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  1. With rapidly dropping sequencing cost, the popularity of whole-genome DNA methylation sequencing has been on the rise. Multiple library preparation protocols currently exist. We have performed 22 whole-genome ...

    Authors: Jacob Morrison, Julie M. Koeman, Benjamin K. Johnson, Kelly K. Foy, Ian Beddows, Wanding Zhou, David W. Chesla, Larissa L. Rossell, Emily J. Siegwald, Marie Adams and Hui Shen
    Citation: Epigenetics & Chromatin 2021 14:28
    Content type: Research Published on:

  2. A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural ...

    Authors: Richard C. Chang, Kara N. Thomas, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell and Michael C. Golding
    Citation: Epigenetics & Chromatin 2021 14:27
    Content type: Research Published on:

  4. DNA methylation is an epigenetic chromatin mark that allows heterochromatin formation and gene silencing. It has a fundamental role in preserving genome stability (including chromosome stability) by controllin...

    Authors: Xena Giada Pappalardo and Viviana Barra
    Citation: Epigenetics & Chromatin 2021 14:25
    Content type: Review Published on:

  5. During epididymal transit, spermatozoa go through several functional maturation steps, resulting from interactions with epididymal secretomes specific to each region. In particular, the sperm membrane is under...

    Authors: Eli Sellem, Sylvain Marthey, Andrea Rau, Luc Jouneau, Aurelie Bonnet, Chrystelle Le Danvic, Benoît Guyonnet, Hélène Kiefer, Hélène Jammes and Laurent Schibler
    Citation: Epigenetics & Chromatin 2021 14:24
    Content type: Research Published on:

  6. Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of t...

    Authors: Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee, Daniel J. Fernandez, Rachel Abrahamson, Alessandra Castaldi, Zea Borok, Brian D. Dynlacht and Woojin An
    Citation: Epigenetics & Chromatin 2021 14:23
    Content type: Research Published on:

  7. Selective gene silencing is key to development. It is generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate...

    Authors: F. Carlier, M. Li, L. Maroc, R. Debuchy, C. Souaid, D. Noordermeer, P. Grognet and F. Malagnac
    Citation: Epigenetics & Chromatin 2021 14:22
    Content type: Research Published on:

  8. DNA methylation is an important epigenetic control mechanism that in many fungi is restricted to genomic regions containing transposable elements (TEs). Two DNA methyltransferases, Dim2 and Dnmt5, are known to...

    Authors: H. Martin Kramer, David E. Cook, Grardy C. M. van den Berg, Michael F. Seidl and Bart P. H. J. Thomma
    Citation: Epigenetics & Chromatin 2021 14:21
    Content type: Research Published on:

  9. ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its bin...

    Authors: Xinyang Yu, Prashant K. Singh, Shamira Tabrejee, Satrajit Sinha and Michael J. Buck
    Citation: Epigenetics & Chromatin 2021 14:20
    Content type: Research Published on:

  10. The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and...

    Authors: Jessica Connacher, Gabrielle A. Josling, Lindsey M. Orchard, Janette Reader, Manuel Llinás and Lyn-Marié Birkholtz
    Citation: Epigenetics & Chromatin 2021 14:19
    Content type: Research Published on:

  11. Maternal protein restriction diet (PRD) increases the risk of metabolic dysfunction in adulthood, the mechanisms during the early life of offspring are still poorly understood. Apart from genetic factors, epig...

    Authors: Yinyu Wang, Yiting Mao, Yiran Zhao, Xianfu Yi, Guolian Ding, Chuanjin Yu, Jianzhong Sheng, Xinmei Liu, Yicong Meng and Hefeng Huang
    Citation: Epigenetics & Chromatin 2021 14:18
    Content type: Research Published on:

  12. Environmental factors, such as oxidative stress, have the potential to modify the epigenetic landscape of cells. We have previously shown that DNA methyltransferase (DNMT) activity can be inhibited by subletha...

    Authors: Annika R. Seddon, Yusmiati Liau, Paul E. Pace, Allison L. Miller, Andrew B. Das, Martin A. Kennedy, Mark B. Hampton and Aaron J. Stevens
    Citation: Epigenetics & Chromatin 2021 14:17
    Content type: Research Published on:

  13. Pita is required for Drosophila development and binds specifically to a long motif in active promoters and insulators. Pita belongs to the Drosophila family of zinc-finger architectural proteins, which also in...

    Authors: Marat Sabirov, Olga Kyrchanova, Galina V. Pokholkova, Artem Bonchuk, Natalia Klimenko, Elena Belova, Igor F. Zhimulev, Oksana Maksimenko and Pavel Georgiev
    Citation: Epigenetics & Chromatin 2021 14:16
    Content type: Research Published on:

  14. The Hi-C technique is widely employed to study the 3-dimensional chromatin architecture and to assemble genomes. The conventional in situ Hi-C protocol employs restriction enzymes to digest chromatin, which re...

    Authors: Maria Gridina, Evgeniy Mozheiko, Emil Valeev, Ludmila P. Nazarenko, Maria E. Lopatkina, Zhanna G. Markova, Maria I. Yablonskaya, Viktoria Yu Voinova, Nadezhda V. Shilova, Igor N. Lebedev and Veniamin Fishman
    Citation: Epigenetics & Chromatin 2021 14:15
    Content type: Methodology Published on:

  16. Down syndrome (DS) is characterized by a genome-wide profile of differential DNA methylation that is skewed towards hypermethylation in most tissues, including brain, and includes pan-tissue differential methy...

    Authors: Benjamin I. Laufer, J. Antonio Gomez, Julia M. Jianu and Janine M. LaSalle
    Citation: Epigenetics & Chromatin 2021 14:13
    Content type: Research Published on:

  17. X-chromosome inactivation (XCI) in eutherian mammals is the epigenetic inactivation of one of the two X chromosomes in XX females in order to compensate for dosage differences with XY males. Not all genes are ...

    Authors: Bradley P. Balaton, Oriol Fornes, Wyeth W. Wasserman and Carolyn J. Brown
    Citation: Epigenetics & Chromatin 2021 14:12
    Content type: Research Published on:

  18. In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determinat...

    Authors: Reza Raeisossadati, Merari F. R. Ferrari, Alexandre Hiroaki Kihara, Issam AlDiri and Jeffrey M. Gross
    Citation: Epigenetics & Chromatin 2021 14:11
    Content type: Review Published on:

  19. Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histo...

    Authors: Kun Li and Ziqiang Wang
    Citation: Epigenetics & Chromatin 2021 14:10
    Content type: Review Published on:

  20. The mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vita...

    Authors: Lawrence T. C. Ong, Stephen D. Schibeci, Nicole L. Fewings, David R. Booth and Grant P. Parnell
    Citation: Epigenetics & Chromatin 2021 14:9
    Content type: Research Published on:

  21. Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood. In this study, we identifi...

    Authors: Martina Weigt, Qingsong Gao, Hyoju Ban, Haijin He, Guido Mastrobuoni, Stefan Kempa, Wei Chen and Fei Li
    Citation: Epigenetics & Chromatin 2021 14:8
    Content type: Research Published on:

  22. Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share...

    Authors: Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche Jr., Carrie R. Graveel and Matthew R. Steensma
    Citation: Epigenetics & Chromatin 2021 14:7
    Content type: Research Published on:

  23. Environmentally induced epigenetic transgenerational inheritance of pathology and phenotypic variation has been demonstrated in all organisms investigated from plants to humans. This non-genetic form of inheri...

    Authors: Daniel Beck, Millissia Ben Maamar and Michael K. Skinner
    Citation: Epigenetics & Chromatin 2021 14:6
    Content type: Research Published on:

  24. The vast majority of methods available to characterize genome-wide chromatin structure exploit differences in DNA accessibility to nucleases or chemical crosslinking. We developed a novel method to gauge genom...

    Authors: Luke T. Marr, Josefina Ocampo, David J. Clark and Jeffrey J. Hayes
    Citation: Epigenetics & Chromatin 2021 14:5
    Content type: Research Published on:

  25. Patterns of methylation influence lifespan, but methylation and lifespan may also depend on diet, or differ between genotypes. Prior to this study, interactions between diet and genotype have not been explored...

    Authors: Jack Hearn, Fiona Plenderleith and Tom J. Little
    Citation: Epigenetics & Chromatin 2021 14:4
    Content type: Research Published on:

  26. H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the e...

    Authors: Vasantha Shalini, Utsa Bhaduri, Anjhana C. Ravikkumar, Anusha Rengarajan and Rao M. R. Satyanarayana
    Citation: Epigenetics & Chromatin 2021 14:3
    Content type: Research Published on:

  27. Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are...

    Authors: Eric W. Martin, Jana Krietsch, Roman E. Reggiardo, Rebekah Sousae, Daniel H. Kim and E. Camilla Forsberg
    Citation: Epigenetics & Chromatin 2021 14:2
    Content type: Research Published on:

  28. DNA methylation has emerged as an important epigenetic regulator of brain processes, including circadian rhythms. However, how DNA methylation intervenes between environmental signals, such as light entrainmen...

    Authors: Federico Tinarelli, Elena Ivanova, Ilaria Colombi, Erica Barini, Edoardo Balzani, Celina Garcia Garcia, Laura Gasparini, Michela Chiappalone, Gavin Kelsey and Valter Tucci
    Citation: Epigenetics & Chromatin 2021 14:1
    Content type: Research Published on:

  29. Environmental impacts on a fetus can disrupt germ cell development leading to epimutations in mature germ cells. Paternal inheritance of adverse health effects through sperm epigenomes, including DNA methylome...

    Authors: Keiko Nohara, Kazuhiko Nakabayashi, Kazuyuki Okamura, Takehiro Suzuki, Shigekatsu Suzuki and Kenichiro Hata
    Citation: Epigenetics & Chromatin 2020 13:53
    Content type: Research Published on:

  30. The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a dep...

    Authors: Takeshi Tsusaka, Kei Fukuda, Chikako Shimura, Masaki Kato and Yoichi Shinkai
    Citation: Epigenetics & Chromatin 2020 13:52
    Content type: Research Published on:

  31. Epigenome-wide association studies (EWAS) have been widely applied to identify methylation CpG sites associated with human disease. To date, the Infinium MethylationEPIC array (EPIC) is commonly used for high-...

    Authors: Chang Shu, Xinyu Zhang, Bradley E. Aouizerat and Ke Xu
    Citation: Epigenetics & Chromatin 2020 13:51
    Content type: Research Published on:

  32. The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nucleosomes in intergenic sequences and poorly understood mechanisms of gene regulation. Variant...

    Authors: Jingyi Tang, Scott A. Chisholm, Lee M. Yeoh, Paul R. Gilson, Anthony T. Papenfuss, Karen P. Day, Michaela Petter and Michael F. Duffy
    Citation: Epigenetics & Chromatin 2020 13:50
    Content type: Research Published on:

  36. Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the...

    Authors: Carme Nuño-Cabanes, Varinia García-Molinero, Manuel Martín-Expósito, María-Eugenia Gas, Paula Oliete-Calvo, Encar García-Oliver, María de la Iglesia-Vayá and Susana Rodríguez-Navarro
    Citation: Epigenetics & Chromatin 2020 13:46
    Content type: Research Published on:

  37. Chlamydia are Gram-negative, obligate intracellular bacterial pathogens responsible for a broad spectrum of human and animal diseases. In humans, Chlamydia trachomatis is the most prevalent bacterial sexually tra...

    Authors: Regan J. Hayward, James W. Marsh, Michael S. Humphrys, Wilhelmina M. Huston and Garry S. A. Myers
    Citation: Epigenetics & Chromatin 2020 13:45
    Content type: Research Published on:

  38. The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent his...

    Authors: Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson and Scott B. Rothbart
    Citation: Epigenetics & Chromatin 2020 13:44
    Content type: Research Published on:

  40. 5′ methylation of cytosines in DNA molecules is an important epigenetic mark in eukaryotes. Bisulfite sequencing is the gold standard of DNA methylation detection, and whole-genome bisulfite sequencing (WGBS) ...

    Authors: Suhua Feng, Zhenhui Zhong, Ming Wang and Steven E. Jacobsen
    Citation: Epigenetics & Chromatin 2020 13:42
    Content type: Research Published on:

  41. Transcription of genes residing within constitutive heterochromatin is paradoxical to the tenets of epigenetic code. The regulatory mechanisms of Drosophila melanogaster heterochromatic gene transcription remain ...

    Authors: Parna Saha, Divya Tej Sowpati, Mamilla Soujanya, Ishanee Srivastava and Rakesh Kumar Mishra
    Citation: Epigenetics & Chromatin 2020 13:41
    Content type: Research Published on:

  43. Partially methylated domains (PMDs) are a hallmark of epigenomes in reproducible and specific biological contexts, including cancer cells, the placenta, and cultured cell lines. Existing methods for deciding w...

    Authors: Benjamin E. Decato, Jianghan Qu, Xiaojing Ji, Elvin Wagenblast, Simon R. V. Knott, Gregory J. Hannon and Andrew D. Smith
    Citation: Epigenetics & Chromatin 2020 13:39
    Content type: Research Published on:

  44. UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate gene activation, but its molecular activities in developmental gene re...

    Authors: Beisi Xu, Brett Mulvey, Muneeb Salie, Xiaoyang Yang, Yurika Matsui, Anjana Nityanandam, Yiping Fan and Jamy C. Peng
    Citation: Epigenetics & Chromatin 2020 13:38
    Content type: Research Published on:

  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Gayathri Govindaraju, Rajashekar Varma Kadumuri, Devadathan Valiyamangalath Sethumadhavan, C. A. Jabeena, Sreenivas Chavali and Arumugam Rajavelu
    Citation: Epigenetics & Chromatin 2020 13:36
    Content type: Correction Published on:

    The original article was published in Epigenetics & Chromatin 2020 13:33

  47. Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. During male germ cell maturation, histone proteins undergo distinct changes that result in a highly co...

    Authors: Marion Crespo, Lacey J. Luense, Marie Arlotto, Jialei Hu, Jean Dorsey, Encar García-Oliver, Parisha P. Shah, Delphine Pflieger, Shelley L. Berger and Jérôme Govin
    Citation: Epigenetics & Chromatin 2020 13:35
    Content type: Research Published on:

  48. DNA methylation, as an essential epigenetic modification found in mammals and plants, has been implicated to play an important role in insect reproduction. However, the functional role and the regulatory mecha...

    Authors: Guanfeng Xu, Yangqin Yi, Hao Lyu, Chengcheng Gong, Qili Feng, Qisheng Song, Xuezhen Peng, Lin Liu and Sichun Zheng
    Citation: Epigenetics & Chromatin 2020 13:34
    Content type: Research Published on:

  49. Plasmodium falciparum exhibits high translational plasticity during its development in RBCs, yet the regulation at the post-transcriptional level is not well understood. The N6-methyl adenosine (m6A) is an import...

    Authors: Gayathri Govindaraju, Rajashekar Varma Kadumuri, Devadathan Valiyamangalath Sethumadhavan, C. A. Jabeena, Sreenivas Chavali and Arumugam Rajavelu
    Citation: Epigenetics & Chromatin 2020 13:33
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2020 13:36

  50. The three-dimensional organization of the genome in the nucleus plays an integral role in many biological processes, including gene expression. The genome is folded into DNA loops that bring together distal re...

    Authors: Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan and Jill M. Dowen
    Citation: Epigenetics & Chromatin 2020 13:32
    Content type: Research Published on:
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Epigenetics & Chromatin

ISSN: 1756-8935