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  1. Heterogametic species display a differential number of sex chromosomes resulting in imbalanced transcription levels for these chromosomes between males and females. To correct this disequilibrium, dosage comp...

    Authors: Gautier Richard, Fabrice Legeai, Nathalie Prunier-Leterme, Anthony Bretaudeau, Denis Tagu, Julie Jaquiéry and Gaël Le Trionnaire
    Citation: Epigenetics & Chromatin 2017 10:30
    Content type: Research Published on:

  2. RNA:DNA hybrids represent a non-canonical nucleic acid structure that has been associated with a range of human diseases and potential transcriptional regulatory functions. Mapping of RNA:DNA hybrids in human ...

    Authors: Julie Nadel, Rodoniki Athanasiadou, Christophe Lemetre, N. Ari Wijetunga, Pilib Ó Broin, Hanae Sato, Zhengdong Zhang, Jeffrey Jeddeloh, Cristina Montagna, Aaron Golden, Cathal Seoighe and John M. Greally
    Citation: Epigenetics & Chromatin 2015 8:46
    Content type: Research Published on:

  3. Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying change in the underlying genomic sequence. A number of studies in animal models have shown that dy...

    Authors: Bridget E. Collins, Celeste B. Greer, Benjamin C. Coleman and J. David Sweatt
    Citation: Epigenetics & Chromatin 2019 12:7
    Content type: Review Published on:

  4. Compensatory liver hyperplasia—or regeneration—induced by two-thirds partial hepatectomy (PH) permits the study of synchronized activation of mammalian gene expression, particularly in relation to cell prolife...

    Authors: Leonor Rib, Dominic Villeneuve, Shilpi Minocha, Viviane Praz, Nouria Hernandez, Nicolas Guex and Winship Herr
    Citation: Epigenetics & Chromatin 2018 11:52
    Content type: Research Published on:

  5. TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been inve...

    Authors: Gabriel Gutiérrez, Gonzalo Millán-Zambrano, Daniel A. Medina, Antonio Jordán-Pla, José E. Pérez-Ortín, Xenia Peñate and Sebastián Chávez
    Citation: Epigenetics & Chromatin 2017 10:58
    Content type: Methodology Published on:

  6. The cohesin complex consists of multiple core subunits that play critical roles in mitosis and transcriptional regulation. The cohesin-associated protein Wapal plays a central role in off-loading cohesin to fa...

    Authors: Cary Stelloh, Michael H. Reimer, Kirthi Pulakanti, Steven Blinka, Jonathan Peterson, Luca Pinello, Shuang Jia, Sergei Roumiantsev, Martin J. Hessner, Samuel Milanovich, Guo-Cheng Yuan and Sridhar Rao
    Citation: Epigenetics & Chromatin 2016 9:14
    Content type: Research Published on:

  7. The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer...

    Authors: Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake and Tilman Borggrefe
    Citation: Epigenetics & Chromatin 2019 12:37
    Content type: Review Published on:

  9. DamID, in which a protein of interest is fused to Dam methylase, enables mapping of protein-DNA binding through readout of adenine methylation in genomic DNA. DamID offers a compelling alternative to chromati...

    Authors: Tomasz Szczesnik, Joshua W. K. Ho and Richard Sherwood
    Citation: Epigenetics & Chromatin 2019 12:36
    Content type: Methodology Published on:

  10. Genome-wide studies in higher eukaryotes have revealed the presence of paused RNA polymerase II (RNA-Pol) at about 30–50 bp downstream of the transcription start site of genes involved in developmental control...

    Authors: Shih-Ying Tsai, Yuh-Long Chang, Krishna B. S. Swamy, Ruei-Lin Chiang and Der-Hwa Huang
    Citation: Epigenetics & Chromatin 2016 9:32
    Content type: Research Published on:

  11. A complex interplay between chromatin and topological machineries is critical for genome architecture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its m...

    Authors: Douglas Maya-Miles, Eloísa Andújar, Mónica Pérez-Alegre, Marina Murillo-Pineda, Marta Barrientos-Moreno, María J. Cabello-Lobato, Elena Gómez-Marín, Macarena Morillo-Huesca and Félix Prado
    Citation: Epigenetics & Chromatin 2019 12:47
    Content type: Research Published on:

  12. The concept of pioneer transcription factors is emerging as an essential part of the epigenetic regulation, taking place during cell development and differentiation. However, the precise molecular mechanism un...

    Authors: Bettina M. Fuglerud, Marit Ledsaak, Marie Rogne, Ragnhild Eskeland and Odd S. Gabrielsen
    Citation: Epigenetics & Chromatin 2018 11:35
    Content type: Research Published on:

  13. DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, im...

    Authors: Thadeous J. Kacmarczyk, Mame P. Fall, Xihui Zhang, Yuan Xin, Yushan Li, Alicia Alonso and Doron Betel
    Citation: Epigenetics & Chromatin 2018 11:21
    Content type: Research Published on:

  14. ChIP-seq is the method of choice for genome-wide studies of protein–DNA interactions. We describe a new method for ChIP-seq sample preparation, termed lobChIP, where the library reactions are performed on cros...

    Authors: Ola Wallerman, Helena Nord, Madhusudhan Bysani, Lisa Borghini and Claes Wadelius
    Citation: Epigenetics & Chromatin 2015 8:25
    Content type: Methodology Published on:

  16. Although technological advances now allow increased tumor profiling, a detailed understanding of the mechanisms leading to the development of different cancers remains elusive. Our approach toward understandin...

    Authors: Suhn Kyong Rhie, Yu Guo, Yu Gyoung Tak, Lijing Yao, Hui Shen, Gerhard A. Coetzee, Peter W. Laird and Peggy J. Farnham
    Citation: Epigenetics & Chromatin 2016 9:50
    Content type: Research Published on:

  17. Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and signific...

    Authors: Alexandra V. Goodnight, Isaac Kremsky, Sujittra Khampang, Yoon Hee Jung, James M. Billingsley, Steven E. Bosinger, Victor G. Corces and Anthony W. S. Chan
    Citation: Epigenetics & Chromatin 2019 12:67
    Content type: Research Published on:

  19. Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood. Using a Drosophila m...

    Authors: Elizaveta Radion, Valeriya Morgunova, Sergei Ryazansky, Natalia Akulenko, Sergey Lavrov, Yuri Abramov, Pavel A. Komarov, Sergey I. Glukhov, Ivan Olovnikov and Alla Kalmykova
    Citation: Epigenetics & Chromatin 2018 11:40
    Content type: Research Published on:

  20. The death domain-associated protein (DAXX) collaborates with accessory proteins to deposit the histone variant H3.3 into mouse telomeric and pericentromeric repeat DNA. Pericentromeric repeats are the main gen...

    Authors: Lindsy M. Rapkin, Kashif Ahmed, Stanimir Dulev, Ren Li, Hiroshi Kimura, Alexander M. Ishov and David P. Bazett-Jones
    Citation: Epigenetics & Chromatin 2015 8:44
    Content type: Research Published on:

  21. The 5 hydroxymethylation (5hmC) mark and TET DNA dioxygenases play a pivotal role in embryonic stem cell differentiation and animal development. However, very little is known about TET enzymes in lineage deter...

    Authors: Dimitrios Cakouros, Sarah Hemming, Kahlia Gronthos, Renjing Liu, Andrew Zannettino, Songtao Shi and Stan Gronthos
    Citation: Epigenetics & Chromatin 2019 12:3
    Content type: Research Published on:

  22. Understanding the function of histone post-translational modifications is the key to deciphering how genomic activities are regulated. Among the least well-understood histone modifications in vivo are those t...

    Authors: Hillary K. Graves, Pingping Wang, Matthew Lagarde, Zhihong Chen and Jessica K. Tyler
    Citation: Epigenetics & Chromatin 2016 9:9
    Content type: Research Published on:

  23. There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail...

    Authors: Christopher Schröder, Elsa Leitão, Stefan Wallner, Gerd Schmitz, Ludger Klein-Hitpass, Anupam Sinha, Karl-Heinz Jöckel, Stefanie Heilmann-Heimbach, Per Hoffmann, Markus M. Nöthen, Michael Steffens, Peter Ebert, Sven Rahmann and Bernhard Horsthemke
    Citation: Epigenetics & Chromatin 2017 10:37
    Content type: Research Published on:

  24. Pax6 is a key regulator of the entire cascade of ocular lens formation through specific binding to promoters and enhancers of batteries of target genes. The promoters and enhancers communicate with each other ...

    Authors: Jian Sun, Yilin Zhao, Rebecca McGreal, Yamit Cohen-Tayar, Shira Rockowitz, Carola Wilczek, Ruth Ashery-Padan, David Shechter, Deyou Zheng and Ales Cvekl
    Citation: Epigenetics & Chromatin 2016 9:37
    Content type: Research Published on:

  25. Histones organize DNA into chromatin through a variety of processes. Among them, a vast diversity of histone variants can be incorporated into chromatin and finely modulate its organization and functionality. ...

    Authors: Sara El Kennani, Annie Adrait, Olga Permiakova, Anne-Marie Hesse, Côme Ialy-Radio, Myriam Ferro, Virginie Brun, Julie Cocquet, Jérôme Govin and Delphine Pflieger
    Citation: Epigenetics & Chromatin 2018 11:2
    Content type: Methodology Published on:

  26. Hematopoietic stem cell renewal and differentiation are regulated through epigenetic processes. The conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC) by ten-eleven-translocation enzymes provid...

    Authors: Xavier Tekpli, Alfonso Urbanucci, Adnan Hashim, Cathrine B. Vågbø, Robert Lyle, Marianne K. Kringen, Anne Cathrine Staff, Ingunn Dybedal, Ian G. Mills, Arne Klungland and Judith Staerk
    Citation: Epigenetics & Chromatin 2016 9:21
    Content type: Research Published on:

  27. Functional regulatory regions in eukaryotic genomes are characterized by the disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin accessibility is one of the key mediators of ...

    Authors: Juan Du, Amy Leung, Candi Trac, Michael Lee, Brian W. Parks, Aldons J. Lusis, Rama Natarajan and Dustin E. Schones
    Citation: Epigenetics & Chromatin 2016 9:28
    Content type: Research Published on:

  29. Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of op...

    Authors: Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, Ross C. Hardison and David M. Bodine
    Citation: Epigenetics & Chromatin 2018 11:22
    Content type: Research Published on:

  31. Meiosis is a specialized germ cell cycle that generates haploid gametes. In the initial stage of meiosis, meiotic prophase I (MPI), homologous chromosomes pair and recombine. Extensive changes in chromatin in ...

    Authors: Valeriya Gaysinskaya, Brendan F. Miller, Chiara De Luca, Godfried W. van der Heijden, Kasper D. Hansen and Alex Bortvin
    Citation: Epigenetics & Chromatin 2018 11:15
    Content type: Research Published on:

  32. The Illumina 450k array has been widely used in epigenetic association studies. Current quality-control (QC) pipelines typically remove certain sets of probes, such as those containing a SNP or with multiple m...

    Authors: Shan V. Andrews, Christine Ladd-Acosta, Andrew P. Feinberg, Kasper D. Hansen and M. Daniele Fallin
    Citation: Epigenetics & Chromatin 2016 9:56
    Content type: Research Published on:

  33. DNA methylomes are extensively reprogrammed during mouse pre-implantation and early germ cell development. The main feature of this reprogramming is a genome-wide decrease in 5-methylcytosine (5mC). Standard h...

    Authors: Julia Arand, Mark Wossidlo, Konstantin Lepikhov, Julian R Peat, Wolf Reik and Jörn Walter
    Citation: Epigenetics & Chromatin 2015 8:1
    Content type: Research Published on:

  34. Histone variants play further important roles in DNA packaging and controlling gene expression. However, our understanding about their composition and their functions is limited.

    Authors: Kyoung-Jae Won, Inchan Choi, Gary LeRoy, Barry M Zee, Simone Sidoli, Michelle Gonzales-Cope and Benjamin A Garcia
    Citation: Epigenetics & Chromatin 2015 8:13
    Content type: Methodology Published on:

  35. In mammals, the regulation of imprinted genes is controlled by differential methylation at imprinting control regions which acquire parent of origin-specific methylation patterns during gametogenesis and retai...

    Authors: Julianna Nechin, Emma Tunstall, Naideline Raymond, Nicole Hamagami, Chris Pathmanabhan, Samantha Forestier and Tamara L. Davis
    Citation: Epigenetics & Chromatin 2019 12:64
    Content type: Research Published on:

  36. DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents th...

    Authors: María-Paz Ramos, Neil Ari Wijetunga, Andrew S McLellan, Masako Suzuki and John M Greally
    Citation: Epigenetics & Chromatin 2015 8:11
    Content type: Research Published on:

  37. Facioscapulohumeral muscular dystrophy 1 (FSHD1) has an autosomal dominant pattern of inheritance and primarily affects skeletal muscle. The genetic cause of FSHD1 is contraction of the D4Z4 macrosatellite arr...

    Authors: Premi Haynes, Karol Bomsztyk and Daniel G. Miller
    Citation: Epigenetics & Chromatin 2018 11:47
    Content type: Research Published on:

  38. TH2B is a major histone variant that replaces about 80–85% of somatic H2B in mammalian spermatocytes and spermatids. The post-translational modifications (PTMs) on TH2B have been well characterised in spermato...

    Authors: Iyer Aditya Mahadevan, Satyakrishna Pentakota, Raktim Roy, Utsa Bhaduri and Manchanahalli R. Satyanarayana Rao
    Citation: Epigenetics & Chromatin 2019 12:53
    Content type: Research Published on:

  39. Defining how epigenetic information is established in the germline during fetal development is key to understanding how epigenetic information is inherited and impacts on evolution and human health and disease.

    Authors: Lexie Prokopuk, Jessica M. Stringer, Kirsten Hogg, Kirstin D. Elgass and Patrick S. Western
    Citation: Epigenetics & Chromatin 2017 10:7
    Content type: Research Published on:

  40. Genetic recombination plays an important role in evolution, facilitating the creation of new, favorable combinations of alleles and the removal of deleterious mutations by unlinking them from surrounding seque...

    Authors: Michael Walker, Timothy Billings, Christopher L. Baker, Natalie Powers, Hui Tian, Ruth L. Saxl, Kwangbom Choi, Matthew A. Hibbs, Gregory W. Carter, Mary Ann Handel, Kenneth Paigen and Petko M. Petkov
    Citation: Epigenetics & Chromatin 2015 8:31
    Content type: Research Published on:

  41. In most mammalian cell lines, chromatin located at the nuclear periphery is represented by condensed heterochromatin, as evidenced by microscopy observations and DamID mapping of lamina-associated domains (LAD...

    Authors: Alexey V. Pindyurin, Artem A. Ilyin, Anton V. Ivankin, Mikhail V. Tselebrovsky, Valentina V. Nenasheva, Elena A. Mikhaleva, Ludo Pagie, Bas van Steensel and Yuri Y. Shevelyov
    Citation: Epigenetics & Chromatin 2018 11:65
    Content type: Research Published on:

  42. In the mammalian zygote, epigenetic reprogramming is a tightly controlled process of coordinated alterations of histone and DNA modifications. The parental genomes of the zygote show distinct patterns of hist...

    Authors: Jie Lan, Konstantin Lepikhov, Pascal Giehr and Joern Walter
    Citation: Epigenetics & Chromatin 2017 10:5
    Content type: Research Published on:

  44. Members of the HMGN protein family modulate chromatin structure and influence epigenetic modifications. HMGN1 and HMGN2 are highly expressed during early development and in the neural stem/progenitor cells of ...

    Authors: Sylvia Garza-Manero, Abdulmajeed Abdulghani A. Sindi, Gokula Mohan, Ohoud Rehbini, Valentine H. M. Jeantet, Mariarca Bailo, Faeezah Abdul Latif, Maureen P. West, Ross Gurden, Lauren Finlayson, Silvija Svambaryte, Adam G. West and Katherine L. West
    Citation: Epigenetics & Chromatin 2019 12:73
    Content type: Research Published on:

  45. ATP-dependent chromatin remodelling complexes are responsible for establishing and maintaining the positions of nucleosomes. Chromatin remodellers are targeted to chromatin by transcription factors and non-cod...

    Authors: Katherine A. Giles, Cathryn M. Gould, Qian Du, Ksenia Skvortsova, Jenny Z. Song, Madhavi P. Maddugoda, Joanna Achinger-Kawecka, Clare Stirzaker, Susan J. Clark and Phillippa C. Taberlay
    Citation: Epigenetics & Chromatin 2019 12:12
    Content type: Research Published on:

  46. Melon (Cucumis melo) is an important vegetable crop from the Cucurbitaceae family and a reference model specie for sex determination, fruit ripening and vascular fluxes studies. Nevertheless, the nature and role ...

    Authors: David Latrasse, Natalia Y. Rodriguez-Granados, Alaguraj Veluchamy, Kiruthiga Gayathri Mariappan, Claudia Bevilacqua, Nicolas Crapart, Celine Camps, Vivien Sommard, Cécile Raynaud, Catherine Dogimont, Adnane Boualem, Moussa Benhamed and Abdelhafid Bendahmane
    Citation: Epigenetics & Chromatin 2017 10:22
    Content type: Research Published on:

  47. DNA methylation is a fundamental epigenetic modification that is involved in many biological systems such as differentiation and disease. We and others recently showed that some transcription factors (TFs) are...

    Authors: Takahiro Suzuki, Shiori Maeda, Erina Furuhata, Yuri Shimizu, Hajime Nishimura, Mami Kishima and Harukazu Suzuki
    Citation: Epigenetics & Chromatin 2017 10:60
    Content type: Methodology Published on:

  48. DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding th...

    Authors: Jianlin He, Xiguang Xu, Aboozar Monavarfeshani, Sharmi Banerjee, Michael A. Fox and Hehuang Xie
    Citation: Epigenetics & Chromatin 2019 12:13
    Content type: Research Published on:

  49. The capacity for plasticity in the adult brain is limited by the anatomical traces laid down during early postnatal life. Removing certain molecular brakes, such as histone deacetylases (HDACs), has proven to ...

    Authors: Andreas Lennartsson, Erik Arner, Michela Fagiolini, Alka Saxena, Robin Andersson, Hazuki Takahashi, Yukihiko Noro, Judy Sng, Albin Sandelin, Takao K. Hensch and Piero Carninci
    Citation: Epigenetics & Chromatin 2015 8:55
    Content type: Research Published on:
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