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  1. Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. ...

    Authors: Derek H. Janssens, Steven J. Wu, Jay F. Sarthy, Michael P. Meers, Carrie H. Myers, James M. Olson, Kami Ahmad and Steven Henikoff

    Citation: Epigenetics & Chromatin 2018 11:74

    Content type: Methodology

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  2. Age reprogramming represents a novel method for generating patient-specific tissues for transplantation. It bypasses the de-differentiation/redifferentiation cycle that is characteristic of the induced pluripo...

    Authors: Prim B. Singh and Andrew G. Newman

    Citation: Epigenetics & Chromatin 2018 11:73

    Content type: Review

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  3. Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for the di- and tri-demethylation of lysine 4 residues on histone 3 (H3K4 me2/3). KDM5C is expressed...

    Authors: Youni Kim, Youngeun Jeong, Kujin Kwon, Tayaba Ismail, Hyun-Kyung Lee, Chowon Kim, Jeen-Woo Park, Oh-Shin Kwon, Beom-Sik Kang, Dong-Seok Lee, Tae Joo Park, Taejoon Kwon and Hyun-Shik Lee

    Citation: Epigenetics & Chromatin 2018 11:72

    Content type: Research

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  4. Polycomb repressive complex 2 (PRC2) is responsible for establishing and maintaining histone H3K27 methylation during cell differentiation and proliferation. H3K27 can be mono-, di-, or trimethylated, resultin...

    Authors: Weipeng Mu, Joshua Starmer, Della Yee and Terry Magnuson

    Citation: Epigenetics & Chromatin 2018 11:71

    Content type: Research

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  5. Epithelial mesenchymal transition (EMT) is tightly regulated by a network of transcription factors (EMT-TFs). Among them is the nuclear factor ZEB2, a member of the zinc-finger E-box binding homeobox family. Z...

    Authors: Nicolas Skrypek, Kenneth Bruneel, Cindy Vandewalle, Eva De Smedt, Bieke Soen, Nele Loret, Joachim Taminau, Steven Goossens, Niels Vandamme and Geert Berx

    Citation: Epigenetics & Chromatin 2018 11:70

    Content type: Research

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  6. The Chromomethylase 1 (CMT1) has long been considered a nonessential gene because, in certain Arabidopsis ecotypes, the CMT1 gene is disrupted by the Evelknievel (EK) retroelement, inserted within exon 13, or con...

    Authors: Narendra Singh Yadav, Janardan Khadka, Katherine Domb, Assaf Zemach and Gideon Grafi

    Citation: Epigenetics & Chromatin 2018 11:69

    Content type: Research

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  8. After publication of this article [1], it was noticed Duane Smoot and Hassan Ashktorab who made and provided the cell line HFE145 were not included in the author list.

    Authors: Saikat Bhattacharya, Divya Reddy, Vinod Jani, Nikhil Gadewal, Sanket Shah, Raja Reddy, Kakoli Bose, Uddhavesh Sonavane, Rajendra Joshi, Duane Smoot, Hassan Ashktorab and Sanjay Gupta

    Citation: Epigenetics & Chromatin 2018 11:67

    Content type: Correction

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    The original article was published in Epigenetics & Chromatin 2017 10:48

  9. Bidirectional promoters (BPs) are prevalent in eukaryotic genomes. However, it is poorly understood how the cell integrates different epigenomic information, such as transcription factor (TF) binding and chrom...

    Authors: Fatemeh Behjati Ardakani, Kathrin Kattler, Karl Nordström, Nina Gasparoni, Gilles Gasparoni, Sarah Fuchs, Anupam Sinha, Matthias Barann, Peter Ebert, Jonas Fischer, Barbara Hutter, Gideon Zipprich, Charles D. Imbusch, Bärbel Felder, Jürgen Eils, Benedikt Brors…

    Citation: Epigenetics & Chromatin 2018 11:66

    Content type: Research

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  10. In most mammalian cell lines, chromatin located at the nuclear periphery is represented by condensed heterochromatin, as evidenced by microscopy observations and DamID mapping of lamina-associated domains (LAD...

    Authors: Alexey V. Pindyurin, Artem A. Ilyin, Anton V. Ivankin, Mikhail V. Tselebrovsky, Valentina V. Nenasheva, Elena A. Mikhaleva, Ludo Pagie, Bas van Steensel and Yuri Y. Shevelyov

    Citation: Epigenetics & Chromatin 2018 11:65

    Content type: Research

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  11. Meiotic recombination hotspots control the frequency and distribution of Spo11 (Rec12)-initiated recombination in the genome. Recombination occurs within and is regulated in part by chromatin structure, but re...

    Authors: Aaron J. Storey, Hsin-Ping Wang, Reine U. Protacio, Mari K. Davidson, Alan J. Tackett and Wayne P. Wahls

    Citation: Epigenetics & Chromatin 2018 11:64

    Content type: Research

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  12. Placental inflammation, often presenting as acute chorioamnionitis (aCA), is commonly associated with preterm birth. Preterm birth can have both immediate and long-term adverse effects on the health of the bab...

    Authors: Chaini Konwar, E. Magda Price, Li Qing Wang, Samantha L. Wilson, Jefferson Terry and Wendy P. Robinson

    Citation: Epigenetics & Chromatin 2018 11:63

    Content type: Research

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  14. Preservation of genome integrity by complete, error-free DNA duplication prior to cell division and by correct DNA damage repair is paramount for the development and maintenance of an organism. This holds true...

    Authors: Francesco Natale, Annina Scholl, Alexander Rapp, Wei Yu, Cathia Rausch and M. Cristina Cardoso

    Citation: Epigenetics & Chromatin 2018 11:61

    Content type: Research

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  15. Reactive oxygen species (ROS)-induced oxidative stress is well known to play a major role in male infertility. Sperm are sensitive to ROS damaging effects because as male germ cells form mature sperm they prog...

    Authors: Sarah Wyck, Carolina Herrera, Cristina E. Requena, Lilli Bittner, Petra Hajkova, Heinrich Bollwein and Raffaella Santoro

    Citation: Epigenetics & Chromatin 2018 11:60

    Content type: Research

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  16. The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. This is particularly important at regulatory regions, suc...

    Authors: Louie N. van de Lagemaat, Maria Flenley, Magnus D. Lynch, David Garrick, Simon R. Tomlinson, Kamil R. Kranc and Douglas Vernimmen

    Citation: Epigenetics & Chromatin 2018 11:59

    Content type: Research

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  18. The parthenogenetic marbled crayfish (Procambarus virginalis) is a novel species that has rapidly invaded and colonized various different habitats. Adaptation to different environments appears to be independent o...

    Authors: Fanny Gatzmann, Cassandra Falckenhayn, Julian Gutekunst, Katharina Hanna, Günter Raddatz, Vitor Coutinho Carneiro and Frank Lyko

    Citation: Epigenetics & Chromatin 2018 11:57

    Content type: Research

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  19. G9a and the related enzyme GLP were originally identified as histone lysine methyltransferases and then shown to also methylate several other non-histone proteins.

    Authors: Takeshi Tsusaka, Masaki Kikuchi, Tadahiro Shimazu, Takehiro Suzuki, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takashi Umehara and Yoichi Shinkai

    Citation: Epigenetics & Chromatin 2018 11:56

    Content type: Research

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  20. Genomic imprinting leads to maternal expression of IGF2R in both mouse and opossum. In mouse, the antisense long noncoding (lnc) RNA Airn, which is paternally expressed from the differentially methylated region (...

    Authors: Shunsuke Suzuki, Geoffrey Shaw and Marilyn B. Renfree

    Citation: Epigenetics & Chromatin 2018 11:55

    Content type: Research

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  21. DNA methylation arrays are widely used in epigenome-wide association studies and methylation quantitative trait locus (mQTL) studies. Here, we performed the first genome-wide analysis of monozygotic (MZ) twin ...

    Authors: Jenny van Dongen, Erik A. Ehli, Rick Jansen, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Jouke J. Hottenga, Noah A. Kallsen, Shanna A. Peyton, Charles E. Breeze, Cornelis Kluft, Bastiaan T. Heijmans, Meike Bartels, Gareth E. Davies and Dorret I. Boomsma

    Citation: Epigenetics & Chromatin 2018 11:54

    Content type: Research

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  22. Contact domains of chromatin serve as a fundamental unit to regulate action of enhancers for target genes. Looping between a pair of CCCTC-binding factor (CTCF)-binding sites in convergent orientations underli...

    Authors: Taro Tsujimura, Osamu Takase, Masahiro Yoshikawa, Etsuko Sano, Matsuhiko Hayashi, Tsuyoshi Takato, Atsushi Toyoda, Hideyuki Okano and Keiichi Hishikawa

    Citation: Epigenetics & Chromatin 2018 11:51

    Content type: Research

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  23. There are multiple copies of mitochondrial DNA (mtDNA) present in each cell type, and they are strictly regulated in a cell-specific manner by a group of nuclear-encoded mtDNA-specific replication factors. Thi...

    Authors: Xin Sun and Justin C. St John

    Citation: Epigenetics & Chromatin 2018 11:53

    Content type: Research

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  24. Compensatory liver hyperplasia—or regeneration—induced by two-thirds partial hepatectomy (PH) permits the study of synchronized activation of mammalian gene expression, particularly in relation to cell prolife...

    Authors: Leonor Rib, Dominic Villeneuve, Shilpi Minocha, Viviane Praz, Nouria Hernandez, Nicolas Guex and Winship Herr

    Citation: Epigenetics & Chromatin 2018 11:52

    Content type: Research

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  25. The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintai...

    Authors: Robin L. Adrianse, Kaleb Smith, Tonibelle Gatbonton-Schwager, Smitha P. Sripathy, Uyen Lao, Eric J. Foss, Ruben G. Boers, Joachim B. Boers, Joost Gribnau and Antonio Bedalov

    Citation: Epigenetics & Chromatin 2018 11:50

    Content type: Research

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  26. Our appreciation of the critical role of the genome’s 3D organization in gene regulation is steadily increasing. Recent 3C-based deep sequencing techniques elucidated a hierarchy of structures that underlie th...

    Authors: Idan Nurick, Ron Shamir and Ran Elkon

    Citation: Epigenetics & Chromatin 2018 11:49

    Content type: Research

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  27. The silkworm, Bombyx mori, a typical representative of metamorphic insects, is of great agricultural and economic importance. The steroid hormone ecdysone (20-hydroxyecdysone, 20E) is the central regulator of ins...

    Authors: Dong Cheng, Tingcai Cheng, Xi Yang, Quan Zhang, Jianfeng Fu, Tieshan Feng, Jiao Gong and Qingyou Xia

    Citation: Epigenetics & Chromatin 2018 11:48

    Content type: Research

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  28. Facioscapulohumeral muscular dystrophy 1 (FSHD1) has an autosomal dominant pattern of inheritance and primarily affects skeletal muscle. The genetic cause of FSHD1 is contraction of the D4Z4 macrosatellite arr...

    Authors: Premi Haynes, Karol Bomsztyk and Daniel G. Miller

    Citation: Epigenetics & Chromatin 2018 11:47

    Content type: Research

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  31. Proliferating cell nuclear antigen (PCNA), a ring-shaped homotrimer complex, promotes DNA replication via binding to DNA polymerase. Trimerized PCNA is critical for DNA replication. Enhancer of zeste homologue...

    Authors: Peng A, Xinyi Xu, Chenglin Wang, Jing Yang, Shida Wang, Jiewen Dai and Ling Ye

    Citation: Epigenetics & Chromatin 2018 11:44

    Content type: Research

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  32. Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific linker histone, and its expression overlaps ...

    Authors: Laxmi Narayan Mishra, Vasantha Shalini, Nikhil Gupta, Krittika Ghosh, Neeraj Suthar, Utsa Bhaduri and M. R. Satyanarayana Rao

    Citation: Epigenetics & Chromatin 2018 11:43

    Content type: Research

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  34. Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (AD). However, strong variation of cell-type prop...

    Authors: Gilles Gasparoni, Sebastian Bultmann, Pavlo Lutsik, Theo F. J. Kraus, Sabrina Sordon, Julia Vlcek, Vanessa Dietinger, Martina Steinmaurer, Melanie Haider, Christopher B. Mulholland, Thomas Arzberger, Sigrun Roeber, Matthias Riemenschneider, Hans A. Kretzschmar, Armin Giese, Heinrich Leonhardt…

    Citation: Epigenetics & Chromatin 2018 11:41

    Content type: Research

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  35. Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood. Using a Drosophila m...

    Authors: Elizaveta Radion, Valeriya Morgunova, Sergei Ryazansky, Natalia Akulenko, Sergey Lavrov, Yuri Abramov, Pavel A. Komarov, Sergey I. Glukhov, Ivan Olovnikov and Alla Kalmykova

    Citation: Epigenetics & Chromatin 2018 11:40

    Content type: Research

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  36. The ability to accurately and efficiently measure DNA methylation is critical to advance the understanding of this epigenetic mechanism and its contribution to common diseases. Here, we present a highly accura...

    Authors: Simone Roeh, Tobias Wiechmann, Susann Sauer, Maik Ködel, Elisabeth B. Binder and Nadine Provençal

    Citation: Epigenetics & Chromatin 2018 11:39

    Content type: Methodology

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  37. Unfortunately, the original version of this article contained a typographical error in one of the author names. The name of the author Alexey Pindyurin was incorrectly spelt as Alexey Pinduyrin. The correct sp...

    Authors: Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel and Anne-Kathrin Classen

    Citation: Epigenetics & Chromatin 2018 11:38

    Content type: Correction

    Published on:

    The original article was published in Epigenetics & Chromatin 2018 11:27

  38. DNA methylation is one of the main epigenetic mechanisms for the regulation of gene expression in eukaryotes. In the standard model, methylation in gene promoters has received the most attention since it is ge...

    Authors: Dafni Anastasiadi, Anna Esteve-Codina and Francesc Piferrer

    Citation: Epigenetics & Chromatin 2018 11:37

    Content type: Research

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  39. Genomic imprinting is governed by allele-specific DNA methylation at imprinting control regions (ICRs), and the mechanism controlling its differential methylation establishment during gametogenesis has been a ...

    Authors: Hitomi Matsuzaki, Eiichi Okamura, Daichi Kuramochi, Aki Ushiki, Katsuhiko Hirakawa, Akiyoshi Fukamizu and Keiji Tanimoto

    Citation: Epigenetics & Chromatin 2018 11:36

    Content type: Research

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  40. The concept of pioneer transcription factors is emerging as an essential part of the epigenetic regulation, taking place during cell development and differentiation. However, the precise molecular mechanism un...

    Authors: Bettina M. Fuglerud, Marit Ledsaak, Marie Rogne, Ragnhild Eskeland and Odd S. Gabrielsen

    Citation: Epigenetics & Chromatin 2018 11:35

    Content type: Research

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  41. In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional n...

    Authors: Kai O. Hensel, Franziska Cantner, Felix Bangert, Stefan Wirth and Jan Postberg

    Citation: Epigenetics & Chromatin 2018 11:34

    Content type: Research

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  42. The lysine-specific histone demethylase 1A (KDM1A) was the first demethylase to challenge the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin adenine dinucleotide (FAD)-depe...

    Authors: Tayaba Ismail, Hyun-Kyung Lee, Chowon Kim, Taejoon Kwon, Tae Joo Park and Hyun-Shik Lee

    Citation: Epigenetics & Chromatin 2018 11:33

    Content type: Review

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  43. Accurate regulation of tissue- and stage-specific expression of genes is prerequisite for normal development in organisms. DNA methylation plays an important role in modulating gene expression in mammals and p...

    Authors: Guanfeng Xu, Jie Zhang, Hao Lyu, Qisheng Song, Qili Feng, Hui Xiang and Sichun Zheng

    Citation: Epigenetics & Chromatin 2018 11:32

    Content type: Research

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  44. During sexual reproduction in the unicellular ciliate Stylonychia somatic macronuclei differentiate from germline micronuclei. Thereby, programmed sequence reduction takes place, leading to the elimination of > 9...

    Authors: Jan Postberg, Franziska Jönsson, Patrick Philipp Weil, Aneta Bulic, Stefan Andreas Juranek and Hans-Joachim Lipps

    Citation: Epigenetics & Chromatin 2018 11:31

    Content type: Research

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  45. The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodom...

    Authors: Veronica Garcia-Carpizo, Sergio Ruiz-Llorente, Jacinto Sarmentero, Osvaldo Graña-Castro, David G. Pisano and Maria J. Barrero

    Citation: Epigenetics & Chromatin 2018 11:30

    Content type: Research

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  46. The dynamics of histone post-translational modifications (PTMs) are sparsely described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs).

    Authors: Tao Wang, Matthew V. Holt and Nicolas L. Young

    Citation: Epigenetics & Chromatin 2018 11:29

    Content type: Research

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  47. Zrsr1 is a paternally expressed imprinted gene located in the first intron of Commd1, and the Zrsr1 promoter resides in a differentially methylated region (DMR) that is maternally methylated in the oocyte. Howeve...

    Authors: Keiichiro Joh, Fumikazu Matsuhisa, Shuji Kitajima, Kenichi Nishioka, Ken Higashimoto, Hitomi Yatsuki, Tomohiro Kono, Haruhiko Koseki and Hidenobu Soejima

    Citation: Epigenetics & Chromatin 2018 11:28

    Content type: Research

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  48. Tracking dynamic protein–chromatin interactions in vivo is key to unravel transcriptional and epigenetic transitions in development and disease. However, limited availability and heterogeneous tissue compositi...

    Authors: Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel and Anne-Kathrin Classen

    Citation: Epigenetics & Chromatin 2018 11:27

    Content type: Research

    Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2018 11:38

  49. Heat-shock molecular chaperone proteins (Hsps) promote the loading of small interfering RNA (siRNA) onto RNA interference (RNAi) effector complexes. While the RNAi process is coupled with heterochromatin assem...

    Authors: Kosuke Okazaki, Hiroaki Kato, Tetsushi Iida, Kaori Shinmyozu, Jun-ichi Nakayama, Yota Murakami and Takeshi Urano

    Citation: Epigenetics & Chromatin 2018 11:26

    Content type: Research

    Published on:

  50. The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples, while conclusions regarding tissue-specificity are typ...

    Authors: Roderick C. Slieker, Caroline L. Relton, Tom R. Gaunt, P. Eline Slagboom and Bastiaan T. Heijmans

    Citation: Epigenetics & Chromatin 2018 11:25

    Content type: Research

    Published on:

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