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Epigenetics & Chromatin

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  1. Content type: Research

    Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood. Using a Drosophila m...

    Authors: Elizaveta Radion, Valeriya Morgunova, Sergei Ryazansky, Natalia Akulenko, Sergey Lavrov, Yuri Abramov, Pavel A. Komarov, Sergey I. Glukhov, Ivan Olovnikov and Alla Kalmykova

    Citation: Epigenetics & Chromatin 2018 11:40

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  2. Content type: Methodology

    The ability to accurately and efficiently measure DNA methylation is critical to advance the understanding of this epigenetic mechanism and its contribution to common diseases. Here, we present a highly accura...

    Authors: Simone Roeh, Tobias Wiechmann, Susann Sauer, Maik Ködel, Elisabeth B. Binder and Nadine Provençal

    Citation: Epigenetics & Chromatin 2018 11:39

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  3. Content type: Correction

    Unfortunately, the original version of this article contained a typographical error in one of the author names. The name of the author Alexey Pindyurin was incorrectly spelt as Alexey Pinduyrin. The correct sp...

    Authors: Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel and Anne-Kathrin Classen

    Citation: Epigenetics & Chromatin 2018 11:38

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    The original article was published in Epigenetics & Chromatin 2018 11:27

  4. Content type: Research

    DNA methylation is one of the main epigenetic mechanisms for the regulation of gene expression in eukaryotes. In the standard model, methylation in gene promoters has received the most attention since it is ge...

    Authors: Dafni Anastasiadi, Anna Esteve-Codina and Francesc Piferrer

    Citation: Epigenetics & Chromatin 2018 11:37

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  5. Content type: Research

    Genomic imprinting is governed by allele-specific DNA methylation at imprinting control regions (ICRs), and the mechanism controlling its differential methylation establishment during gametogenesis has been a ...

    Authors: Hitomi Matsuzaki, Eiichi Okamura, Daichi Kuramochi, Aki Ushiki, Katsuhiko Hirakawa, Akiyoshi Fukamizu and Keiji Tanimoto

    Citation: Epigenetics & Chromatin 2018 11:36

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  6. Content type: Research

    The concept of pioneer transcription factors is emerging as an essential part of the epigenetic regulation, taking place during cell development and differentiation. However, the precise molecular mechanism un...

    Authors: Bettina M. Fuglerud, Marit Ledsaak, Marie Rogne, Ragnhild Eskeland and Odd S. Gabrielsen

    Citation: Epigenetics & Chromatin 2018 11:35

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  7. Content type: Research

    In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional n...

    Authors: Kai O. Hensel, Franziska Cantner, Felix Bangert, Stefan Wirth and Jan Postberg

    Citation: Epigenetics & Chromatin 2018 11:34

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  8. Content type: Review

    The lysine-specific histone demethylase 1A (KDM1A) was the first demethylase to challenge the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin adenine dinucleotide (FAD)-depe...

    Authors: Tayaba Ismail, Hyun-Kyung Lee, Chowon Kim, Taejoon Kwon, Tae Joo Park and Hyun-Shik Lee

    Citation: Epigenetics & Chromatin 2018 11:33

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  9. Content type: Research

    Accurate regulation of tissue- and stage-specific expression of genes is prerequisite for normal development in organisms. DNA methylation plays an important role in modulating gene expression in mammals and p...

    Authors: Guanfeng Xu, Jie Zhang, Hao Lyu, Qisheng Song, Qili Feng, Hui Xiang and Sichun Zheng

    Citation: Epigenetics & Chromatin 2018 11:32

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  10. Content type: Research

    During sexual reproduction in the unicellular ciliate Stylonychia somatic macronuclei differentiate from germline micronuclei. Thereby, programmed sequence reduction takes place, leading to the elimination of > 9...

    Authors: Jan Postberg, Franziska Jönsson, Patrick Philipp Weil, Aneta Bulic, Stefan Andreas Juranek and Hans-Joachim Lipps

    Citation: Epigenetics & Chromatin 2018 11:31

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  11. Content type: Research

    The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodom...

    Authors: Veronica Garcia-Carpizo, Sergio Ruiz-Llorente, Jacinto Sarmentero, Osvaldo Graña-Castro, David G. Pisano and Maria J. Barrero

    Citation: Epigenetics & Chromatin 2018 11:30

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  12. Content type: Research

    The dynamics of histone post-translational modifications (PTMs) are sparsely described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs).

    Authors: Tao Wang, Matthew V. Holt and Nicolas L. Young

    Citation: Epigenetics & Chromatin 2018 11:29

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  13. Content type: Research

    Zrsr1 is a paternally expressed imprinted gene located in the first intron of Commd1, and the Zrsr1 promoter resides in a differentially methylated region (DMR) that is maternally methylated in the oocyte. Howeve...

    Authors: Keiichiro Joh, Fumikazu Matsuhisa, Shuji Kitajima, Kenichi Nishioka, Ken Higashimoto, Hitomi Yatsuki, Tomohiro Kono, Haruhiko Koseki and Hidenobu Soejima

    Citation: Epigenetics & Chromatin 2018 11:28

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  14. Content type: Research

    Tracking dynamic protein–chromatin interactions in vivo is key to unravel transcriptional and epigenetic transitions in development and disease. However, limited availability and heterogeneous tissue compositi...

    Authors: Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel and Anne-Kathrin Classen

    Citation: Epigenetics & Chromatin 2018 11:27

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    The Correction to this article has been published in Epigenetics & Chromatin 2018 11:38

  15. Content type: Research

    Heat-shock molecular chaperone proteins (Hsps) promote the loading of small interfering RNA (siRNA) onto RNA interference (RNAi) effector complexes. While the RNAi process is coupled with heterochromatin assem...

    Authors: Kosuke Okazaki, Hiroaki Kato, Tetsushi Iida, Kaori Shinmyozu, Jun-ichi Nakayama, Yota Murakami and Takeshi Urano

    Citation: Epigenetics & Chromatin 2018 11:26

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  16. Content type: Research

    The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples, while conclusions regarding tissue-specificity are typ...

    Authors: Roderick C. Slieker, Caroline L. Relton, Tom R. Gaunt, P. Eline Slagboom and Bastiaan T. Heijmans

    Citation: Epigenetics & Chromatin 2018 11:25

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  17. Content type: Methodology

    Comprehensive genome-wide DNA methylation profiling is critical to gain insights into epigenetic reprogramming during development and disease processes. Among the different genome-wide DNA methylation technolo...

    Authors: Shalima S. Nair, Phuc-Loi Luu, Wenjia Qu, Madhavi Maddugoda, Lily Huschtscha, Roger Reddel, Georgia Chenevix-Trench, Martina Toso, James G. Kench, Lisa G. Horvath, Vanessa M. Hayes, Phillip D. Stricker, Timothy P. Hughes, Deborah L. White, John E. J. Rasko, Justin J.-L. Wong…

    Citation: Epigenetics & Chromatin 2018 11:24

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  18. Content type: Research

    MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture. Although H3 acetylation at K18 has been shown to stim...

    Authors: Kyunghwan Kim, Yonghwan Shin, Jinman Kim, Tobias S. Ulmer and Woojin An

    Citation: Epigenetics & Chromatin 2018 11:23

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  19. Content type: Research

    Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of op...

    Authors: Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, Ross C. Hardison and David M. Bodine

    Citation: Epigenetics & Chromatin 2018 11:22

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  20. Content type: Research

    The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both intrauterine and postnatal metabolic exposure factors, while the impact of intrauterin...

    Authors: Jun Ren, Yi Cheng, Zhen-Hua Ming, Xin-Yan Dong, Yu-Zhong Zhou, Guo-Lian Ding, Hai-Yan Pang, Tanzil Ur Rahman, Rubab Akbar, He-Feng Huang and Jian-Zhong Sheng

    Citation: Epigenetics & Chromatin 2018 11:20

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  21. Content type: Research

    DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, im...

    Authors: Thadeous J. Kacmarczyk, Mame P. Fall, Xihui Zhang, Yuan Xin, Yushan Li, Alicia Alonso and Doron Betel

    Citation: Epigenetics & Chromatin 2018 11:21

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  22. Content type: Research

    Anti-Silencing Factor 1 (ASF1) is a conserved H3–H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an...

    Authors: Béatrice Horard, Laure Sapey-Triomphe, Emilie Bonnefoy and Benjamin Loppin

    Citation: Epigenetics & Chromatin 2018 11:19

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  23. Content type: Research

    Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycl...

    Authors: Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P. Brown, Prim B. Singh and W. Robb MacLellan

    Citation: Epigenetics & Chromatin 2018 11:18

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  25. Content type: Research

    The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis. The centromere position is...

    Authors: Jing Zhu, Kevin Chi Lok Cheng and Karen Wing Yee Yuen

    Citation: Epigenetics & Chromatin 2018 11:16

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Epigenetics & Chromatin

ISSN: 1756-8935