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  1. The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation i...

    Authors: Ya-Hui Chi, Wan-Ping Wang, Ming-Chun Hung, Gunn-Guang Liou, Jing-Ya Wang and Pen-Hsiu Grace Chao
    Citation: Epigenetics & Chromatin 2022 15:1
    Content type: Research Published on:

  2. Directed differentiation of mouse embryonic stem cells (mESCs) or induced pluripotent stem cells (iPSCs) provides powerful models to dissect the molecular mechanisms leading to the formation of specific cell l...

    Authors: Claudia Baumann, Xiangyu Zhang, Ling Zhu, Yuhong Fan and Rabindranath De La Fuente
    Citation: Epigenetics & Chromatin 2021 14:58
    Content type: Research Published on:

  3. Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently, lactylation has been reported as a novel ...

    Authors: Wanting Yang, Peijun Wang, Pengbo Cao, Shuang Wang, Yuxiao Yang, Huimin Su and Buhe Nashun
    Citation: Epigenetics & Chromatin 2021 14:57
    Content type: Research Published on:

  4. DNA methylation plays an important role in regulating gene expression in mammals. The covalent DNMT1 inhibitors 5-azacytidine and decitabine are widely used in research to reduce DNA methylation levels, but th...

    Authors: Nathalia Azevedo Portilho, Deepak Saini, Ishtiaque Hossain, Jacinthe Sirois, Christopher Moraes and William A. Pastor
    Citation: Epigenetics & Chromatin 2021 14:56
    Content type: Methodology Published on:

  5. Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two paralogous genes, Asf1a and Asf1b exist in mammals, but their role during fertilization and early...

    Authors: Xuemei Wang, Lu Wang, Jie Dou, Tianjiao Yu, Pengbo Cao, Na Fan, Uyunbilig Borjigin and Buhe Nashun
    Citation: Epigenetics & Chromatin 2021 14:55
    Content type: Research Published on:

  6. Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are mo...

    Authors: Chaini Konwar, Rebecca Asiimwe, Amy M. Inkster, Sarah M. Merrill, Gian L. Negri, Maria J. Aristizabal, Christopher F. Rider, Julie L. MacIsaac, Christopher Carlsten and Michael S. Kobor
    Citation: Epigenetics & Chromatin 2021 14:54
    Content type: Research Published on:

  7. Accessible chromatin landscape allows binding of transcription factors, and remodeling of promoter and enhancer elements during development. Chromatin accessibility along with integrated multiomics approaches ...

    Authors: Udayakumar S. Vishnu, Pierre-Olivier Estève, Hang Gyeong Chin and Sriharsa Pradhan
    Citation: Epigenetics & Chromatin 2021 14:53
    Content type: Methodology Published on:

  8. Neural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with NTDs eventually develop lifelong disability, which cause significant morbidity and mortali...

    Authors: Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu, Jun Xu and Jun Xie
    Citation: Epigenetics & Chromatin 2021 14:52
    Content type: Research Published on:

  9. Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here, we characterize the nature of nuclear granules formed by R...

    Authors: Carlos Rivera, Daniel Verbel-Vergara, Duxan Arancibia, Anna Lappala, Marcela González, Fabián Guzmán, Gianluca Merello, Jeannie T. Lee and María Estela Andrés
    Citation: Epigenetics & Chromatin 2021 14:51
    Content type: Research Published on:

  10. The review begins with a concise description of the principles of phase separation. This is followed by a comprehensive section on phase separation of chromatin, in which we recount the 60 years history of chr...

    Authors: Jeffrey C. Hansen, Kazuhiro Maeshima and Michael J. Hendzel
    Citation: Epigenetics & Chromatin 2021 14:50
    Content type: Review Published on:

  11. Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been im...

    Authors: Varsha P. Desai, Jihed Chouaref, Haoyu Wu, William A. Pastor, Ryan L. Kan, Harald M. Oey, Zheng Li, Jamie Ho, Kelly K. D. Vonk, David San Leon Granado, Michael A. Christopher, Amander T. Clark, Steven E. Jacobsen and Lucia Daxinger
    Citation: Epigenetics & Chromatin 2021 14:49
    Content type: Research Published on:

  12. 5-Methylcytosine (5mC) is an important epigenetic mark in eukaryotes. Little information about its role exists for invertebrates. To investigate the contribution of 5mC to phenotypic variation in invertebrates...

    Authors: Nelia Luviano, Marie Lopez, Fleur Gawehns, Cristian Chaparro, Paola B. Arimondo, Slavica Ivanovic, Patrice David, Koen Verhoeven, Céline Cosseau and Christoph Grunau
    Citation: Epigenetics & Chromatin 2021 14:48
    Content type: Research Published on:

  13. Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows differences associated with various processes such a...

    Authors: Tanja Vojvoda Zeljko, Đurđica Ugarković and Željka Pezer
    Citation: Epigenetics & Chromatin 2021 14:47
    Content type: Research Published on:

  14. Knowing chromatin components at a DNA regulatory element at any given time is essential for understanding how the element works during cellular proliferation, differentiation and development. A region-specific...

    Authors: Satoru Ide, Asuka Sasaki, Yusuke Kawamoto, Toshikazu Bando, Hiroshi Sugiyama and Kazuhiro Maeshima
    Citation: Epigenetics & Chromatin 2021 14:46
    Content type: Methodology Published on:

  15. It is established that protein-coding exons are preferentially localized in nucleosomes. To examine whether the same is true for non-coding exons, we analysed nucleosome occupancy in and adjacent to internal e...

    Authors: Pinki Dey and John S. Mattick
    Citation: Epigenetics & Chromatin 2021 14:45
    Content type: Research Published on:

  16. Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for det...

    Authors: Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T. Dermitzakis, Yurii S. Aulchenko, Thomas Lengauer, Paul A. Lyons, Michel Georges and Jörn Walter
    Citation: Epigenetics & Chromatin 2021 14:44
    Content type: Research Published on:

  17. Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility, such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and alter gene expre...

    Authors: Yujuan Gui, Kamil Grzyb, Mélanie H. Thomas, Jochen Ohnmacht, Pierre Garcia, Manuel Buttini, Alexander Skupin, Thomas Sauter and Lasse Sinkkonen
    Citation: Epigenetics & Chromatin 2021 14:43
    Content type: Research Published on:

  18. Environmental fluctuation during embryonic and fetal development can permanently alter an organism’s morphology, physiology, and behaviour. This phenomenon, known as developmental plasticity, is particularly r...

    Authors: Ilan Ruhr, Jacob Bierstedt, Turk Rhen, Debojyoti Das, Sunil Kumar Singh, Soleille Miller, Dane A. Crossley II and Gina L. J. Galli
    Citation: Epigenetics & Chromatin 2021 14:42
    Content type: Research Published on:

  19. Eukaryotic genomes are highly organised within the nucleus of a cell, allowing widely dispersed regulatory elements such as enhancers to interact with gene promoters through physical contacts in three-dimensio...

    Authors: Ning Liu, Wai Yee Low, Hamid Alinejad-Rokny, Stephen Pederson, Timothy Sadlon, Simon Barry and James Breen
    Citation: Epigenetics & Chromatin 2021 14:41
    Content type: Review Published on:

  20. Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studi...

    Authors: Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li and Chong Tang
    Citation: Epigenetics & Chromatin 2021 14:40
    Content type: Research Published on:

  21. Panobinostat (PB), a histone deacetylase (HDAC) inhibitor drug, is clinically used in the treatment of cancers. We investigated the effects of PB on murine ovarian functions in embryos and adult animals.

    Authors: Louis Legoff, Ouzna Dali, Elena De La Mata Santaella, Christian Jaulin, Shereen Cynthia D’Cruz and Fatima Smagulova
    Citation: Epigenetics & Chromatin 2021 14:39
    Content type: Research Published on:

  22. Notch signaling controls cell fate decisions in many contexts during development and adult stem cell homeostasis and, when dysregulated, leads to carcinogenesis. The central transcription factor RBPJ assembles...

    Authors: Małgorzata Sotomska, Robert Liefke, Francesca Ferrante, Heiko Schwederski, Franz Oswald and Tilman Borggrefe
    Citation: Epigenetics & Chromatin 2021 14:38
    Content type: Research Published on:

  23. Condensation of chromatin prior to enucleation is an essential component of terminal erythroid maturation, and defects in this process are associated with inefficient erythropoiesis and anemia. However, the me...

    Authors: Nazish N. Jeffery, Christina Davidson, Scott A. Peslak, Paul D. Kingsley, Yukio Nakamura, James Palis and Michael Bulger
    Citation: Epigenetics & Chromatin 2021 14:37
    Content type: Research Published on:

  24. Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-r...

    Authors: Arkadiy K. Golov, Anastasia V. Golova, Alexey A. Gavrilov and Sergey V. Razin
    Citation: Epigenetics & Chromatin 2021 14:36
    Content type: Research Published on:

  25. Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of h...

    Authors: Sheldon Decombe, François Loll, Laura Caccianini, Kévin Affannoukoué, Ignacio Izeddin, Julien Mozziconacci, Christophe Escudé and Judith Lopes
    Citation: Epigenetics & Chromatin 2021 14:35
    Content type: Research Published on:

  26. Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttransl...

    Authors: Yinjie Lian, Huijuan Hao, Jing Xu, Tao Bo, Aihua Liang and Wei Wang
    Citation: Epigenetics & Chromatin 2021 14:34
    Content type: Research Published on:

  28. The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific tra...

    Authors: Deniz Uğurlu-Çimen, Deniz Odluyurt, Kenan Sevinç, Nazlı Ezgi Özkan-Küçük, Burcu Özçimen, Deniz Demirtaş, Eray Enüstün, Can Aztekin, Martin Philpott, Udo Oppermann, Nurhan Özlü and Tamer T. Önder
    Citation: Epigenetics & Chromatin 2021 14:32
    Content type: Research Published on:

  29. Exposure to early life stress (ELS) during childhood or prenatally increases the risk of future psychiatric disorders. The effect of stress exposure during the neonatal period is less well understood. In prete...

    Authors: Eamon Fitzgerald, Matthew C. Sinton, Sara Wernig-Zorc, Nicholas M. Morton, Megan C. Holmes, James P. Boardman and Amanda J. Drake
    Citation: Epigenetics & Chromatin 2021 14:31
    Content type: Research Published on:

  31. Drosophila dosage compensation is an important model system for defining how active chromatin domains are formed. The male-specific lethal dosage compensation complex (MSLc) increases transcript levels of genes a...

    Authors: William Jordan III and Erica Larschan
    Citation: Epigenetics & Chromatin 2021 14:29
    Content type: Research Published on:

  32. With rapidly dropping sequencing cost, the popularity of whole-genome DNA methylation sequencing has been on the rise. Multiple library preparation protocols currently exist. We have performed 22 whole-genome ...

    Authors: Jacob Morrison, Julie M. Koeman, Benjamin K. Johnson, Kelly K. Foy, Ian Beddows, Wanding Zhou, David W. Chesla, Larissa L. Rossell, Emily J. Siegwald, Marie Adams and Hui Shen
    Citation: Epigenetics & Chromatin 2021 14:28
    Content type: Research Published on:

  33. A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural ...

    Authors: Richard C. Chang, Kara N. Thomas, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell and Michael C. Golding
    Citation: Epigenetics & Chromatin 2021 14:27
    Content type: Research Published on:

  35. DNA methylation is an epigenetic chromatin mark that allows heterochromatin formation and gene silencing. It has a fundamental role in preserving genome stability (including chromosome stability) by controllin...

    Authors: Xena Giada Pappalardo and Viviana Barra
    Citation: Epigenetics & Chromatin 2021 14:25
    Content type: Review Published on:

  36. During epididymal transit, spermatozoa go through several functional maturation steps, resulting from interactions with epididymal secretomes specific to each region. In particular, the sperm membrane is under...

    Authors: Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Chrystelle Le Danvic, Benoît Guyonnet, Hélène Kiefer, Hélène Jammes and Laurent Schibler
    Citation: Epigenetics & Chromatin 2021 14:24
    Content type: Research Published on:

  37. Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of t...

    Authors: Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee, Daniel J. Fernandez, Rachel Abrahamson, Alessandra Castaldi, Zea Borok, Brian D. Dynlacht and Woojin An
    Citation: Epigenetics & Chromatin 2021 14:23
    Content type: Research Published on:

  38. Selective gene silencing is key to development. It is generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate...

    Authors: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet and F. Malagnac
    Citation: Epigenetics & Chromatin 2021 14:22
    Content type: Research Published on:

  39. DNA methylation is an important epigenetic control mechanism that in many fungi is restricted to genomic regions containing transposable elements (TEs). Two DNA methyltransferases, Dim2 and Dnmt5, are known to...

    Authors: H. Martin Kramer, David E. Cook, Grardy C. M. van den Berg, Michael F. Seidl and Bart P. H. J. Thomma
    Citation: Epigenetics & Chromatin 2021 14:21
    Content type: Research Published on:

  40. ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its bin...

    Authors: Xinyang Yu, Prashant K. Singh, Shamira Tabrejee, Satrajit Sinha and Michael J. Buck
    Citation: Epigenetics & Chromatin 2021 14:20
    Content type: Research Published on:

  41. The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and...

    Authors: Jessica Connacher, Gabrielle A. Josling, Lindsey M. Orchard, Janette Reader, Manuel Llinás and Lyn-Marié Birkholtz
    Citation: Epigenetics & Chromatin 2021 14:19
    Content type: Research Published on:

  42. Maternal protein restriction diet (PRD) increases the risk of metabolic dysfunction in adulthood, the mechanisms during the early life of offspring are still poorly understood. Apart from genetic factors, epig...

    Authors: Yinyu Wang, Yiting Mao, Yiran Zhao, Xianfu Yi, Guolian Ding, Chuanjin Yu, Jianzhong Sheng, Xinmei Liu, Yicong Meng and Hefeng Huang
    Citation: Epigenetics & Chromatin 2021 14:18
    Content type: Research Published on:

  43. Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by subletha...

    Authors: Annika R. Seddon, Yusmiati Liau, Paul E. Pace, Allison L. Miller, Andrew B. Das, Martin A. Kennedy, Mark B. Hampton and Aaron J. Stevens
    Citation: Epigenetics & Chromatin 2021 14:17
    Content type: Research Published on:

  44. Pita is required for Drosophila development and binds specifically to a long motif in active promoters and insulators. Pita belongs to the Drosophila family of zinc-finger architectural proteins, which also in...

    Authors: Marat Sabirov, Olga Kyrchanova, Galina V. Pokholkova, Artem Bonchuk, Natalia Klimenko, Elena Belova, Igor F. Zhimulev, Oksana Maksimenko and Pavel Georgiev
    Citation: Epigenetics & Chromatin 2021 14:16
    Content type: Research Published on:

  45. The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which re...

    Authors: Maria Gridina, Evgeniy Mozheiko, Emil Valeev, Ludmila P. Nazarenko, Maria E. Lopatkina, Zhanna G. Markova, Maria I. Yablonskaya, Viktoria Yu Voinova, Nadezhda V. Shilova, Igor N. Lebedev and Veniamin Fishman
    Citation: Epigenetics & Chromatin 2021 14:15
    Content type: Methodology Published on:

  47. Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methy...

    Authors: Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu and Janine M. LaSalle
    Citation: Epigenetics & Chromatin 2021 14:13
    Content type: Research Published on:

  48. X-chromosome inactivation (XCI) in eutherian mammals is the epigenetic inactivation of one of the two X chromosomes in XX females in order to compensate for dosage differences with XY males. Not all genes are ...

    Authors: Bradley P. Balaton, Oriol Fornes, Wyeth W. Wasserman and Carolyn J. Brown
    Citation: Epigenetics & Chromatin 2021 14:12
    Content type: Research Published on:

  49. In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determinat...

    Authors: Reza Raeisossadati, Merari F. R. Ferrari, Alexandre Hiroaki Kihara, Issam AlDiri and Jeffrey M. Gross
    Citation: Epigenetics & Chromatin 2021 14:11
    Content type: Review Published on:

  50. Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histo...

    Authors: Kun Li and Ziqiang Wang
    Citation: Epigenetics & Chromatin 2021 14:10
    Content type: Review Published on:
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ISSN: 1756-8935