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  1. The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histon...

    Authors: Nichole A. Lewis, Rachel Herndon Klein, Cailin Kelly, Jennifer Yee and Paul S. Knoepfler
    Citation: Epigenetics & Chromatin 2022 15:18
    Content type: Research Published on:

  2. The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response....

    Authors: Ulysses Tsz Fung Lam, Bryan Kok Yan Tan, John Jia Xin Poh and Ee Sin Chen
    Citation: Epigenetics & Chromatin 2022 15:17
    Content type: Review Published on:

  3. Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes. Chromatin remodeling c...

    Authors: Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin and Roberto J. Pezza
    Citation: Epigenetics & Chromatin 2022 15:16
    Content type: Research Published on:

  4. Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, littl...

    Authors: Marcela Maria de Souza, Simone Cristina Méo Niciura, Marina Ibelli Pereira Rocha, Zhangyuan Pan, Huaijun Zhou, Jennifer Jessica Bruscadin, Wellison Jarles da Silva Diniz, Juliana Afonso, Priscila Silva Neubern de Oliveira, Gerson B. Mourão, Adhemar Zerlotini, Luiz Lehmann Coutinho, James E. Koltes and Luciana Correia de Almeida Regitano
    Citation: Epigenetics & Chromatin 2022 15:15
    Content type: Research Published on:

  5. In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators ...

    Authors: John M. Schoelz and Nicole C. Riddle
    Citation: Epigenetics & Chromatin 2022 15:14
    Content type: Review Published on:

  6. Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant DNA methylation patterns have recurrently been linked to dysregulation of the regulatory program...

    Authors: Roza Berhanu Lemma, Thomas Fleischer, Emily Martinsen, Marit Ledsaak, Vessela Kristensen, Ragnhild Eskeland, Odd Stokke Gabrielsen and Anthony Mathelier
    Citation: Epigenetics & Chromatin 2022 15:13
    Content type: Research Published on:

  7. Mitochondrial DNA (mtDNA) copy number in oocytes correlates with oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA through mitochondrial supplementation of mtDNA-deficient S...

    Authors: Takashi Okada, Stephen McIlfatrick, Nhi Hin, Nader Aryamanesh, James Breen and Justin C. St. John
    Citation: Epigenetics & Chromatin 2022 15:12
    Content type: Research Published on:

  8. Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence in...

    Authors: Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković and Melita S. Vidaković
    Citation: Epigenetics & Chromatin 2022 15:11
    Content type: Research Published on:

  9. Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA...

    Authors: Dylane Detilleux, Yannick G. Spill, Delphine Balaramane, Michaël Weber and Anaïs Flore Bardet
    Citation: Epigenetics & Chromatin 2022 15:10
    Content type: Research Published on:

  10. The epigenetic age can now be extrapolated from one of several epigenetic clocks, which are based on age-related changes in DNA methylation levels at specific multiple CpG sites. Accelerated aging, calculated ...

    Authors: Tamar Shahal, Elad Segev, Thomas Konstantinovsky, Yonit Marcus, Gabi Shefer, Metsada Pasmanik-Chor, Assaf Buch, Yuval Ebenstein, Paul Zimmet and Naftali Stern
    Citation: Epigenetics & Chromatin 2022 15:9
    Content type: Research Published on:

  11. Methylation at cytosines (mCG) is a well-known regulator of gene expression, but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied cellular differentiation model sys...

    Authors: Joshua Disatham, Lisa Brennan, Xiaodong Jiao, Zhiwei Ma, J. Fielding Hejtmancik and Marc Kantorow
    Citation: Epigenetics & Chromatin 2022 15:8
    Content type: Research Published on:

  12. The Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex involved in repressing the transcription of diverse developmental genes. PRC2 consists of a core complex; possessing H3K27 ...

    Authors: Sabrina Fischer, Lisa Marie Weber and Robert Liefke
    Citation: Epigenetics & Chromatin 2022 15:7
    Content type: Review Published on:

  13. Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the i...

    Authors: Thomas Dixon-McDougall and Carolyn J. Brown
    Citation: Epigenetics & Chromatin 2022 15:6
    Content type: Research Published on:

  14. Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heteroch...

    Authors: Junsoo Oh, Soojin Yeom, Jiyeon Park and Jung-Shin Lee
    Citation: Epigenetics & Chromatin 2022 15:5
    Content type: Review Published on:

  15. Topologically associating domains (TADs) are thought to act as functional units in the genome. TADs co-localise genes and their regulatory elements as well as forming the unit of genome switching between activ...

    Authors: Helen S. Long, Simon Greenaway, George Powell, Ann-Marie Mallon, Cecilia M. Lindgren and Michelle M. Simon
    Citation: Epigenetics & Chromatin 2022 15:4
    Content type: Research Published on:

  16. Although paternal exposure to cigarette smoke may contribute to obesity and metabolic syndrome in offspring, the underlying mechanisms remain uncertain.

    Authors: Yunyun Liu, Shengzhu Chen, Dejian Pang, Jiayi Zhou, Xiuting Xu, Si Yang, Zhaofeng Huang and Bolan Yu
    Citation: Epigenetics & Chromatin 2022 15:3
    Content type: Research Published on:

  17. Paternal lifestyle choices and male exposure history have a critical influence on the health and fitness of the next generation. Accordingly, defining the processes of germline programming is essential to reso...

    Authors: Yudhishtar S. Bedi, Alexis N. Roach, Kara N. Thomas, Nicole A. Mehta and Michael C. Golding
    Citation: Epigenetics & Chromatin 2022 15:2
    Content type: Research Published on:

  18. The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation i...

    Authors: Ya-Hui Chi, Wan-Ping Wang, Ming-Chun Hung, Gunn-Guang Liou, Jing-Ya Wang and Pen-Hsiu Grace Chao
    Citation: Epigenetics & Chromatin 2022 15:1
    Content type: Research Published on:

  19. Directed differentiation of mouse embryonic stem cells (mESCs) or induced pluripotent stem cells (iPSCs) provides powerful models to dissect the molecular mechanisms leading to the formation of specific cell l...

    Authors: Claudia Baumann, Xiangyu Zhang, Ling Zhu, Yuhong Fan and Rabindranath De La Fuente
    Citation: Epigenetics & Chromatin 2021 14:58
    Content type: Research Published on:

  20. Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently, lactylation has been reported as a novel ...

    Authors: Wanting Yang, Peijun Wang, Pengbo Cao, Shuang Wang, Yuxiao Yang, Huimin Su and Buhe Nashun
    Citation: Epigenetics & Chromatin 2021 14:57
    Content type: Research Published on:

  21. DNA methylation plays an important role in regulating gene expression in mammals. The covalent DNMT1 inhibitors 5-azacytidine and decitabine are widely used in research to reduce DNA methylation levels, but th...

    Authors: Nathalia Azevedo Portilho, Deepak Saini, Ishtiaque Hossain, Jacinthe Sirois, Christopher Moraes and William A. Pastor
    Citation: Epigenetics & Chromatin 2021 14:56
    Content type: Methodology Published on:

  22. Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two paralogous genes, Asf1a and Asf1b exist in mammals, but their role during fertilization and early...

    Authors: Xuemei Wang, Lu Wang, Jie Dou, Tianjiao Yu, Pengbo Cao, Na Fan, Uyunbilig Borjigin and Buhe Nashun
    Citation: Epigenetics & Chromatin 2021 14:55
    Content type: Research Published on:

  23. Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are mo...

    Authors: Chaini Konwar, Rebecca Asiimwe, Amy M. Inkster, Sarah M. Merrill, Gian L. Negri, Maria J. Aristizabal, Christopher F. Rider, Julie L. MacIsaac, Christopher Carlsten and Michael S. Kobor
    Citation: Epigenetics & Chromatin 2021 14:54
    Content type: Research Published on:

  24. Accessible chromatin landscape allows binding of transcription factors, and remodeling of promoter and enhancer elements during development. Chromatin accessibility along with integrated multiomics approaches ...

    Authors: Udayakumar S. Vishnu, Pierre-Olivier Estève, Hang Gyeong Chin and Sriharsa Pradhan
    Citation: Epigenetics & Chromatin 2021 14:53
    Content type: Methodology Published on:

  25. Neural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with NTDs eventually develop lifelong disability, which cause significant morbidity and mortali...

    Authors: Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu, Jun Xu and Jun Xie
    Citation: Epigenetics & Chromatin 2021 14:52
    Content type: Research Published on:

  26. Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here, we characterize the nature of nuclear granules formed by R...

    Authors: Carlos Rivera, Daniel Verbel-Vergara, Duxan Arancibia, Anna Lappala, Marcela González, Fabián Guzmán, Gianluca Merello, Jeannie T. Lee and María Estela Andrés
    Citation: Epigenetics & Chromatin 2021 14:51
    Content type: Research Published on:

  27. The review begins with a concise description of the principles of phase separation. This is followed by a comprehensive section on phase separation of chromatin, in which we recount the 60 years history of chr...

    Authors: Jeffrey C. Hansen, Kazuhiro Maeshima and Michael J. Hendzel
    Citation: Epigenetics & Chromatin 2021 14:50
    Content type: Review Published on:

  28. Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been im...

    Authors: Varsha P. Desai, Jihed Chouaref, Haoyu Wu, William A. Pastor, Ryan L. Kan, Harald M. Oey, Zheng Li, Jamie Ho, Kelly K. D. Vonk, David San Leon Granado, Michael A. Christopher, Amander T. Clark, Steven E. Jacobsen and Lucia Daxinger
    Citation: Epigenetics & Chromatin 2021 14:49
    Content type: Research Published on:

  29. 5-Methylcytosine (5mC) is an important epigenetic mark in eukaryotes. Little information about its role exists for invertebrates. To investigate the contribution of 5mC to phenotypic variation in invertebrates...

    Authors: Nelia Luviano, Marie Lopez, Fleur Gawehns, Cristian Chaparro, Paola B. Arimondo, Slavica Ivanovic, Patrice David, Koen Verhoeven, Céline Cosseau and Christoph Grunau
    Citation: Epigenetics & Chromatin 2021 14:48
    Content type: Research Published on:

  30. Trimethylation of histone H3 on lysine 9 (H3K9me3) at satellite DNA sequences has been primarily studied at (peri)centromeric regions, where its level shows differences associated with various processes such a...

    Authors: Tanja Vojvoda Zeljko, Đurđica Ugarković and Željka Pezer
    Citation: Epigenetics & Chromatin 2021 14:47
    Content type: Research Published on:

  31. Knowing chromatin components at a DNA regulatory element at any given time is essential for understanding how the element works during cellular proliferation, differentiation and development. A region-specific...

    Authors: Satoru Ide, Asuka Sasaki, Yusuke Kawamoto, Toshikazu Bando, Hiroshi Sugiyama and Kazuhiro Maeshima
    Citation: Epigenetics & Chromatin 2021 14:46
    Content type: Methodology Published on:

  32. It is established that protein-coding exons are preferentially localized in nucleosomes. To examine whether the same is true for non-coding exons, we analysed nucleosome occupancy in and adjacent to internal e...

    Authors: Pinki Dey and John S. Mattick
    Citation: Epigenetics & Chromatin 2021 14:45
    Content type: Research Published on:

  33. Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. There is a need for systematic approaches not only for det...

    Authors: Michael Scherer, Gilles Gasparoni, Souad Rahmouni, Tatiana Shashkova, Marion Arnoux, Edouard Louis, Arina Nostaeva, Diana Avalos, Emmanouil T. Dermitzakis, Yurii S. Aulchenko, Thomas Lengauer, Paul A. Lyons, Michel Georges and Jörn Walter
    Citation: Epigenetics & Chromatin 2021 14:44
    Content type: Research Published on:

  34. Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility, such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and alter gene expre...

    Authors: Yujuan Gui, Kamil Grzyb, Mélanie H. Thomas, Jochen Ohnmacht, Pierre Garcia, Manuel Buttini, Alexander Skupin, Thomas Sauter and Lasse Sinkkonen
    Citation: Epigenetics & Chromatin 2021 14:43
    Content type: Research Published on:

  35. Environmental fluctuation during embryonic and fetal development can permanently alter an organism’s morphology, physiology, and behaviour. This phenomenon, known as developmental plasticity, is particularly r...

    Authors: Ilan Ruhr, Jacob Bierstedt, Turk Rhen, Debojyoti Das, Sunil Kumar Singh, Soleille Miller, Dane A. Crossley II and Gina L. J. Galli
    Citation: Epigenetics & Chromatin 2021 14:42
    Content type: Research Published on:

  36. Eukaryotic genomes are highly organised within the nucleus of a cell, allowing widely dispersed regulatory elements such as enhancers to interact with gene promoters through physical contacts in three-dimensio...

    Authors: Ning Liu, Wai Yee Low, Hamid Alinejad-Rokny, Stephen Pederson, Timothy Sadlon, Simon Barry and James Breen
    Citation: Epigenetics & Chromatin 2021 14:41
    Content type: Review Published on:

  37. Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studi...

    Authors: Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li and Chong Tang
    Citation: Epigenetics & Chromatin 2021 14:40
    Content type: Research Published on:

  38. Panobinostat (PB), a histone deacetylase (HDAC) inhibitor drug, is clinically used in the treatment of cancers. We investigated the effects of PB on murine ovarian functions in embryos and adult animals.

    Authors: Louis Legoff, Ouzna Dali, Elena De La Mata Santaella, Christian Jaulin, Shereen Cynthia D’Cruz and Fatima Smagulova
    Citation: Epigenetics & Chromatin 2021 14:39
    Content type: Research Published on:

  39. Notch signaling controls cell fate decisions in many contexts during development and adult stem cell homeostasis and, when dysregulated, leads to carcinogenesis. The central transcription factor RBPJ assembles...

    Authors: Małgorzata Sotomska, Robert Liefke, Francesca Ferrante, Heiko Schwederski, Franz Oswald and Tilman Borggrefe
    Citation: Epigenetics & Chromatin 2021 14:38
    Content type: Research Published on:

  40. Condensation of chromatin prior to enucleation is an essential component of terminal erythroid maturation, and defects in this process are associated with inefficient erythropoiesis and anemia. However, the me...

    Authors: Nazish N. Jeffery, Christina Davidson, Scott A. Peslak, Paul D. Kingsley, Yukio Nakamura, James Palis and Michael Bulger
    Citation: Epigenetics & Chromatin 2021 14:37
    Content type: Research Published on:

  41. Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-r...

    Authors: Arkadiy K. Golov, Anastasia V. Golova, Alexey A. Gavrilov and Sergey V. Razin
    Citation: Epigenetics & Chromatin 2021 14:36
    Content type: Research Published on:

  42. Centromeric regions of human chromosomes contain large numbers of tandemly repeated α-satellite sequences. These sequences are covered with constitutive heterochromatin which is enriched in trimethylation of h...

    Authors: Sheldon Decombe, François Loll, Laura Caccianini, Kévin Affannoukoué, Ignacio Izeddin, Julien Mozziconacci, Christophe Escudé and Judith Lopes
    Citation: Epigenetics & Chromatin 2021 14:35
    Content type: Research Published on:

  43. Histone chaperones facilitate DNA replication and repair by promoting chromatin assembly, disassembly and histone exchange. Following histones synthesis and nucleosome assembly, the histones undergo posttransl...

    Authors: Yinjie Lian, Huijuan Hao, Jing Xu, Tao Bo, Aihua Liang and Wei Wang
    Citation: Epigenetics & Chromatin 2021 14:34
    Content type: Research Published on:

  45. The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific tra...

    Authors: Deniz Uğurlu-Çimen, Deniz Odluyurt, Kenan Sevinç, Nazlı Ezgi Özkan-Küçük, Burcu Özçimen, Deniz Demirtaş, Eray Enüstün, Can Aztekin, Martin Philpott, Udo Oppermann, Nurhan Özlü and Tamer T. Önder
    Citation: Epigenetics & Chromatin 2021 14:32
    Content type: Research Published on:

  46. Exposure to early life stress (ELS) during childhood or prenatally increases the risk of future psychiatric disorders. The effect of stress exposure during the neonatal period is less well understood. In prete...

    Authors: Eamon Fitzgerald, Matthew C. Sinton, Sara Wernig-Zorc, Nicholas M. Morton, Megan C. Holmes, James P. Boardman and Amanda J. Drake
    Citation: Epigenetics & Chromatin 2021 14:31
    Content type: Research Published on:

  48. Drosophila dosage compensation is an important model system for defining how active chromatin domains are formed. The male-specific lethal dosage compensation complex (MSLc) increases transcript levels of genes a...

    Authors: William Jordan III and Erica Larschan
    Citation: Epigenetics & Chromatin 2021 14:29
    Content type: Research Published on:

  49. With rapidly dropping sequencing cost, the popularity of whole-genome DNA methylation sequencing has been on the rise. Multiple library preparation protocols currently exist. We have performed 22 whole-genome ...

    Authors: Jacob Morrison, Julie M. Koeman, Benjamin K. Johnson, Kelly K. Foy, Ian Beddows, Wanding Zhou, David W. Chesla, Larissa L. Rossell, Emily J. Siegwald, Marie Adams and Hui Shen
    Citation: Epigenetics & Chromatin 2021 14:28
    Content type: Research Published on:

  50. A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural ...

    Authors: Richard C. Chang, Kara N. Thomas, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell and Michael C. Golding
    Citation: Epigenetics & Chromatin 2021 14:27
    Content type: Research Published on:
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Epigenetics & Chromatin

ISSN: 1756-8935