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Page 7 of 13

  1. Content type: Research

    The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling...

    Authors: Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira

    Citation: Epigenetics & Chromatin 2014 7:29

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  2. Content type: Research

    Genome-wide DNA methylation at a single nucleotide resolution in different primary cells of the mammalian genome helps to determine the characteristics and functions of tissue-specific hypomethylated regions (...

    Authors: Raghunath Chatterjee, Ximiao He, Di Huang, Peter FitzGerald, Andrew Smith and Charles Vinson

    Citation: Epigenetics & Chromatin 2014 7:35

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  3. Content type: Research

    The interplay between epigenetic modifications and chromatin structure are integral to our understanding of genome function. Methylation of cytosine (5mC) at CG dinucleotides, traditionally associated with tra...

    Authors: Ximiao He, Raghunath Chatterjee, Desiree Tillo, Andrew Smith, Peter FitzGerald and Charles Vinson

    Citation: Epigenetics & Chromatin 2014 7:34

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  4. Content type: Research

    Transcription factors (TFs) and histone modifications (HMs) play critical roles in gene expression by regulating mRNA transcription. Modelling frameworks have been developed to integrate high-throughput omics ...

    Authors: David M Budden, Daniel G Hurley, Joseph Cursons, John F Markham, Melissa J Davis and Edmund J Crampin

    Citation: Epigenetics & Chromatin 2014 7:36

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  5. Content type: Review

    Transcriptional activation throughout the eukaryotic lineage has been tightly linked with disruption of nucleosome organization at promoters, enhancers, silencers, insulators and locus control regions due to t...

    Authors: Maria Tsompana and Michael J Buck

    Citation: Epigenetics & Chromatin 2014 7:33

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  6. Content type: Research

    Chromatin consists of ordered nucleosomal arrays that are controlled by highly conserved adenosine triphosphate (ATP)-dependent chromatin remodeling complexes. One such remodeler, chromodomain helicase DNA bin...

    Authors: Daechan Park, Haridha Shivram and Vishwanath R Iyer

    Citation: Epigenetics & Chromatin 2014 7:32

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  7. Content type: Research

    The activity of a single gene is influenced by the composition of the chromatin in which it is embedded. Nucleosome turnover, conformational dynamics, and covalent histone modifications each induce changes in ...

    Authors: Lisette C M Anink-Groenen, Timo R Maarleveld, Pernette J Verschure and Frank J Bruggeman

    Citation: Epigenetics & Chromatin 2014 7:30

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  8. Content type: Research

    DNA methylation is thought to play an important role in the regulation of mammalian gene expression, partly based on the observation that a lack of CpG island methylation in gene promoters is associated with h...

    Authors: Rachel Edgar, Powell Patrick Cheng Tan, Elodie Portales-Casamar and Paul Pavlidis

    Citation: Epigenetics & Chromatin 2014 7:28

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  9. Content type: Research

    Epigenetic modifications such as histone and DNA methylation are essential for silencing pluripotency genes during embryonic stem cell (ESC) differentiation. G9a is the major histone H3 Lys9 (H3K9) methyltrans...

    Authors: Danielle Bittencourt, Brian H Lee, Lu Gao, Daniel S Gerke and Michael R Stallcup

    Citation: Epigenetics & Chromatin 2014 7:27

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  10. Content type: Research

    Epigenetic reprogramming during early mammalian embryonic and germ cell development is a genome-wide process. CpG islands (CGIs), central to the regulation of mammalian gene expression, are exceptional in term...

    Authors: Heba Saadeh and Reiner Schulz

    Citation: Epigenetics & Chromatin 2014 7:26

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  11. Content type: Research

    Repression of retrotransposons is essential for genome integrity and the development of germ cells. Among retrotransposons, the establishment of CpG DNA methylation and epigenetic silencing of LINE1 (L1) eleme...

    Authors: Monica Di Giacomo, Stefano Comazzetto, Srihari C Sampath, Srinath C Sampath and Dónal O’Carroll

    Citation: Epigenetics & Chromatin 2014 7:24

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  12. Content type: Research

    The formation of chromatin domains is an important step in lineage commitment. In human hematopoietic stem and progenitor cells (HSPCs), G9a/GLP-dependent H3K9me2 chromatin territories form de novo during lineage...

    Authors: Dustin E Schones, Xiaoji Chen, Candi Trac, Ryan Setten and Patrick J Paddison

    Citation: Epigenetics & Chromatin 2014 7:23

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  13. Content type: Research

    Stored, soluble histones in eggs are essential for early development, in particular during the maternally controlled early cell cycles in the absence of transcription. Histone post-translational modifications ...

    Authors: Wei-Lin Wang, Lissa C Anderson, Joshua J Nicklay, Hongshan Chen, Matthew J Gamble, Jeffrey Shabanowitz, Donald F Hunt and David Shechter

    Citation: Epigenetics & Chromatin 2014 7:22

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  14. Content type: Research

    Dendritic cells (DCs) are important mediators of innate and adaptive immune responses, but the gene networks governing their lineage differentiation and maturation are poorly understood. To gain insight into t...

    Authors: Xue Zhang, Ashley Ulm, Hari K Somineni, Sunghee Oh, Matthew T Weirauch, Hong-Xuan Zhang, Xiaoting Chen, Maria A Lehn, Edith M Janssen and Hong Ji

    Citation: Epigenetics & Chromatin 2014 7:21

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  15. Content type: Research

    Targeted gene silencing is an important approach in both drug development and basic research. However, the selection of a potent suppressor has become a significant hurdle to implementing maximal gene inhibiti...

    Authors: Ai-Niu Ma, Hong Wang, Rui Guo, Yong-Xiang Wang, Wei Li, Jiuwei Cui, Guanjun Wang, Andrew R Hoffman and Ji-Fan Hu

    Citation: Epigenetics & Chromatin 2014 7:20

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  16. Content type: Research

    Epigenetic reprogramming of fetal germ cells involves the genome-wide erasure and subsequent re-establishment of DNA methylation. Mouse studies indicate that DNA demethylation may be initiated at embryonic day...

    Authors: Catherine M Rose, Sander van den Driesche, Richard M Sharpe, Richard R Meehan and Amanda J Drake

    Citation: Epigenetics & Chromatin 2014 7:19

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  17. Content type: Methodology

    The recent introduction of pathology tissue-chromatin immunoprecipitation (PAT-ChIP), a technique allowing chromatin immunoprecipitation from formalin-fixed and paraffin-embedded (FFPE) tissues, has expanded t...

    Authors: Stefano Amatori, Marco Ballarini, Alice Faversani, Elena Belloni, Fulvia Fusar, Silvano Bosari, Pier Giuseppe Pelicci, Saverio Minucci and Mirco Fanelli

    Citation: Epigenetics & Chromatin 2014 7:18

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  18. Content type: Research

    Methyl-CpG binding protein 2 (MECP2) is a protein that specifically binds methylated DNA, thus regulating transcription and chromatin organization. Mutations in the gene have been identified as the principal c...

    Authors: Congdi Song, Yana Feodorova, Jacky Guy, Leo Peichl, Katharina Laurence Jost, Hiroshi Kimura, Maria Cristina Cardoso, Adrian Bird, Heinrich Leonhardt, Boris Joffe and Irina Solovei

    Citation: Epigenetics & Chromatin 2014 7:17

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  19. Content type: Research

    Within the nucleus of eukaryotic cells, chromatin is organized into compact, silent regions called heterochromatin and more loosely packaged regions of euchromatin where transcription is more active. Although ...

    Authors: Na Xu, Alexander V Emelyanov, Dmitry V Fyodorov and Arthur I Skoultchi

    Citation: Epigenetics & Chromatin 2014 7:16

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  20. Content type: Research

    The chromatin remodeler NAP1L1, which is upregulated in small intestinal neuroendocrine neoplasms (NENs), has been implicated in cell cycle progression. As p57Kip2 (CDKN1C), a negative regulator of proliferation ...

    Authors: Simon Schimmack, Andrew Taylor, Ben Lawrence, Daniele Alaimo, Hubertus Schmitz-Winnenthal, Markus W Büchler, Irvin M Modlin and Mark Kidd

    Citation: Epigenetics & Chromatin 2014 7:15

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  21. Content type: Methodology

    Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containi...

    Authors: Martin Philpott, Catherine M Rogers, Clarence Yapp, Chris Wells, Jean-Philippe Lambert, Claire Strain-Damerell, Nicola A Burgess-Brown, Anne-Claude Gingras, Stefan Knapp and Susanne Müller

    Citation: Epigenetics & Chromatin 2014 7:14

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  22. Content type: Research

    X chromosome inactivation (XCI) is a developmental program of heterochromatin formation that initiates during early female mammalian embryonic development and is maintained through a lifetime of cell divisions...

    Authors: Alissa Minkovsky, Anna Sahakyan, Elyse Rankin-Gee, Giancarlo Bonora, Sanjeet Patel and Kathrin Plath

    Citation: Epigenetics & Chromatin 2014 7:12

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  23. Content type: Research

    Silencing of the paternal X chromosome (Xp), a phenomenon known as imprinted X-chromosome inactivation (I-XCI), characterises, amongst mouse extraembryonic lineages, the primitive endoderm and the extraembryon...

    Authors: Sarra Merzouk, Jane Lynda Deuve, Agnès Dubois, Pablo Navarro, Philip Avner and Céline Morey

    Citation: Epigenetics & Chromatin 2014 7:11

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  24. Content type: Research

    Significant efforts have recently been put into the investigation of the spatial organization and the chromatin-interaction networks of genomes. Chromosome conformation capture (3C) technology and its derivati...

    Authors: Petros Kolovos, Harmen JG van de Werken, Nick Kepper, Jessica Zuin, Rutger WW Brouwer, Christel EM Kockx, Kerstin S Wendt, Wilfred FJ van IJcken, Frank Grosveld and Tobias A Knoch

    Citation: Epigenetics & Chromatin 2014 7:10

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  25. Content type: Research

    Differential distribution of DNA methylation on the parental alleles of imprinted genes distinguishes the alleles from each other and dictates their parent of origin-specific expression patterns. While differe...

    Authors: Alyssa Gagne, Abigail Hochman, Mahvish Qureshi, Celia Tong, Jessica Arbon, Kayla McDaniel and Tamara L Davis

    Citation: Epigenetics & Chromatin 2014 7:9

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  26. Content type: Research

    A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quant...

    Authors: Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer, Lothar Schermelleh and Marion Cremer

    Citation: Epigenetics & Chromatin 2014 7:8

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  27. Content type: Methodology

    Histone post-translational modifications (PTMs) are key epigenetic regulators in chromatin-based processes. Increasing evidence suggests that vast combinations of PTMs exist within chromatin histones. These co...

    Authors: Zhangli Su, Melissa D Boersma, Jin-Hee Lee, Samuel S Oliver, Shichong Liu, Benjamin A Garcia and John M Denu

    Citation: Epigenetics & Chromatin 2014 7:7

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  28. Content type: Research

    Genomic imprinting is the epigenetic marking of genes that results in parent-of-origin monoallelic expression. Most imprinted domains are associated with differentially DNA methylated regions (DMRs) that origi...

    Authors: Franck Court, Cristina Camprubi, Cristina Vicente Garcia, Amy Guillaumet-Adkins, Angela Sparago, Davide Seruggia, Juan Sandoval, Manel Esteller, Alex Martin-Trujillo, Andrea Riccio, Lluis Montoliu and David Monk

    Citation: Epigenetics & Chromatin 2014 7:5

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  29. Content type: Research

    Regulation of chromatin structure involves deposition of selective histone variants into nucleosome arrays. Numerous histone H3 variants become differentially expressed by individual nanochromosomes in the cou...

    Authors: Sakeh Forcob, Aneta Bulic, Franziska Jönsson, Hans J Lipps and Jan Postberg

    Citation: Epigenetics & Chromatin 2014 7:4

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  30. Content type: Research

    Epigenetic modifications, such as cytosine methylation in CpG-rich regions, regulate multiple functions in mammalian development. Maternal nutrients affecting one-carbon metabolism during gestation can exert l...

    Authors: Subit Barua, Salomon Kuizon, Kathryn K Chadman, Michael J Flory, W Ted Brown and Mohammed A Junaid

    Citation: Epigenetics & Chromatin 2014 7:3

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  31. Content type: Research

    Ring chromosome 17 syndrome is a rare disease that arises from the breakage and reunion of the short and long arms of chromosome 17. Usually this abnormality results in deletion of genetic material, which expl...

    Authors: Cecilia Surace, Francesco Berardinelli, Andrea Masotti, Maria Cristina Roberti, Letizia Da Sacco, Gemma D’Elia, Pietro Sirleto, Maria Cristina Digilio, Raffaella Cusmai, Simona Grotta, Stefano Petrocchi, May El Hachem, Elisa Pisaneschi, Laura Ciocca, Serena Russo, Francesca Romana Lepri…

    Citation: Epigenetics & Chromatin 2014 7:1

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  32. Content type: Research

    Cellular differentiation and reprogramming are accompanied by changes in replication timing and 3D organization of large-scale (400 to 800 Kb) chromosomal domains (‘replication domains’), but few gene products...

    Authors: Shin-ichiro Takebayashi, Ienglam Lei, Tyrone Ryba, Takayo Sasaki, Vishnu Dileep, Dana Battaglia, Xiaolin Gao, Peng Fang, Yong Fan, Miguel A Esteban, Jiong Tang, Gerald R Crabtree, Zhong Wang and David M Gilbert

    Citation: Epigenetics & Chromatin 2013 6:42

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  33. Content type: Review

    The remarkable ability of many parasites to evade host immunity is the key to their success and pervasiveness. The immune evasion is directly linked to the silencing of the members of extended families of gene...

    Authors: Brandon A Wyse, Roxanne Oshidari, Daniel CB Jeffery and Krassimir Y Yankulov

    Citation: Epigenetics & Chromatin 2013 6:40

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  34. Content type: Research

    DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation....

    Authors: Fátima Santos, Julian Peat, Heather Burgess, Cristina Rada, Wolf Reik and Wendy Dean

    Citation: Epigenetics & Chromatin 2013 6:39

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  35. Content type: Research

    The discovery of gene body methylation, which refers to DNA methylation within gene coding region, suggests an as yet unknown role of DNA methylation at actively transcribed genes. In invertebrates, gene bodie...

    Authors: Miho M Suzuki, Akiko Yoshinari, Madoka Obara, Shohei Takuno, Shuji Shigenobu, Yasunori Sasakura, Alastair RW Kerr, Shaun Webb, Adrian Bird and Atsuo Nakayama

    Citation: Epigenetics & Chromatin 2013 6:38

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  36. Content type: Research

    Germ cells in animals are highly specialized to preserve the genome. A distinct set of chromatin structures must be properly established in germ cells to maintain cell fate and genome integrity. We describe DN...

    Authors: Sam Guoping Gu, Barbara Goszczynski, James D McGhee and Andrew Z Fire

    Citation: Epigenetics & Chromatin 2013 6:37

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  37. Content type: Research

    Altered DNA methylation patterns represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Several studies have described global and complex age-related methylatio...

    Authors: Günter Raddatz, Sabine Hagemann, Dvir Aran, Jörn Söhle, Pranav P Kulkarni, Lars Kaderali, Asaf Hellman, Marc Winnefeld and Frank Lyko

    Citation: Epigenetics & Chromatin 2013 6:36

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  38. Content type: Research

    The incorporation of histone variants into nucleosomes is one of the main strategies that the cell uses to regulate the structure and function of chromatin. Histone H2A.Z is an evolutionarily conserved histone...

    Authors: Kyunghwan Kim, Vasu Punj, Jongkyu Choi, Kyu Heo, Jin-Man Kim, Peter W Laird and Woojin An

    Citation: Epigenetics & Chromatin 2013 6:34

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  39. Content type: Methodology

    The growing interest in the role of epigenetic modifications in human health and disease has led to the development of next-generation sequencing methods for whole genome analysis of DNA methylation patterns. ...

    Authors: Dustin R Masser, Arthur S Berg and Willard M Freeman

    Citation: Epigenetics & Chromatin 2013 6:33

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  40. Content type: Review

    DNA replication is a highly conserved process that accurately copies the genetic information from one generation to the next. The processes of chromatin disassembly and reassembly during DNA replication also h...

    Authors: Varija N Budhavarapu, Myrriah Chavez and Jessica K Tyler

    Citation: Epigenetics & Chromatin 2013 6:32

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  41. Content type: Research

    Enhancer elements determine the level of target gene transcription in a tissue-specific manner, providing for individual patterns of gene expression in different cells. Knowledge of the mechanisms controlling ...

    Authors: Maksim Erokhin, Anna Davydova, Alexander Parshikov, Vasily M Studitsky, Pavel Georgiev and Darya Chetverina

    Citation: Epigenetics & Chromatin 2013 6:31

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  42. Content type: Methodology

    Genome-wide maps of transcription factor binding sites in primary tissues can expand our understanding of genome function, transcriptional regulation, and genetic alterations that contribute to disease risk. H...

    Authors: Daniel Savic, Jason Gertz, Preti Jain, Gregory M Cooper and Richard M Myers

    Citation: Epigenetics & Chromatin 2013 6:30

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