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  1. DNA methylation arrays are widely used in epigenome-wide association studies and methylation quantitative trait locus (mQTL) studies. Here, we performed the first genome-wide analysis of monozygotic (MZ) twin ...

    Authors: Jenny van Dongen, Erik A. Ehli, Rick Jansen, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Jouke J. Hottenga, Noah A. Kallsen, Shanna A. Peyton, Charles E. Breeze, Cornelis Kluft, Bastiaan T. Heijmans, Meike Bartels, Gareth E. Davies and Dorret I. Boomsma
    Citation: Epigenetics & Chromatin 2018 11:54
    Content type: Research Published on:

  2. The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping ...

    Authors: Ksenia Skvortsova, Elena Zotenko, Phuc-Loi Luu, Cathryn M. Gould, Shalima S. Nair, Susan J. Clark and Clare Stirzaker
    Citation: Epigenetics & Chromatin 2017 10:16
    Content type: Research Published on:

  3. DNA methylation is important for the maintenance of the silent state of genes on the inactive X chromosome (Xi). Here, we screened for siRNAs and chemicals that reactivate an Xi-linked reporter in the presence...

    Authors: Alissa Minkovsky, Anna Sahakyan, Giancarlo Bonora, Robert Damoiseaux, Elizabeth Dimitrova, Liudmilla Rubbi, Matteo Pellegrini, Caius G. Radu and Kathrin Plath
    Citation: Epigenetics & Chromatin 2015 8:42
    Content type: Research Published on:

  4. The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, char...

    Authors: Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce and Michael S. Kobor
    Citation: Epigenetics & Chromatin 2019 12:1
    Content type: Research Published on:

  7. In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-gl...

    Authors: Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Arkadiy K. Golov, Ekaterina E. Khrameeva, Maxim V. Imakaev, Nezar A. Abdennur, Mikhail S. Gelfand, Alexey A. Gavrilov and Sergey V. Razin
    Citation: Epigenetics & Chromatin 2017 10:35
    Content type: Research Published on:

  8. Adaptive evolution is not possible without the generation of phenotypic variants. The origin of these variations has been a central topic in evolutionary biology. Up to now, it was commonly accepted that stand...

    Authors: Sara Fneich, André Théron, Céline Cosseau, Anne Rognon, Benoit Aliaga, Jérôme Buard, David Duval, Nathalie Arancibia, Jérôme Boissier, David Roquis, Guillaume Mitta and Christoph Grunau
    Citation: Epigenetics & Chromatin 2016 9:27
    Content type: Research Published on:

  9. Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt–Ada–Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and ...

    Authors: Varinia García-Molinero, José García-Martínez, Rohit Reja, Pedro Furió-Tarí, Oreto Antúnez, Vinesh Vinayachandran, Ana Conesa, B. Franklin Pugh, José E. Pérez-Ortín and Susana Rodríguez-Navarro
    Citation: Epigenetics & Chromatin 2018 11:13
    Content type: Research Published on:

  10. DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation remains poorly unde...

    Authors: Keith D. Harris, James P. B. Lloyd, Katherine Domb, Daniel Zilberman and Assaf Zemach
    Citation: Epigenetics & Chromatin 2019 12:62
    Content type: Research Published on:

  11. DNA methylation and histone 3 lysine 9 (H3K9) methylation are considered as epigenetic marks that can be inherited through cell divisions. To explore the functional consequences and stability of these modifica...

    Authors: Goran Kungulovski, Suneetha Nunna, Maria Thomas, Ulrich M Zanger, Richard Reinhardt and Albert Jeltsch
    Citation: Epigenetics & Chromatin 2015 8:12
    Content type: Research Published on:

  12. Tip60 (KAT5) is the histone acetyltransferase (HAT) of the mammalian Tip60/NuA4 complex. While Tip60 is important for early mouse development and mouse embryonic stem cell (mESC) pluripotency, the function of Tip...

    Authors: Sarina Ravens, Changwei Yu, Tao Ye, Matthieu Stierle and Laszlo Tora
    Citation: Epigenetics & Chromatin 2015 8:45
    Content type: Research Published on:

  13. In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins like heterochromatin-bi...

    Authors: Aristea Magaraki, Godfried van der Heijden, Esther Sleddens-Linkels, Leonidas Magarakis, Wiggert A. van Cappellen, Antoine H. F. M. Peters, Joost Gribnau, Willy M. Baarends and Maureen Eijpe
    Citation: Epigenetics & Chromatin 2017 10:11
    Content type: Research Published on:

  14. In the Metazoan nucleus, core histones assemble the genomic DNA to form nucleosome arrays, which are further compacted into dense chromatin structures by the linker histone H1. The extraordinary density of chr...

    Authors: Qian Zhang, Holli A. Giebler, Marisa K. Isaacson and Jennifer K. Nyborg
    Citation: Epigenetics & Chromatin 2015 8:30
    Content type: Research Published on:

  15. In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional n...

    Authors: Kai O. Hensel, Franziska Cantner, Felix Bangert, Stefan Wirth and Jan Postberg
    Citation: Epigenetics & Chromatin 2018 11:34
    Content type: Research Published on:

  16. The dynamics of histone modifications in Plasmodium falciparum indicates the existence of unique mechanisms that link epigenetic factors with transcription. Here, we studied the impact of acetylated histone code ...

    Authors: Archana P. Gupta, Lei Zhu, Jaishree Tripathi, Michal Kucharski, Alok Patra and Zbynek Bozdech
    Citation: Epigenetics & Chromatin 2017 10:40
    Content type: Research Published on:

  17. Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR i...

    Authors: Hitomi Matsuzaki, Daichi Kuramochi, Eiichi Okamura, Katsuhiko Hirakawa, Aki Ushiki and Keiji Tanimoto
    Citation: Epigenetics & Chromatin 2020 13:2
    Content type: Research Published on:

  19. The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perce...

    Authors: John R. Edwards, Olya Yarychkivska, Mathieu Boulard and Timothy H. Bestor
    Citation: Epigenetics & Chromatin 2017 10:23
    Content type: Review Published on:

  20. SWI/SNF is a large heterogeneous multi-subunit chromatin remodeling complex. It consists of multiple sets of mutually exclusive components. Understanding how loss of one sibling of a mutually exclusive pair af...

    Authors: Jesse R. Raab, John S. Runge, Camarie C. Spear and Terry Magnuson
    Citation: Epigenetics & Chromatin 2017 10:62
    Content type: Research Published on:

  21. Differential DNA methylation plays a critical role in the regulation of imprinted genes. The differentially methylated state of the imprinting control region is inherited via the gametes at fertilization, and ...

    Authors: Megan Guntrum, Ekaterina Vlasova and Tamara L. Davis
    Citation: Epigenetics & Chromatin 2017 10:31
    Content type: Research Published on:

  22. Wilson disease (WD) is an autosomal recessive disease caused by mutations in ATP7B encoding a copper transporter. Consequent copper accumulation results in a variable WD clinical phenotype involving hepatic, neur...

    Authors: Charles E. Mordaunt, Dorothy A. Kieffer, Noreene M. Shibata, Anna Członkowska, Tomasz Litwin, Karl-Heinz Weiss, Yihui Zhu, Christopher L. Bowlus, Souvik Sarkar, Stewart Cooper, Yu-Jui Yvonne Wan, Mohamed R. Ali, Janine M. LaSalle and Valentina Medici
    Citation: Epigenetics & Chromatin 2019 12:10
    Content type: Research Published on:

  23. Specific genomic loci, termed Piwi-interacting RNA (piRNA) clusters, manufacture piRNAs that serve as guides for the inactivation of complementary transposable elements (TEs). The piRNA pathway has been accura...

    Authors: Phillip George, Silke Jensen, Romain Pogorelcnik, Jiyoung Lee, Yi Xing, Emilie Brasset, Chantal Vaury and Igor V. Sharakhov
    Citation: Epigenetics & Chromatin 2015 8:50
    Content type: Research Published on:

  24. Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer progression. More recently, an oxidized form of 5-mC, 5-hydroxymethylcytos...

    Authors: Sara Wernig-Zorc, Mukesh Pratap Yadav, Pradeep Kumar Kopparapu, Mats Bemark, Hallgerdur Lind Kristjansdottir, Per-Ola Andersson, Chandrasekhar Kanduri and Meena Kanduri
    Citation: Epigenetics & Chromatin 2019 12:4
    Content type: Research Published on:

  25. The presence of histone 3 lysine 9 (H3K9) methylation on the mouse inactive X chromosome has been controversial over the last 15 years, and the functional role of H3K9 methylation in X chromosome inactivation...

    Authors: Andrew Keniry, Linden J. Gearing, Natasha Jansz, Joy Liu, Aliaksei Z. Holik, Peter F. Hickey, Sarah A. Kinkel, Darcy L. Moore, Kelsey Breslin, Kelan Chen, Ruijie Liu, Catherine Phillips, Miha Pakusch, Christine Biben, Julie M. Sheridan, Benjamin T. Kile…
    Citation: Epigenetics & Chromatin 2016 9:16
    Content type: Research Published on:

  26. Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multipl...

    Authors: Henriette O’Geen, Sofie L. Bates, Sakereh S. Carter, Karly A. Nisson, Julian Halmai, Kyle D. Fink, Suhn K. Rhie, Peggy J. Farnham and David J. Segal
    Citation: Epigenetics & Chromatin 2019 12:26
    Content type: Research Published on:

  27. Anti-Silencing Factor 1 (ASF1) is a conserved H3–H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an...

    Authors: Béatrice Horard, Laure Sapey-Triomphe, Emilie Bonnefoy and Benjamin Loppin
    Citation: Epigenetics & Chromatin 2018 11:19
    Content type: Research Published on:

  28. How cells respond and adapt to environmental changes, such as nutrient flux, remains poorly understood. Evolutionarily conserved nutrient signaling cascades can regulate chromatin to contribute to genome regul...

    Authors: Hongfeng Chen, Jason J. Workman, Brian D. Strahl and R. Nicholas Laribee
    Citation: Epigenetics & Chromatin 2016 9:34
    Content type: Research Published on:

  29. Maintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents prolonged stalling of the ...

    Authors: Joanna Brühl, Jonathan Trautwein, Agnes Schäfer, Uwe Linne and Karim Bouazoune
    Citation: Epigenetics & Chromatin 2019 12:52
    Content type: Research Published on:

  30. The ability to accurately and efficiently measure DNA methylation is critical to advance the understanding of this epigenetic mechanism and its contribution to common diseases. Here, we present a highly accura...

    Authors: Simone Roeh, Tobias Wiechmann, Susann Sauer, Maik Ködel, Elisabeth B. Binder and Nadine Provençal
    Citation: Epigenetics & Chromatin 2018 11:39
    Content type: Methodology Published on:

  31. The well-established association of chronological age with changes in DNA methylation is primarily founded on the analysis of large sets of blood samples, while conclusions regarding tissue-specificity are typ...

    Authors: Roderick C. Slieker, Caroline L. Relton, Tom R. Gaunt, P. Eline Slagboom and Bastiaan T. Heijmans
    Citation: Epigenetics & Chromatin 2018 11:25
    Content type: Research Published on:

  32. Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast Schizosaccharomyces pombe contains heterochromatin at centromeres, subtelomeres, and mating type gen...

    Authors: Cristina Cotobal, María Rodríguez-López, Caia Duncan, Ayesha Hasan, Akira Yamashita, Masayuki Yamamoto, Jürg Bähler and Juan Mata
    Citation: Epigenetics & Chromatin 2015 8:28
    Content type: Research Published on:

  33. The parthenogenetic marbled crayfish (Procambarus virginalis) is a novel species that has rapidly invaded and colonized various different habitats. Adaptation to different environments appears to be independent o...

    Authors: Fanny Gatzmann, Cassandra Falckenhayn, Julian Gutekunst, Katharina Hanna, Günter Raddatz, Vitor Coutinho Carneiro and Frank Lyko
    Citation: Epigenetics & Chromatin 2018 11:57
    Content type: Research Published on:

  34. The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET domain-catalysed methylation of H3K4. It is essential for normal embryonic de...

    Authors: Maaike Wiersma, Marianne Bussiere, John A. Halsall, Nil Turan, Robert Slany, Bryan M. Turner and Karl P. Nightingale
    Citation: Epigenetics & Chromatin 2016 9:52
    Content type: Research Published on:

  35. Chromatin-based transcriptional silencing is often described as a stochastic process, largely because of the mosaic expression observed in position effect variegation (PEV), where a euchromatic reporter gene i...

    Authors: Sidney H. Wang and Sarah C. R. Elgin
    Citation: Epigenetics & Chromatin 2019 12:70
    Content type: Research Published on:

  36. Exposure to environmental stressors during development may lead to latent and transgenerational adverse health effects. To understand the role of DNA methylation in these effects, we used zebrafish as a verteb...

    Authors: Jorke H. Kamstra, Liana Bastos Sales, Peter Aleström and Juliette Legler
    Citation: Epigenetics & Chromatin 2017 10:20
    Content type: Research Published on:

  37. Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (AD). However, strong variation of cell-type prop...

    Authors: Gilles Gasparoni, Sebastian Bultmann, Pavlo Lutsik, Theo F. J. Kraus, Sabrina Sordon, Julia Vlcek, Vanessa Dietinger, Martina Steinmaurer, Melanie Haider, Christopher B. Mulholland, Thomas Arzberger, Sigrun Roeber, Matthias Riemenschneider, Hans A. Kretzschmar, Armin Giese, Heinrich Leonhardt…
    Citation: Epigenetics & Chromatin 2018 11:41
    Content type: Research Published on:

  38. Genetic and epigenetic variability contributes to the susceptibility and pathogenesis of autoimmune diseases. T cells play an important role in several autoimmune conditions, including lupus, which is more com...

    Authors: Patrick Coit, Mikhail Ognenovski, Elizabeth Gensterblum, Kathleen Maksimowicz-McKinnon, Jonathan D. Wren and Amr H. Sawalha
    Citation: Epigenetics & Chromatin 2015 8:49
    Content type: Research Published on:

  39. 5-Hydroxymethylcytosine (5hmC) is an oxidation product of 5-methylcytosine (5mC), and adjacent CpG sites in mammalian genome can be co-methylated and co-hydroxymethylated due to the processivity of DNMT and TE...

    Authors: Qin Ma, Zhengzheng Xu, Huan Lu, Ziying Xu, Yuanyuan Zhou, Bifeng Yuan and Weimin Ci
    Citation: Epigenetics & Chromatin 2018 11:75
    Content type: Research Published on:

  40. Accumulating animal and human data indicate that environmental exposures experienced during sensitive developmental periods may strongly influence risk of adult disease. Moreover, the effects triggered by deve...

    Authors: Alexander M. Vaiserman, Alexander K. Koliada and Randy L. Jirtle
    Citation: Epigenetics & Chromatin 2017 10:38
    Content type: Review Published on:

  41. Human histone H3.5 is a non-allelic H3 variant evolutionally derived from H3.3. The H3.5 mRNA is highly expressed in human testis. However, the function of H3.5 has remained poorly understood.

    Authors: Takashi Urahama, Akihito Harada, Kazumitsu Maehara, Naoki Horikoshi, Koichi Sato, Yuko Sato, Koji Shiraishi, Norihiro Sugino, Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Hiroshi Kimura, Yasuyuki Ohkawa and Hitoshi Kurumizaka
    Citation: Epigenetics & Chromatin 2016 9:2
    Content type: Research Published on:

  42. The mechanism by which protein complexes interact to regulate the deposition of post-translational modifications of histones remains poorly understood. This is particularly important at regulatory regions, suc...

    Authors: Louie N. van de Lagemaat, Maria Flenley, Magnus D. Lynch, David Garrick, Simon R. Tomlinson, Kamil R. Kranc and Douglas Vernimmen
    Citation: Epigenetics & Chromatin 2018 11:59
    Content type: Research Published on:

  43. Chromatin containing the histone variant CENP-A (CEN chromatin) exists as an essential domain at every centromere and heritably marks the location of kinetochore assembly. The size of the CEN chromatin domain ...

    Authors: Justyne E. Ross, Kaitlin Stimpson Woodlief and Beth A. Sullivan
    Citation: Epigenetics & Chromatin 2016 9:20
    Content type: Research Published on:

  44. Both tissue-specific and ubiquitously expressed transcription factors, such as Sp-family members, are required for correct development. However, the molecular details of how ubiquitous factors are involved in ...

    Authors: Jane Gilmour, Leigh O’Connor, Christopher P. Middleton, Peter Keane, Nynke Gillemans, Jean-Baptiste Cazier, Sjaak Philipsen and Constanze Bonifer
    Citation: Epigenetics & Chromatin 2019 12:33
    Content type: Research Published on:

  45. The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57kip2 expression is finely regulated by several epigene...

    Authors: Oriella Andresini, Marianna Nicoletta Rossi, Francesca Matteini, Stefano Petrai, Tiziana Santini and Rossella Maione
    Citation: Epigenetics & Chromatin 2019 12:8
    Content type: Research Published on:

  46. Tracking dynamic protein–chromatin interactions in vivo is key to unravel transcriptional and epigenetic transitions in development and disease. However, limited availability and heterogeneous tissue compositi...

    Authors: Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel and Anne-Kathrin Classen
    Citation: Epigenetics & Chromatin 2018 11:27
    Content type: Research Published on:

    The Correction to this article has been published in Epigenetics & Chromatin 2018 11:38

  47. TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phospho...

    Authors: Ting Zhang, Xiaowen Guan, Un Lam Choi, Qiang Dong, Melody M. T. Lam, Jianming Zeng, Jun Xiong, Xianju Wang, Terence C. W. Poon, Hongjie Zhang, Xuanjun Zhang, Hailin Wang, Ruiyu Xie, Bing Zhu and Gang Li
    Citation: Epigenetics & Chromatin 2019 12:32
    Content type: Research Published on:

  48. Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In con...

    Authors: Elior Rahmani, Liat Shenhav, Regev Schweiger, Paul Yousefi, Karen Huen, Brenda Eskenazi, Celeste Eng, Scott Huntsman, Donglei Hu, Joshua Galanter, Sam S. Oh, Melanie Waldenberger, Konstantin Strauch, Harald Grallert, Thomas Meitinger, Christian Gieger…
    Citation: Epigenetics & Chromatin 2017 10:1
    Content type: Methodology Published on:

  49. A comprehensive assessment of the epigenetic dynamics in cancer cells is the key to understanding the molecular mechanisms underlying cancer and to improving cancer diagnostics, prognostics and treatment. By c...

    Authors: Michiel E. Adriaens, Peggy Prickaerts, Michelle Chan-Seng-Yue, Twan van den Beucken, Vivian E. H. Dahlmans, Lars M. Eijssen, Timothy Beck, Bradly G. Wouters, Jan Willem Voncken and Chris T. A. Evelo
    Citation: Epigenetics & Chromatin 2016 9:48
    Content type: Research Published on:

  50. Histone isoforms and their post-translational modifications (PTMs) play an important role in the control of many chromatin-related processes including transcription and DNA damage. Variants of histones H2A and...

    Authors: Rosalynn C Molden, Natarajan V Bhanu, Gary LeRoy, Anna M Arnaudo and Benjamin A Garcia
    Citation: Epigenetics & Chromatin 2015 8:15
    Content type: Methodology Published on:
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