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  1. The physiological function of eukaryotic DNA occurs in the context of nucleosomal arrays that can expose or obscure defined segments of the genome. Certain DNA sequences are capable of strongly positioning a n...

    Authors: Lia E Gracey, Zhi-Ying Chen, Jay M Maniar, Anton Valouev, Arend Sidow, Mark A Kay and Andrew Z Fire
    Citation: Epigenetics & Chromatin 2010 3:13
    Content type: Research Published on:

  4. X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist....

    Authors: Y Amy Tang, Derek Huntley, Giovanni Montana, Andrea Cerase, Tatyana B Nesterova and Neil Brockdorff
    Citation: Epigenetics & Chromatin 2010 3:10
    Content type: Research Published on:

  5. HP1 proteins are conserved components of eukaryotic constitutive heterochromatin. In mammals, there are three genes that encode HP1-like proteins, termed HP1α, HP1β and HP1γ, which have a high degree of homolo...

    Authors: Jeremy P Brown, Jörn Bullwinkel, Bettina Baron-Lühr, Mustafa Billur, Philipp Schneider, Heinz Winking and Prim B Singh
    Citation: Epigenetics & Chromatin 2010 3:9
    Content type: Research Published on:

    The Erratum to this article has been published in Epigenetics & Chromatin 2012 5:18

  6. Vertebrate heterochromatin contains a non-allelic variant of the histone H2A called macroH2A1, which has the characteristic of being three times the size of the canonical H2A. The macroH2A1 C-terminal extensio...

    Authors: Mathieu Boulard, Sébastien Storck, Rong Cong, Rodrigo Pinto, Hélène Delage and Philippe Bouvet
    Citation: Epigenetics & Chromatin 2010 3:8
    Content type: Research Published on:

  7. The linker histone H1 has a key role in establishing and maintaining higher order chromatin structure and in regulating gene expression. Mammals express up to 11 different H1 variants, with H1.2 and H1.4 being...

    Authors: Thomas Weiss, Sonja Hergeth, Ulrike Zeissler, Annalisa Izzo, Philipp Tropberger, Barry M Zee, Miroslav Dundr, Benjamin A Garcia, Sylvain Daujat and Robert Schneider
    Citation: Epigenetics & Chromatin 2010 3:7
    Content type: Research Published on:

  8. Centromeres are responsible for the proper segregation of replicated chromatids during cell division. Neocentromeres are fully functional ectopic human centromeres that form on low-copy DNA sequences and permi...

    Authors: Alicia Alonso, Dan Hasson, Fanny Cheung and Peter E Warburton
    Citation: Epigenetics & Chromatin 2010 3:6
    Content type: Research Published on:

  9. Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S protea...

    Authors: Olivia I Koues, Ninad T Mehta, Agnieszka D Truax, R Kyle Dudley, Jeanne K Brooks and Susanna F Greer
    Citation: Epigenetics & Chromatin 2010 3:5
    Content type: Research Published on:

  10. When the nuclei of mammalian somatic cells are transplanted to amphibian oocytes in the first meiotic prophase, they are rapidly induced to begin transcribing several pluripotency genes, including Sox2 and Oct...

    Authors: Kazutaka Murata, Tony Kouzarides, Andrew J Bannister and John B Gurdon
    Citation: Epigenetics & Chromatin 2010 3:4
    Content type: Research Published on:

  13. During early mouse development, two extra-embryonic lineages form alongside the future embryo: the trophectoderm (TE) and the primitive endoderm (PrE). Epigenetic changes known to take place during these early...

    Authors: Joana Santos, C Filipe Pereira, Aida Di-Gregorio, Thomas Spruce, Olivia Alder, Tristan Rodriguez, Véronique Azuara, Matthias Merkenschlager and Amanda G Fisher
    Citation: Epigenetics & Chromatin 2010 3:1
    Content type: Research Published on:

  14. In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect. There is large variation in the level of t...

    Authors: Esther R Loney, Peter W Inglis, Sarah Sharp, Fiona E Pryde, Nicholas A Kent, Jane Mellor and Edward J Louis
    Citation: Epigenetics & Chromatin 2009 2:18
    Content type: Research Published on:

  15. Acetylation of promoter nucleosomes is tightly correlated and mechanistically linked to gene activity. However, transcription is not necessary for promoter acetylation. It seems, therefore, that external and e...

    Authors: Ina Horst, Sascha Offermann, Bjoern Dreesen, Markus Niessen and Christoph Peterhansel
    Citation: Epigenetics & Chromatin 2009 2:17
    Content type: Research Published on:

  16. The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. In this study, we investigated how higher-order chromatin structure modulates differential expression o...

    Authors: Sima Kheradmand Kia, Parham Solaimani Kartalaei, Elnaz Farahbakhshian, Farzin Pourfarzad, Marieke von Lindern and C Peter Verrijzer
    Citation: Epigenetics & Chromatin 2009 2:16
    Content type: Research Published on:

  18. The archetypal epigenetic phenomenon of position effect variegation (PEV) in Drosophila occurs when a gene is brought abnormally close to heterochromatin, resulting in stochastic silencing of the affected gene in...

    Authors: Kyoko Hiragami-Hamada, Sheila Q Xie, Alexander Saveliev, Santiago Uribe-Lewis, Ana Pombo and Richard Festenstein
    Citation: Epigenetics & Chromatin 2009 2:14
    Content type: Research Published on:

  20. Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells. Transcriptional regulators, such as Oct4, are critic...

    Authors: Leng-Siew Yeap, Katsuhiko Hayashi and M Azim Surani
    Citation: Epigenetics & Chromatin 2009 2:12
    Content type: Research Published on:

  21. Dynamic changes to the chromatin structure play a critical role in transcriptional regulation. This is exemplified by the Spt6-mediated histone deposition on to histone-depleted promoters that results in displ...

    Authors: Ryosuke Ohsawa, Melissa Adkins and Jessica K Tyler
    Citation: Epigenetics & Chromatin 2009 2:11
    Content type: Research Published on:

  23. Argonaute2 protein (Ago2) is a key component of RNA-induced gene silencing complex, which is crucial for microRNA-mediated repression of target genes. The function of Ago2 in the mouse oocyte and early embryon...

    Authors: Masahiro Kaneda, Fuchou Tang, Dónal O'Carroll, Kaiqin Lao and M Azim Surani
    Citation: Epigenetics & Chromatin 2009 2:9
    Content type: Research Published on:

  24. Delimiting distinct chromatin domains is essential for temporal and spatial regulation of gene expression. Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtapos...

    Authors: Pablo Navarro, Sophie Chantalat, Mario Foglio, Corinne Chureau, Sébastien Vigneau, Philippe Clerc, Philip Avner and Claire Rougeulle
    Citation: Epigenetics & Chromatin 2009 2:8
    Content type: Research Published on:

  25. DNA methylation is a major epigenetic modification important for regulating gene expression and suppressing spurious transcription. Most methods to scan the genome in different tissues for differentially methy...

    Authors: Cecilia De Bustos, Edward Ramos, Janet M Young, Robert K Tran, Uwe Menzel, Cordelia F Langford, Evan E Eichler, Li Hsu, Steve Henikoff, Jan P Dumanski and Barbara J Trask
    Citation: Epigenetics & Chromatin 2009 2:7
    Content type: Research Published on:

  27. Histone methylation is thought to be central to the epigenetic mechanisms that maintain and confine cellular identity in multi-cellular organisms. To examine epigenetic roles in cellular homeostasis, we condit...

    Authors: Stefan Glaser, Sandra Lubitz, Kate L Loveland, Kazu Ohbo, Lorraine Robb, Frieder Schwenk, Jost Seibler, Daniela Roellig, Andrea Kranz, Konstantinos Anastassiadis and A Francis Stewart
    Citation: Epigenetics & Chromatin 2009 2:5
    Content type: Research Published on:

  28. Genome-wide mappings of nucleosome occupancy in different species have shown presence of well-positioned nucleosomes. While the DNA sequences may help decide their locations, the observed positions in vivo are en...

    Authors: Vinesh Vinayachandran, Rama-Haritha Pusarla and Purnima Bhargava
    Citation: Epigenetics & Chromatin 2009 2:4
    Content type: Research Published on:

    The Erratum to this article has been published in Epigenetics & Chromatin 2011 4:8

  29. DNA methylation plays a vital role in normal cellular function, with aberrant methylation signatures being implicated in a growing number of human pathologies and complex human traits. Methods based on the mod...

    Authors: Sophia J Docherty, Oliver SP Davis, Claire MA Haworth, Robert Plomin and Jonathan Mill
    Citation: Epigenetics & Chromatin 2009 2:3
    Content type: Methodology Published on:

  30. Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. Th...

    Authors: Kenneth K Lee, Selene K Swanson, Laurence Florens, Michael P Washburn and Jerry L Workman
    Citation: Epigenetics & Chromatin 2009 2:2
    Content type: Research Published on:

  31. Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that sho...

    Authors: Maartje J Vogel, Ludo Pagie, Wendy Talhout, Marja Nieuwland, Ron M Kerkhoven and Bas van Steensel
    Citation: Epigenetics & Chromatin 2009 2:1
    Content type: Research Published on:

  32. Direct visualization of chromatin has the potential to provide important insights into epigenetic processes. In particular, atomic force microscopy (AFM) can visualize single nucleosomes under physiological io...

    Authors: Hongda Wang, Yamini Dalal, Steven Henikoff and Stuart Lindsay
    Citation: Epigenetics & Chromatin 2008 1:10
    Content type: Methodology Published on:

  33. The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks,...

    Authors: Christoffel Dinant, Adriaan B Houtsmuller and Wim Vermeulen
    Citation: Epigenetics & Chromatin 2008 1:9
    Content type: Review Published on:

  34. In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zy...

    Authors: Konstantin Lepikhov, Valeri Zakhartchenko, Ru Hao, Feikun Yang, Christine Wrenzycki, Heiner Niemann, Eckhard Wolf and Joern Walter
    Citation: Epigenetics & Chromatin 2008 1:8
    Content type: Research Published on:

  35. Methylation-sensitive high resolution melting (MS-HRM) methodology is able to recognise heterogeneously methylated sequences by their characteristic melting profiles. To further analyse heterogeneously methyla...

    Authors: Ida LM Candiloro, Thomas Mikeska, Peter Hokland and Alexander Dobrovic
    Citation: Epigenetics & Chromatin 2008 1:7
    Content type: Methodology Published on:

  36. Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. Th...

    Authors: Asako J Nakamura, Y Jeffrey Chiang, Karen S Hathcock, Izumi Horikawa, Olga A Sedelnikova, Richard J Hodes and William M Bonner
    Citation: Epigenetics & Chromatin 2008 1:6
    Content type: Research Published on:

  37. Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. We initiated a study of telomeric silencing in Neurospora crassa, a fungus that sports DNA methylation, ...

    Authors: Kristina M Smith, Gregory O Kothe, Cindy B Matsen, Tamir K Khlafallah, Keyur K Adhvaryu, Melissa Hemphill, Michael Freitag, Mohammad R Motamedi and Eric U Selker
    Citation: Epigenetics & Chromatin 2008 1:5
    Content type: Research Published on:

  38. Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution th...

    Authors: Xueying Wang, Zvi Kam, Peter M Carlton, Lifeng Xu, John W Sedat and Elizabeth H Blackburn
    Citation: Epigenetics & Chromatin 2008 1:4
    Content type: Research Published on:

  39. In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequence...

    Authors: Jan Postberg, Katharina Heyse, Marion Cremer, Thomas Cremer and Hans J Lipps
    Citation: Epigenetics & Chromatin 2008 1:3
    Content type: Research Published on:

  40. X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-co...

    Authors: Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager and Neil Brockdorff
    Citation: Epigenetics & Chromatin 2008 1:2
    Content type: Research Published on:
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