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Articles
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Citation: Epigenetics & Chromatin 2023 16:22
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Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin
Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of three-dimensional (3D) chromatin...
Citation: Epigenetics & Chromatin 2023 16:21 -
CpG DNA methylation changes during epididymal sperm maturation in bulls
During epididymal transit spermatozoa acquire specific morphological features which enhance their ability to swim in a progressive manner and interact with the oocytes. At the same time, sperm cells undergo sp...
Citation: Epigenetics & Chromatin 2023 16:20 -
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations
Patients with balanced X-autosome translocations and premature ovarian insufficiency (POI) constitute an interesting paradigm to study the effect of chromosome repositioning. Their breakpoints are clustered wi...
Citation: Epigenetics & Chromatin 2023 16:19 -
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in differe...
Citation: Epigenetics & Chromatin 2023 16:18 -
Loss of CpG island immunity to DNA methylation induced by mutation
The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715–731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI...
Citation: Epigenetics & Chromatin 2023 16:17 -
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes
Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome. Altho...
Citation: Epigenetics & Chromatin 2023 16:16 -
Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3
Histone modifications are one of the many key mechanisms that regulate gene expression. Ash1 is a histone H3K36 methyltransferase and is involved in gene activation. Ash1 forms a large complex with Mrg15 and C...
Citation: Epigenetics & Chromatin 2023 16:15 -
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies
Single-cell technologies to analyze transcription and chromatin structure have been widely used in many research areas to reveal the functions and molecular properties of cells at single-cell resolution. Sampl...
Citation: Epigenetics & Chromatin 2023 16:14 -
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas
IDH1/2 hotspot mutations are well known to drive oncogenic mutations in gliomas and are well-defined in the WHO 2021 classification of central nervous system tumors. Specifically, IDH mutations lead to aberrant h...
Citation: Epigenetics & Chromatin 2023 16:13 -
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart
Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberran...
Citation: Epigenetics & Chromatin 2023 16:12 -
Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
Epigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are largely unknown.
Citation: Epigenetics & Chromatin 2023 16:11 -
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of h...
Citation: Epigenetics & Chromatin 2023 16:10 -
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including tumorigenesis. However, the function and expression of PCGF6 i...
Citation: Epigenetics & Chromatin 2023 16:9 -
Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5
KDM5 family proteins are multi-domain regulators of transcription that when dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate transcription through their histone demethy...
Citation: Epigenetics & Chromatin 2023 16:8 -
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period
Allele-specific methylation of the imprinting control region (ICR) is the molecular basis for the genomic imprinting phenomenon that is unique to placental mammals. We previously showed that the ICR at the mouse
Citation: Epigenetics & Chromatin 2023 16:7 -
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In eukaryotes, three SMC complexes (cohesin, condensin and SMC5/6) play key roles i...
Citation: Epigenetics & Chromatin 2023 16:6 -
The impact of spatial correlation on methylation entropy with application to mouse brain methylome
With the advance of bisulfite sequencing technologies, massive amount of methylation data have been generated, which provide unprecedented opportunities to study the epigenetic mechanism and its relationship t...
Citation: Epigenetics & Chromatin 2023 16:5 -
Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation
Cellular differentiation is marked by temporally and spatially coordinated gene expression regulated at multiple levels. DNA methylation represents a universal mechanism to control chromatin organization and i...
Citation: Epigenetics & Chromatin 2023 16:4 -
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization
Preconception exposure to phthalates such as the anti-androgenic dibutyl-phthalate (DBP) impacts both male and female reproduction, yet how this occurs largely remains unknown. Previously we defined a series o...
Citation: Epigenetics & Chromatin 2023 16:3 -
ATAC-seq and RNA-seq analysis unravel the mechanism of sex differentiation and infertility in sex reversal chicken
Sex determination and differentiation are complex and delicate processes. In female chickens, the process of sex differentiation is sensitive and prone to be affected by the administration of aromatase inhibit...
Citation: Epigenetics & Chromatin 2023 16:2 -
Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data
Many human disease phenotypes manifest differently by sex, making the development of methods for incorporating X and Y-chromosome data into analyses vital. Unfortunately, X and Y chromosome data are frequently...
Citation: Epigenetics & Chromatin 2023 16:1 -
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C
Regulatory elements such as promoters, enhancers, and insulators interact each other to mediate molecular processes. To capture chromatin interactions of regulatory elements, 3C-derived methods such as Hi-C an...
Citation: Epigenetics & Chromatin 2022 15:41 -
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system
Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in targe...
Citation: Epigenetics & Chromatin 2022 15:40 -
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical region of human chromosome 21 (HSA21). Major studies were conducted in recent years to ...
Citation: Epigenetics & Chromatin 2022 15:39 -
Manipulating chromatin architecture in C. elegans
Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Unders...
Citation: Epigenetics & Chromatin 2022 15:38 -
Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or ...
Citation: Epigenetics & Chromatin 2022 15:37 -
De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the ...
Citation: Epigenetics & Chromatin 2022 15:36 -
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model
Three-dimensional (3D) cell culture has emerged as an alternative approach to 2D flat culture to model more accurately the phenotype of solid tissue in laboratories. Culturing cells in 3D more precisely recapi...
Citation: Epigenetics & Chromatin 2022 15:35 -
A standardized nomenclature for mammalian histone genes
Histones have a long history of research in a wide range of species, leaving a legacy of complex nomenclature in the literature. Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resul...
Citation: Epigenetics & Chromatin 2022 15:34 -
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
Cannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and whether the effects are heritable.
Citation: Epigenetics & Chromatin 2022 15:33 -
Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals
The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute ...
Citation: Epigenetics & Chromatin 2022 15:32 -
An epigenetically inherited UV hyper-resistance phenotype in Saccharomyces cerevisiae
Epigenetics refers to inheritable phenotypic changes that occur in the absence of genetic alteration. Such adaptations can provide phenotypic plasticity in reaction to environmental cues. While prior studies s...
Citation: Epigenetics & Chromatin 2022 15:31 -
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome
Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene expression. The core cohesin trimer interacts with various HEAT repeat accessory subun...
Citation: Epigenetics & Chromatin 2022 15:30 -
Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity
Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other typ...
Citation: Epigenetics & Chromatin 2022 15:29 -
Prenatal vitamin intake in first month of pregnancy and DNA methylation in cord blood and placenta in two prospective cohorts
Prenatal vitamin use is recommended before and during pregnancies for normal fetal development. Prenatal vitamins do not have a standard formulation, but many contain calcium, folic acid, iodine, iron, omega-3...
Citation: Epigenetics & Chromatin 2022 15:28 -
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite the...
Citation: Epigenetics & Chromatin 2022 15:27 -
Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation
Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic patterning of the zygotic genome. We previously reported that one ...
Citation: Epigenetics & Chromatin 2022 15:26 -
Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci
Citation: Epigenetics & Chromatin 2022 15:25 -
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk
Genome-wide association studies (GWAS) have enabled the discovery of single nucleotide polymorphisms (SNPs) that are significantly associated with many autoimmune diseases including type 1 diabetes (T1D). Howe...
Citation: Epigenetics & Chromatin 2022 15:24 -
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin
Nucleosomal binding proteins, HMGN, is a family of chromatin architectural proteins that are expressed in all vertebrate nuclei. Although previous studies have discovered that HMGN proteins have important role...
Citation: Epigenetics & Chromatin 2022 15:23 -
Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci
Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters with unrelated functions. Moreover, there is no d...
Citation: Epigenetics & Chromatin 2022 15:22 -
Viral histones: pickpocket’s prize or primordial progenitor?
The common histones H2A, H2B, H3, and H4 are the characteristic components of eukaryotic nucleosomes, which function to wrap DNA and compact the genome as well as to regulate access to DNA for transcription an...
Citation: Epigenetics & Chromatin 2022 15:21 -
Structural comparisons reveal diverse binding modes between nucleosome assembly proteins and histones
Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in facilitating chromatin assembly/disassembly which is of fundamental importance for DNA replication, gene expression regula...
Citation: Epigenetics & Chromatin 2022 15:20 -
Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish
Heterosis of growth traits in allotriploid fish has benefited the production of aquaculture for many years, yet its genetic and molecular basis has remained obscure. Now, an allotriploid complex, including two...
Citation: Epigenetics & Chromatin 2022 15:19 -
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG
The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histon...
Citation: Epigenetics & Chromatin 2022 15:18 -
Structural and functional specificity of H3K36 methylation
The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response....
Citation: Epigenetics & Chromatin 2022 15:17 -
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes. Chromatin remodeling c...
Citation: Epigenetics & Chromatin 2022 15:16 -
DNA methylation may affect beef tenderness through signal transduction in Bos indicus
Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, littl...
Citation: Epigenetics & Chromatin 2022 15:15 -
Functions of HP1 proteins in transcriptional regulation
In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators ...
Citation: Epigenetics & Chromatin 2022 15:14
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Citation Impact 2023
Journal Impact Factor: 4.2
5-year Journal Impact Factor: 4.9
Source Normalized Impact per Paper (SNIP): 0.892
SCImago Journal Rank (SJR): 2.062Speed 2023
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