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  2. Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activa...

    Authors: Taosui Li, Jacob W. Hodgson, Svetlana Petruk, Alexander Mazo and Hugh W. Brock
    Citation: Epigenetics & Chromatin 2017 10:43
    Content type: Research Published on:

  3. Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is believed to ensure a condensed and transcriptionally inert chromatin conformation. Pericentromeres consist of repetit...

    Authors: Nehmé Saksouk, Elisabeth Simboeck and Jérôme Déjardin
    Citation: Epigenetics & Chromatin 2015 8:3
    Content type: Review Published on:

  4. DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited. Cytosine meth...

    Authors: Satyanarayan Rao, Tsu-Pei Chiu, Judith F. Kribelbauer, Richard S. Mann, Harmen J. Bussemaker and Remo Rohs
    Citation: Epigenetics & Chromatin 2018 11:6
    Content type: Research Published on:

  5. Cnidarians are a group of early branching animals including corals, jellyfish and hydroids that are renowned for their high regenerative ability, growth plasticity and longevity. Because cnidarian genomes are ...

    Authors: Anna Török, Philipp H. Schiffer, Christine E. Schnitzler, Kris Ford, James C. Mullikin, Andreas D. Baxevanis, Antony Bacic, Uri Frank and Sebastian G. Gornik
    Citation: Epigenetics & Chromatin 2016 9:36
    Content type: Research Published on:

  6. The influence of genetics on variation in DNA methylation (DNAme) is well documented. Yet confounding from population stratification is often unaccounted for in DNAme association studies. Existing approaches t...

    Authors: Victor Yuan, E. Magda Price, Giulia Del Gobbo, Sara Mostafavi, Brian Cox, Alexandra M. Binder, Karin B. Michels, Carmen Marsit and Wendy P. Robinson
    Citation: Epigenetics & Chromatin 2019 12:51
    Content type: Methodology Published on:

  7. MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture. Although H3 acetylation at K18 has been shown to stim...

    Authors: Kyunghwan Kim, Yonghwan Shin, Jinman Kim, Tobias S. Ulmer and Woojin An
    Citation: Epigenetics & Chromatin 2018 11:23
    Content type: Research Published on:

  8. The ability to measure DNA methylation precisely and efficiently continues to drive our understanding of this modification in development and disease. Whole genome bisulfite sequencing has the advantage of the...

    Authors: Michael J. Ziller, Elena K. Stamenova, Hongcang Gu, Andreas Gnirke and Alexander Meissner
    Citation: Epigenetics & Chromatin 2016 9:55
    Content type: Methodology Published on:

  9. DNA methylation is an epigenetic mark that balances plasticity with stability. While DNA methylation exhibits tissue specificity, it can also vary with age and potentially environmental exposures. In studies o...

    Authors: Pau Farré, Meaghan J Jones, Michael J Meaney, Eldon Emberly, Gustavo Turecki and Michael S Kobor
    Citation: Epigenetics & Chromatin 2015 8:19
    Content type: Research Published on:

  11. The Nicoya Peninsula in Costa Rica has one of the highest old-age life expectancies in the world, but the underlying biological mechanisms of this longevity are not well understood. As DNA methylation is hypot...

    Authors: Lisa M. McEwen, Alexander M. Morin, Rachel D. Edgar, Julia L. MacIsaac, Meaghan J. Jones, William H. Dow, Luis Rosero-Bixby, Michael S. Kobor and David H. Rehkopf
    Citation: Epigenetics & Chromatin 2017 10:21
    Content type: Research Published on:

  12. In recent years, we have come to recognize that a multitude of in utero exposures have the capacity to induce the development of congenital and metabolic defects. As most of these encounters manifest their eff...

    Authors: Kylee J. Veazey, Scott E. Parnell, Rajesh C. Miranda and Michael C. Golding
    Citation: Epigenetics & Chromatin 2015 8:39
    Content type: Research Published on:

  13. Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resultin...

    Authors: Weipeng Mu, Joshua Starmer, Della Yee and Terry Magnuson
    Citation: Epigenetics & Chromatin 2018 11:71
    Content type: Research Published on:

  14. Proliferating cell nuclear antigen (PCNA), a ring-shaped homotrimer complex, promotes DNA replication via binding to DNA polymerase. Trimerized PCNA is critical for DNA replication. Enhancer of zeste homologue...

    Authors: Peng A, Xinyi Xu, Chenglin Wang, Jing Yang, Shida Wang, Jiewen Dai and Ling Ye
    Citation: Epigenetics & Chromatin 2018 11:44
    Content type: Research Published on:

  15. The major human fungal pathogen Candida albicans possesses a diploid genome, but responds to growth in challenging environments by employing chromosome aneuploidy as an adaptation mechanism. For example, we have...

    Authors: Hironao Wakabayashi, Christopher Tucker, Gabor Bethlendy, Anatoliy Kravets, Stephen L. Welle, Michael Bulger, Jeffrey J. Hayes and Elena Rustchenko
    Citation: Epigenetics & Chromatin 2017 10:49
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2017 10:52

  17. Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3). KDM5C is expressed...

    Authors: Youni Kim, Youngeun Jeong, Kujin Kwon, Tayaba Ismail, Hyun-Kyung Lee, Chowon Kim, Jeen-Woo Park, Oh-Shin Kwon, Beom-Sik Kang, Dong-Seok Lee, Tae Joo Park, Taejoon Kwon and Hyun-Shik Lee
    Citation: Epigenetics & Chromatin 2018 11:72
    Content type: Research Published on:

  18. The incidence of neural tube defects (NTDs) declined by about 40 % in Canada with the introduction of a national folic acid (FA) fortification program. Despite the fact that few Canadians currently exhibit fol...

    Authors: E. Magda Price, Maria S. Peñaherrera, Elodie Portales-Casamar, Paul Pavlidis, Margot I. Van Allen, Deborah E. McFadden and Wendy P. Robinson
    Citation: Epigenetics & Chromatin 2016 9:6
    Content type: Research Published on:

  19. The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation. In the course of evolution from yeast to mammals, the BAF...

    Authors: Amelie Alfert, Natalia Moreno and Kornelius Kerl
    Citation: Epigenetics & Chromatin 2019 12:19
    Content type: Review Published on:

  20. Considerable progress towards an understanding of complex diseases has been made in recent years due to the development of high-throughput genotyping technologies. Using microarrays that contain millions of si...

    Authors: Yu Gyoung Tak and Peggy J. Farnham
    Citation: Epigenetics & Chromatin 2015 8:57
    Content type: Review Published on:

  21. Heat-shock molecular chaperone proteins (Hsps) promote the loading of small interfering RNA (siRNA) onto RNA interference (RNAi) effector complexes. While the RNAi process is coupled with heterochromatin assem...

    Authors: Kosuke Okazaki, Hiroaki Kato, Tetsushi Iida, Kaori Shinmyozu, Jun-ichi Nakayama, Yota Murakami and Takeshi Urano
    Citation: Epigenetics & Chromatin 2018 11:26
    Content type: Research Published on:

  23. In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a gen...

    Authors: Anna Mallol, Maria Guirola and Bernhard Payer
    Citation: Epigenetics & Chromatin 2019 12:38
    Content type: Research Published on:

  24. Controlled modulation of nucleosomal DNA accessibility via post-translational modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs in the globular histone core—including...

    Authors: Andrew T. Fenley, Ramu Anandakrishnan, Yared H. Kidane and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2018 11:11
    Content type: Research Published on:

  26. Cyclins and cyclin-dependent kinases (CDKs) are essential for cell cycle regulation and are functionally associated with proteins involved in epigenetic maintenance of transcriptional patterns in various devel...

    Authors: Camille A Dupont, Delphine Dardalhon-Cuménal, Michael Kyba, Hugh W Brock, Neel B Randsholt and Frédérique Peronnet
    Citation: Epigenetics & Chromatin 2015 8:18
    Content type: Research Published on:

  27. The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintai...

    Authors: Robin L. Adrianse, Kaleb Smith, Tonibelle Gatbonton-Schwager, Smitha P. Sripathy, Uyen Lao, Eric J. Foss, Ruben G. Boers, Joachim B. Boers, Joost Gribnau and Antonio Bedalov
    Citation: Epigenetics & Chromatin 2018 11:50
    Content type: Research Published on:

  28. Plant homeodomain (PHD) fingers are central “readers” of histone post-translational modifications (PTMs) with > 100 PHD finger-containing proteins encoded by the human genome. Many of the PHDs studied to date ...

    Authors: Kanishk Jain, Caroline S. Fraser, Matthew R. Marunde, Madison M. Parker, Cari Sagum, Jonathan M. Burg, Nathan Hall, Irina K. Popova, Keli L. Rodriguez, Anup Vaidya, Krzysztof Krajewski, Michael-Christopher Keogh, Mark T. Bedford and Brian D. Strahl
    Citation: Epigenetics & Chromatin 2020 13:3
    Content type: Research Published on:

  29. Allele-specific methylation (ASM) occurs when DNA methylation patterns exhibit asymmetry among alleles. ASM occurs at imprinted loci, but its presence elsewhere across the human genome is indicative of wider i...

    Authors: Miles C. Benton, Rodney A. Lea, Donia Macartney-Coxson, Heidi G. Sutherland, Nicole White, Daniel Kennedy, Kerry Mengersen, Larisa M. Haupt and Lyn R. Griffiths
    Citation: Epigenetics & Chromatin 2019 12:60
    Content type: Research Published on:

  30. Transient induction of the Src oncoprotein in a non-transformed breast cell line can initiate an epigenetic switch to a cancer cell via a positive feedback loop that involves activation of the signal transduce...

    Authors: Joseph D Fleming, Paul G Giresi, Marianne Lindahl-Allen, Elsa B Krall, Jason D Lieb and Kevin Struhl
    Citation: Epigenetics & Chromatin 2015 8:7
    Content type: Research Published on:

  31. Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The ...

    Authors: Stephanie B. Hatch, Clarence Yapp, Raquel C. Montenegro, Pavel Savitsky, Vicki Gamble, Anthony Tumber, Gian Filippo Ruda, Vassilios Bavetsias, Oleg Fedorov, Butrus Atrash, Florence Raynaud, Rachel Lanigan, LeAnne Carmichael, Kathy Tomlin, Rosemary Burke, Susan M. Westaway…
    Citation: Epigenetics & Chromatin 2017 10:9
    Content type: Methodology Published on:

  32. During sexual reproduction in the unicellular ciliate Stylonychia somatic macronuclei differentiate from germline micronuclei. Thereby, programmed sequence reduction takes place, leading to the elimination of > 9...

    Authors: Jan Postberg, Franziska Jönsson, Patrick Philipp Weil, Aneta Bulic, Stefan Andreas Juranek and Hans-Joachim Lipps
    Citation: Epigenetics & Chromatin 2018 11:31
    Content type: Research Published on:

  33. The selective incorporation of appropriate histone variants into chromatin is critical for the regulation of genome function. Although many histone variants have been identified, a complete list has not been c...

    Authors: Kazumitsu Maehara, Akihito Harada, Yuko Sato, Masaki Matsumoto, Keiichi I. Nakayama, Hiroshi Kimura and Yasuyuki Ohkawa
    Citation: Epigenetics & Chromatin 2015 8:35
    Content type: Research Published on:

  35. Our appreciation of the critical role of the genome’s 3D organization in gene regulation is steadily increasing. Recent 3C-based deep sequencing techniques elucidated a hierarchy of structures that underlie th...

    Authors: Idan Nurick, Ron Shamir and Ran Elkon
    Citation: Epigenetics & Chromatin 2018 11:49
    Content type: Research Published on:

  36. Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and transcription...

    Authors: Jennifer N. Wu, Luca Pinello, Elinor Yissachar, Jonathan W. Wischhusen, Guo-Cheng Yuan and Charles W. M. Roberts
    Citation: Epigenetics & Chromatin 2015 8:53
    Content type: Research Published on:

  37. In eukaryotes, heterochromatin replicates late in S phase of the cell cycle and contains specific covalent modifications of histones. SuUR mutation found in Drosophila makes heterochromatin replicate earlier than...

    Authors: Olga V. Posukh, Daniil A. Maksimov, Petr P. Laktionov, Dmitry E. Koryakov and Stepan N. Belyakin
    Citation: Epigenetics & Chromatin 2017 10:56
    Content type: Research Published on:

  38. Obesity has tremendous impact on the health systems. Its epigenetic bases are unclear. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, reg...

    Authors: Valerio Pazienza, Concetta Panebianco, Francesca Rappa, Domenico Memoli, Michela Borghesan, Sara Cannito, Asami Oji, Giuseppe Mazza, Domenico Tamburrino, Giuseppe Fusai, Rosario Barone, Giulia Bolasco, Francesc Villarroya, Joan Villarroya, Kiyotaka Hatsuzawa, Francesco Cappello…
    Citation: Epigenetics & Chromatin 2016 9:45
    Content type: Research Published on:

  39. It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic response...

    Authors: Vincenzo Cavalieri and Giovanni Spinelli
    Citation: Epigenetics & Chromatin 2017 10:46
    Content type: Review Published on:

  40. Fragile X syndrome (FXS) is caused by CGG expansion over 200 repeats at the 5′ UTR of the FMR1 gene and subsequent DNA methylation of both the expanded sequence and the CpGs of the promoter region. This epigeneti...

    Authors: Elisabetta Tabolacci, Giorgia Mancano, Stella Lanni, Federica Palumbo, Martina Goracci, Fabrizio Ferrè, Manuela Helmer-Citterich and Giovanni Neri
    Citation: Epigenetics & Chromatin 2016 9:12
    Content type: Research Published on:

  41. Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive. In this ...

    Authors: Chiaki Noguchi, Tanu Singh, Melissa A. Ziegler, Jasmine D. Peake, Lyne Khair, Ana Aza, Toru M. Nakamura and Eishi Noguchi
    Citation: Epigenetics & Chromatin 2019 12:24
    Content type: Research Published on:

  42. In C. elegans, in order to equalize gene expression between the sexes and balance X and autosomal expression, two steps are believed to be required. First, an unknown mechanism is hypothesized to upregulate the X...

    Authors: Alyssa C. Lau, Kevin P. Zhu, Elizabeth A. Brouhard, Michael B. Davis and Györgyi Csankovszki
    Citation: Epigenetics & Chromatin 2016 9:44
    Content type: Research Published on:

  43. The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control ...

    Authors: Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli and Didier Trono
    Citation: Epigenetics & Chromatin 2018 11:7
    Content type: Research Published on:

  44. Changes to the epigenome with aging, and DNA modifications in particular, have been proposed as a central regulator of the aging process, a predictor of mortality, and a contributor to the pathogenesis of age-...

    Authors: Niran Hadad, Dustin R. Masser, Sreemathi Logan, Benjamin Wronowski, Colleen A. Mangold, Nicholas Clark, Laura Otalora, Archana Unnikrishnan, Matthew M. Ford, Cory B. Giles, Jonathan D. Wren, Arlan Richardson, William E. Sonntag, David R. Stanford and Willard Freeman
    Citation: Epigenetics & Chromatin 2016 9:30
    Content type: Research Published on:

  45. Gonadotrope lineage differentiation is a stepwise process taking place during pituitary development. The early step of gonadotrope lineage specification is characterized by the expression of the Nr5a1 transcripti...

    Authors: Vincent Pacini, Florence Petit, Bruno Querat, Jean-Noël Laverriere, Joëlle Cohen-Tannoudji and David L’hôte
    Citation: Epigenetics & Chromatin 2019 12:48
    Content type: Research Published on:

  46. The genome of some vole rodents exhibit large blocks of heterochromatin coupled to their sex chromosomes. The DNA composition and transcriptional activity of these heterochromatin blocks have been studied, but...

    Authors: Kathrin S. Heinz, Alexander Rapp, Corella S. Casas-Delucchi, Anne Lehmkuhl, Ismael Romero-Fernández, Antonio Sánchez, Oliver H. Krämer, J. Alberto Marchal and M. Cristina Cardoso
    Citation: Epigenetics & Chromatin 2019 12:18
    Content type: Research Published on:

  47. Methylation of cytosines is an evolutionarily conserved epigenetic mark that is essential for the control of chromatin activity in many taxa. It acts mainly repressively, causing transcriptional gene silencing...

    Authors: Adéla Přibylová, Vojtěch Čermák, Dimitrij Tyč and Lukáš Fischer
    Citation: Epigenetics & Chromatin 2019 12:54
    Content type: Research Published on:

  48. Due to the hyper-activation of WNT signaling in a variety of cancer types, there has been a strong drive to develop pathway-specific inhibitors with the eventual goal of providing a chemotherapeutic antagonist...

    Authors: Malaina Gaddis, Diana Gerrard, Seth Frietze and Peggy J Farnham
    Citation: Epigenetics & Chromatin 2015 8:9
    Content type: Research Published on:

  49. Stretch enhancers (SEs) are large chromatin-defined regulatory elements that are at least 3,000 base pairs (bps) long, in contrast to the median enhancer length of 800 bps. SEs tend to be cell-type specific, r...

    Authors: Daniel X Quang, Michael R Erdos, Stephen C J Parker and Francis S Collins
    Citation: Epigenetics & Chromatin 2015 8:23
    Content type: Research Published on:

  50. Preservation of genome integrity by complete, error-free DNA duplication prior to cell division and by correct DNA damage repair is paramount for the development and maintenance of an organism. This holds true...

    Authors: Francesco Natale, Annina Scholl, Alexander Rapp, Wei Yu, Cathia Rausch and M. Cristina Cardoso
    Citation: Epigenetics & Chromatin 2018 11:61
    Content type: Research Published on:
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