Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers
by Musa Idris, Louis Coussement, Maria M. Alves, Tim De Meyer & Veerle Melotte
This interesting research article “confirms the presence of a neural-related DNA hypermethylation fingerprint in various cancers, of genes linked to neural differentiation, and points to REST as a possible regulator of this mechanism.” Read full article here.
O-GlcNAcylation: the sweet side of epigenetics
The new Review article from Thomas Dupas, Benjamin Lauzier and Serge McGraw. “This review provides a current overview of our knowledge of how O-GlcNAcylation impacts the histone code both directly and by regulating other chromatin modifying enzymes. This highlights the pivotal emerging role of O-GlcNAcylation as an essential epigenetic marker.” Read full article here.
Chromatin balances cell redox and energy homeostasis
In this article by Tamaki Suganuma & Jerry L. Workman the authors “review alterations of chromatin that are fundamental to cell responses to metabolic changes due to stress and aging to maintain redox and energy homeostasis.” They “discuss the relationship between spatiotemporal control of energy and chromatin function, as this emerging concept must be considered to understand how cell homeostasis is maintained.” Read full article here.
Etiology of super-enhancer reprogramming and activation in cancer
This review article by Royce W. Zhou & Ramon E. Parsons covers “the expanding cell-intrinsic and cell-extrinsic etiology of these super-enhancer changes in cancer, including somatic mutations, copy number variation, fusion events, extrachromosomal DNA, and 3D chromatin architecture, as well as those activated by inflammation, extra-cellular signaling, and the tumor microenvironment.” Read full article here.