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  1. The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodom...

    Authors: Veronica Garcia-Carpizo, Sergio Ruiz-Llorente, Jacinto Sarmentero, Osvaldo Graña-Castro, David G. Pisano and Maria J. Barrero
    Citation: Epigenetics & Chromatin 2018 11:30
    Content type: Research Published on:

  2. The dynamics of histone post-translational modifications (PTMs) are sparsely described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs).

    Authors: Tao Wang, Matthew V. Holt and Nicolas L. Young
    Citation: Epigenetics & Chromatin 2018 11:29
    Content type: Research Published on:

  3. Zrsr1 is a paternally expressed imprinted gene located in the first intron of Commd1, and the Zrsr1 promoter resides in a differentially methylated region (DMR) that is maternally methylated in the oocyte. Howeve...

    Authors: Keiichiro Joh, Fumikazu Matsuhisa, Shuji Kitajima, Kenichi Nishioka, Ken Higashimoto, Hitomi Yatsuki, Tomohiro Kono, Haruhiko Koseki and Hidenobu Soejima
    Citation: Epigenetics & Chromatin 2018 11:28
    Content type: Research Published on:

  4. Tracking dynamic protein–chromatin interactions in vivo is key to unravel transcriptional and epigenetic transitions in development and disease. However, limited availability and heterogeneous tissue compositi...

    Authors: Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel and Anne-Kathrin Classen
    Citation: Epigenetics & Chromatin 2018 11:27
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2018 11:38

  5. Heat-shock molecular chaperone proteins (Hsps) promote the loading of small interfering RNA (siRNA) onto RNA interference (RNAi) effector complexes. While the RNAi process is coupled with heterochromatin assem...

    Authors: Kosuke Okazaki, Hiroaki Kato, Tetsushi Iida, Kaori Shinmyozu, Jun-ichi Nakayama, Yota Murakami and Takeshi Urano
    Citation: Epigenetics & Chromatin 2018 11:26
    Content type: Research Published on:

  6. The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples, while conclusions regarding tissue-specificity are typ...

    Authors: Roderick C. Slieker, Caroline L. Relton, Tom R. Gaunt, P. Eline Slagboom and Bastiaan T. Heijmans
    Citation: Epigenetics & Chromatin 2018 11:25
    Content type: Research Published on:

  7. Comprehensive genome-wide DNA methylation profiling is critical to gain insights into epigenetic reprogramming during development and disease processes. Among the different genome-wide DNA methylation technolo...

    Authors: Shalima S. Nair, Phuc-Loi Luu, Wenjia Qu, Madhavi Maddugoda, Lily Huschtscha, Roger Reddel, Georgia Chenevix-Trench, Martina Toso, James G. Kench, Lisa G. Horvath, Vanessa M. Hayes, Phillip D. Stricker, Timothy P. Hughes, Deborah L. White, John E. J. Rasko, Justin J.-L. Wong…
    Citation: Epigenetics & Chromatin 2018 11:24
    Content type: Methodology Published on:

  8. MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture. Although H3 acetylation at K18 has been shown to stim...

    Authors: Kyunghwan Kim, Yonghwan Shin, Jinman Kim, Tobias S. Ulmer and Woojin An
    Citation: Epigenetics & Chromatin 2018 11:23
    Content type: Research Published on:

  9. Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of op...

    Authors: Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, Ross C. Hardison and David M. Bodine
    Citation: Epigenetics & Chromatin 2018 11:22
    Content type: Research Published on:

  10. DNA methylation in CpG context is fundamental to the epigenetic regulation of gene expression in higher eukaryotes. Changes in methylation patterns are implicated in many diseases, cellular differentiation, im...

    Authors: Thadeous J. Kacmarczyk, Mame P. Fall, Xihui Zhang, Yuan Xin, Yushan Li, Alicia Alonso and Doron Betel
    Citation: Epigenetics & Chromatin 2018 11:21
    Content type: Research Published on:

  11. The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both intrauterine and postnatal metabolic exposure factors, while the impact of intrauterin...

    Authors: Jun Ren, Yi Cheng, Zhen-Hua Ming, Xin-Yan Dong, Yu-Zhong Zhou, Guo-Lian Ding, Hai-Yan Pang, Tanzil Ur Rahman, Rubab Akbar, He-Feng Huang and Jian-Zhong Sheng
    Citation: Epigenetics & Chromatin 2018 11:20
    Content type: Research Published on:

  12. Anti-Silencing Factor 1 (ASF1) is a conserved H3–H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an...

    Authors: Béatrice Horard, Laure Sapey-Triomphe, Emilie Bonnefoy and Benjamin Loppin
    Citation: Epigenetics & Chromatin 2018 11:19
    Content type: Research Published on:

  13. Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycl...

    Authors: Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P. Brown, Prim B. Singh and W. Robb MacLellan
    Citation: Epigenetics & Chromatin 2018 11:18
    Content type: Research Published on:

  15. The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis. The centromere position is...

    Authors: Jing Zhu, Kevin Chi Lok Cheng and Karen Wing Yee Yuen
    Citation: Epigenetics & Chromatin 2018 11:16
    Content type: Research Published on:

  16. Meiosis is a specialized germ cell cycle that generates haploid gametes. In the initial stage of meiosis, meiotic prophase I (MPI), homologous chromosomes pair and recombine. Extensive changes in chromatin in ...

    Authors: Valeriya Gaysinskaya, Brendan F. Miller, Chiara De Luca, Godfried W. van der Heijden, Kasper D. Hansen and Alex Bortvin
    Citation: Epigenetics & Chromatin 2018 11:15
    Content type: Research Published on:

  17. During Drosophila spermatogenesis, testis-specific meiotic arrest complex (tMAC) and testis-specific TBP-associated factors (tTAF) contribute to activation of hundreds of genes required for meiosis and spermio...

    Authors: Petr P. Laktionov, Daniil A. Maksimov, Stanislav E. Romanov, Polina A. Antoshina, Olga V. Posukh, Helen White-Cooper, Dmitry E. Koryakov and Stepan N. Belyakin
    Citation: Epigenetics & Chromatin 2018 11:14
    Content type: Research Published on:

  18. Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt–Ada–Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and ...

    Authors: Varinia García-Molinero, José García-Martínez, Rohit Reja, Pedro Furió-Tarí, Oreto Antúnez, Vinesh Vinayachandran, Ana Conesa, B. Franklin Pugh, José E. Pérez-Ortín and Susana Rodríguez-Navarro
    Citation: Epigenetics & Chromatin 2018 11:13
    Content type: Research Published on:

  19. DNA methylation plays a vital role in the cell, but loss-of-function mutations of the maintenance methyltransferase DNMT1 in normal human cells are lethal, precluding target identification, and existing hypomorph...

    Authors: Karla M. O’Neill, Rachelle E. Irwin, Sarah-Jayne Mackin, Sara-Jayne Thursby, Avinash Thakur, Ciske Bertens, Laura Masala, Jayne E. P. Loughery, Darragh G. McArt and Colum P. Walsh
    Citation: Epigenetics & Chromatin 2018 11:12
    Content type: Research Published on:

  20. Controlled modulation of nucleosomal DNA accessibility via post-translational modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs in the globular histone core—including...

    Authors: Andrew T. Fenley, Ramu Anandakrishnan, Yared H. Kidane and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2018 11:11
    Content type: Research Published on:

  21. The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, t...

    Authors: Alejandro Saettone, Jyoti Garg, Jean-Philippe Lambert, Syed Nabeel-Shah, Marcelo Ponce, Alyson Burtch, Cristina Thuppu Mudalige, Anne-Claude Gingras, Ronald E. Pearlman and Jeffrey Fillingham
    Citation: Epigenetics & Chromatin 2018 11:10
    Content type: Research Published on:

  22. It has been reported that USP7 (ubiquitin-specific protease 7) prevents ubiquitylation and degradation of DNA methyltransferase 1 (DNMT1) by direct binding of USP7 to the glycine-lysine (GK) repeats that join ...

    Authors: Olya Yarychkivska, Omid Tavana, Wei Gu and Timothy H. Bestor
    Citation: Epigenetics & Chromatin 2018 11:9
    Content type: Research Published on:

  23. Environmental toxicants such as DDT have been shown to induce the epigenetic transgenerational inheritance of disease (e.g., obesity) through the germline. The current study was designed to investigate the DDT...

    Authors: Michael K. Skinner, Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Margaux McBirney, Rachel Klukovich, Yeming Xie, Chong Tang and Wei Yan
    Citation: Epigenetics & Chromatin 2018 11:8
    Content type: Research Published on:

  24. The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control ...

    Authors: Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli and Didier Trono
    Citation: Epigenetics & Chromatin 2018 11:7
    Content type: Research Published on:

  25. DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited. Cytosine meth...

    Authors: Satyanarayan Rao, Tsu-Pei Chiu, Judith F. Kribelbauer, Richard S. Mann, Harmen J. Bussemaker and Remo Rohs
    Citation: Epigenetics & Chromatin 2018 11:6
    Content type: Research Published on:

  26. The estrogen receptor (ER) is a ligand-dependant transcription factor expressed in many breast cancers and is the target of many endocrine-based cancer therapies. Genome-wide studies have shown that the ER bin...

    Authors: Bart Kolendowski, Haider Hassan, Milica Krstic, Majdina Isovic, Gobi Thillainadesan, Ann F. Chambers, Alan B. Tuck and Joseph Torchia
    Citation: Epigenetics & Chromatin 2018 11:5
    Content type: Research Published on:

  27. Protein posttranslational modifications (PTMs) occur broadly in the human proteome, and their biological outcome is often mediated indirectly by reader proteins that specifically bind to modified proteins and ...

    Authors: Agnieszka Anna Rawłuszko-Wieczorek, Franziska Knodel, Raluca Tamas, Arunkumar Dhayalan and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2018 11:4
    Content type: Methodology Published on:

  28. It is well recognized that the interphase chromatin of higher eukaryotes folds into non-random configurations forming territories within the nucleus. Chromosome territories have biologically significant proper...

    Authors: Nicholas Allen Kinney, Igor V. Sharakhov and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2018 11:3
    Content type: Research Published on:

  29. Histones organize DNA into chromatin through a variety of processes. Among them, a vast diversity of histone variants can be incorporated into chromatin and finely modulate its organization and functionality. ...

    Authors: Sara El Kennani, Annie Adrait, Olga Permiakova, Anne-Marie Hesse, Côme Ialy-Radio, Myriam Ferro, Virginie Brun, Julie Cocquet, Jérôme Govin and Delphine Pflieger
    Citation: Epigenetics & Chromatin 2018 11:2
    Content type: Methodology Published on:

  30. The timing of the first cell divisions may predict the developmental potential of an embryo, including its ability to establish pregnancy. Besides differences related to metabolism, stress, and survival, embr...

    Authors: Jessica Ispada, Camila Bruna de Lima, Marc-André Sirard, Patrícia Kubo Fontes, Marcelo Fábio Gouveia Nogueira, Kelly Annes and Marcella Pecora Milazzotto
    Citation: Epigenetics & Chromatin 2018 11:1
    Content type: Research Published on:

  31. The main chromatin unit, the nucleosome, can be modulated by the incorporation of histone variants that, in combination with posttranslational histones modifications, determine epigenetics properties of chroma...

    Authors: Viacheslav M. Morozov, Serena Giovinazzi and Alexander M. Ishov
    Citation: Epigenetics & Chromatin 2017 10:63
    Content type: Research Published on:

  32. SWI/SNF is a large heterogeneous multi-subunit chromatin remodeling complex. It consists of multiple sets of mutually exclusive components. Understanding how loss of one sibling of a mutually exclusive pair af...

    Authors: Jesse R. Raab, John S. Runge, Camarie C. Spear and Terry Magnuson
    Citation: Epigenetics & Chromatin 2017 10:62
    Content type: Research Published on:

  34. DNA methylation is a fundamental epigenetic modification that is involved in many biological systems such as differentiation and disease. We and others recently showed that some transcription factors (TFs) are...

    Authors: Takahiro Suzuki, Shiori Maeda, Erina Furuhata, Yuri Shimizu, Hajime Nishimura, Mami Kishima and Harukazu Suzuki
    Citation: Epigenetics & Chromatin 2017 10:60
    Content type: Methodology Published on:

  35. The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methylt...

    Authors: Laia Ribas, Konstantinos Vanezis, Marco Antonio Imués and Francesc Piferrer
    Citation: Epigenetics & Chromatin 2017 10:59
    Content type: Research Published on:

  36. TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been inve...

    Authors: Gabriel Gutiérrez, Gonzalo Millán-Zambrano, Daniel A. Medina, Antonio Jordán-Pla, José E. Pérez-Ortín, Xenia Peñate and Sebastián Chávez
    Citation: Epigenetics & Chromatin 2017 10:58
    Content type: Methodology Published on:

  38. In eukaryotes, heterochromatin replicates late in S phase of the cell cycle and contains specific covalent modifications of histones. SuUR mutation found in Drosophila makes heterochromatin replicate earlier than...

    Authors: Olga V. Posukh, Daniil A. Maksimov, Petr P. Laktionov, Dmitry E. Koryakov and Stepan N. Belyakin
    Citation: Epigenetics & Chromatin 2017 10:56
    Content type: Research Published on:

  40. Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells and has been associated with various diseases, including many cancers. It is a multifunctiona...

    Authors: Aleksandar Ilic, Sumin Lu, Vikram Bhatia, Farhana Begum, Thomas Klonisch, Prasoon Agarwal, Wayne Xu and James R. Davie
    Citation: Epigenetics & Chromatin 2017 10:54
    Content type: Research Published on:

  42. After the publication of this work [1], it was noticed that an initial was missing from the author name: Jeffrey Hayes. His name should be written as: Jeffrey J. Hayes.

    Authors: Hironao Wakabayashi, Christopher Tucker, Gabor Bethlendy, Anatoliy Kravets, Stephen L. Welle, Michael Bulger, Jeffrey J. Hayes and Elena Rustchenko
    Citation: Epigenetics & Chromatin 2017 10:52
    Content type: Correction Published on:

    The original article was published in Epigenetics & Chromatin 2017 10:49

  43. We have previously reported a novel O-GlcNAc modification at serine 40 (S40) of H2A (H2AS40Gc). S40-type H2A isoforms susceptible to O-GlcNAcylation are evolutionarily new and restricted to the viviparous animals...

    Authors: Koji Hayakawa, Mitsuko Hirosawa, Ruiko Tani, Chikako Yoneda, Satoshi Tanaka and Kunio Shiota
    Citation: Epigenetics & Chromatin 2017 10:51
    Content type: Research Published on:

  44. Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of w...

    Authors: Elena Denisenko, Reto Guler, Musa M. Mhlanga, Harukazu Suzuki, Frank Brombacher and Sebastian Schmeier
    Citation: Epigenetics & Chromatin 2017 10:50
    Content type: Research Published on:

  45. The major human fungal pathogen Candida albicans possesses a diploid genome, but responds to growth in challenging environments by employing chromosome aneuploidy as an adaptation mechanism. For example, we have...

    Authors: Hironao Wakabayashi, Christopher Tucker, Gabor Bethlendy, Anatoliy Kravets, Stephen L. Welle, Michael Bulger, Jeffrey J. Hayes and Elena Rustchenko
    Citation: Epigenetics & Chromatin 2017 10:49
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2017 10:52

  46. The distinct functional effects of the replication-dependent histone H2A isoforms have been demonstrated; however, the mechanistic basis of the non-redundancy remains unclear. Here, we have investigated the sp...

    Authors: Saikat Bhattacharya, Divya Reddy, Vinod Jani, Nikhil Gadewal, Sanket Shah, Raja Reddy, Kakoli Bose, Uddhavesh Sonavane, Rajendra Joshi and Sanjay Gupta
    Citation: Epigenetics & Chromatin 2017 10:48
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2018 11:67

  47. Epigenetics allows for the inheritance of information in cellular lineages during differentiation, independent of changes to the underlying genetic sequence. This raises the question of whether epigenetic mech...

    Authors: Michael A. Christopher, Stephanie M. Kyle and David J. Katz
    Citation: Epigenetics & Chromatin 2017 10:47
    Content type: Review Published on:

  48. It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic response...

    Authors: Vincenzo Cavalieri and Giovanni Spinelli
    Citation: Epigenetics & Chromatin 2017 10:46
    Content type: Review Published on:

  49. Histone post-translational modifications (PTMs) play central roles in chromatin-templated processes. Combinations of two or more histone PTMs form unique interfaces for readout and recruitment of chromatin int...

    Authors: Rebekka Mauser, Goran Kungulovski, Corinna Keup, Richard Reinhardt and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2017 10:45
    Content type: Methodology Published on:

  50. Gene promoters in vertebrate genomes show distinct chromatin features such as stably positioned nucleosome array and DNA hypomethylation. The nucleosomes are known to have certain sequence preferences, and the...

    Authors: Ryohei Nakamura, Ayako Uno, Masahiko Kumagai, Shinichi Morishita and Hiroyuki Takeda
    Citation: Epigenetics & Chromatin 2017 10:44
    Content type: Research Published on:
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Epigenetics & Chromatin

ISSN: 1756-8935