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Research
The association of active transcription regulatory elements (TREs) with DNAse I hypersensitivity (DHS[+]) and an ‘open’ local chromatin configuration has long been known. However, the 3D topography of TREs wi...
Epigenetics & Chromatin 2017 10:39
Published on: 7 August 2017
Review
Accumulating animal and human data indicate that environmental exposures experienced during sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by deve...
Epigenetics & Chromatin 2017 10:38
Published on: 27 July 2017
Research
There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail...
Epigenetics & Chromatin 2017 10:37
Published on: 26 July 2017
Research
Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that v...
Epigenetics & Chromatin 2017 10:36
Published on: 12 July 2017
Research
In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-gl...
Epigenetics & Chromatin 2017 10:35
Published on: 11 July 2017
Methodology
Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttransla...
Epigenetics & Chromatin 2017 10:34
Published on: 6 July 2017
Research
Chromatin insulators shield promoters and chromatin domains from neighboring enhancers or chromatin regions with opposing activities. Insulator-binding proteins and their cofactors mediate the boundary functio...
Epigenetics & Chromatin 2017 10:32
Published on: 4 July 2017
Research
The protein Zelda was shown to play a key role in early Drosophila development, binding thousands of promoters and enhancers prior to maternal-to-zygotic transition (MZT), and marking them for transcriptional ...
Epigenetics & Chromatin 2017 10:33
Published on: 4 July 2017
Research
Differential DNA methylation plays a critical role in the regulation of imprinted genes. The differentially methylated state of the imprinting control region is inherited via the gametes at fertilization, and ...
Epigenetics & Chromatin 2017 10:31
Published on: 21 June 2017
Research
Heterogametic species display a differential number of sex chromosomes resulting in imbalanced transcription levels for these chromosomes between males and females. To correct this disequilibrium, dosage comp...
Epigenetics & Chromatin 2017 10:30
Published on: 15 June 2017
Research
Melon (Cucumis melo) is an important vegetable crop from the Cucurbitaceae family and a reference model specie for sex determination, fruit ripening and vascular fluxes studies. Nevertheless, the nature and role ...
Epigenetics & Chromatin 2017 10:22
Published on: 6 June 2017
Research
Structural variation among histone H1 variants confers distinct modes of chromatin binding that are important for differential regulation of chromatin condensation, gene expression and other processes. Changes...
Epigenetics & Chromatin 2017 10:29
Published on: 22 May 2017
Research
DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent sex determination (TSD) epitomizes phenotypic plasticity where environmental ...
Epigenetics & Chromatin 2017 10:28
Published on: 19 May 2017
Research
The ubiquitin protein E3A ligase gene (UBE3A) gene is imprinted with maternal-specific expression in neurons and biallelically expressed in all other cell types. Both loss-of-function and gain-of-function mutatio...
Epigenetics & Chromatin 2017 10:27
Published on: 15 May 2017
Methodology
In the last decade, advanced functional genomics approaches and deep sequencing have allowed large-scale mapping of histone modifications and other epigenetic marks, highlighting functional relationships betw...
Epigenetics & Chromatin 2017 10:26
Published on: 15 May 2017
Research
Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established larg...
Epigenetics & Chromatin 2017 10:25
Published on: 12 May 2017
Research
Epigenome editing is expected to manipulate transcription and cell fates and to elucidate the gene expression mechanisms in various cell types. For functional epigenome editing, assessing the chromatin context...
Epigenetics & Chromatin 2017 10:24
Published on: 8 May 2017
Review
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perce...
Epigenetics & Chromatin 2017 10:23
Published on: 8 May 2017
Research
The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypot...
Epigenetics & Chromatin 2017 10:21
Published on: 27 April 2017
Research
The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping ...
Epigenetics & Chromatin 2017 10:16
Published on: 20 April 2017
Research
Exposure to environmental stressors during development may lead to latent and transgenerational adverse health effects. To understand the role of DNA methylation in these effects, we used zebrafish as a verteb...
Epigenetics & Chromatin 2017 10:20
Published on: 12 April 2017
Research
Epigenetic reprogramming is a critical step in male germ cell development that occurs during perinatal life. It is characterized by the remodeling of different epigenetic marks such as DNA methylation (5mC) an...
Epigenetics & Chromatin 2017 10:19
Published on: 11 April 2017
Research
DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator o...
Epigenetics & Chromatin 2017 10:18
Published on: 11 April 2017
Research
Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 vari...
Epigenetics & Chromatin 2017 10:17
Published on: 4 April 2017
Research
Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that th...
Epigenetics & Chromatin 2017 10:15
Published on: 23 March 2017
