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  1. Content type: Research

    Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes ...

    Authors: Eriko Oya, Mickaël Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli and Karl Ekwall

    Citation: Epigenetics & Chromatin 2019 12:45

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  2. Content type: Research

    Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream eff...

    Authors: Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann and Dustin E. Schones

    Citation: Epigenetics & Chromatin 2019 12:44

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  3. Content type: Research

    While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. DNA methyltransferases and ten-eleven t...

    Authors: Candace J. Poole, Atul Lodh, Jeong-Hyeon Choi and Jan van Riggelen

    Citation: Epigenetics & Chromatin 2019 12:41

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  4. Content type: Research

    In animals, H3K4me2 and H3K4me3 are enriched at the transcription start site (TSS) and function as epigenetic marks that regulate gene transcription, but their functions in plants have not been fully character...

    Authors: Yuhao Liu, Kunpeng Liu, Liufan Yin, Yu Yu, Ji Qi, Wen-Hui Shen, Jun Zhu, Yijing Zhang and Aiwu Dong

    Citation: Epigenetics & Chromatin 2019 12:40

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  5. Content type: Research

    Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene tra...

    Authors: P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes and P. Grandi

    Citation: Epigenetics & Chromatin 2019 12:39

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  6. Content type: Research

    In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a gen...

    Authors: Anna Mallol, Maria Guirola and Bernhard Payer

    Citation: Epigenetics & Chromatin 2019 12:38

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  7. Content type: Review

    The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer...

    Authors: Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake and Tilman Borggrefe

    Citation: Epigenetics & Chromatin 2019 12:37

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  8. Content type: Methodology

    DamID, in which a protein of interest is fused to Dam methylase, enables mapping of protein-DNA binding through readout of adenine methylation in genomic DNA. DamID offers a compelling alternative to chromati...

    Authors: Tomasz Szczesnik, Joshua W. K. Ho and Richard Sherwood

    Citation: Epigenetics & Chromatin 2019 12:36

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  9. Content type: Research

    Laryngeal squamous cell carcinoma (LSCC) is among the most common malignant tumors with poor prognosis. Accumulating evidences have identified the important roles of long noncoding RNAs (lncRNAs) in the initia...

    Authors: Baoshan Wang, Lei Zhao, Weiwei Chi, Huan Cao, Weina Cui and Wenxia Meng

    Citation: Epigenetics & Chromatin 2019 12:35

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  10. Content type: Research

    Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epig...

    Authors: Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans and Menno P. J. de Winther

    Citation: Epigenetics & Chromatin 2019 12:34

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  11. Content type: Research

    Both tissue-specific and ubiquitously expressed transcription factors, such as Sp-family members, are required for correct development. However, the molecular details of how ubiquitous factors are involved in ...

    Authors: Jane Gilmour, Leigh O’Connor, Christopher P. Middleton, Peter Keane, Nynke Gillemans, Jean-Baptiste Cazier, Sjaak Philipsen and Constanze Bonifer

    Citation: Epigenetics & Chromatin 2019 12:33

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  12. Content type: Research

    TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phospho...

    Authors: Ting Zhang, Xiaowen Guan, Un Lam Choi, Qiang Dong, Melody M. T. Lam, Jianming Zeng, Jun Xiong, Xianju Wang, Terence C. W. Poon, Hongjie Zhang, Xuanjun Zhang, Hailin Wang, Ruiyu Xie, Bing Zhu and Gang Li

    Citation: Epigenetics & Chromatin 2019 12:32

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  13. Content type: Research

    Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a...

    Authors: Louis Legoff, Ouzna Dali, Shereen Cynthia D’Cruz, Antonio Suglia, Aurore Gely-Pernot, Chloé Hémery, Pierre-Yves Kernanec, Abbassia Demmouche, Christine Kervarrec, Sergei Tevosian, Luc Multigner and Fatima Smagulova

    Citation: Epigenetics & Chromatin 2019 12:29

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  14. Content type: Research

    Localized functional domains within chromosomes, known as topologically associating domains (TADs), have been recently highlighted. In Drosophila, TADs are biochemically defined by epigenetic marks, this suggesti...

    Authors: Antony Lesage, Vincent Dahirel, Jean-Marc Victor and Maria Barbi

    Citation: Epigenetics & Chromatin 2019 12:28

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  15. Content type: Research

    Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding tran...

    Authors: Yilin Zhao, Deyou Zheng and Ales Cvekl

    Citation: Epigenetics & Chromatin 2019 12:27

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  16. Content type: Research

    Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multipl...

    Authors: Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham and David J. Segal

    Citation: Epigenetics & Chromatin 2019 12:26

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  17. Content type: Research

    MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates wit...

    Authors: Yonghwan Shin, Nikhil B. Ghate, Byoungsan Moon, Kyungpyo Park, Wange Lu and Woojin An

    Citation: Epigenetics & Chromatin 2019 12:25

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  18. Content type: Research

    Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive. In this ...

    Authors: Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura and Eishi Noguchi

    Citation: Epigenetics & Chromatin 2019 12:24

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  19. Content type: Research

    Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV...

    Authors: Chuan Li, Guillaume Mousseau and Susana T. Valente

    Citation: Epigenetics & Chromatin 2019 12:23

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  20. Content type: Research

    Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principa...

    Authors: Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue and Tony Kouzarides

    Citation: Epigenetics & Chromatin 2019 12:21

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  21. Content type: Research

    Positioning of nucleosomes along DNA is an integral regulator of chromatin accessibility and gene expression in diverse cell types. However, the precise nature of how histone demethylases including the histone...

    Authors: Jiji T. Kurup, Ion J. Campeanu and Benjamin L. Kidder

    Citation: Epigenetics & Chromatin 2019 12:20

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  22. Content type: Review

    The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation. In the course of evolution from yeast to mammals, the BAF...

    Authors: Amelie Alfert, Natalia Moreno and Kornelius Kerl

    Citation: Epigenetics & Chromatin 2019 12:19

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  23. Content type: Research

    The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of these heterochromatin blocks have been studied, but...

    Authors: Kathrin S. Heinz, Alexander Rapp, Corella S. Casas-Delucchi, Anne Lehmkuhl, Ismael Romero-Fernández, Antonio Sánchez, Oliver H. Krämer, J. Alberto Marchal and M. Cristina Cardoso

    Citation: Epigenetics & Chromatin 2019 12:18

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  24. Content type: Research

    Epigenetic modifications have a central role in transcriptional regulation. While several studies using next-generation sequencing have revealed genome-wide associations between epigenetic modifications and tr...

    Authors: Hiroto S. Fukushima, Hiroyuki Takeda and Ryohei Nakamura

    Citation: Epigenetics & Chromatin 2019 12:17

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  25. Content type: Research

    The assay for transposase-accessible chromatin (ATAC-seq) is a powerful method to examine chromatin accessibility. While many studies have reported a positive correlation between gene expression and promoter a...

    Authors: Rebekah R. Starks, Anilisa Biswas, Ashish Jain and Geetu Tuteja

    Citation: Epigenetics & Chromatin 2019 12:16

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  26. Content type: Research

    Recently, we showed that PARP1 is involved in cotranscriptional splicing, possibly by bridging chromatin to RNA and recruiting splicing factors. It also can influence alternative splicing decisions through the...

    Authors: Elena A. Matveeva, Qamar M. H. Al-Tinawi, Eric C. Rouchka and Yvonne N. Fondufe-Mittendorf

    Citation: Epigenetics & Chromatin 2019 12:15

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  27. Content type: Research

    Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted gen...

    Authors: René A. M. Dirks, Guido van Mierlo, Hindrik H. D. Kerstens, Andreia S. Bernardo, Julianna Kobolák, István Bock, Julien Maruotti, Roger A. Pedersen, András Dinnyés, Martijn A. Huynen, Alice Jouneau and Hendrik Marks

    Citation: Epigenetics & Chromatin 2019 12:14

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  28. Content type: Research

    DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding th...

    Authors: Jianlin He, Xiguang Xu, Aboozar Monavarfeshani, Sharmi Banerjee, Michael A. Fox and Hehuang Xie

    Citation: Epigenetics & Chromatin 2019 12:13

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  29. Content type: Research

    ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-cod...

    Authors: Katherine A. Giles, Cathryn M. Gould, Qian Du, Ksenia Skvortsova, Jenny Z. Song, Madhavi P. Maddugoda, Joanna Achinger-Kawecka, Clare Stirzaker, Susan J. Clark and Phillippa C. Taberlay

    Citation: Epigenetics & Chromatin 2019 12:12

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  30. Content type: Research

    Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer propagation. It can be orchestrated by the activation of multiple signaling pathways, which have been found to be highly coordinated wi...

    Authors: Congcong Lu, Simone Sidoli, Katarzyna Kulej, Karen Ross, Cathy H. Wu and Benjamin A. Garcia

    Citation: Epigenetics & Chromatin 2019 12:11

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  31. Content type: Research

    Wilson disease (WD) is an autosomal recessive disease caused by mutations in ATP7B encoding a copper transporter. Consequent copper accumulation results in a variable WD clinical phenotype involving hepatic, neur...

    Authors: Charles E. Mordaunt, Dorothy A. Kieffer, Noreene M. Shibata, Anna Członkowska, Tomasz Litwin, Karl-Heinz Weiss, Yihui Zhu, Christopher L. Bowlus, Souvik Sarkar, Stewart Cooper, Yu-Jui Yvonne Wan, Mohamed R. Ali, Janine M. LaSalle and Valentina Medici

    Citation: Epigenetics & Chromatin 2019 12:10

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  32. Content type: Research

    Although clinical data support an association between paternal alcohol use and deficits in child neurocognitive development, the relationship between paternal drinking and alcohol-induced growth phenotypes rem...

    Authors: Richard C. Chang, Haiqing Wang, Yudhishtar Bedi and Michael C. Golding

    Citation: Epigenetics & Chromatin 2019 12:9

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  33. Content type: Research

    The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57kip2 expression is finely regulated by several epigene...

    Authors: Oriella Andresini, Marianna Nicoletta Rossi, Francesca Matteini, Stefano Petrai, Tiziana Santini and Rossella Maione

    Citation: Epigenetics & Chromatin 2019 12:8

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  34. Content type: Review

    Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying change in the underlying genomic sequence. A number of studies in animal models have shown that dy...

    Authors: Bridget E. Collins, Celeste B. Greer, Benjamin C. Coleman and J. David Sweatt

    Citation: Epigenetics & Chromatin 2019 12:7

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  35. Content type: Research

    Infection by the human malaria parasite leads to important changes in mosquito phenotypic traits related to vector competence. However, we still lack a clear understanding of the underlying mechanisms and, in ...

    Authors: José L. Ruiz, Rakiswendé S. Yerbanga, Thierry Lefèvre, Jean B. Ouedraogo, Victor G. Corces and Elena Gómez-Díaz

    Citation: Epigenetics & Chromatin 2019 12:5

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  36. Content type: Research

    Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression. More recently, an oxidized form of 5-mC, 5-hydroxymethylcytos...

    Authors: Sara Wernig-Zorc, Mukesh Pratap Yadav, Pradeep Kumar Kopparapu, Mats Bemark, Hallgerdur Lind Kristjansdottir, Per-Ola Andersson, Chandrasekhar Kanduri and Meena Kanduri

    Citation: Epigenetics & Chromatin 2019 12:4

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  37. Content type: Research

    The 5 hydroxymethylation (5hmC) mark and TET DNA dioxygenases play a pivotal role in embryonic stem cell differentiation and animal development. However, very little is known about TET enzymes in lineage deter...

    Authors: Dimitrios Cakouros, Sarah Hemming, Kahlia Gronthos, Renjing Liu, Andrew Zannettino, Songtao Shi and Stan Gronthos

    Citation: Epigenetics & Chromatin 2019 12:3

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  38. Content type: Research

    Boundaries in the Drosophila bithorax complex delimit autonomous regulatory domains that activate the parasegment (PS)-specific expression of homeotic genes. The Fab-7 boundary separates the iab-6 and iab-7 regul...

    Authors: Anna Fedotova, Chaevia Clendinen, Artem Bonchuk, Vladic Mogila, Tsutomu Aoki, Pavel Georgiev and Paul Schedl

    Citation: Epigenetics & Chromatin 2019 12:2

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  39. Content type: Research

    The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, char...

    Authors: Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce and Michael S. Kobor

    Citation: Epigenetics & Chromatin 2019 12:1

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  40. Content type: Research

    5-Hydroxymethylcytosine (5hmC) is an oxidation product of 5-methylcytosine (5mC), and adjacent CpG sites in mammalian genome can be co-methylated and co-hydroxymethylated due to the processivity of DNMT and TE...

    Authors: Qin Ma, Zhengzheng Xu, Huan Lu, Ziying Xu, Yuanyuan Zhou, Bifeng Yuan and Weimin Ci

    Citation: Epigenetics & Chromatin 2018 11:75

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  41. Content type: Methodology

    Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. ...

    Authors: Derek H. Janssens, Steven J. Wu, Jay F. Sarthy, Michael P. Meers, Carrie H. Myers, James M. Olson, Kami Ahmad and Steven Henikoff

    Citation: Epigenetics & Chromatin 2018 11:74

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  42. Content type: Review

    Age reprogramming represents a novel method for generating patient-specific tissues for transplantation. It bypasses the de-differentiation/redifferentiation cycle that is characteristic of the induced pluripo...

    Authors: Prim B. Singh and Andrew G. Newman

    Citation: Epigenetics & Chromatin 2018 11:73

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  43. Content type: Research

    Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3). KDM5C is expressed...

    Authors: Youni Kim, Youngeun Jeong, Kujin Kwon, Tayaba Ismail, Hyun-Kyung Lee, Chowon Kim, Jeen-Woo Park, Oh-Shin Kwon, Beom-Sik Kang, Dong-Seok Lee, Tae Joo Park, Taejoon Kwon and Hyun-Shik Lee

    Citation: Epigenetics & Chromatin 2018 11:72

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  44. Content type: Research

    Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resultin...

    Authors: Weipeng Mu, Joshua Starmer, Della Yee and Terry Magnuson

    Citation: Epigenetics & Chromatin 2018 11:71

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