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  1. Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid even in the presence of ample oxygen and provides intermediate metabolites to support ca...

    Authors: Srinivasu Karri, Quinn Dickinson, Jing Jia, Yi Yang, Haiyun Gan, Zhiquan Wang, Yibin Deng and Chuanhe Yu
    Citation: Epigenetics & Chromatin 2024 17:27
    Content type: Research Published on:

  3. While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the tissue-specificity of age-related DNAm changes remains an active area of research. Studie...

    Authors: Niyati Jain, James L. Li, Lin Tong, Farzana Jasmine, Muhammad G. Kibriya, Kathryn Demanelis, Meritxell Oliva, Lin S. Chen and Brandon L. Pierce
    Citation: Epigenetics & Chromatin 2024 17:25
    Content type: Research Published on:

  4. Diesel exhaust particles (DEP), which contain hazardous compounds, are emitted during the combustion of diesel. As approximately one-third of the vehicles worldwide use diesel, there are growing concerns about...

    Authors: Alexandra Lukyanchuk, Naomi Muraki, Tomoko Kawai, Takehiro Sato, Kenichiro Hata, Tsuyoshi Ito and Atsushi Tajima
    Citation: Epigenetics & Chromatin 2024 17:24
    Content type: Research Published on:

  6. Regenerative potential is governed by a complex process of transcriptional reprogramming, involving chromatin reorganization and dynamics in transcription factor binding patterns throughout the genome. The deg...

    Authors: Phu Duong, Anjelica Rodriguez-Parks, Junsu Kang and Patrick J. Murphy
    Citation: Epigenetics & Chromatin 2024 17:22
    Content type: Methodology Published on:

  7. Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse functions and respond to external stimuli. Understanding CREs is essential for personalized med...

    Authors: Chris Hartl, Jiali Zhuang, Aaron Tyler, Bing Zhou, Emily Wong, David Merberg, Brad Farrell, Chris DeBoever, Julie Bryant and Dorothée Diogo
    Citation: Epigenetics & Chromatin 2024 17:21
    Content type: Methodology Published on:

  8. Paternal allele-specific DNA methylation of the imprinting control region (H19 ICR) controls genomic imprinting at the Igf2/H19 locus. We previously demonstrated that the mouse H19 ICR transgene acquires imprinte...

    Authors: Hitomi Matsuzaki, Minami Kimura, Mizuki Morihashi and Keiji Tanimoto
    Citation: Epigenetics & Chromatin 2024 17:20
    Content type: Research Published on:

  9. Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would otherwise be impossible. The challenging nature of certain nuclear pro...

    Authors: Minh Bui, Songjoon Baek, Reda S. Bentahar, Daniël P. Melters and Yamini Dalal
    Citation: Epigenetics & Chromatin 2024 17:19
    Content type: Research Published on:

  10. The three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularly in the human brain. This review explores the intricacies of chromatin organization, h...

    Authors: Diana Zagirova, Anna Kononkova, Nikita Vaulin and Ekaterina Khrameeva
    Citation: Epigenetics & Chromatin 2024 17:18
    Content type: Review Published on:

  11. Insulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. While the involvement of several IBPs in organising chromatin architecture in Drosophila h...

    Authors: Nadezhda E. Vorobyeva, Alexey N. Krasnov, Maksim Erokhin, Darya Chetverina and Marina Mazina
    Citation: Epigenetics & Chromatin 2024 17:17
    Content type: Research Published on:

  13. UHRF1 as a member of RING-finger type E3 ubiquitin ligases family, is an epigenetic regulator with five structural domains. It has been involved in the regulation of a series of biological functions, such as D...

    Authors: Lili Gu, Yongming Fu and Xiong Li
    Citation: Epigenetics & Chromatin 2024 17:15
    Content type: Review Published on:

  14. Prenatal nicotine exposure (PNE) has been documented to cause numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cells are still not well u...

    Authors: Ouzna Dali, Jose Antonio Muriel-Muriel, Ana Vargas-Baco, Sergei Tevosian, Jasenka Zubcevic, Fatima Smagulova and Linda F. Hayward
    Citation: Epigenetics & Chromatin 2024 17:14
    Content type: Methodology Published on:

  15. Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, espe...

    Authors: Alexander Y. Afanasyev, Yoonjin Kim, Igor S. Tolokh, Igor V. Sharakhov and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2024 17:13
    Content type: Research Published on:

  16. Regulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for the treatment of obesity and diabetes. Our preliminary analyses of RNA...

    Authors: Bethany C. Taylor, Loic H. Steinthal, Michelle Dias, Hari Krishna Yalamanchili, Scott A. Ochsner, Gladys E. Zapata, Nitesh R. Mehta, Neil J. McKenna, Nicolas L. Young and Alli M. Nuotio-Antar
    Citation: Epigenetics & Chromatin 2024 17:12
    Content type: Research Published on:

  17. In mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryonic cells upon induction by the surrounding tissues during gastrulation, according to mec...

    Authors: Clémence Kress, Luc Jouneau and Bertrand Pain
    Citation: Epigenetics & Chromatin 2024 17:11
    Content type: Research Published on:

  18. Nuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “closed” chromatin compartments, topologically associated domains (TADs) and chromatin loops. The DNA- and ...

    Authors: Michael Camerino, William Chang and Ales Cvekl
    Citation: Epigenetics & Chromatin 2024 17:10
    Content type: Research Published on:

  19. CTCF is highly likely to be the ancestor of proteins that contain large clusters of C2H2 zinc finger domains, and its conservation is observed across most bilaterian organisms. In mammals, CTCF is the primary ...

    Authors: Sofia Kamalyan, Olga Kyrchanova, Natalia Klimenko, Valentin Babosha, Yulia Vasileva, Elena Belova, Dariya Fursenko, Oksana Maksimenko and Pavel Georgiev
    Citation: Epigenetics & Chromatin 2024 17:9
    Content type: Research Published on:

  20. Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through histone modifications and chromatin organisation, but exactly how these factors relate t...

    Authors: Stefan A. Koestler, Madeleine L. Ball, Leila Muresan, Vineet Dinakaran and Robert White
    Citation: Epigenetics & Chromatin 2024 17:8
    Content type: Research Published on:

  21. Fusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘bakanae’ or stunting, most likely due to the production of various natural products (NPs) during infection. Fusaria have the gene...

    Authors: Anna K. Atanasoff-Kardjalieff, Harald Berger, Katharina Steinert, Slavica Janevska, Nadia Ponts, Hans-Ulrich Humpf, Svetlana Kalinina and Lena Studt-Reinhold
    Citation: Epigenetics & Chromatin 2024 17:7
    Content type: Research Published on:

  22. Prostate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high rate of large genomic rearrangements are often observed in PRAD.

    Authors: R. Sultanov, A. Mulyukina, O. Zubkova, A. Fedoseeva, A. Bogomazova, K. Klimina, A. Larin, T. Zatsepin, T. Prikazchikova, M. Lukina, M. Bogomiakova, E. Sharova, E. Generozov, M. Lagarkova and G. Arapidi
    Citation: Epigenetics & Chromatin 2024 17:6
    Content type: Research Published on:

  24. In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an ATP-dependent chromatin remodeling complex whose mutations are associat...

    Authors: Kexuan Li, Baocai Wang and Haolin Hu
    Citation: Epigenetics & Chromatin 2024 17:4
    Content type: Review Published on:

  25. Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-associated H3K27me3 histone modifications on opposite tails of the same nucleosome occur...

    Authors: Janith A. Seneviratne, William W. H. Ho, Eleanor Glancy and Melanie A. Eckersley-Maslin
    Citation: Epigenetics & Chromatin 2024 17:3
    Content type: Methodology Published on:

  26. Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal an...

    Authors: Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles and Gregory David
    Citation: Epigenetics & Chromatin 2024 17:2
    Content type: Research Published on:

  27. The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inacti...

    Authors: Sombodhi Bhattacharya, Debasmita Sadhukhan and Radha Saraswathy
    Citation: Epigenetics & Chromatin 2024 17:1
    Content type: Review Published on:

  28. Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tube to close during early embryogenesis. Maternal folate deficiency could impact the occu...

    Authors: Xue Li, Pei Pei, Jinying Shen, Juan Yu, Fang Wang, Lei Wang, Changyun Liu and Shan Wang
    Citation: Epigenetics & Chromatin 2023 16:50
    Content type: Research Published on:

  29. Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function witho...

    Authors: Thomas Dupas, Benjamin Lauzier and Serge McGraw
    Citation: Epigenetics & Chromatin 2023 16:49
    Content type: Review Published on:

  30. This study presents a novel approach for mapping global chromatin interactions using S1 nuclease, a sequence-agnostic enzyme. We develop and outline a protocol that leverages S1 nuclease's ability to effective...

    Authors: Gridina Maria, Popov Andrey, Shadskiy Artem, Torgunakov Nikita, Kechin Andrey, Khrapov Evgeny, Ryzhkova Oxana, Filipenko Maxim and Fishman Veniamin
    Citation: Epigenetics & Chromatin 2023 16:48
    Content type: Research Published on:

  31. Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) is known to be involved in the deposition of the di- and tri-methyl marks on H3K9 (H3K9m...

    Authors: Hanshen Luo, Xingliang Wu, Xue-Hai Zhu, Xin Yi, Dunfeng Du and Ding-Sheng Jiang
    Citation: Epigenetics & Chromatin 2023 16:47
    Content type: Review Published on:

  32. Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessible consumes energy, and compaction of chromatin preserves energy. Alteration of chroma...

    Authors: Tamaki Suganuma and Jerry L. Workman
    Citation: Epigenetics & Chromatin 2023 16:46
    Content type: Review Published on:

  33. Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate and characterize the epigenomes of specific ...

    Authors: Kyla B. Tooley, Ana J. Chucair-Elliott, Sarah R. Ocañas, Adeline H. Machalinski, Kevin D. Pham, Walker Hoolehan, Adam M. Kulpa, David R. Stanford and Willard M. Freeman
    Citation: Epigenetics & Chromatin 2023 16:45
    Content type: Research Published on:

  35. During early mammalian development, DNA methylation undergoes two waves of reprogramming, enabling transitions between somatic cells, oocyte and embryo. The first wave of de novo DNA methylation establishment ...

    Authors: Lirik Behluli, Alyssa M. Fontanilla, Laura Andessner-Angleitner, Nikolas Tolar, Julia M. Molina and Lenka Gahurova
    Citation: Epigenetics & Chromatin 2023 16:43
    Content type: Research Published on:

  36. Cell–cell communication is mediated by membrane receptors and their ligands, such as the Eph/ephrin system, orchestrating cell migration during development and in diverse cancer types. Epigenetic mechanisms ar...

    Authors: Can Bora Yildiz, Tathagata Kundu, Julia Gehrmann, Jannis Koesling, Amin Ravaei, Philip Wolff, Florian Kraft, Tiago Maié, Mira Jakovcevski, Daniel Pensold, Olav Zimmermann, Giulia Rossetti, Ivan G. Costa and Geraldine Zimmer-Bensch
    Citation: Epigenetics & Chromatin 2023 16:42
    Content type: Research Published on:

  37. Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can l...

    Authors: Nivethika Rajaram, Alexandra G. Kouroukli, Susanne Bens, Pavel Bashtrykov and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2023 16:41
    Content type: Methodology Published on:

  38. Classical studies on position effect variegation in Drosophila have demonstrated the existence of bi-modal Active/Silent state of the genes juxtaposed to heterochromatin. Later studies with irreversible methods f...

    Authors: Safia Mahabub Sauty and Krassimir Yankulov
    Citation: Epigenetics & Chromatin 2023 16:40
    Content type: Research Published on:

  39. Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling pro...

    Authors: Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez and Miguel R. Branco
    Citation: Epigenetics & Chromatin 2023 16:39
    Content type: Research Published on:

  41. Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina Infinium Methylation bead arrays is often used to explore the connections between in utero exposures, placental pathology, and fetal ...

    Authors: A. Khan, A. M. Inkster, M. S. Peñaherrera, S. King, S. Kildea, T. F. Oberlander, D. M. Olson, C. Vaillancourt, U. Brain, E. O. Beraldo, A. G. Beristain, V. L. Clifton, G. F. Del Gobbo, W. L. Lam, G. A. S. Metz, J. W. Y. Ng…
    Citation: Epigenetics & Chromatin 2023 16:37
    Content type: Research Published on:

  42. NPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to NPM1, probably through interaction with other nuclear factors. DOT1L is one interaction ...

    Authors: Annalisa Izzo, Ipek Akol, Alejandro Villarreal, Shannon Lebel, Marta Garcia-Miralles, Arquimedes Cheffer, Patrick Bovio, Stefanie Heidrich and Tanja Vogel
    Citation: Epigenetics & Chromatin 2023 16:36
    Content type: Research Published on:

  43. Blood-based tests have public appeal in screening cancers due to their minimally invasive nature, ability to integrate with other routine blood tests, and high compliance. This study aimed to investigate wheth...

    Authors: Jia-Yi Hou, Ning Li, Jie Wang, Li-Juan Gao, Jia-Song Chang and Ji-Min Cao
    Citation: Epigenetics & Chromatin 2023 16:35
    Content type: Research Published on:

  44. Despite well-documented effects on human health, the action modes of environmental pollutants are incompletely understood. Although transcriptome-based approaches are widely used to predict associations betwee...

    Authors: Zhaonan Zou, Yuka Yoshimura, Yoshihiro Yamanishi and Shinya Oki
    Citation: Epigenetics & Chromatin 2023 16:34
    Content type: Methodology Published on:

  45. Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation and fragmentation profiles. Nevertheless, simultaneously detecting bo...

    Authors: Jun Wang, Yanqin Niu, Ming Yang, Lirong Shu, Hongxian Wang, Xiaoqian Wu, Yaqin He, Peng Chen, Guocheng Zhong, Zhixiong Tang, Shasha Zhang, Qianwen Guo, Yun Wang, Li Yu and Deming Gou
    Citation: Epigenetics & Chromatin 2023 16:33
    Content type: Research Published on:

  46. Cardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emerging as key players in this intricate process. Among these modifications, N6-methyladenosi...

    Authors: Xue-Hong Liu, Zhun Liu, Ze-Hui Ren, Hong-Xuan Chen, Ying Zhang, Zhang Zhang, Nan Cao and Guan-Zheng Luo
    Citation: Epigenetics & Chromatin 2023 16:32
    Content type: Research Published on:

  47. DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we identified a neural-related DNA hypermethylation fingerprint in colon ca...

    Authors: Musa Idris, Louis Coussement, Maria M. Alves, Tim De Meyer and Veerle Melotte
    Citation: Epigenetics & Chromatin 2023 16:31
    Content type: Research Published on:

  48. Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular ...

    Authors: Ranjan Kumar Maji, Beate Czepukojc, Michael Scherer, Sascha Tierling, Cristina Cadenas, Kathrin Gianmoena, Nina Gasparoni, Karl Nordström, Gilles Gasparoni, Stephan Laggai, Xinyi Yang, Anupam Sinha, Peter Ebert, Maren Falk-Paulsen, Sarah Kinkley, Jessica Hoppstädter…
    Citation: Epigenetics & Chromatin 2023 16:30
    Content type: Research Published on:

  50. The function of DNA methyltransferase genes of insects is a puzzle, because an association between gene expression and methylation is not universal for insects. If the genes normally involved in cytosine methy...

    Authors: Christopher B. Cunningham, Emily A. Shelby, Elizabeth C. McKinney, Robert J. Schmitz, Allen J. Moore and Patricia J. Moore
    Citation: Epigenetics & Chromatin 2023 16:28
    Content type: Research Published on:
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Epigenetics & Chromatin

ISSN: 1756-8935