Brandi ML, Agarwal SK, Perrier ND, Lines KE, Valk GD, Thakker RV. Multiple endocrine neoplasia type 1: latest insights. Endocr Rev. 2020;42(2):1333.
Google Scholar
Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 1997;276(5311):404–7.
Article
CAS
PubMed
Google Scholar
Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science. 2011;331(6021):1199–203.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hoadley KA, Yau C, Hinoue T, Wolf DM, Lazar AJ, Drill E, et al. Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer. Cell. 2018;173(2):291-304.e6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dreijerink KMA, Timmers HTM, Brown M. Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1. Endocr Relat Cancer. 2017;24(10):T135–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell. 2004;13(4):587–97.
Article
CAS
PubMed
Google Scholar
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci USA. 2011;108(33):13379–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, et al. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature. 2012;482(7386):542–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell. 1999;96(1):143–52.
Article
CAS
PubMed
Google Scholar
van Nuland R, Smits AH, Pallaki P, Jansen PW, Vermeulen M, Timmers HT. Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes. Mol Cell Biol. 2013;33(10):2067–77.
Article
PubMed
PubMed Central
CAS
Google Scholar
Grembecka J, He S, Shi A, Purohit T, Muntean AG, Sorenson RJ, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. 2012;8(3):277–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ozyerli-Goknar E, Nizamuddin S, Timmers HTM. A box of chemistry to inhibit the MEN1 tumor suppressor gene promoting leukemia. ChemMedChem. 2021;16(9):1391–402.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yokoyama A, Somervaille TC, Smith KS, Rozenblatt-Rosen O, Meyerson M, Cleary ML. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell. 2005;123(2):207–18.
Article
CAS
PubMed
Google Scholar
Dzama MM, Steiner M, Rausch J, Sasca D, Schönfeld J, Kunz K, et al. Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition. Blood. 2020;136(21):2442–56.
Article
PubMed
PubMed Central
Google Scholar
Klossowski S, Miao H, Kempinska K, Wu T, Purohit T, Kim E, et al. Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest. 2020;130(2):981–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Krivtsov AV, Evans K, Gadrey JY, Eschle BK, Hatton C, Uckelmann HJ, et al. A menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia. Cancer Cell. 2019;36(6):660-73.e11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Uckelmann HJ, Kim SM, Wong EM, Hatton C, Giovinazzo H, Gadrey JY, et al. Therapeutic targeting of preleukemia cells in a mouse model of. Science. 2020;367(6477):586–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M. Therapeutic implications of menin inhibition in acute leukemias. Leukemia. 2021;35(9):2482–95.
Article
CAS
PubMed
Google Scholar
Zetoune AB, Fontanière S, Magnin D, Anczuków O, Buisson M, Zhang CX, et al. Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues. BMC Genet. 2008;9:83.
Article
PubMed
PubMed Central
CAS
Google Scholar
Canaff L, Vanbellinghen JF, Kanazawa I, Kwak H, Garfield N, Vautour L, et al. Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA. J Clin Endocrinol Metab. 2012;97(2):E282–91.
Article
CAS
PubMed
Google Scholar
Yaguchi H, Ohkura N, Takahashi M, Nagamura Y, Kitabayashi I, Tsukada T. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol. 2004;24(15):6569–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hou R, Manwaring LP, Moley JF, Whelan A. A novel missense mutation in the MEN1 gene in a patient with multiple endocrine neoplasia type 1. Endocr Pract. 2011;17(3):e63–7.
Article
PubMed
Google Scholar
Bartsch D, Kopp I, Bergenfelz A, Rieder H, Münch K, Jäger K, et al. MEN1 gene mutations in 12 MEN1 families and their associated tumors. Eur J Endocrinol. 1998;139(4):416–20.
Article
CAS
PubMed
Google Scholar
Jäger AC, Friis-Hansen L, Hansen TV, Eskildsen PC, Sølling K, Knigge U, et al. Characteristics of the Danish families with multiple endocrine neoplasia type 1. Mol Cell Endocrinol. 2006;249(1–2):123–32.
Article
PubMed
CAS
Google Scholar
Poncin J, Abs R, Velkeniers B, Bonduelle M, Abramowicz M, Legros JJ, et al. Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases. Hum Mutat. 1999;13(1):54–60.
Article
CAS
PubMed
Google Scholar
Wang EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E, Sawicki MP. Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Res. 1998;58(19):4417–20.
CAS
PubMed
Google Scholar
Teh BT, Esapa CT, Houlston R, Grandell U, Farnebo F, Nordenskjöld M, et al. A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors. Am J Hum Genet. 1998;63(5):1544–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Böni R, Vortmeyer AO, Pack S, Park WS, Burg G, Hofbauer G, et al. Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas. J Invest Dermatol. 1998;111(3):539–40.
Article
PubMed
Google Scholar
Darling TN, Skarulis MC, Steinberg SM, Marx SJ, Spiegel AM, Turner M. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Dermatol. 1997;133(7):853–7.
Article
CAS
PubMed
Google Scholar
Dreijerink KM, Mulder KW, Winkler GS, Höppener JW, Lips CJ, Timmers HT. Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Res. 2006;66(9):4929–35.
Article
CAS
PubMed
Google Scholar
Finka A, Sharma SK, Goloubinoff P. Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones. Front Mol Biosci. 2015;2:29.
Article
PubMed
PubMed Central
CAS
Google Scholar
Skene PJ, Henikoff JG, Henikoff S. Targeted in situ genome-wide profiling with high efficiency for low cell numbers. Nat Protoc. 2018;13(5):1006–19.
Article
CAS
PubMed
Google Scholar
Koidl S, Timmers HTM. greenCUT&RUN: efficient genomic profiling of GFP-tagged transcription factors and chromatin regulators. Curr Protoc. 2021;1(10):e266.
Article
CAS
PubMed
Google Scholar
Nizamuddin S, Koidl S, Bhuiyan T, Werner TV, Biniossek ML, Bonvin AMJJ, et al. Integrating quantitative proteomics with accurate genome profiling of transcription factors by greenCUT&RUN. Nucleic Acids Res. 2021;49(9):e49.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dreijerink KMA, Groner AC, Vos ESM, Font-Tello A, Gu L, Chi D, et al. Enhancer-mediated oncogenic function of the menin tumor suppressor in breast cancer. Cell Rep. 2017;18(10):2359–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, et al. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Nat Commun. 2021;12(1):7216.
Article
CAS
PubMed
PubMed Central
Google Scholar
Biancaniello C, D’Argenio A, Giordano D, Dotolo S, Scafuri B, Marabotti A, et al. Investigating the effects of amino acid variations in human menin. Molecules. 2022;27(5):1747.
Article
CAS
PubMed
PubMed Central
Google Scholar
Caswell RC, Owens MM, Gunning AC, Ellard S, Wright CF. Using structural analysis. J Endocr Soc. 2019;3(12):2258–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, et al. Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly. Nat Struct Mol Biol. 2018;25(12):1119–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shimazu S, Nagamura Y, Yaguchi H, Ohkura N, Tsukada T. Correlation of mutant menin stability with clinical expression of multiple endocrine neoplasia type 1 and its incomplete forms. Cancer Sci. 2011;102(11):2097–102.
Article
CAS
PubMed
Google Scholar
Yang X, Pan Y, Qiu Z, Du Z, Zhang Y, Fa P, et al. RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHEK1 inhibitor efficacy in breast cancer cells. Clin Cancer Res. 2018;24(7):1629–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Human gene mutation database. http://www.hgmd.cf.ac.uk/ac/index.php. Accessed 27 June 2022.
Catalogue of somatic mutations in cancer. https://cancer.sanger.ac.uk/cosmic. Accessed 27 June 2022.
Visual molecular dynamics. http://www.ks.uiuc.edu/Research/vmd/. Accessed 27 June 2022.
Research collaboratory for structural bioinformatics. https://www.rcsb.org/pages/about-us/index. Accessed 27 June 2022.
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, et al. UCSF Chimera–a visualization system for exploratory research and analysis. J Comput Chem. 2004;25(13):1605–12.
Article
CAS
PubMed
Google Scholar
Dreijerink KM, Varier RA, van Beekum O, Jeninga EH, Höppener JW, Lips CJ, et al. The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation. Mol Cell Biol. 2009;29(18):5060–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
ImageJ. https://imagej.nih.gov/ij/. Accessed 27 June 2022.
Spruijt CG, Baymaz HI, Vermeulen M. Identifying specific protein-DNA interactions using SILAC-based quantitative proteomics. Methods Mol Biol. 2013;977:137–57.
Article
CAS
PubMed
Google Scholar
Tyanova S, Temu T, Cox J. The MaxQuant computational platform for mass spectrometry-based shotgun proteomics. Nat Protoc. 2016;11(12):2301–19.
Article
CAS
PubMed
Google Scholar
Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, et al. Global quantification of mammalian gene expression control. Nature. 2011;473(7347):337–42.
Article
PubMed
CAS
Google Scholar
Sequence read archive. https://www.ncbi.nlm.nih.gov/sra. Accessed 27 June 2022.
Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Method. 2012;9(4):357–9.
Article
CAS
Google Scholar
Ramírez F, Dündar F, Diehl S, Grüning BA, Manke T. deepTools: a flexible platform for exploring deep-sequencing data. Nucleic Acids Res. 2014;42:W187–91.
Article
PubMed
PubMed Central
CAS
Google Scholar
Tarasov A, Vilella AJ, Cuppen E, Nijman IJ, Prins P. Sambamba: fast processing of NGS alignment formats. Bioinformatics. 2015;31(12):2032–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nizamuddin S. Command lines voor menin peak analysis. https://github.com/snizam001/MEN1. Accessed 27 June 2022.