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  1. Chromatin-based transcriptional silencing is often described as a stochastic process, largely because of the mosaic expression observed in position effect variegation (PEV), where a euchromatic reporter gene i...

    Authors: Sidney H. Wang and Sarah C. R. Elgin

    Citation: Epigenetics & Chromatin 2019 12:70

    Content type: Research

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  2. Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases...

    Authors: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang and Ting Zhang

    Citation: Epigenetics & Chromatin 2019 12:69

    Content type: Research

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  3. BRM (BRAHMA) is a core, SWI2/SNF2-type ATPase subunit of SWI/SNF chromatin-remodelling complex (CRC) involved in various important regulatory processes including development. Mutations in SMARCA2, a BRM-encoding ...

    Authors: Iga Jancewicz, Janusz A. Siedlecki, Tomasz J. Sarnowski and Elzbieta Sarnowska

    Citation: Epigenetics & Chromatin 2019 12:68

    Content type: Review

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  4. Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and signific...

    Authors: Alexandra V. Goodnight, Isaac Kremsky, Sujittra Khampang, Yoon Hee Jung, James M. Billingsley, Steven E. Bosinger, Victor G. Corces and Anthony W. S. Chan

    Citation: Epigenetics & Chromatin 2019 12:67

    Content type: Research

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  5. Numerous cell types can be identified within plant tissues and animal organs, and the epigenetic modifications underlying such enormous cellular heterogeneity are just beginning to be understood. It remains a ...

    Authors: Liduo Yin, Yanting Luo, Xiguang Xu, Shiyu Wen, Xiaowei Wu, Xuemei Lu and Hehuang Xie

    Citation: Epigenetics & Chromatin 2019 12:66

    Content type: Methodology

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  7. In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retai...

    Authors: Julianna Nechin, Emma Tunstall, Naideline Raymond, Nicole Hamagami, Chris Pathmanabhan, Samantha Forestier and Tamara L. Davis

    Citation: Epigenetics & Chromatin 2019 12:64

    Content type: Research

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  8. MeCP2—a chromatin-binding protein associated with Rett syndrome—has two main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues. Previous studies have shown brain region-specifi...

    Authors: Alexia Martínez de Paz, Leila Khajavi, Hélène Martin, Rafael Claveria-Gimeno, Susanne Tom Dieck, Manjinder S. Cheema, Jose V. Sanchez-Mut, Malgorzata M. Moksa, Annaick Carles, Nick I. Brodie, Taimoor I. Sheikh, Melissa E. Freeman, Evgeniy V. Petrotchenko, Christoph H. Borchers, Erin M. Schuman, Matthias Zytnicki…

    Citation: Epigenetics & Chromatin 2019 12:63

    Content type: Research

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  9. DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation remains poorly unde...

    Authors: Keith D. Harris, James P. B. Lloyd, Katherine Domb, Daniel Zilberman and Assaf Zemach

    Citation: Epigenetics & Chromatin 2019 12:62

    Content type: Research

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  10. Comparisons of Hi–C data sets between cell types and conditions have revealed differences in topologically associated domains (TADs) and A/B compartmentalization, which are correlated with differences in gene ...

    Authors: Lila Rieber and Shaun Mahony

    Citation: Epigenetics & Chromatin 2019 12:61

    Content type: Methodology

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  11. Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider i...

    Authors: Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Heidi G. Sutherland, Nicole White, Daniel Kennedy, Kerry Mengersen, Larisa M. Haupt and Lyn R. Griffiths

    Citation: Epigenetics & Chromatin 2019 12:60

    Content type: Research

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  12. The stability of p53 is mainly controlled by ubiquitin-dependent degradation, which is triggered by the E3 ubiquitin ligase MDM2. The chromatin modifier lymphoid-specific helicase (LSH) is essential for DNA me...

    Authors: Ling Chen, Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai, Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu, Zanxian Xia and Yongguang Tao

    Citation: Epigenetics & Chromatin 2019 12:59

    Content type: Research

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  13. Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification r...

    Authors: Niran Hadad, Dustin R. Masser, Laura Blanco-Berdugo, David R. Stanford and Willard M. Freeman

    Citation: Epigenetics & Chromatin 2019 12:58

    Content type: Research

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  14. CGGBP1 is a repeat-binding protein with diverse functions in the regulation of gene expression, cytosine methylation, repeat silencing and genomic integrity. CGGBP1 has also been identified as a cooperator of ...

    Authors: Divyesh Patel, Manthan Patel, Subhamoy Datta and Umashankar Singh

    Citation: Epigenetics & Chromatin 2019 12:57

    Content type: Research

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  15. Biofilm formation or flocculation is a major phenotype in wild type budding yeasts but rarely seen in laboratory yeast strains. Here, we analysed flocculation phenotypes and the expression of FLO genes in laborat...

    Authors: Hollie Rowlands, Kholoud Shaban, Barret Foster, Yannic Proteau and Krassimir Yankulov

    Citation: Epigenetics & Chromatin 2019 12:56

    Content type: Research

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  16. Polycomb group (PcG) and trithorax group (trxG) proteins contribute to the specialization of cell types by maintaining differential gene expression patterns. Initially discovered as positive regulators of HOX ...

    Authors: Zain Umer, Jawad Akhtar, Muhammad Haider Farooq Khan, Najma Shaheen, Muhammad Abdul Haseeb, Khalida Mazhar, Aziz Mithani, Saima Anwar and Muhammad Tariq

    Citation: Epigenetics & Chromatin 2019 12:55

    Content type: Research

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  17. Methylation of cytosines is an evolutionarily conserved epigenetic mark that is essential for the control of chromatin activity in many taxa. It acts mainly repressively, causing transcriptional gene silencing...

    Authors: Adéla Přibylová, Vojtěch Čermák, Dimitrij Tyč and Lukáš Fischer

    Citation: Epigenetics & Chromatin 2019 12:54

    Content type: Research

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  18. TH2B is a major histone variant that replaces about 80–85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermato...

    Authors: Iyer Aditya Mahadevan, Satyakrishna Pentakota, Raktim Roy, Utsa Bhaduri and Manchanahalli R. Satyanarayana Rao

    Citation: Epigenetics & Chromatin 2019 12:53

    Content type: Research

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  19. Maintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents prolonged stalling of the ...

    Authors: Joanna Brühl, Jonathan Trautwein, Agnes Schäfer, Uwe Linne and Karim Bouazoune

    Citation: Epigenetics & Chromatin 2019 12:52

    Content type: Research

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  20. The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches t...

    Authors: Victor Yuan, E. Magda Price, Giulia Del Gobbo, Sara Mostafavi, Brian Cox, Alexandra M. Binder, Karin B. Michels, Carmen Marsit and Wendy P. Robinson

    Citation: Epigenetics & Chromatin 2019 12:51

    Content type: Methodology

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  21. The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyan...

    Authors: Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, Stacie K. Loftus and William J. Pavan

    Citation: Epigenetics & Chromatin 2019 12:50

    Content type: Research

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  22. KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous retr...

    Authors: Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger and Anne C. Ferguson-Smith

    Citation: Epigenetics & Chromatin 2019 12:49

    Content type: Research

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  23. Gonadotrope lineage differentiation is a stepwise process taking place during pituitary development. The early step of gonadotrope lineage specification is characterized by the expression of the Nr5a1 transcripti...

    Authors: Vincent Pacini, Florence Petit, Bruno Querat, Jean-Noël Laverriere, Joëlle Cohen-Tannoudji and David L’hôte

    Citation: Epigenetics & Chromatin 2019 12:48

    Content type: Research

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  24. A complex interplay between chromatin and topological machineries is critical for genome architecture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its m...

    Authors: Douglas Maya-Miles, Eloísa Andújar, Mónica Pérez-Alegre, Marina Murillo-Pineda, Marta Barrientos-Moreno, María J. Cabello-Lobato, Elena Gómez-Marín, Macarena Morillo-Huesca and Félix Prado

    Citation: Epigenetics & Chromatin 2019 12:47

    Content type: Research

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  25. Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination and maintenance of cell identity. In macrophages, spec...

    Authors: Federica Ferri, Vanessa Petit, Vilma Barroca and Paul-Henri Romeo

    Citation: Epigenetics & Chromatin 2019 12:46

    Content type: Research

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  26. Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes ...

    Authors: Eriko Oya, Mickaël Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli and Karl Ekwall

    Citation: Epigenetics & Chromatin 2019 12:45

    Content type: Research

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  27. Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream eff...

    Authors: Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann and Dustin E. Schones

    Citation: Epigenetics & Chromatin 2019 12:44

    Content type: Research

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  30. While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. DNA methyltransferases and ten-eleven t...

    Authors: Candace J. Poole, Atul Lodh, Jeong-Hyeon Choi and Jan van Riggelen

    Citation: Epigenetics & Chromatin 2019 12:41

    Content type: Research

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  31. In animals, H3K4me2 and H3K4me3 are enriched at the transcription start site (TSS) and function as epigenetic marks that regulate gene transcription, but their functions in plants have not been fully character...

    Authors: Yuhao Liu, Kunpeng Liu, Liufan Yin, Yu Yu, Ji Qi, Wen-Hui Shen, Jun Zhu, Yijing Zhang and Aiwu Dong

    Citation: Epigenetics & Chromatin 2019 12:40

    Content type: Research

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  32. Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene tra...

    Authors: P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes and P. Grandi

    Citation: Epigenetics & Chromatin 2019 12:39

    Content type: Research

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  33. In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a gen...

    Authors: Anna Mallol, Maria Guirola and Bernhard Payer

    Citation: Epigenetics & Chromatin 2019 12:38

    Content type: Research

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  34. The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer...

    Authors: Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake and Tilman Borggrefe

    Citation: Epigenetics & Chromatin 2019 12:37

    Content type: Review

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  35. DamID, in which a protein of interest is fused to Dam methylase, enables mapping of protein-DNA binding through readout of adenine methylation in genomic DNA. DamID offers a compelling alternative to chromati...

    Authors: Tomasz Szczesnik, Joshua W. K. Ho and Richard Sherwood

    Citation: Epigenetics & Chromatin 2019 12:36

    Content type: Methodology

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  36. Laryngeal squamous cell carcinoma (LSCC) is among the most common malignant tumors with poor prognosis. Accumulating evidences have identified the important roles of long noncoding RNAs (lncRNAs) in the initia...

    Authors: Baoshan Wang, Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui and Wenxia Meng

    Citation: Epigenetics & Chromatin 2019 12:35

    Content type: Research

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  37. Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epig...

    Authors: Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans and Menno P. J. de Winther

    Citation: Epigenetics & Chromatin 2019 12:34

    Content type: Research

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  38. Both tissue-specific and ubiquitously expressed transcription factors, such as Sp-family members, are required for correct development. However, the molecular details of how ubiquitous factors are involved in ...

    Authors: Jane Gilmour, Leigh O’Connor, Christopher P. Middleton, Peter Keane, Nynke Gillemans, Jean-Baptiste Cazier, Sjaak Philipsen and Constanze Bonifer

    Citation: Epigenetics & Chromatin 2019 12:33

    Content type: Research

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  39. TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phospho...

    Authors: Ting Zhang, Xiaowen Guan, Un Lam Choi, Qiang Dong, Melody M. T. Lam, Jianming Zeng, Jun Xiong, Xianju Wang, Terence C. W. Poon, Hongjie Zhang, Xuanjun Zhang, Hailin Wang, Ruiyu Xie, Bing Zhu and Gang Li

    Citation: Epigenetics & Chromatin 2019 12:32

    Content type: Research

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  42. Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a...

    Authors: Louis Legoff, Ouzna Dali, Shereen Cynthia D’Cruz, Antonio Suglia, Aurore Gely-Pernot, Chloé Hémery, Pierre-Yves Kernanec, Abbassia Demmouche, Christine Kervarrec, Sergei Tevosian, Luc Multigner and Fatima Smagulova

    Citation: Epigenetics & Chromatin 2019 12:29

    Content type: Research

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  43. Localized functional domains within chromosomes, known as topologically associating domains (TADs), have been recently highlighted. In Drosophila, TADs are biochemically defined by epigenetic marks, this suggesti...

    Authors: Antony Lesage, Vincent Dahirel, Jean-Marc Victor and Maria Barbi

    Citation: Epigenetics & Chromatin 2019 12:28

    Content type: Research

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  44. Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding tran...

    Authors: Yilin Zhao, Deyou Zheng and Ales Cvekl

    Citation: Epigenetics & Chromatin 2019 12:27

    Content type: Research

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  45. Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multipl...

    Authors: Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham and David J. Segal

    Citation: Epigenetics & Chromatin 2019 12:26

    Content type: Research

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  46. MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates wit...

    Authors: Yonghwan Shin, Nikhil B. Ghate, Byoungsan Moon, Kyungpyo Park, Wange Lu and Woojin An

    Citation: Epigenetics & Chromatin 2019 12:25

    Content type: Research

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  47. Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive. In this ...

    Authors: Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura and Eishi Noguchi

    Citation: Epigenetics & Chromatin 2019 12:24

    Content type: Research

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  48. Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV...

    Authors: Chuan Li, Guillaume Mousseau and Susana T. Valente

    Citation: Epigenetics & Chromatin 2019 12:23

    Content type: Research

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  50. Positioning of nucleosomes along DNA is an integral regulator of chromatin accessibility and gene expression in diverse cell types. However, the precise nature of how histone demethylases including the histone...

    Authors: Jiji T. Kurup, Ion J. Campeanu and Benjamin L. Kidder

    Citation: Epigenetics & Chromatin 2019 12:20

    Content type: Research

    Published on:

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Epigenetics & Chromatin

ISSN: 1756-8935