in the deposition of the di- and tri-methyl marks on H3K9 (H3K9m...

    Authors: Hanshen Luo, Xingliang Wu, Xue-Hai Zhu, Xin Yi, Dunfeng Du and Ding-Sheng Jiang
    Citation: Epigenetics & Chromatin 2023 16:47
  9. Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chroma...

    Authors: Tamaki Suganuma and Jerry L. Workman
    Citation: Epigenetics & Chromatin 2023 16:46
  10. Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate and characterize the epigenomes of specific ...

    Authors: Kyla B. Tooley, Ana J. Chucair-Elliott, Sarah R. Ocañas, Adeline H. Machalinski, Kevin D. Pham, Walker Hoolehan, Adam M. Kulpa, David R. Stanford and Willard M. Freeman
    Citation: Epigenetics & Chromatin 2023 16:45
  11. During early mammalian development, DNA methylation undergoes two waves of reprogramming, enabling transitions between somatic cells, oocyte and embryo. The first wave of de novo DNA methylation establishment ...

    Authors: Lirik Behluli, Alyssa M. Fontanilla, Laura Andessner-Angleitner, Nikolas Tolar, Julia M. Molina and Lenka Gahurova
    Citation: Epigenetics & Chromatin 2023 16:43
  12. Cell–cell communication is mediated by membrane receptors and their ligands, such as the Eph/ephrin system, orchestrating cell migration during development and in diverse cancer types. Epigenetic mechanisms ar...

    Authors: Can Bora Yildiz, Tathagata Kundu, Julia Gehrmann, Jannis Koesling, Amin Ravaei, Philip Wolff, Florian Kraft, Tiago Maié, Mira Jakovcevski, Daniel Pensold, Olav Zimmermann, Giulia Rossetti, Ivan G. Costa and Geraldine Zimmer-Bensch
    Citation: Epigenetics & Chromatin 2023 16:42
  13. Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can l...

    Authors: Nivethika Rajaram, Alexandra G. Kouroukli, Susanne Bens, Pavel Bashtrykov and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2023 16:41
  14. Classical studies on position effect variegation in Drosophila have demonstrated the existence of bi-modal Active/Silent state of the genes juxtaposed to heterochromatin. Later studies with irreversible methods f...

    Authors: Safia Mahabub Sauty and Krassimir Yankulov
    Citation: Epigenetics & Chromatin 2023 16:40
  15. Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling pro...

    Authors: Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez and Miguel R. Branco
    Citation: Epigenetics & Chromatin 2023 16:39
  16. Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina Infinium Methylation bead arrays is often used to explore the connections between in utero exposures, placental pathology, and fetal ...

    Authors: A. Khan, A. M. Inkster, M. S. Peñaherrera, S. King, S. Kildea, T. F. Oberlander, D. M. Olson, C. Vaillancourt, U. Brain, E. O. Beraldo, A. G. Beristain, V. L. Clifton, G. F. Del Gobbo, W. L. Lam, G. A. S. Metz, J. W. Y. Ng…
    Citation: Epigenetics & Chromatin 2023 16:37
  17. NPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to NPM1, probably through interaction with other nuclear factors. DOT1L is one interaction ...

    Authors: Annalisa Izzo, Ipek Akol, Alejandro Villarreal, Shannon Lebel, Marta Garcia-Miralles, Arquimedes Cheffer, Patrick Bovio, Stefanie Heidrich and Tanja Vogel
    Citation: Epigenetics & Chromatin 2023 16:36
  18. Blood-based tests have public appeal in screening cancers due to their minimally invasive nature, ability to integrate with other routine blood tests, and high compliance. This study aimed to investigate wheth...

    Authors: Jia-Yi Hou, Ning Li, Jie Wang, Li-Juan Gao, Jia-Song Chang and Ji-Min Cao
    Citation: Epigenetics & Chromatin 2023 16:35
  19. Despite well-documented effects on human health, the action modes of environmental pollutants are incompletely understood. Although transcriptome-based approaches are widely used to predict associations betwee...

    Authors: Zhaonan Zou, Yuka Yoshimura, Yoshihiro Yamanishi and Shinya Oki
    Citation: Epigenetics & Chromatin 2023 16:34
  20. Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation and fragmentation profiles. Nevertheless, simultaneously detecting bo...

    Authors: Jun Wang, Yanqin Niu, Ming Yang, Lirong Shu, Hongxian Wang, Xiaoqian Wu, Yaqin He, Peng Chen, Guocheng Zhong, Zhixiong Tang, Shasha Zhang, Qianwen Guo, Yun Wang, Li Yu and Deming Gou
    Citation: Epigenetics & Chromatin 2023 16:33
  21. Cardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emerging as key players in this intricate process. Among these modifications, N6-methyladenosi...

    Authors: Xue-Hong Liu, Zhun Liu, Ze-Hui Ren, Hong-Xuan Chen, Ying Zhang, Zhang Zhang, Nan Cao and Guan-Zheng Luo
    Citation: Epigenetics & Chromatin 2023 16:32
  22. DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we identified a neural-related DNA hypermethylation fingerprint in colon ca...

    Authors: Musa Idris, Louis Coussement, Maria M. Alves, Tim De Meyer and Veerle Melotte
    Citation: Epigenetics & Chromatin 2023 16:31
  23. Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular ...

    Authors: Ranjan Kumar Maji, Beate Czepukojc, Michael Scherer, Sascha Tierling, Cristina Cadenas, Kathrin Gianmoena, Nina Gasparoni, Karl Nordström, Gilles Gasparoni, Stephan Laggai, Xinyi Yang, Anupam Sinha, Peter Ebert, Maren Falk-Paulsen, Sarah Kinkley, Jessica Hoppstädter…
    Citation: Epigenetics & Chromatin 2023 16:30
  24. The function of DNA methyltransferase genes of insects is a puzzle, because an association between gene expression and methylation is not universal for insects. If the genes normally involved in cytosine methy...

    Authors: Christopher B. Cunningham, Emily A. Shelby, Elizabeth C. McKinney, Robert J. Schmitz, Allen J. Moore and Patricia J. Moore
    Citation: Epigenetics & Chromatin 2023 16:28
  25. Our understanding of the organization of the chromatin fiber within the cell nucleus has made great progress in the last few years. High-resolution techniques based on next-generation sequencing as well as opt...

    Authors: Jente van Staalduinen, Thomas van Staveren, Frank Grosveld and Kerstin S. Wendt
    Citation: Epigenetics & Chromatin 2023 16:27
  26. RNA modifications have been known for many years, but their function has not been fully elucidated yet. For instance, the regulatory role of acetylation on N4-cytidine (ac4C) in RNA can be explored not only in...

    Authors: Alena Svobodová Kovaříková, Lenka Stixová, Aleš Kovařík and Eva Bártová
    Citation: Epigenetics & Chromatin 2023 16:26
  27. Gene expression in malaria parasites is subject to various layers of regulation, including histone post-translational modifications (PTMs). Gene regulatory mechanisms have been extensively studied during the m...

    Authors: Ashley B. Reers, Rodriel Bautista, James McLellan, Beatriz Morales, Rolando Garza, Sebastiaan Bol, Kirsten K. Hanson and Evelien M. Bunnik
    Citation: Epigenetics & Chromatin 2023 16:25
  28. The three-dimensional configuration of the eukaryotic genome is an emerging area of research. Chromosome conformation capture outlined genome segregation into large scale A and B compartments corresponding mai...

    Authors: Alla Krasikova, Tatiana Kulikova, Juan Sebastian Rodriguez Ramos and Antonina Maslova
    Citation: Epigenetics & Chromatin 2023 16:24
  29. High-throughput sequencing (HTS) offers unprecedented opportunities for the discovery of causative gene variants in multiple human disorders including cancers, and has revolutionized clinical diagnostics. Howe...

    Authors: Mohammad Salma, Elina Alaterre, Jérôme Moreaux and Eric Soler
    Citation: Epigenetics & Chromatin 2023 16:23
  30. Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of three-dimensional (3D) chromatin...

    Authors: Igor S. Tolokh, Nicholas Allen Kinney, Igor V. Sharakhov and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2023 16:21
  31. During epididymal transit spermatozoa acquire specific morphological features which enhance their ability to swim in a progressive manner and interact with the oocytes. At the same time, sperm cells undergo sp...

    Authors: Emanuele Capra, F. Turri, B. Lazzari, S. Biffani, A. Lange Consiglio, P. Ajmone Marsan, A. Stella and F. Pizzi
    Citation: Epigenetics & Chromatin 2023 16:20
  32. Patients with balanced X-autosome translocations and premature ovarian insufficiency (POI) constitute an interesting paradigm to study the effect of chromosome repositioning. Their breakpoints are clustered wi...

    Authors: Adriana Di-Battista, Bianca Pereira Favilla, Malú Zamariolli, Natália Nunes, Alexandre Defelicibus, Lucia Armelin-Correa, Israel Tojal da Silva, Alexandre Reymond, Mariana Moyses-Oliveira and Maria Isabel Melaragno
    Citation: Epigenetics & Chromatin 2023 16:19
  33. Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in differe...

    Authors: Eva Monte-Serrano, Patricia Morejón-García, Ignacio Campillo-Marcos, Aurora Campos-Díaz, Elena Navarro-Carrasco and Pedro A. Lazo
    Citation: Epigenetics & Chromatin 2023 16:18
  34. Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome. Altho...

    Authors: Benjamin H. Weekley and Judd C. Rice
    Citation: Epigenetics & Chromatin 2023 16:16
  35. Single-cell technologies to analyze transcription and chromatin structure have been widely used in many research areas to reveal the functions and molecular properties of cells at single-cell resolution. Sampl...

    Authors: Betelehem Solomon Bera, Taylor V. Thompson, Eric Sosa, Hiroko Nomaru, David Reynolds, Robert A. Dubin, Shahina B. Maqbool, Deyou Zheng, Bernice E. Morrow, John M. Greally and Masako Suzuki
    Citation: Epigenetics & Chromatin 2023 16:14
  36. IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant h...

    Authors: Xinyu Wang, Lijun Dai, Yang Liu, Chenghao Li, Dandan Fan, Yue Zhou, Pengcheng Li, Qingran Kong and Jianzhong Su
    Citation: Epigenetics & Chromatin 2023 16:13
  37. Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberran...

    Authors: Rohini Dhat, Dattatray Mongad, Sivarupa Raji, Silpa Arkat, Nitish R. Mahapatra, Nishant Singhal and Sandhya L. Sitasawad
    Citation: Epigenetics & Chromatin 2023 16:12
  38. Epigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are largely unknown.

    Authors: Jiamin Jin, Peipei Ren, Xiang Li, Yinyi Zhang, Weijie Yang, Yerong Ma, Mengru Lai, Chao Yu, Songying Zhang and Yin-Li Zhang
    Citation: Epigenetics & Chromatin 2023 16:11
  39. Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of h...

    Authors: Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert and Jeffrey Fillingham
    Citation: Epigenetics & Chromatin 2023 16:10
  40. Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including tumorigenesis. However, the function and expression of PCGF6 i...

    Authors: Meng Zhu, Ruo-Nan Zhang, Hong Zhang, Chang-bao Qu, Xiao-chong Zhang, Li-Xin Ren, Zhan Yang and Jun-Fei Gu
    Citation: Epigenetics & Chromatin 2023 16:9
  41. Allele-specific methylation of the imprinting control region (ICR) is the molecular basis for the genomic imprinting phenomenon that is unique to placental mammals. We previously showed that the ICR at the mouse

    Authors: Hitomi Matsuzaki, Shokichi Sugihara and Keiji Tanimoto
    Citation: Epigenetics & Chromatin 2023 16:7
  42. Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In eukaryotes, three SMC complexes (cohesin, condensin and SMC5/6) play key roles i...

    Authors: L. Mahrik, B. Stefanovie, A. Maresova, J. Princova, P. Kolesar, E. Lelkes, C. Faux, D. Helmlinger, M. Prevorovsky and J. J. Palecek
    Citation: Epigenetics & Chromatin 2023 16:6

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