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  1. Content type: Methodology

    Chromatin proteins control gene activity in a concerted manner. We developed a high-throughput assay to study the effects of the local chromatin environment on the regulatory activity of a protein of interest....

    Authors: Laura Brueckner, Joris van Arensbergen, Waseem Akhtar, Ludo Pagie and Bas van Steensel

    Citation: Epigenetics & Chromatin 2016 9:43

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  2. Content type: Methodology

    In epigenetic research, both the increasing ease of high-throughput sequencing and a greater interest in genome-wide studies have resulted in an exponential flooding of epigenetic-related data in public domai...

    Authors: SriGanesh Jammula and Diego Pasini

    Citation: Epigenetics & Chromatin 2016 9:42

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  3. Content type: Research

    In mammals, tight regulation of cytosine methylation is required for embryonic development and cellular differentiation. The trans-acting DNA methyltransferases that catalyze this modification have been identifi...

    Authors: David H. Taylor, Chelsea M. McLean, Warren L. Wu, Alex B. Wang and Paul D. Soloway

    Citation: Epigenetics & Chromatin 2016 9:41

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  4. Content type: Research

    The nucleosome remodeling and deacetylase complex promotes cell fate decisions throughout embryonic development. Its core enzymatic subunit, the SNF2-like ATPase and Helicase Mi2, is well conserved throughout ...

    Authors: Stéphanie Käser-Pébernard, Catherine Pfefferli, Caroline Aschinger and Chantal Wicky

    Citation: Epigenetics & Chromatin 2016 9:39

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  5. Content type: Research

    Pax6 is a key regulator of the entire cascade of ocular lens formation through specific binding to promoters and enhancers of batteries of target genes. The promoters and enhancers communicate with each other ...

    Authors: Jian Sun, Yilin Zhao, Rebecca McGreal, Yamit Cohen-Tayar, Shira Rockowitz, Carola Wilczek, Ruth Ashery-Padan, David Shechter, Deyou Zheng and Ales Cvekl

    Citation: Epigenetics & Chromatin 2016 9:37

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  6. Content type: Research

    Cnidarians are a group of early branching animals including corals, jellyfish and hydroids that are renowned for their high regenerative ability, growth plasticity and longevity. Because cnidarian genomes are ...

    Authors: Anna Török, Philipp H. Schiffer, Christine E. Schnitzler, Kris Ford, James C. Mullikin, Andreas D. Baxevanis, Antony Bacic, Uri Frank and Sebastian G. Gornik

    Citation: Epigenetics & Chromatin 2016 9:36

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  7. Content type: Research

    A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transc...

    Authors: Elena M. Pugacheva, Evgeny Teplyakov, Qiongfang Wu, Jingjing Li, Cheng Chen, Chengcheng Meng, Jian Liu, Susan Robinson, Dmitry Loukinov, Abdelhalim Boukaba, Andrew Paul Hutchins, Victor Lobanenkov and Alexander Strunnikov

    Citation: Epigenetics & Chromatin 2016 9:35

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  8. Content type: Research

    How cells respond and adapt to environmental changes, such as nutrient flux, remains poorly understood. Evolutionarily conserved nutrient signaling cascades can regulate chromatin to contribute to genome regul...

    Authors: Hongfeng Chen, Jason J. Workman, Brian D. Strahl and R. Nicholas Laribee

    Citation: Epigenetics & Chromatin 2016 9:34

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  9. Content type: Research

    Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to an...

    Authors: Stefan Wallner, Christopher Schröder, Elsa Leitão, Tea Berulava, Claudia Haak, Daniela Beißer, Sven Rahmann, Andreas S. Richter, Thomas Manke, Ulrike Bönisch, Laura Arrigoni, Sebastian Fröhler, Filippos Klironomos, Wei Chen, Nikolaus Rajewsky, Fabian Müller…

    Citation: Epigenetics & Chromatin 2016 9:33

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  10. Content type: Research

    Genome-wide studies in higher eukaryotes have revealed the presence of paused RNA polymerase II (RNA-Pol) at about 30–50 bp downstream of the transcription start site of genes involved in developmental control...

    Authors: Shih-Ying Tsai, Yuh-Long Chang, Krishna B. S. Swamy, Ruei-Lin Chiang and Der-Hwa Huang

    Citation: Epigenetics & Chromatin 2016 9:32

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  11. Content type: Review

    Epigenetic inheritance plays a crucial role in many biological processes, such as gene expression in early embryo development, imprinting and the silencing of transposons. It has recently been established that...

    Authors: Kostas A. Triantaphyllopoulos, Ioannis Ikonomopoulos and Andrew J. Bannister

    Citation: Epigenetics & Chromatin 2016 9:31

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  12. Content type: Research

    Changes to the epigenome with aging, and DNA modifications in particular, have been proposed as a central regulator of the aging process, a predictor of mortality, and a contributor to the pathogenesis of age-...

    Authors: Niran Hadad, Dustin R. Masser, Sreemathi Logan, Benjamin Wronowski, Colleen A. Mangold, Nicholas Clark, Laura Otalora, Archana Unnikrishnan, Matthew M. Ford, Cory B. Giles, Jonathan D. Wren, Arlan Richardson, William E. Sonntag, David R. Stanford and Willard Freeman

    Citation: Epigenetics & Chromatin 2016 9:30

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  13. Content type: Research

    Lentiviral vectors (LV) are widely used for various gene transfer or gene therapy applications. The effects of LV on target cells are expected to be limited to gene delivery. Yet, human hematopoietic CD34+ cel...

    Authors: Tamas Aranyi, Daniel Stockholm, Roseline Yao, Catherine Poinsignon, Thibaut Wiart, Guillaume Corre, Nizar Touleimat, Jörg Tost, Anne Galy and Andràs Paldi

    Citation: Epigenetics & Chromatin 2016 9:29

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  14. Content type: Research

    Functional regulatory regions in eukaryotic genomes are characterized by the disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin accessibility is one of the key mediators of ...

    Authors: Juan Du, Amy Leung, Candi Trac, Michael Lee, Brian W. Parks, Aldons J. Lusis, Rama Natarajan and Dustin E. Schones

    Citation: Epigenetics & Chromatin 2016 9:28

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  15. Content type: Research

    Adaptive evolution is not possible without the generation of phenotypic variants. The origin of these variations has been a central topic in evolutionary biology. Up to now, it was commonly accepted that stand...

    Authors: Sara Fneich, André Théron, Céline Cosseau, Anne Rognon, Benoit Aliaga, Jérôme Buard, David Duval, Nathalie Arancibia, Jérôme Boissier, David Roquis, Guillaume Mitta and Christoph Grunau

    Citation: Epigenetics & Chromatin 2016 9:27

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  16. Content type: Research

    Prenatal alcohol exposure is the leading preventable cause of behavioral and cognitive deficits, which may affect between 2 and 5 % of children in North America. While the underlying mechanisms of alcohol’s ef...

    Authors: Elodie Portales-Casamar, Alexandre A. Lussier, Meaghan J. Jones, Julia L. MacIsaac, Rachel D. Edgar, Sarah M. Mah, Amina Barhdadi, Sylvie Provost, Louis-Philippe Lemieux-Perreault, Max S. Cynader, Albert E. Chudley, Marie-Pierre Dubé, James N. Reynolds, Paul Pavlidis and Michael S. Kobor

    Citation: Epigenetics & Chromatin 2016 9:25

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  17. Content type: Review

    DNA methylation is an epigenetic modification that plays an important role in regulating gene expression and therefore a broad range of biological processes and diseases. DNA methylation is tissue-specific, dy...

    Authors: Wai-Shin Yong, Fei-Man Hsu and Pao-Yang Chen

    Citation: Epigenetics & Chromatin 2016 9:26

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  18. Content type: Research

    During the process of spermatogenesis, male germ cells undergo dramatic chromatin reorganization, whereby most histones are replaced by protamines, as part of the pathway to compact the genome into the small n...

    Authors: Lacey J. Luense, Xiaoshi Wang, Samantha B. Schon, Angela H. Weller, Enrique Lin Shiao, Jessica M. Bryant, Marisa S. Bartolomei, Christos Coutifaris, Benjamin A. Garcia and Shelley L. Berger

    Citation: Epigenetics & Chromatin 2016 9:24

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  19. Content type: Research

    Chromatin containing the histone variant CENP-A (CEN chromatin) exists as an essential domain at every centromere and heritably marks the location of kinetochore assembly. The size of the CEN chromatin domain ...

    Authors: Justyne E. Ross, Kaitlin Stimpson Woodlief and Beth A. Sullivan

    Citation: Epigenetics & Chromatin 2016 9:20

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  20. Content type: Research

    Hematopoietic stem cell renewal and differentiation are regulated through epigenetic processes. The conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC) by ten-eleven-translocation enzymes provid...

    Authors: Xavier Tekpli, Alfonso Urbanucci, Adnan Hashim, Cathrine B. Vågbø, Robert Lyle, Marianne K. Kringen, Anne Cathrine Staff, Ingunn Dybedal, Ian G. Mills, Arne Klungland and Judith Staerk

    Citation: Epigenetics & Chromatin 2016 9:21

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  21. Content type: Research

    Transcriptional regulation is impacted by multiple layers of genome organization. A general feature of transcriptionally active chromatin is sensitivity to DNase I and association with acetylated histones. How...

    Authors: Sanzida Jahan, Wayne Xu, Shihua He, Carolina Gonzalez, Geneviève P. Delcuve and James R. Davie

    Citation: Epigenetics & Chromatin 2016 9:19

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  22. Content type: Research

    The presence of histone 3 lysine 9 (H3K9) methylation on the mouse inactive X chromosome has been controversial over the last 15 years, and the functional role of H3K9 methylation in X chromosome inactivation...

    Authors: Andrew Keniry, Linden J. Gearing, Natasha Jansz, Joy Liu, Aliaksei Z. Holik, Peter F. Hickey, Sarah A. Kinkel, Darcy L. Moore, Kelsey Breslin, Kelan Chen, Ruijie Liu, Catherine Phillips, Miha Pakusch, Christine Biben, Julie M. Sheridan, Benjamin T. Kile…

    Citation: Epigenetics & Chromatin 2016 9:16

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  23. Content type: Research

    Eukaryotic genome duplication starts at discrete sequences (replication origins) that coordinate cell cycle progression, ensure genomic stability and modulate gene expression. Origins share some sequence featu...

    Authors: Owen K. Smith, RyanGuk Kim, Haiqing Fu, Melvenia M. Martin, Chii Mei Lin, Koichi Utani, Ya Zhang, Anna B. Marks, Marc Lalande, Stormy Chamberlain, Maxwell W. Libbrecht, Eric E. Bouhassira, Michael C. Ryan, William S. Noble and Mirit I. Aladjem

    Citation: Epigenetics & Chromatin 2016 9:18

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  24. Content type: Research

    Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer agents for particular malignancies. However, clinical use is often confounded by toxicity, perhaps due to indiscriminate hyp...

    Authors: Christopher L. Frank, Dinesh Manandhar, Raluca Gordân and Gregory E. Crawford

    Citation: Epigenetics & Chromatin 2016 9:15

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  25. Content type: Research

    The cohesin complex consists of multiple core subunits that play critical roles in mitosis and transcriptional regulation. The cohesin-associated protein Wapal plays a central role in off-loading cohesin to fa...

    Authors: Cary Stelloh, Michael H. Reimer, Kirthi Pulakanti, Steven Blinka, Jonathan Peterson, Luca Pinello, Shuang Jia, Sergei Roumiantsev, Martin J. Hessner, Samuel Milanovich, Guo-Cheng Yuan and Sridhar Rao

    Citation: Epigenetics & Chromatin 2016 9:14

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  26. Content type: Research

    Fragile X syndrome (FXS) is caused by CGG expansion over 200 repeats at the 5′ UTR of the FMR1 gene and subsequent DNA methylation of both the expanded sequence and the CpGs of the promoter region. This epigeneti...

    Authors: Elisabetta Tabolacci, Giorgia Mancano, Stella Lanni, Federica Palumbo, Martina Goracci, Fabrizio Ferrè, Manuela Helmer-Citterich and Giovanni Neri

    Citation: Epigenetics & Chromatin 2016 9:12

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  27. Content type: Research

    There is growing evidence that DNA methylation alterations contribute to carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the proportion of tissue-specific versus tissue-indepe...

    Authors: Yuting Chen, Charles E. Breeze, Shao Zhen, Stephan Beck and Andrew E. Teschendorff

    Citation: Epigenetics & Chromatin 2016 9:10

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  28. Content type: Research

    Understanding the function of histone post-translational modifications is the key to deciphering how genomic activities are regulated. Among the least well-understood histone modifications in vivo are those t...

    Authors: Hillary K. Graves, Pingping Wang, Matthew Lagarde, Zhihong Chen and Jessica K. Tyler

    Citation: Epigenetics & Chromatin 2016 9:9

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  29. Content type: Research

    DNA methylation is one way to encode epigenetic information and plays a crucial role in regulating gene expression during embryonic development. DNA methylation marks are established by the DNA methyltransfera...

    Authors: Yun Liu, William Duong, Claudia Krawczyk, Nancy Bretschneider, Gábor Borbély, Mukesh Varshney, Christian Zinser, Primo Schär and Joëlle Rüegg

    Citation: Epigenetics & Chromatin 2016 9:7

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  30. Content type: Research

    The incidence of neural tube defects (NTDs) declined by about 40 % in Canada with the introduction of a national folic acid (FA) fortification program. Despite the fact that few Canadians currently exhibit fol...

    Authors: E. Magda Price, Maria S. Peñaherrera, Elodie Portales-Casamar, Paul Pavlidis, Margot I. Van Allen, Deborah E. McFadden and Wendy P. Robinson

    Citation: Epigenetics & Chromatin 2016 9:6

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  31. Content type: Research

    Chromatin epigenetics participate in control of gene expression during metazoan development. DNA methylation and post-translational modifications (PTMs) of histones have been extensively characterised in cell ...

    Authors: Clémence Kress, Guillaume Montillet, Christian Jean, Aurélie Fuet and Bertrand Pain

    Citation: Epigenetics & Chromatin 2016 9:5

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  32. Content type: Research

    Regulation of gene expression by histone-modifying enzymes is essential to control cell fate decisions and developmental processes. Two histone-modifying enzymes, RPD3, a deacetylase, and dKDM5/LID, a demethyl...

    Authors: Ambikai Gajan, Valerie L. Barnes, Mengying Liu, Nirmalya Saha and Lori A. Pile

    Citation: Epigenetics & Chromatin 2016 9:4

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  33. Content type: Research

    Environmental stress-induced transgenerational epigenetic effects have been observed in various model organisms and human. The capacity and mechanism of such phenomena are poorly understood. In C. elegans, siRNA ...

    Authors: Julie Zhouli Ni, Natallia Kalinava, Esteban Chen, Alex Huang, Thi Trinh and Sam Guoping Gu

    Citation: Epigenetics & Chromatin 2016 9:3

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  34. Content type: Research

    Human histone H3.5 is a non-allelic H3 variant evolutionally derived from H3.3. The H3.5 mRNA is highly expressed in human testis. However, the function of H3.5 has remained poorly understood.

    Authors: Takashi Urahama, Akihito Harada, Kazumitsu Maehara, Naoki Horikoshi, Koichi Sato, Yuko Sato, Koji Shiraishi, Norihiro Sugino, Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Hiroshi Kimura, Yasuyuki Ohkawa and Hitoshi Kurumizaka

    Citation: Epigenetics & Chromatin 2016 9:2

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  35. Content type: Research

    The regulation of specific target genes by transcription factors is central to our understanding of gene network control in developmental and physiological processes yet how target specificity is achieved is s...

    Authors: Ching Yew Beh, Sherif El-Sharnouby, Aikaterini Chatzipli, Steven Russell, Siew Woh Choo and Robert White

    Citation: Epigenetics & Chromatin 2016 9:1

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  36. Content type: Review

    Considerable progress towards an understanding of complex diseases has been made in recent years due to the development of high-throughput genotyping technologies. Using microarrays that contain millions of si...

    Authors: Yu Gyoung Tak and Peggy J. Farnham

    Citation: Epigenetics & Chromatin 2015 8:57

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  37. Content type: Research

    The capacity for plasticity in the adult brain is limited by the anatomical traces laid down during early postnatal life. Removing certain molecular brakes, such as histone deacetylases (HDACs), has proven to ...

    Authors: Andreas Lennartsson, Erik Arner, Michela Fagiolini, Alka Saxena, Robin Andersson, Hazuki Takahashi, Yukihiko Noro, Judy Sng, Albin Sandelin, Takao K. Hensch and Piero Carninci

    Citation: Epigenetics & Chromatin 2015 8:55

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  38. Content type: Research

    Phenotypic variability among inbred littermates reared in controlled environments remains poorly understood. Metastable epialleles refer to loci that intrinsically behave in this way and a few examples have be...

    Authors: Harald Oey, Luke Isbel, Peter Hickey, Basant Ebaid and Emma Whitelaw

    Citation: Epigenetics & Chromatin 2015 8:54

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  39. Content type: Research

    Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and transcription...

    Authors: Jennifer N. Wu, Luca Pinello, Elinor Yissachar, Jonathan W. Wischhusen, Guo-Cheng Yuan and Charles W. M. Roberts

    Citation: Epigenetics & Chromatin 2015 8:53

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  40. Content type: Methodology

    DNA methylation at cytosine nucleotides constitutes epigenetic gene regulation impacting cellular development and a wide range of diseases. Cytosine bases of the DNA are converted to 5-methylcytosine by the me...

    Authors: Jens Preussner, Julia Bayer, Carsten Kuenne and Mario Looso

    Citation: Epigenetics & Chromatin 2015 8:51

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  41. Content type: Research

    In female mice, while the presence of two-active X-chromosomes characterises pluripotency, it is not tolerated in most other cellular contexts. In particular, in the trophoblastic lineage, impairment of patern...

    Authors: Julie Prudhomme, Agnès Dubois, Pablo Navarro, Danielle Arnaud, Philip Avner and Céline Morey

    Citation: Epigenetics & Chromatin 2015 8:52

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