Skip to main content

Articles

Page 1 of 16

  1. Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been im...

    Authors: Varsha P. Desai, Jihed Chouaref, Haoyu Wu, William A. Pastor, Ryan L. Kan, Harald M. Oey, Zheng Li, Jamie Ho, Kelly K. D. Vonk, David San Leon Granado, Michael A. Christopher, Amander T. Clark, Steven E. Jacobsen and Lucia Daxinger

    Citation: Epigenetics & Chromatin 2021 14:49

    Content type: Research

    Published on:

  2. 5-Methylcytosine (5mC) is an important epigenetic mark in eukaryotes. Little information about its role exists for invertebrates. To investigate the contribution of 5mC to phenotypic variation in invertebrates...

    Authors: Nelia Luviano, Marie Lopez, Fleur Gawehns, Cristian Chaparro, Paola B. Arimondo, Slavica Ivanovic, Patrice David, Koen Verhoeven, Céline Cosseau and Christoph Grunau

    Citation: Epigenetics & Chromatin 2021 14:48

    Content type: Research

    Published on:

  3. Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows differences associated with various processes such a...

    Authors: Tanja Vojvoda Zeljko, Đurđica Ugarković and Željka Pezer

    Citation: Epigenetics & Chromatin 2021 14:47

    Content type: Research

    Published on:

  4. Knowing chromatin components at a DNA regulatory element at any given time is essential for understanding how the element works during cellular proliferation, differentiation and development. A region-specific...

    Authors: Satoru Ide, Asuka Sasaki, Yusuke Kawamoto, Toshikazu Bando, Hiroshi Sugiyama and Kazuhiro Maeshima

    Citation: Epigenetics & Chromatin 2021 14:46

    Content type: Methodology

    Published on:

  5. It is established that protein-coding exons are preferentially localized in nucleosomes. To examine whether the same is true for non-coding exons, we analysed nucleosome occupancy in and adjacent to internal e...

    Authors: Pinki Dey and John S. Mattick

    Citation: Epigenetics & Chromatin 2021 14:45

    Content type: Research

    Published on:

  6. Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for det...

    Authors: Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T. Dermitzakis, Yurii S. Aulchenko, Thomas Lengauer, Paul A. Lyons, Michel Georges and Jörn Walter

    Citation: Epigenetics & Chromatin 2021 14:44

    Content type: Research

    Published on:

  7. Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility, such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and alter gene expre...

    Authors: Yujuan Gui, Kamil Grzyb, Mélanie H. Thomas, Jochen Ohnmacht, Pierre Garcia, Manuel Buttini, Alexander Skupin, Thomas Sauter and Lasse Sinkkonen

    Citation: Epigenetics & Chromatin 2021 14:43

    Content type: Research

    Published on:

  8. Environmental fluctuation during embryonic and fetal development can permanently alter an organism’s morphology, physiology, and behaviour. This phenomenon, known as developmental plasticity, is particularly r...

    Authors: Ilan Ruhr, Jacob Bierstedt, Turk Rhen, Debojyoti Das, Sunil Kumar Singh, Soleille Miller, Dane A. Crossley II and Gina L. J. Galli

    Citation: Epigenetics & Chromatin 2021 14:42

    Content type: Research

    Published on:

  9. Eukaryotic genomes are highly organised within the nucleus of a cell, allowing widely dispersed regulatory elements such as enhancers to interact with gene promoters through physical contacts in three-dimensio...

    Authors: Ning Liu, Wai Yee Low, Hamid Alinejad-Rokny, Stephen Pederson, Timothy Sadlon, Simon Barry and James Breen

    Citation: Epigenetics & Chromatin 2021 14:41

    Content type: Review

    Published on:

  10. Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studi...

    Authors: Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li and Chong Tang

    Citation: Epigenetics & Chromatin 2021 14:40

    Content type: Research

    Published on:

  11. Panobinostat (PB), a histone deacetylase (HDAC) inhibitor drug, is clinically used in the treatment of cancers. We investigated the effects of PB on murine ovarian functions in embryos and adult animals.

    Authors: Louis Legoff, Ouzna Dali, Elena De La Mata Santaella, Christian Jaulin, Shereen Cynthia D’Cruz and Fatima Smagulova

    Citation: Epigenetics & Chromatin 2021 14:39

    Content type: Research

    Published on:

  12. Notch signaling controls cell fate decisions in many contexts during development and adult stem cell homeostasis and, when dysregulated, leads to carcinogenesis. The central transcription factor RBPJ assembles...

    Authors: Małgorzata Sotomska, Robert Liefke, Francesca Ferrante, Heiko Schwederski, Franz Oswald and Tilman Borggrefe

    Citation: Epigenetics & Chromatin 2021 14:38

    Content type: Research

    Published on:

  13. Condensation of chromatin prior to enucleation is an essential component of terminal erythroid maturation, and defects in this process are associated with inefficient erythropoiesis and anemia. However, the me...

    Authors: Nazish N. Jeffery, Christina Davidson, Scott A. Peslak, Paul D. Kingsley, Yukio Nakamura, James Palis and Michael Bulger

    Citation: Epigenetics & Chromatin 2021 14:37

    Content type: Research

    Published on:

  14. Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-r...

    Authors: Arkadiy K. Golov, Anastasia V. Golova, Alexey A. Gavrilov and Sergey V. Razin

    Citation: Epigenetics & Chromatin 2021 14:36

    Content type: Research

    Published on:

  15. Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of h...

    Authors: Sheldon Decombe, François Loll, Laura Caccianini, Kévin Affannoukoué, Ignacio Izeddin, Julien Mozziconacci, Christophe Escudé and Judith Lopes

    Citation: Epigenetics & Chromatin 2021 14:35

    Content type: Research

    Published on:

  16. Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttransl...

    Authors: Yinjie Lian, Huijuan Hao, Jing Xu, Tao Bo, Aihua Liang and Wei Wang

    Citation: Epigenetics & Chromatin 2021 14:34

    Content type: Research

    Published on:

  18. The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific tra...

    Authors: Deniz Uğurlu-Çimen, Deniz Odluyurt, Kenan Sevinç, Nazlı Ezgi Özkan-Küçük, Burcu Özçimen, Deniz Demirtaş, Eray Enüstün, Can Aztekin, Martin Philpott, Udo Oppermann, Nurhan Özlü and Tamer T. Önder

    Citation: Epigenetics & Chromatin 2021 14:32

    Content type: Research

    Published on:

  19. Exposure to early life stress (ELS) during childhood or prenatally increases the risk of future psychiatric disorders. The effect of stress exposure during the neonatal period is less well understood. In prete...

    Authors: Eamon Fitzgerald, Matthew C. Sinton, Sara Wernig-Zorc, Nicholas M. Morton, Megan C. Holmes, James P. Boardman and Amanda J. Drake

    Citation: Epigenetics & Chromatin 2021 14:31

    Content type: Research

    Published on:

  21. Drosophila dosage compensation is an important model system for defining how active chromatin domains are formed. The male-specific lethal dosage compensation complex (MSLc) increases transcript levels of genes a...

    Authors: William Jordan III and Erica Larschan

    Citation: Epigenetics & Chromatin 2021 14:29

    Content type: Research

    Published on:

  22. With rapidly dropping sequencing cost, the popularity of whole-genome DNA methylation sequencing has been on the rise. Multiple library preparation protocols currently exist. We have performed 22 whole-genome ...

    Authors: Jacob Morrison, Julie M. Koeman, Benjamin K. Johnson, Kelly K. Foy, Ian Beddows, Wanding Zhou, David W. Chesla, Larissa L. Rossell, Emily J. Siegwald, Marie Adams and Hui Shen

    Citation: Epigenetics & Chromatin 2021 14:28

    Content type: Research

    Published on:

  23. A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural ...

    Authors: Richard C. Chang, Kara N. Thomas, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell and Michael C. Golding

    Citation: Epigenetics & Chromatin 2021 14:27

    Content type: Research

    Published on:

  25. DNA methylation is an epigenetic chromatin mark that allows heterochromatin formation and gene silencing. It has a fundamental role in preserving genome stability (including chromosome stability) by controllin...

    Authors: Xena Giada Pappalardo and Viviana Barra

    Citation: Epigenetics & Chromatin 2021 14:25

    Content type: Review

    Published on:

  26. During epididymal transit, spermatozoa go through several functional maturation steps, resulting from interactions with epididymal secretomes specific to each region. In particular, the sperm membrane is under...

    Authors: Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Chrystelle Le Danvic, Benoît Guyonnet, Hélène Kiefer, Hélène Jammes and Laurent Schibler

    Citation: Epigenetics & Chromatin 2021 14:24

    Content type: Research

    Published on:

  27. Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of t...

    Authors: Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee, Daniel J. Fernandez, Rachel Abrahamson, Alessandra Castaldi, Zea Borok, Brian D. Dynlacht and Woojin An

    Citation: Epigenetics & Chromatin 2021 14:23

    Content type: Research

    Published on:

  28. Selective gene silencing is key to development. It is generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate...

    Authors: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet and F. Malagnac

    Citation: Epigenetics & Chromatin 2021 14:22

    Content type: Research

    Published on:

  29. DNA methylation is an important epigenetic control mechanism that in many fungi is restricted to genomic regions containing transposable elements (TEs). Two DNA methyltransferases, Dim2 and Dnmt5, are known to...

    Authors: H. Martin Kramer, David E. Cook, Grardy C. M. van den Berg, Michael F. Seidl and Bart P. H. J. Thomma

    Citation: Epigenetics & Chromatin 2021 14:21

    Content type: Research

    Published on:

  30. ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its bin...

    Authors: Xinyang Yu, Prashant K. Singh, Shamira Tabrejee, Satrajit Sinha and Michael J. Buck

    Citation: Epigenetics & Chromatin 2021 14:20

    Content type: Research

    Published on:

  31. The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and...

    Authors: Jessica Connacher, Gabrielle A. Josling, Lindsey M. Orchard, Janette Reader, Manuel Llinás and Lyn-Marié Birkholtz

    Citation: Epigenetics & Chromatin 2021 14:19

    Content type: Research

    Published on:

  32. Maternal protein restriction diet (PRD) increases the risk of metabolic dysfunction in adulthood, the mechanisms during the early life of offspring are still poorly understood. Apart from genetic factors, epig...

    Authors: Yinyu Wang, Yiting Mao, Yiran Zhao, Xianfu Yi, Guolian Ding, Chuanjin Yu, Jianzhong Sheng, Xinmei Liu, Yicong Meng and Hefeng Huang

    Citation: Epigenetics & Chromatin 2021 14:18

    Content type: Research

    Published on:

  33. Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by subletha...

    Authors: Annika R. Seddon, Yusmiati Liau, Paul E. Pace, Allison L. Miller, Andrew B. Das, Martin A. Kennedy, Mark B. Hampton and Aaron J. Stevens

    Citation: Epigenetics & Chromatin 2021 14:17

    Content type: Research

    Published on:

  34. Pita is required for Drosophila development and binds specifically to a long motif in active promoters and insulators. Pita belongs to the Drosophila family of zinc-finger architectural proteins, which also in...

    Authors: Marat Sabirov, Olga Kyrchanova, Galina V. Pokholkova, Artem Bonchuk, Natalia Klimenko, Elena Belova, Igor F. Zhimulev, Oksana Maksimenko and Pavel Georgiev

    Citation: Epigenetics & Chromatin 2021 14:16

    Content type: Research

    Published on:

  35. The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which re...

    Authors: Maria Gridina, Evgeniy Mozheiko, Emil Valeev, Ludmila P. Nazarenko, Maria E. Lopatkina, Zhanna G. Markova, Maria I. Yablonskaya, Viktoria Yu Voinova, Nadezhda V. Shilova, Igor N. Lebedev and Veniamin Fishman

    Citation: Epigenetics & Chromatin 2021 14:15

    Content type: Methodology

    Published on:

  37. Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methy...

    Authors: Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu and Janine M. LaSalle

    Citation: Epigenetics & Chromatin 2021 14:13

    Content type: Research

    Published on:

  38. X-chromosome inactivation (XCI) in eutherian mammals is the epigenetic inactivation of one of the two X chromosomes in XX females in order to compensate for dosage differences with XY males. Not all genes are ...

    Authors: Bradley P. Balaton, Oriol Fornes, Wyeth W. Wasserman and Carolyn J. Brown

    Citation: Epigenetics & Chromatin 2021 14:12

    Content type: Research

    Published on:

  39. In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determinat...

    Authors: Reza Raeisossadati, Merari F. R. Ferrari, Alexandre Hiroaki Kihara, Issam AlDiri and Jeffrey M. Gross

    Citation: Epigenetics & Chromatin 2021 14:11

    Content type: Review

    Published on:

  40. Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histo...

    Authors: Kun Li and Ziqiang Wang

    Citation: Epigenetics & Chromatin 2021 14:10

    Content type: Review

    Published on:

  41. The mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vita...

    Authors: Lawrence T. C. Ong, Stephen D. Schibeci, Nicole L. Fewings, David R. Booth and Grant P. Parnell

    Citation: Epigenetics & Chromatin 2021 14:9

    Content type: Research

    Published on:

  42. Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood. In this study, we identifi...

    Authors: Martina Weigt, Qingsong Gao, Hyoju Ban, Haijin He, Guido Mastrobuoni, Stefan Kempa, Wei Chen and Fei Li

    Citation: Epigenetics & Chromatin 2021 14:8

    Content type: Research

    Published on:

  43. Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share...

    Authors: Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche Jr., Carrie R. Graveel and Matthew R. Steensma

    Citation: Epigenetics & Chromatin 2021 14:7

    Content type: Research

    Published on:

  44. Environmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheri...

    Authors: Daniel Beck, Millissia Ben Maamar and Michael K. Skinner

    Citation: Epigenetics & Chromatin 2021 14:6

    Content type: Research

    Published on:

  45. The vast majority of methods available to characterize genome-wide chromatin structure exploit differences in DNA accessibility to nucleases or chemical crosslinking. We developed a novel method to gauge genom...

    Authors: Luke T. Marr, Josefina Ocampo, David J. Clark and Jeffrey J. Hayes

    Citation: Epigenetics & Chromatin 2021 14:5

    Content type: Research

    Published on:

  46. Patterns of methylation influence lifespan, but methylation and lifespan may also depend on diet, or differ between genotypes. Prior to this study, interactions between diet and genotype have not been explored...

    Authors: Jack Hearn, Fiona Plenderleith and Tom J. Little

    Citation: Epigenetics & Chromatin 2021 14:4

    Content type: Research

    Published on:

  47. H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the e...

    Authors: Vasantha Shalini, Utsa Bhaduri, Anjhana C. Ravikkumar, Anusha Rengarajan and Rao M. R. Satyanarayana

    Citation: Epigenetics & Chromatin 2021 14:3

    Content type: Research

    Published on:

  48. Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are...

    Authors: Eric W. Martin, Jana Krietsch, Roman E. Reggiardo, Rebekah Sousae, Daniel H. Kim and E. Camilla Forsberg

    Citation: Epigenetics & Chromatin 2021 14:2

    Content type: Research

    Published on:

  49. DNA methylation has emerged as an important epigenetic regulator of brain processes, including circadian rhythms. However, how DNA methylation intervenes between environmental signals, such as light entrainmen...

    Authors: Federico Tinarelli, Elena Ivanova, Ilaria Colombi, Erica Barini, Edoardo Balzani, Celina Garcia Garcia, Laura Gasparini, Michela Chiappalone, Gavin Kelsey and Valter Tucci

    Citation: Epigenetics & Chromatin 2021 14:1

    Content type: Research

    Published on:

  50. Environmental impacts on a fetus can disrupt germ cell development leading to epimutations in mature germ cells. Paternal inheritance of adverse health effects through sperm epigenomes, including DNA methylome...

    Authors: Keiko Nohara, Kazuhiko Nakabayashi, Kazuyuki Okamura, Takehiro Suzuki, Shigekatsu Suzuki and Kenichiro Hata

    Citation: Epigenetics & Chromatin 2020 13:53

    Content type: Research

    Published on:

Submit manuscript

Follow

Annual Journal Metrics

Epigenetics & Chromatin

ISSN: 1756-8935