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  1. Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by subletha...

    Authors: Annika R. Seddon, Yusmiati Liau, Paul E. Pace, Allison L. Miller, Andrew B. Das, Martin A. Kennedy, Mark B. Hampton and Aaron J. Stevens
    Citation: Epigenetics & Chromatin 2021 14:17
  2. Pita is required for Drosophila development and binds specifically to a long motif in active promoters and insulators. Pita belongs to the Drosophila family of zinc-finger architectural proteins, which also in...

    Authors: Marat Sabirov, Olga Kyrchanova, Galina V. Pokholkova, Artem Bonchuk, Natalia Klimenko, Elena Belova, Igor F. Zhimulev, Oksana Maksimenko and Pavel Georgiev
    Citation: Epigenetics & Chromatin 2021 14:16
  3. The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which re...

    Authors: Maria Gridina, Evgeniy Mozheiko, Emil Valeev, Ludmila P. Nazarenko, Maria E. Lopatkina, Zhanna G. Markova, Maria I. Yablonskaya, Viktoria Yu Voinova, Nadezhda V. Shilova, Igor N. Lebedev and Veniamin Fishman
    Citation: Epigenetics & Chromatin 2021 14:15
  4. Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methy...

    Authors: Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu and Janine M. LaSalle
    Citation: Epigenetics & Chromatin 2021 14:13
  5. X-chromosome inactivation (XCI) in eutherian mammals is the epigenetic inactivation of one of the two X chromosomes in XX females in order to compensate for dosage differences with XY males. Not all genes are ...

    Authors: Bradley P. Balaton, Oriol Fornes, Wyeth W. Wasserman and Carolyn J. Brown
    Citation: Epigenetics & Chromatin 2021 14:12
  6. In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determinat...

    Authors: Reza Raeisossadati, Merari F. R. Ferrari, Alexandre Hiroaki Kihara, Issam AlDiri and Jeffrey M. Gross
    Citation: Epigenetics & Chromatin 2021 14:11
  7. Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histo...

    Authors: Kun Li and Ziqiang Wang
    Citation: Epigenetics & Chromatin 2021 14:10
  8. The mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vita...

    Authors: Lawrence T. C. Ong, Stephen D. Schibeci, Nicole L. Fewings, David R. Booth and Grant P. Parnell
    Citation: Epigenetics & Chromatin 2021 14:9
  9. Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood. In this study, we identifi...

    Authors: Martina Weigt, Qingsong Gao, Hyoju Ban, Haijin He, Guido Mastrobuoni, Stefan Kempa, Wei Chen and Fei Li
    Citation: Epigenetics & Chromatin 2021 14:8
  10. Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share...

    Authors: Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche Jr., Carrie R. Graveel and Matthew R. Steensma
    Citation: Epigenetics & Chromatin 2021 14:7
  11. Environmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheri...

    Authors: Daniel Beck, Millissia Ben Maamar and Michael K. Skinner
    Citation: Epigenetics & Chromatin 2021 14:6
  12. The vast majority of methods available to characterize genome-wide chromatin structure exploit differences in DNA accessibility to nucleases or chemical crosslinking. We developed a novel method to gauge genom...

    Authors: Luke T. Marr, Josefina Ocampo, David J. Clark and Jeffrey J. Hayes
    Citation: Epigenetics & Chromatin 2021 14:5
  13. Patterns of methylation influence lifespan, but methylation and lifespan may also depend on diet, or differ between genotypes. Prior to this study, interactions between diet and genotype have not been explored...

    Authors: Jack Hearn, Fiona Plenderleith and Tom J. Little
    Citation: Epigenetics & Chromatin 2021 14:4
  14. H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the e...

    Authors: Vasantha Shalini, Utsa Bhaduri, Anjhana C. Ravikkumar, Anusha Rengarajan and Rao M. R. Satyanarayana
    Citation: Epigenetics & Chromatin 2021 14:3
  15. Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are...

    Authors: Eric W. Martin, Jana Krietsch, Roman E. Reggiardo, Rebekah Sousae, Daniel H. Kim and E. Camilla Forsberg
    Citation: Epigenetics & Chromatin 2021 14:2
  16. DNA methylation has emerged as an important epigenetic regulator of brain processes, including circadian rhythms. However, how DNA methylation intervenes between environmental signals, such as light entrainmen...

    Authors: Federico Tinarelli, Elena Ivanova, Ilaria Colombi, Erica Barini, Edoardo Balzani, Celina Garcia Garcia, Laura Gasparini, Michela Chiappalone, Gavin Kelsey and Valter Tucci
    Citation: Epigenetics & Chromatin 2021 14:1
  17. Environmental impacts on a fetus can disrupt germ cell development leading to epimutations in mature germ cells. Paternal inheritance of adverse health effects through sperm epigenomes, including DNA methylome...

    Authors: Keiko Nohara, Kazuhiko Nakabayashi, Kazuyuki Okamura, Takehiro Suzuki, Shigekatsu Suzuki and Kenichiro Hata
    Citation: Epigenetics & Chromatin 2020 13:53
  18. The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a dep...

    Authors: Takeshi Tsusaka, Kei Fukuda, Chikako Shimura, Masaki Kato and Yoichi Shinkai
    Citation: Epigenetics & Chromatin 2020 13:52
  19. Epigenome-wide association studies (EWAS) have been widely applied to identify methylation CpG sites associated with human disease. To date, the Infinium MethylationEPIC array (EPIC) is commonly used for high-...

    Authors: Chang Shu, Xinyu Zhang, Bradley E. Aouizerat and Ke Xu
    Citation: Epigenetics & Chromatin 2020 13:51
  20. The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nucleosomes in intergenic sequences and poorly understood mechanisms of gene regulation. Variant...

    Authors: Jingyi Tang, Scott A. Chisholm, Lee M. Yeoh, Paul R. Gilson, Anthony T. Papenfuss, Karen P. Day, Michaela Petter and Michael F. Duffy
    Citation: Epigenetics & Chromatin 2020 13:50
  21. Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the...

    Authors: Carme Nuño-Cabanes, Varinia García-Molinero, Manuel Martín-Expósito, María-Eugenia Gas, Paula Oliete-Calvo, Encar García-Oliver, María de la Iglesia-Vayá and Susana Rodríguez-Navarro
    Citation: Epigenetics & Chromatin 2020 13:46
  22. Chlamydia are Gram-negative, obligate intracellular bacterial pathogens responsible for a broad spectrum of human and animal diseases. In humans, Chlamydia trachomatis is the most prevalent bacterial sexually tra...

    Authors: Regan J. Hayward, James W. Marsh, Michael S. Humphrys, Wilhelmina M. Huston and Garry S. A. Myers
    Citation: Epigenetics & Chromatin 2020 13:45
  23. The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent his...

    Authors: Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson and Scott B. Rothbart
    Citation: Epigenetics & Chromatin 2020 13:44
  24. 5′ methylation of cytosines in DNA molecules is an important epigenetic mark in eukaryotes. Bisulfite sequencing is the gold standard of DNA methylation detection, and whole-genome bisulfite sequencing (WGBS) ...

    Authors: Suhua Feng, Zhenhui Zhong, Ming Wang and Steven E. Jacobsen
    Citation: Epigenetics & Chromatin 2020 13:42
  25. Transcription of genes residing within constitutive heterochromatin is paradoxical to the tenets of epigenetic code. The regulatory mechanisms of Drosophila melanogaster heterochromatic gene transcription remain ...

    Authors: Parna Saha, Divya Tej Sowpati, Mamilla Soujanya, Ishanee Srivastava and Rakesh Kumar Mishra
    Citation: Epigenetics & Chromatin 2020 13:41
  26. Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, and cultured cell lines. Existing methods for deciding w...

    Authors: Benjamin E. Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R. V. Knott, Gregory J. Hannon and Andrew D. Smith
    Citation: Epigenetics & Chromatin 2020 13:39
  27. UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate gene activation, but its molecular activities in developmental gene re...

    Authors: Beisi Xu, Brett Mulvey, Muneeb Salie, Xiaoyang Yang, Yurika Matsui, Anjana Nityanandam, Yiping Fan and Jamy C. Peng
    Citation: Epigenetics & Chromatin 2020 13:38
  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Gayathri Govindaraju, Rajashekar Varma Kadumuri, Devadathan Valiyamangalath Sethumadhavan, C. A. Jabeena, Sreenivas Chavali and Arumugam Rajavelu
    Citation: Epigenetics & Chromatin 2020 13:36

    The original article was published in Epigenetics & Chromatin 2020 13:33

  29. Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly co...

    Authors: Marion Crespo, Lacey J. Luense, Marie Arlotto, Jialei Hu, Jean Dorsey, Encar García-Oliver, Parisha P. Shah, Delphine Pflieger, Shelley L. Berger and Jérôme Govin
    Citation: Epigenetics & Chromatin 2020 13:35
  30. DNA methylation, as an essential epigenetic modification found in mammals and plants, has been implicated to play an important role in insect reproduction. However, the functional role and the regulatory mecha...

    Authors: Guanfeng Xu, Yangqin Yi, Hao Lyu, Chengcheng Gong, Qili Feng, Qisheng Song, Xuezhen Peng, Lin Liu and Sichun Zheng
    Citation: Epigenetics & Chromatin 2020 13:34
  31. Plasmodium falciparum exhibits high translational plasticity during its development in RBCs, yet the regulation at the post-transcriptional level is not well understood. The N6-methyl adenosine (m6A) is an import...

    Authors: Gayathri Govindaraju, Rajashekar Varma Kadumuri, Devadathan Valiyamangalath Sethumadhavan, C. A. Jabeena, Sreenivas Chavali and Arumugam Rajavelu
    Citation: Epigenetics & Chromatin 2020 13:33

    The Correction to this article has been published in Epigenetics & Chromatin 2020 13:36

  32. The three-dimensional organization of the genome in the nucleus plays an integral role in many biological processes, including gene expression. The genome is folded into DNA loops that bring together distal re...

    Authors: Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan and Jill M. Dowen
    Citation: Epigenetics & Chromatin 2020 13:32
  33. Epigenetics research is progressing in basic, pre-clinical and clinical studies using various model systems. Hence, updating the knowledge and integration of biological data emerging from in silico, in vitro a...

    Authors: Sanket G. Shah, Tushar Mandloi, Pooja Kunte, Abhiram Natu, Mudasir Rashid, Divya Reddy, Nikhil Gadewal and Sanjay Gupta
    Citation: Epigenetics & Chromatin 2020 13:31
  34. Several thousand sex-differential distal enhancers have been identified in mouse liver; however, their links to sex-biased genes and the impact of any sex-differences in nuclear organization and chromatin inte...

    Authors: Bryan J. Matthews and David J. Waxman
    Citation: Epigenetics & Chromatin 2020 13:30
  35. H2A.B, the most divergent histone variant of H2A, can significantly modulate nucleosome and chromatin structures. However, the related structural details and the underlying mechanism remain elusive to date. In...

    Authors: Junhui Peng, Chuang Yuan, Xinfan Hua and Zhiyong Zhang
    Citation: Epigenetics & Chromatin 2020 13:28
  36. Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is ...

    Authors: Yan Zhang, Zhaoqiang Li, Shasha Bian, Hao Zhao, Delong Feng, Yanhong Chen, Yuhe Hou, Qifa Liu and Bingtao Hao
    Citation: Epigenetics & Chromatin 2020 13:27
  37. Histone H1 is the most mobile histone in the cell nucleus. Defining the positions of H1 on chromatin in situ, therefore, represents a challenge. Immunoprecipitation of formaldehyde-fixed and sonicated chromati...

    Authors: Vladimir B. Teif, Travis J. Gould, Christopher T. Clarkson, Logan Boyd, Enoch B. Antwi, Naveed Ishaque, Ada L. Olins and Donald E. Olins
    Citation: Epigenetics & Chromatin 2020 13:26
  38. DNA methylation is a highly studied epigenetic signature that is associated with regulation of gene expression, whereby genes with high levels of promoter methylation are generally repressed. Genomic imprintin...

    Authors: Stephany Orjuela, Dania Machlab, Mirco Menigatti, Giancarlo Marra and Mark D. Robinson
    Citation: Epigenetics & Chromatin 2020 13:25
  39. The YEATS domain is a highly conserved protein structure that interacts with acetylated and crotonylated lysine residues in N-terminal tails of histones. The budding yeast genome encodes three YEATS domain pro...

    Authors: Kadri Peil, Henel Jürgens, Johanna Luige, Kersti Kristjuhan and Arnold Kristjuhan
    Citation: Epigenetics & Chromatin 2020 13:24
  40. DNA packaging into chromatin regulates all DNA-related processes and at chromosomal ends could affect both essential functions of telomeres: protection against DNA damage response and telomere replication. Des...

    Authors: Emeline Pasquier and Raymund J. Wellinger
    Citation: Epigenetics & Chromatin 2020 13:23
  41. Chromatin dysregulation is associated with developmental disorders and cancer. Numerous methods for measuring genome-wide chromatin accessibility have been developed in the genomic era to interrogate the funct...

    Authors: Jake J. Reske, Mike R. Wilson and Ronald L. Chandler
    Citation: Epigenetics & Chromatin 2020 13:22
  42. Next-generation sequencing allows genome-wide analysis of changes in chromatin states and gene expression. Data analysis of these increasingly used methods either requires multiple analysis steps, or extensive...

    Authors: Lorinc S. Pongor, Jacob M. Gross, Roberto Vera Alvarez, Junko Murai, Sang-Min Jang, Hongliang Zhang, Christophe Redon, Haiqing Fu, Shar-Yin Huang, Bhushan Thakur, Adrian Baris, Leonardo Marino-Ramirez, David Landsman, Mirit I. Aladjem and Yves Pommier
    Citation: Epigenetics & Chromatin 2020 13:21

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