Frank Grosveld, Erasmus University Medical Center
Steven Henikoff, Fred Hutchinson Cancer Research Center
Featured review: Viral histones: pickpocket’s prize or primordial progenitor?
Epigenetics & Chromatin is proud to publish a new review from Paul B. Talbert, Karim-Jean Armache & Steven Henikoff.
Homologues of eukaryotic histones H2A, H2B, H3 and H4 that are encoded in genomes of some giant DNA viruses have recently been shown to wrap DNA into nucleosome-like structures. In this comprehensive review, our authors describe what is known of viral histones and discuss their possible origins and functions. Viral histones can resemble eukaryotic histones in primary sequence, suggesting acquisition from eukaryotic hosts, or can be radically divergent and may occur as conjoined histone doublets, triplets, or quadruplets, suggesting origins prior to the divergence of modern eukaryotes.
Editors-in-Chief
Articles
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Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts
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The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
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Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation
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3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk
Aims and scope
Epigenetics & Chromatin is a peer-reviewed, open access journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.
Efficient peer review
Expedited: we recognise that scientifically sound, high quality manuscripts are often turned away from broad-scope "high-impact" journals based on the issue of "general interest." As a specialist journal, Epigenetics & Chromatin will consider rapid publication of such manuscripts if they are submitted as presubmission inquiries together with the original peer reviewer reports, letter of rejection, and a brief rebuttal.
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