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Featured review: The solid and liquid states of chromatin

New Content ItemEpigenetics & Chromatin is proud to publish a new review from Jeffrey C. Hansen, Kazuhiro Maeshima and Michael J. Hendzel. 

The organization and material state of chromatin in the nucleus is the subject of active investigation. In this comprehensive review our authors discuss the history, determinants, and mechanism of chromatin phase separation, the phase separation of proteins that are components of heterochromatin and euchromatin, and the emerging concept that chromatin in the nucleus behaves as solid on the mesoscale and a liquid on the nanoscale.  The role of chromatin self-interaction in shaping chromatin organization in vitro and in the nucleus is emphasized.


Frank Grosveld, Erasmus University Medical Center
Steven Henikoff, Fred Hutchinson Cancer Research Center


Aims and scope

Epigenetics & Chromatin is a peer-reviewed, open access journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.

Efficient peer review

Expedited: we recognise that scientifically sound, high quality manuscripts are often turned away from broad-scope "high-impact" journals based on the issue of "general interest." As a specialist journal, Epigenetics & Chromatin will consider rapid publication of such manuscripts if they are submitted as presubmission inquiries together with the original peer reviewer reports, letter of rejection, and a brief rebuttal.

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