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Research
Epigenetic reprogramming is a critical step in male germ cell development that occurs during perinatal life. It is characterized by the remodeling of different epigenetic marks such as DNA methylation (5mC) an...
Epigenetics & Chromatin 2017 10:19
Published on: 11 April 2017
Research
DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator o...
Epigenetics & Chromatin 2017 10:18
Published on: 11 April 2017
Research
Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 vari...
Epigenetics & Chromatin 2017 10:17
Published on: 4 April 2017
Research
Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that th...
Epigenetics & Chromatin 2017 10:15
Published on: 23 March 2017
Research
The compaction of DNA in chromatin in eukaryotes allowed the expansion of genome size and coincided with significant evolutionary diversification. However, chromatin generally represses DNA function, and mecha...
Epigenetics & Chromatin 2017 10:14
Published on: 20 March 2017
Research
Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmet...
Epigenetics & Chromatin 2017 10:13
Published on: 15 March 2017
Research
Histone posttranslational modifications (PTMs) function to regulate chromatin structure and function in part through the recruitment of effector proteins that harbor specialized “reader” domains. Despite effor...
Epigenetics & Chromatin 2017 10:12
Published on: 14 March 2017
Research
In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins like heterochromatin-bi...
Epigenetics & Chromatin 2017 10:11
Published on: 11 March 2017
Research
Alpha thalassemia/mental retardation X-linked syndrome (ATR-X) is caused by a mutation at the chromatin regulator gene ATRX. The mechanisms involved in the ATR-X pathology are not completely understood, but may i...
Epigenetics & Chromatin 2017 10:10
Published on: 10 March 2017
Methodology
Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The ...
Epigenetics & Chromatin 2017 10:9
Published on: 1 March 2017
Research
Epigenetic regulation of chromatin states is thought to control the self-renewal and differentiation of embryonic stem (ES) cells. However, the roles of repressive histone modifications such as trimethylated h...
Epigenetics & Chromatin 2017 10:8
Published on: 23 February 2017
Research
Defining how epigenetic information is established in the germline during fetal development is key to understanding how epigenetic information is inherited and impacts on evolution and human health and disease.
Epigenetics & Chromatin 2017 10:7
Published on: 20 February 2017
Research
Germline nuclear RNAi in C. elegans is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous...
Epigenetics & Chromatin 2017 10:6
Published on: 15 February 2017
Research
In the mammalian zygote, epigenetic reprogramming is a tightly controlled process of coordinated alterations of histone and DNA modifications. The parental genomes of the zygote show distinct patterns of hist...
Epigenetics & Chromatin 2017 10:5
Published on: 14 February 2017
Research
Intrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of...
Epigenetics & Chromatin 2017 10:4
Published on: 26 January 2017
Research
In multicellular organisms, epigenome dynamics are associated with transitions in the cell cycle, development, germline specification, gametogenesis and inheritance. Evolutionarily, regulatory space has increa...
Epigenetics & Chromatin 2017 10:3
Published on: 17 January 2017
Methodology
Histones and histone variants are essential components of the nuclear chromatin. While mass spectrometry has opened a large window to their characterization and functional studies, their identification from pr...
Epigenetics & Chromatin 2017 10:2
Published on: 10 January 2017
Methodology
Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In con...
Epigenetics & Chromatin 2017 10:1
Published on: 3 January 2017
Research
The dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function—the storage, expression, and replication of genetic information—is still one of the central i...
Epigenetics & Chromatin 2016 9:58
Published on: 24 December 2016
Research
Genome organization into subchromosomal topologically associating domains (TADs) is linked to cell-type-specific gene expression programs. However, dynamic properties of such domains remain elusive, and it is ...
Epigenetics & Chromatin 2016 9:57
Published on: 24 December 2016
Research
The Illumina 450k array has been widely used in epigenetic association studies. Current quality-control (QC) pipelines typically remove certain sets of probes, such as those containing a SNP or with multiple m...
Epigenetics & Chromatin 2016 9:56
Published on: 7 December 2016
Research
The nuclear pore complex (NPC) mediates nuclear transport of RNA and proteins into and out of the nucleus. Certain nucleoporins have additional functions in chromatin organization and transcription regulation....
Epigenetics & Chromatin 2016 9:54
Published on: 3 December 2016
Methodology
The ability to measure DNA methylation precisely and efficiently continues to drive our understanding of this modification in development and disease. Whole genome bisulfite sequencing has the advantage of the...
Epigenetics & Chromatin 2016 9:55
Published on: 3 December 2016
Research
Imprinted loci are paradigms of epigenetic regulation and are associated with a number of genetic disorders in human. A key characteristic of imprints is the presence of a gametic differentially methylated reg...
Epigenetics & Chromatin 2016 9:53
Published on: 22 November 2016
Research
The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET domain-catalysed methylation of H3K4. It is essential for normal embryonic de...
Epigenetics & Chromatin 2016 9:52
Published on: 11 November 2016
