Beausejour CM, Campisi J: Ageing: balancing regeneration and cancer. Nature. 2006, 443: 404-405. 10.1038/nature05221.
Article
CAS
PubMed
Google Scholar
Finkel T, Serrano M, Blasco MA: The common biology of cancer and ageing. Nature. 2007, 448: 767-774. 10.1038/nature05985.
Article
CAS
PubMed
Google Scholar
Gil J, Peters G: Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol. 2006, 7: 667-677. 10.1038/nrm1987.
Article
CAS
PubMed
Google Scholar
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT: Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006, 443: 421-426.
CAS
PubMed
Google Scholar
Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ: Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006, 443: 448-452. 10.1038/nature05091.
Article
PubMed Central
CAS
PubMed
Google Scholar
Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE: p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 2006, 443: 453-457. 10.1038/nature05092.
Article
CAS
PubMed
Google Scholar
Kim WY, Sharpless NE: The Regulation of INK4/ARF in cancer and ageing. Cell. 2006, 127: 265-275. 10.1016/j.cell.2006.10.003.
Article
CAS
PubMed
Google Scholar
Lowe SW, Sherr CJ: Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev. 2003, 13 (1): 77-83. 10.1016/S0959-437X(02)00013-8.
Article
CAS
PubMed
Google Scholar
Sparmann A, van Lohuizen M: Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer. 2006, 6: 846-856. 10.1038/nrc1991.
Article
CAS
PubMed
Google Scholar
Jacobs JJL, Kieboom K, Marino S, DePinho RA, van Lohuizen M: The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 1999, 397: 164-168. 10.1038/16476.
Article
CAS
PubMed
Google Scholar
Agger K, Cloos PAC, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K: The H3K27 me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 2009, 23: 1171-1176. 10.1101/gad.510809.
Article
PubMed Central
CAS
PubMed
Google Scholar
Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M: Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS One. 2009, 4: e5622-10.1371/journal.pone.0005622.
Article
PubMed Central
PubMed
Google Scholar
Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J: Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009, 23: 1177-1182. 10.1101/gad.511109.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bernard D, Martinez-Leal JF, Rizzo S, Martinez D, Hudson D, Visakorpi T, Peters G, Carnero A, Beach D, Gil J: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Oncogene. 2005, 24: 5543-5551. 10.1038/sj.onc.1208735.
Article
CAS
PubMed
Google Scholar
Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Monch K, Minucci S, Porse BT, Marine J-C: The Polycomb group proteins bind throughout the INK4a-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21: 525-530. 10.1101/gad.415507.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen H, Gu X, Su I, Bottino R, Contreras J, Tarakhovsky A, Kim S: Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev. 2009, 23: 975-985. 10.1101/gad.1742509.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH: Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. Embo J. 2007, 26: 1637-1648. 10.1038/sj.emboj.7601632.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E: Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009, 136: 1122-1135. 10.1016/j.cell.2008.12.043.
Article
PubMed Central
CAS
PubMed
Google Scholar
He J, Kallin EM, Tsukada Y, Zhang Y: The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15. Nat Struct Mol Biol. 2008, 15: 1169-1175. 10.1038/nsmb.1499.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kheradmand Kia S, Gorski MM, Giannakopoulos S, Verrijzer CP: SWI/SNF Mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. MCB. 2008, 28: 3457-3464.
Article
Google Scholar
Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J, Rodriguez-Niedenführ M, Gil J, Peters G: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS One. 2009, 4: e6380-10.1371/journal.pone.0006380.
Article
PubMed Central
PubMed
Google Scholar
Rizo A, Olthof S, Han L, Vellenga E, de Haan G, Schuringa JJ: Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis. Blood. 2009, 114: 1498-1505. 10.1182/blood-2009-03-209734.
Article
CAS
PubMed
Google Scholar
Müller J, Verrijzer P: Biochemical mechanisms of gene regulation by polycomb group protein complexes. curr Opin Genet Dev. 2009, 19: 150-158. 10.1016/j.gde.2009.03.001.
Article
PubMed
Google Scholar
Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G: Genome Regulation by polycomb and trithorax proteins. Cell. 2007, 128: 735-745. 10.1016/j.cell.2007.02.009.
Article
CAS
PubMed
Google Scholar
Schwartz YB, Pirrotta V: Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet. 2007, 8: 9-22. 10.1038/nrg1981.
Article
CAS
PubMed
Google Scholar
Lagarou A, Mohd-Sarip A, Moshkin YM, Chalkley GE, Bezstarosti K, Demmers J, Verrijzer CP: dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev. 2008, 22: 2799-2810. 10.1101/gad.484208.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol. 2006, 26: 6880-6889. 10.1128/MCB.00630-06.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sánchez C, Sánchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics. 2007, 6: 820-834. 10.1074/mcp.M600275-MCP200.
Article
PubMed
Google Scholar
Gambetta MC, Oktaba K, Muller J: Essential Role of the glycosyltransferase Sxc/Ogt in polycomb repression. Science. 2009, 325: 93-96. 10.1126/science.1169727.
Article
CAS
PubMed
Google Scholar
Lanzuolo C, Roure V, Dekker J, Bantignies F, Orlando V: Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex. Nat Cell Biol. 2007, 9: 1167-1174. 10.1038/ncb1637.
Article
CAS
PubMed
Google Scholar
Tiwari VK, McGarvey KM, Licchesi JDF, Ohm JE, Herman JG, Sch , uuml , beler D, Baylin SB: PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol. 2008, 6 (12): 2911-2927. 10.1371/journal.pbio.0060306.
Article
CAS
PubMed
Google Scholar
Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K: The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol. 2007, 27: 3769-3779. 10.1128/MCB.01432-06.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pietersen AM, Evers B, Prasad AA, Tanger E, Cornelissen-Steijger P, Jonkers J, van Lohuizen M: Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Curr Biol. 2008, 18: 1094-1099. 10.1016/j.cub.2008.06.070.
Article
CAS
PubMed
Google Scholar
Pietersen AM, van Lohuizen M: Stem cell regulation by polycomb repressors: postponing commitment. Curr Opin Cell Biol. 2008, 20: 201-207. 10.1016/j.ceb.2008.01.004.
Article
CAS
PubMed
Google Scholar
Bruggeman S, Hulsman D, Tanger E, Buckle TBM, Zevenhoven J, van Tellingen O, van Lohuizen M: Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma. Cancer Cell. 2007, 12: 328-341. 10.1016/j.ccr.2007.08.032.
Article
CAS
PubMed
Google Scholar
Caretti G, Di Padova M, Micales B, Lyons G, Sartorelli V: The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 2004, 18: 2627-2638. 10.1101/gad.1241904.
Article
PubMed Central
CAS
PubMed
Google Scholar
Blank U, Karlsson G, Karlsson S: Signaling pathways governing stem-cell fate. Blood. 2008, 111: 492-503. 10.1182/blood-2007-07-075168.
Article
CAS
PubMed
Google Scholar
Roberts CW, Orkin SH: The SWI/SNF complex--chromatin and cancer. Nat Rev Cancer. 2004, 4: 133-142.
Article
CAS
PubMed
Google Scholar
Oruetxebarria I, Venturini F, Kekarainen T, Houweling A, Zuijderduijn LM, Mohd-Sarip A, Vries RG, Hoeben RC, Verrijzer CP: p16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. J Biol Chem. 2004, 279: 3807-3816. 10.1074/jbc.M309333200.
Article
CAS
PubMed
Google Scholar
Simon J, Lange C: Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008, 647: 21-29.
Article
CAS
PubMed
Google Scholar
Dekker J, Rippe K, Dekker M, Kleckner N: Capturing Chromosome Conformation. Science. 2002, 295: 1306-1311. 10.1126/science.1067799.
Article
CAS
PubMed
Google Scholar
Simonis M, Kooren J, de Laat W: An evaluation of 3C-based methods to capture DNA interactions. Nat methods. 2007, 4: 895-901. 10.1038/nmeth1114.
Article
CAS
PubMed
Google Scholar
Kamminga LM, Bystrykh LV, de Boer A, Houwer S, Douma J, Weersing E, Dontje B, de Haan G: The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood. 2006, 107: 2170-2179. 10.1182/blood-2005-09-3585.
Article
PubMed Central
CAS
PubMed
Google Scholar
Peters G: An INKlination for epigenetic control of senescence. Nat Struct Mol Biol. 2008, 15: 1133-1134. 10.1038/nsmb1108-1133.
Article
CAS
PubMed
Google Scholar
Tamkun JW, Deuring R, Scott MP, Kissinger M, Pattatucci AM, Kaufman TC, Kennison JA: Brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell. 1992, 68: 561-572. 10.1016/0092-8674(92)90191-E.
Article
CAS
PubMed
Google Scholar
Cleard F, Moshkin Y, Karch F, Maeda RK: Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification. Nat Genet. 2006, 38: 931-935. 10.1038/ng1833.
Article
CAS
PubMed
Google Scholar
de Laat W, Klous P, Kooren J, Noordermeer D, Palstra R, Simonis M, Splinter E, Grosveld F, James JB: 3-Dimensional organization of gene expression in erythroid cells. Current Topics in Developmental Biology. 2008, Academic Press, 82: 117-139. full_text.
Google Scholar
Madan Babu M, Janga SC, de Santiago I, Pombo A: Eukaryotic gene regulation in three dimensions and its impact on genome evolution. Curr Opin Genet Dev. 2008, 18 (6): 571-582. 10.1016/j.gde.2008.10.002.
Article
PubMed
Google Scholar
Maeda RK, Karch F: Making connections: boundaries and insulators in Drosophila. Curr Opin Genet Dev. 2007, 17 (5): 394-399. 10.1016/j.gde.2007.08.002.
Article
CAS
PubMed
Google Scholar
Talbert PB, Henikoff S: Spreading of silent chromatin: inaction at a distance. Nat Rev Genet. 2006, 7: 793-803. 10.1038/nrg1920.
Article
CAS
PubMed
Google Scholar
Tolhuis B, Palstra R-J, Splinter E, Grosveld F, de Laat W: Looping and interaction between hypersensitive sites in the active β-globin locus. Molecular Cell. 2002, 10: 1453-1465. 10.1016/S1097-2765(02)00781-5.
Article
CAS
PubMed
Google Scholar
Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M: Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature. 2006, 440: 702-706. 10.1038/nature04585.
Article
CAS
PubMed
Google Scholar
Mahmoudi T, Katsani KR, Verrijzer CP: GAGA can mediate enhancer function in trans by linking two separate DNA molecules. EMBO J. 2002, 21: 1775-1781. 10.1093/emboj/21.7.1775.
Article
PubMed Central
CAS
PubMed
Google Scholar
Petrascheck M, Escher D, Mahmoudi T, Verrijzer CP, Schaffner W, Barberis A: DNA looping induced by a transcriptional enhancer in vivo. Nucl Acids Res. 2005, 33: 3743-3750. 10.1093/nar/gki689.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ptashne M: Gene regulation by proteins acting nearby and at a distance. Nature. 1986, 322 (6081): 697-701. 10.1038/322697a0.
Article
CAS
PubMed
Google Scholar
Merchav S, Wagemaker G: Detection of murine bone marrow granulocyte/macrophage progenitor cells (GM-CFU) in serum-free cultures stimulated with purified M-CSF or GM-CSF. Int J Cell Cloning. 1984, 2: 356-367. 10.1002/stem.5530020604.
Article
CAS
PubMed
Google Scholar
Leberbauer C, Boulme F, Unfried G, Huber J, Beug H, Mullner EW: Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors. Blood. 2005, 105: 85-94. 10.1182/blood-2004-03-1002.
Article
CAS
PubMed
Google Scholar
Beug H, Palmieri S, Freudenstein C, Zentgraf H, Graf T: Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus. Cell. 1982, 28: 907-919. 10.1016/0092-8674(82)90070-8.
Article
CAS
PubMed
Google Scholar
Follenzi A, Sabatino G, Lombardo A, Boccaccio C, Naldini L: Efficient Gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum Gene Ther. 2002, 13: 243-260. 10.1089/10430340252769770.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-[Delta][Delta]CT method. Methods. 2001, 25: 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Hagege H, Klous P, Braem C, Splinter E, Dekker J, Cathala G, de Laat W, Forne T: Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc. 2007, 2 (7): 1722-1733. 10.1038/nprot.2007.243.
Article
CAS
PubMed
Google Scholar