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  1. Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Unders...

    Authors: John L. Carter, Colton E. Kempton, Emily D. S. Hales and Steven M. Johnson
    Citation: Epigenetics & Chromatin 2022 15:38
  2. The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or ...

    Authors: Ana Cuadrado, Daniel Giménez-Llorente, Magali De Koninck, Miguel Ruiz-Torres, Aleksandar Kojic, Miriam Rodríguez-Corsino and Ana Losada
    Citation: Epigenetics & Chromatin 2022 15:37
  3. Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the ...

    Authors: David A. Vinson, Kimberly E. Stephens, Robert N. O’Meally, Shri Bhat, Blair C. R. Dancy, Robert N. Cole, Srinivasan Yegnasubramanian and Sean D. Taverna
    Citation: Epigenetics & Chromatin 2022 15:36
  4. Three-dimensional (3D) cell culture has emerged as an alternative approach to 2D flat culture to model more accurately the phenotype of solid tissue in laboratories. Culturing cells in 3D more precisely recapi...

    Authors: Stephanie Stransky, Ronald Cutler, Jennifer Aguilan, Edward Nieves and Simone Sidoli
    Citation: Epigenetics & Chromatin 2022 15:35
  5. Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resul...

    Authors: Ruth L. Seal, Paul Denny, Elspeth A. Bruford, Anna K. Gribkova, David Landsman, William F. Marzluff, Monica McAndrews, Anna R. Panchenko, Alexey K. Shaytan and Paul B. Talbert
    Citation: Epigenetics & Chromatin 2022 15:34
  6. Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and whether the effects are heritable.

    Authors: Rose Schrott, Jennifer L. Modliszewski, Andrew B. Hawkey, Carole Grenier, Zade Holloway, Janequia Evans, Erica Pippen, David L. Corcoran, Edward D. Levin and Susan K. Murphy
    Citation: Epigenetics & Chromatin 2022 15:33
  7. The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute ...

    Authors: Teruhito Ishihara, Oliver W. Griffith, Shunsuke Suzuki and Marilyn B. Renfree
    Citation: Epigenetics & Chromatin 2022 15:32
  8. Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can provide phenotypic plasticity in reaction to environmental cues. While prior studies s...

    Authors: Rachel M. Reardon, Amanda K. Walsh, Clairine I. Larsen, LauraAnn H. Schmidberger, Lillian A. Morrow, Adriane E. Thompson, Isabel M. Wellik and Jeffrey S. Thompson
    Citation: Epigenetics & Chromatin 2022 15:31
  9. Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene expression. The core cohesin trimer interacts with various HEAT repeat accessory subun...

    Authors: Nicole L. Arruda, Audra F. Bryan and Jill M. Dowen
    Citation: Epigenetics & Chromatin 2022 15:30
  10. Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other typ...

    Authors: Koen M. A. Dreijerink, Ezgi Ozyerli-Goknar, Stefanie Koidl, Ewoud J. van der Lelij, Priscilla van den Heuvel, Jeffrey J. Kooijman, Martin L. Biniossek, Kees W. Rodenburg, Sheikh Nizamuddin and H. T. Marc Timmers
    Citation: Epigenetics & Chromatin 2022 15:29
  11. Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3...

    Authors: John F. Dou, Lauren Y. M. Middleton, Yihui Zhu, Kelly S. Benke, Jason I. Feinberg, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, Janine M. LaSalle, Daniele Fallin, Rebecca J. Schmidt and Kelly M. Bakulski
    Citation: Epigenetics & Chromatin 2022 15:28
  12. Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite the...

    Authors: Basilia Acurzio, Francesco Cecere, Carlo Giaccari, Ankit Verma, Rosita Russo, Mariangela Valletta, Bruno Hay Mele, Claudia Angelini, Angela Chambery and Andrea Riccio
    Citation: Epigenetics & Chromatin 2022 15:27
  13. Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic patterning of the zygotic genome. We previously reported that one ...

    Authors: Iromi Wanigasuriya, Sarah A. Kinkel, Tamara Beck, Ellise A. Roper, Kelsey Breslin, Heather J. Lee, Andrew Keniry, Matthew E. Ritchie, Marnie E. Blewitt and Quentin Gouil
    Citation: Epigenetics & Chromatin 2022 15:26
  14. Authors: Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Bispo Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Héllida Marina Costa-Silva, Camila Silva Gonçalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado Motta, Ariel M. Silber, M. Carolina Elias and Julia Pinheiro Chagas da Cunha
    Citation: Epigenetics & Chromatin 2022 15:25

    The original article was published in Epigenetics & Chromatin 2022 15:22

  15. Genome-wide association studies (GWAS) have enabled the discovery of single nucleotide polymorphisms (SNPs) that are significantly associated with many autoimmune diseases including type 1 diabetes (T1D). Howe...

    Authors: Ning Liu, Timothy Sadlon, Ying Y. Wong, Stephen Pederson, James Breen and Simon C. Barry
    Citation: Epigenetics & Chromatin 2022 15:24
  16. Nucleosomal binding proteins, HMGN, is a family of chromatin architectural proteins that are expressed in all vertebrate nuclei. Although previous studies have discovered that HMGN proteins have important role...

    Authors: Bing He, Iris Zhu, Yuri Postnikov, Takashi Furusawa, Lisa Jenkins, Ravikanth Nanduri, Michael Bustin and David Landsman
    Citation: Epigenetics & Chromatin 2022 15:23
  17. Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters with unrelated functions. Moreover, there is no d...

    Authors: Alex Ranieri Jerônimo Lima, Herbert Guimarães de Sousa Silva, Saloe Poubel, Juliana Nunes Rosón, Loyze Paola Oliveira de Lima, Héllida Marina Costa-Silva, Camila Silva Gonçalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado Motta, Ariel M. Silber, M. Carolina Elias and Julia Pinheiro Chagas da Cunha
    Citation: Epigenetics & Chromatin 2022 15:22

    The Correction to this article has been published in Epigenetics & Chromatin 2022 15:25

  18. The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wrap DNA and compact the genome as well as to regulate access to DNA for transcription an...

    Authors: Paul B. Talbert, Karim-Jean Armache and Steven Henikoff
    Citation: Epigenetics & Chromatin 2022 15:21
  19. Heterosis of growth traits in allotriploid fish has benefited the production of aquaculture for many years, yet its genetic and molecular basis has remained obscure. Now, an allotriploid complex, including two...

    Authors: Li Ren, Hong Zhang, Mengxue Luo, Xin Gao, Jialin Cui, Xueyin Zhang and Shaojun Liu
    Citation: Epigenetics & Chromatin 2022 15:19
  20. The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histon...

    Authors: Nichole A. Lewis, Rachel Herndon Klein, Cailin Kelly, Jennifer Yee and Paul S. Knoepfler
    Citation: Epigenetics & Chromatin 2022 15:18
  21. The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response....

    Authors: Ulysses Tsz Fung Lam, Bryan Kok Yan Tan, John Jia Xin Poh and Ee Sin Chen
    Citation: Epigenetics & Chromatin 2022 15:17
  22. Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes. Chromatin remodeling c...

    Authors: Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin and Roberto J. Pezza
    Citation: Epigenetics & Chromatin 2022 15:16
  23. Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, littl...

    Authors: Marcela Maria de Souza, Simone Cristina Méo Niciura, Marina Ibelli Pereira Rocha, Zhangyuan Pan, Huaijun Zhou, Jennifer Jessica Bruscadin, Wellison Jarles da Silva Diniz, Juliana Afonso, Priscila Silva Neubern de Oliveira, Gerson B. Mourão, Adhemar Zerlotini, Luiz Lehmann Coutinho, James E. Koltes and Luciana Correia de Almeida Regitano
    Citation: Epigenetics & Chromatin 2022 15:15
  24. In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators ...

    Authors: John M. Schoelz and Nicole C. Riddle
    Citation: Epigenetics & Chromatin 2022 15:14
  25. Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methylation patterns have recurrently been linked to dysregulation of the regulatory program...

    Authors: Roza Berhanu Lemma, Thomas Fleischer, Emily Martinsen, Marit Ledsaak, Vessela Kristensen, Ragnhild Eskeland, Odd Stokke Gabrielsen and Anthony Mathelier
    Citation: Epigenetics & Chromatin 2022 15:13
  26. Mitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA through mitochondrial supplementation of mtDNA-deficient S...

    Authors: Takashi Okada, Stephen McIlfatrick, Nhi Hin, Nader Aryamanesh, James Breen and Justin C. St. John
    Citation: Epigenetics & Chromatin 2022 15:12
  27. Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence in...

    Authors: Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković and Melita S. Vidaković
    Citation: Epigenetics & Chromatin 2022 15:11
  28. Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA...

    Authors: Dylane Detilleux, Yannick G. Spill, Delphine Balaramane, Michaël Weber and Anaïs Flore Bardet
    Citation: Epigenetics & Chromatin 2022 15:10
  29. The epigenetic age can now be extrapolated from one of several epigenetic clocks, which are based on age-related changes in DNA methylation levels at specific multiple CpG sites. Accelerated aging, calculated ...

    Authors: Tamar Shahal, Elad Segev, Thomas Konstantinovsky, Yonit Marcus, Gabi Shefer, Metsada Pasmanik-Chor, Assaf Buch, Yuval Ebenstein, Paul Zimmet and Naftali Stern
    Citation: Epigenetics & Chromatin 2022 15:9
  30. Methylation at cytosines (mCG) is a well-known regulator of gene expression, but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied cellular differentiation model sys...

    Authors: Joshua Disatham, Lisa Brennan, Xiaodong Jiao, Zhiwei Ma, J. Fielding Hejtmancik and Marc Kantorow
    Citation: Epigenetics & Chromatin 2022 15:8
  31. The Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex involved in repressing the transcription of diverse developmental genes. PRC2 consists of a core complex; possessing H3K27 ...

    Authors: Sabrina Fischer, Lisa Marie Weber and Robert Liefke
    Citation: Epigenetics & Chromatin 2022 15:7
  32. Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the i...

    Authors: Thomas Dixon-McDougall and Carolyn J. Brown
    Citation: Epigenetics & Chromatin 2022 15:6
  33. Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heteroch...

    Authors: Junsoo Oh, Soojin Yeom, Jiyeon Park and Jung-Shin Lee
    Citation: Epigenetics & Chromatin 2022 15:5
  34. Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between activ...

    Authors: Helen S. Long, Simon Greenaway, George Powell, Ann-Marie Mallon, Cecilia M. Lindgren and Michelle M. Simon
    Citation: Epigenetics & Chromatin 2022 15:4
  35. Although paternal exposure to cigarette smoke may contribute to obesity and metabolic syndrome in offspring, the underlying mechanisms remain uncertain.

    Authors: Yunyun Liu, Shengzhu Chen, Dejian Pang, Jiayi Zhou, Xiuting Xu, Si Yang, Zhaofeng Huang and Bolan Yu
    Citation: Epigenetics & Chromatin 2022 15:3
  36. Paternal lifestyle choices and male exposure history have a critical influence on the health and fitness of the next generation. Accordingly, defining the processes of germline programming is essential to reso...

    Authors: Yudhishtar S. Bedi, Alexis N. Roach, Kara N. Thomas, Nicole A. Mehta and Michael C. Golding
    Citation: Epigenetics & Chromatin 2022 15:2
  37. The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation i...

    Authors: Ya-Hui Chi, Wan-Ping Wang, Ming-Chun Hung, Gunn-Guang Liou, Jing-Ya Wang and Pen-Hsiu Grace Chao
    Citation: Epigenetics & Chromatin 2022 15:1
  38. Directed differentiation of mouse embryonic stem cells (mESCs) or induced pluripotent stem cells (iPSCs) provides powerful models to dissect the molecular mechanisms leading to the formation of specific cell l...

    Authors: Claudia Baumann, Xiangyu Zhang, Ling Zhu, Yuhong Fan and Rabindranath De La Fuente
    Citation: Epigenetics & Chromatin 2021 14:58
  39. Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently, lactylation has been reported as a novel ...

    Authors: Wanting Yang, Peijun Wang, Pengbo Cao, Shuang Wang, Yuxiao Yang, Huimin Su and Buhe Nashun
    Citation: Epigenetics & Chromatin 2021 14:57
  40. DNA methylation plays an important role in regulating gene expression in mammals. The covalent DNMT1 inhibitors 5-azacytidine and decitabine are widely used in research to reduce DNA methylation levels, but th...

    Authors: Nathalia Azevedo Portilho, Deepak Saini, Ishtiaque Hossain, Jacinthe Sirois, Christopher Moraes and William A. Pastor
    Citation: Epigenetics & Chromatin 2021 14:56
  41. Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two paralogous genes, Asf1a and Asf1b exist in mammals, but their role during fertilization and early...

    Authors: Xuemei Wang, Lu Wang, Jie Dou, Tianjiao Yu, Pengbo Cao, Na Fan, Uyunbilig Borjigin and Buhe Nashun
    Citation: Epigenetics & Chromatin 2021 14:55
  42. Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are mo...

    Authors: Chaini Konwar, Rebecca Asiimwe, Amy M. Inkster, Sarah M. Merrill, Gian L. Negri, Maria J. Aristizabal, Christopher F. Rider, Julie L. MacIsaac, Christopher Carlsten and Michael S. Kobor
    Citation: Epigenetics & Chromatin 2021 14:54
  43. Accessible chromatin landscape allows binding of transcription factors, and remodeling of promoter and enhancer elements during development. Chromatin accessibility along with integrated multiomics approaches ...

    Authors: Udayakumar S. Vishnu, Pierre-Olivier Estève, Hang Gyeong Chin and Sriharsa Pradhan
    Citation: Epigenetics & Chromatin 2021 14:53
  44. Neural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with NTDs eventually develop lifelong disability, which cause significant morbidity and mortali...

    Authors: Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu, Jun Xu and Jun Xie
    Citation: Epigenetics & Chromatin 2021 14:52
  45. Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here, we characterize the nature of nuclear granules formed by R...

    Authors: Carlos Rivera, Daniel Verbel-Vergara, Duxan Arancibia, Anna Lappala, Marcela González, Fabián Guzmán, Gianluca Merello, Jeannie T. Lee and María Estela Andrés
    Citation: Epigenetics & Chromatin 2021 14:51
  46. The review begins with a concise description of the principles of phase separation. This is followed by a comprehensive section on phase separation of chromatin, in which we recount the 60 years history of chr...

    Authors: Jeffrey C. Hansen, Kazuhiro Maeshima and Michael J. Hendzel
    Citation: Epigenetics & Chromatin 2021 14:50
  47. Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been im...

    Authors: Varsha P. Desai, Jihed Chouaref, Haoyu Wu, William A. Pastor, Ryan L. Kan, Harald M. Oey, Zheng Li, Jamie Ho, Kelly K. D. Vonk, David San Leon Granado, Michael A. Christopher, Amander T. Clark, Steven E. Jacobsen and Lucia Daxinger
    Citation: Epigenetics & Chromatin 2021 14:49
  48. 5-Methylcytosine (5mC) is an important epigenetic mark in eukaryotes. Little information about its role exists for invertebrates. To investigate the contribution of 5mC to phenotypic variation in invertebrates...

    Authors: Nelia Luviano, Marie Lopez, Fleur Gawehns, Cristian Chaparro, Paola B. Arimondo, Slavica Ivanovic, Patrice David, Koen Verhoeven, Céline Cosseau and Christoph Grunau
    Citation: Epigenetics & Chromatin 2021 14:48
  49. Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows differences associated with various processes such a...

    Authors: Tanja Vojvoda Zeljko, Đurđica Ugarković and Željka Pezer
    Citation: Epigenetics & Chromatin 2021 14:47

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