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  1. Content type: Review

    The remarkable ability of many parasites to evade host immunity is the key to their success and pervasiveness. The immune evasion is directly linked to the silencing of the members of extended families of gene...

    Authors: Brandon A Wyse, Roxanne Oshidari, Daniel CB Jeffery and Krassimir Y Yankulov

    Citation: Epigenetics & Chromatin 2013 6:40

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  2. Content type: Research

    DNA methylation in mammals is an epigenetic mark necessary for normal embryogenesis. During development active loss of methylation occurs in the male pronucleus during the first cell cycle after fertilisation....

    Authors: Fátima Santos, Julian Peat, Heather Burgess, Cristina Rada, Wolf Reik and Wendy Dean

    Citation: Epigenetics & Chromatin 2013 6:39

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  3. Content type: Research

    The discovery of gene body methylation, which refers to DNA methylation within gene coding region, suggests an as yet unknown role of DNA methylation at actively transcribed genes. In invertebrates, gene bodie...

    Authors: Miho M Suzuki, Akiko Yoshinari, Madoka Obara, Shohei Takuno, Shuji Shigenobu, Yasunori Sasakura, Alastair RW Kerr, Shaun Webb, Adrian Bird and Atsuo Nakayama

    Citation: Epigenetics & Chromatin 2013 6:38

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  4. Content type: Research

    Germ cells in animals are highly specialized to preserve the genome. A distinct set of chromatin structures must be properly established in germ cells to maintain cell fate and genome integrity. We describe DN...

    Authors: Sam Guoping Gu, Barbara Goszczynski, James D McGhee and Andrew Z Fire

    Citation: Epigenetics & Chromatin 2013 6:37

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  5. Content type: Research

    Altered DNA methylation patterns represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Several studies have described global and complex age-related methylatio...

    Authors: Günter Raddatz, Sabine Hagemann, Dvir Aran, Jörn Söhle, Pranav P Kulkarni, Lars Kaderali, Asaf Hellman, Marc Winnefeld and Frank Lyko

    Citation: Epigenetics & Chromatin 2013 6:36

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  6. Content type: Research

    The incorporation of histone variants into nucleosomes is one of the main strategies that the cell uses to regulate the structure and function of chromatin. Histone H2A.Z is an evolutionarily conserved histone...

    Authors: Kyunghwan Kim, Vasu Punj, Jongkyu Choi, Kyu Heo, Jin-Man Kim, Peter W Laird and Woojin An

    Citation: Epigenetics & Chromatin 2013 6:34

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  7. Content type: Methodology

    The growing interest in the role of epigenetic modifications in human health and disease has led to the development of next-generation sequencing methods for whole genome analysis of DNA methylation patterns. ...

    Authors: Dustin R Masser, Arthur S Berg and Willard M Freeman

    Citation: Epigenetics & Chromatin 2013 6:33

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  8. Content type: Review

    DNA replication is a highly conserved process that accurately copies the genetic information from one generation to the next. The processes of chromatin disassembly and reassembly during DNA replication also h...

    Authors: Varija N Budhavarapu, Myrriah Chavez and Jessica K Tyler

    Citation: Epigenetics & Chromatin 2013 6:32

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  9. Content type: Research

    Enhancer elements determine the level of target gene transcription in a tissue-specific manner, providing for individual patterns of gene expression in different cells. Knowledge of the mechanisms controlling ...

    Authors: Maksim Erokhin, Anna Davydova, Alexander Parshikov, Vasily M Studitsky, Pavel Georgiev and Darya Chetverina

    Citation: Epigenetics & Chromatin 2013 6:31

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  10. Content type: Methodology

    Genome-wide maps of transcription factor binding sites in primary tissues can expand our understanding of genome function, transcriptional regulation, and genetic alterations that contribute to disease risk. H...

    Authors: Daniel Savic, Jason Gertz, Preti Jain, Gregory M Cooper and Richard M Myers

    Citation: Epigenetics & Chromatin 2013 6:30

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  11. Content type: Research

    The target of rapamycin complex 1 (TORC1) is an evolutionarily conserved signal transduction pathway activated by environmental nutrients that regulates gene transcription to control cell growth and proliferat...

    Authors: Hongfeng Chen, Jason J Workman, Alexa Tenga and R Nicholas Laribee

    Citation: Epigenetics & Chromatin 2013 6:29

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  12. Content type: Research

    The epithelial-mesenchymal transition (EMT) is a de-differentiation process required for wound healing and development. In tumors of epithelial origin aberrant induction of EMT contributes to cancer progressio...

    Authors: Marcin Cieślik, Stephen A Hoang, Natalya Baranova, Sanjay Chodaparambil, Manish Kumar, David F Allison, Xiaojiang Xu, J Jacob Wamsley, Lisa Gray, David R Jones, Marty W Mayo and Stefan Bekiranov

    Citation: Epigenetics & Chromatin 2013 6:28

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  13. Content type: Research

    Histone deacetylases (HDACs) play a critical role in the maintenance of genome stability. Class I HDACs, histone deacetylase 1 and 2 (Hdac1 and Hdac2) are recruited to the replication fork by virtue of their i...

    Authors: Srividya Bhaskara, Vincent Jacques, James R Rusche, Eric N Olson, Bradley R Cairns and Mahesh B Chandrasekharan

    Citation: Epigenetics & Chromatin 2013 6:27

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  14. Content type: Research

    DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study d...

    Authors: Roderick C Slieker, Steffan D Bos, Jelle J Goeman, Judith VMG Bovée, Rudolf P Talens, Ruud van der Breggen, H Eka D Suchiman, Eric-Wubbo Lameijer, Hein Putter, Erik B van den Akker, Yanju Zhang, J Wouter Jukema, P Eline Slagboom, Ingrid Meulenbelt and Bastiaan T Heijmans

    Citation: Epigenetics & Chromatin 2013 6:26

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  15. Content type: Research

    Tight regulation of homeobox genes is essential for vertebrate development. In a study of genome-wide differential methylation, we recently found that homeobox genes, including those in the HOX gene clusters, wer...

    Authors: Koji Tsumagari, Carl Baribault, Jolyon Terragni, Sruti Chandra, Chloe Renshaw, Zhiyi Sun, Lingyun Song, Gregory E Crawford, Sriharsa Pradhan, Michelle Lacey and Melanie Ehrlich

    Citation: Epigenetics & Chromatin 2013 6:25

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  16. Content type: Research

    The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silenci...

    Authors: Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton and Carolyn J Brown

    Citation: Epigenetics & Chromatin 2013 6:23

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  17. Content type: Research

    The specific deposition of histone variants into chromatin is an important epigenetic mechanism that contributes to gene regulation through chromatin architectural changes. The histone variant H2A.Z is essenti...

    Authors: Nicolas Guillermo Simonet, Mauricio Reyes, Gino Nardocci, Alfredo Molina and Marco Alvarez

    Citation: Epigenetics & Chromatin 2013 6:22

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  18. Content type: Research

    Previous elegant studies performed in the fission yeast Schizosaccharomyces pombe have identified a requirement for heterochromatin protein 1 (HP1) for spindle pole formation and appropriate cell division. In mam...

    Authors: Adrienne Grzenda, Phoebe Leonard, Seungmae Seo, Angela J Mathison, Guillermo Urrutia, Ezequiel Calvo, Juan Iovanna, Raul Urrutia and Gwen Lomberk

    Citation: Epigenetics & Chromatin 2013 6:21

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  19. Content type: Methodology

    An integral component of cancer biology is the understanding of molecular properties uniquely distinguishing one cancer type from another. One class of such properties is histone post-translational modificatio...

    Authors: Gary LeRoy, Peter A DiMaggio, Eric Y Chan, Barry M Zee, M Andres Blanco, Barbara Bryant, Ian Z Flaniken, Sherry Liu, Yibin Kang, Patrick Trojer and Benjamin A Garcia

    Citation: Epigenetics & Chromatin 2013 6:20

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  20. Content type: Research

    Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not al...

    Authors: Arne W Mould, Zhenyi Pang, Miha Pakusch, Ian D Tonks, Mitchell Stark, Dianne Carrie, Pamela Mukhopadhyay, Annica Seidel, Jonathan J Ellis, Janine Deakin, Matthew J Wakefield, Lutz Krause, Marnie E Blewitt and Graham F Kay

    Citation: Epigenetics & Chromatin 2013 6:19

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  21. Content type: Methodology

    Growing evidence suggests that DNA methylation plays a role in tissue-specific differentiation. Current approaches to methylome analysis using enrichment with the methyl-binding domain protein (MBD) are restri...

    Authors: Verity F Oliver, Jun Wan, Saurabh Agarwal, Donald J Zack, Jiang Qian and Shannath L Merbs

    Citation: Epigenetics & Chromatin 2013 6:17

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  22. Content type: Review

    The packaging of eukaryotic DNA into nucleosomal arrays permits cells to tightly regulate and fine-tune gene expression. The ordered disassembly and reassembly of these nucleosomes allows RNA polymerase II (RN...

    Authors: Swaminathan Venkatesh, Jerry L Workman and Michaela Smolle

    Citation: Epigenetics & Chromatin 2013 6:16

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  23. Content type: Research

    In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTas...

    Authors: Irina A Maksakova, Peter J Thompson, Preeti Goyal, Steven JM Jones, Prim B Singh, Mohammad M Karimi and Matthew C Lorincz

    Citation: Epigenetics & Chromatin 2013 6:15

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  24. Content type: Research

    DNA methylation and repressive histone modifications cooperate to silence promoters. One mechanism by which regions of methylated DNA could acquire repressive histone modifications is via methyl DNA-binding tr...

    Authors: Adam Blattler, Lijing Yao, Yao Wang, Zhenqing Ye, Victor X Jin and Peggy J Farnham

    Citation: Epigenetics & Chromatin 2013 6:13

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  25. Content type: Research

    Recognition of histone modifications by specialized protein domains is a key step in the regulation of DNA-mediated processes like gene transcription. The structural basis of these interactions is usually stud...

    Authors: Rick van Nuland, Frederik MA van Schaik, Marieke Simonis, Sebastiaan van Heesch, Edwin Cuppen, Rolf Boelens, HT Marc Timmers and Hugo van Ingen

    Citation: Epigenetics & Chromatin 2013 6:12

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  26. Content type: Research

    Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics and chemotherapeutic agents, but the pat...

    Authors: Elsa Boudadi, Hannah Stower, John A Halsall, Charlotte E Rutledge, Martin Leeb, Anton Wutz, Laura P O’Neill, Karl P Nightingale and Bryan M Turner

    Citation: Epigenetics & Chromatin 2013 6:11

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  27. Content type: Research

    DNA methylation is one of the most phylogenetically widespread epigenetic modifications of genomic DNA. In particular, DNA methylation of transcription units (‘gene bodies’) is highly conserved across diverse ...

    Authors: Iksoo Huh, Jia Zeng, Taesung Park and Soojin V Yi

    Citation: Epigenetics & Chromatin 2013 6:9

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    The Erratum to this article has been published in Epigenetics & Chromatin 2014 7:13

  28. Content type: Research

    Hox genes impart segment identity to body structures along the anterior-posterior axis and are crucial for the proper development of all organisms. Multiple regulatory elements, best defined in Drosophila melanog...

    Authors: Surabhi Srivastava, Deepika Puri, Hita Sony Garapati, Jyotsna Dhawan and Rakesh K Mishra

    Citation: Epigenetics & Chromatin 2013 6:8

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  29. Content type: Research

    The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. ...

    Authors: Kelly M Bush, Benjamin TK Yuen, Bonnie L Barrilleaux, John W Riggs, Henriette O’Geen, Rebecca F Cotterman and Paul S Knoepfler

    Citation: Epigenetics & Chromatin 2013 6:7

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  30. Content type: Poster presentation

    Authors: Hisato Kobayashi, Takayuki Sakurai, Fumihito Miura, Misaki Imai, Kentaro Mochiduki, Eikichi Yanagisawa, Akihiko Sakashita, Takuya Wakai, Yutaka Suzuki, Takashi lto, Yasuhisa Matsui and Tomohiro Kono

    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P116

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    This article is part of a Supplement: Volume 6 Supplement 1

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