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  1. Genome-wide maps of transcription factor binding sites in primary tissues can expand our understanding of genome function, transcriptional regulation, and genetic alterations that contribute to disease risk. H...

    Authors: Daniel Savic, Jason Gertz, Preti Jain, Gregory M Cooper and Richard M Myers
    Citation: Epigenetics & Chromatin 2013 6:30
  2. The target of rapamycin complex 1 (TORC1) is an evolutionarily conserved signal transduction pathway activated by environmental nutrients that regulates gene transcription to control cell growth and proliferat...

    Authors: Hongfeng Chen, Jason J Workman, Alexa Tenga and R Nicholas Laribee
    Citation: Epigenetics & Chromatin 2013 6:29
  3. The epithelial-mesenchymal transition (EMT) is a de-differentiation process required for wound healing and development. In tumors of epithelial origin aberrant induction of EMT contributes to cancer progressio...

    Authors: Marcin Cieślik, Stephen A Hoang, Natalya Baranova, Sanjay Chodaparambil, Manish Kumar, David F Allison, Xiaojiang Xu, J Jacob Wamsley, Lisa Gray, David R Jones, Marty W Mayo and Stefan Bekiranov
    Citation: Epigenetics & Chromatin 2013 6:28
  4. Histone deacetylases (HDACs) play a critical role in the maintenance of genome stability. Class I HDACs, histone deacetylase 1 and 2 (Hdac1 and Hdac2) are recruited to the replication fork by virtue of their i...

    Authors: Srividya Bhaskara, Vincent Jacques, James R Rusche, Eric N Olson, Bradley R Cairns and Mahesh B Chandrasekharan
    Citation: Epigenetics & Chromatin 2013 6:27
  5. DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study d...

    Authors: Roderick C Slieker, Steffan D Bos, Jelle J Goeman, Judith VMG Bovée, Rudolf P Talens, Ruud van der Breggen, H Eka D Suchiman, Eric-Wubbo Lameijer, Hein Putter, Erik B van den Akker, Yanju Zhang, J Wouter Jukema, P Eline Slagboom, Ingrid Meulenbelt and Bastiaan T Heijmans
    Citation: Epigenetics & Chromatin 2013 6:26
  6. Tight regulation of homeobox genes is essential for vertebrate development. In a study of genome-wide differential methylation, we recently found that homeobox genes, including those in the HOX gene clusters, wer...

    Authors: Koji Tsumagari, Carl Baribault, Jolyon Terragni, Sruti Chandra, Chloe Renshaw, Zhiyi Sun, Lingyun Song, Gregory E Crawford, Sriharsa Pradhan, Michelle Lacey and Melanie Ehrlich
    Citation: Epigenetics & Chromatin 2013 6:25
  7. The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silenci...

    Authors: Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton and Carolyn J Brown
    Citation: Epigenetics & Chromatin 2013 6:23
  8. The specific deposition of histone variants into chromatin is an important epigenetic mechanism that contributes to gene regulation through chromatin architectural changes. The histone variant H2A.Z is essenti...

    Authors: Nicolas Guillermo Simonet, Mauricio Reyes, Gino Nardocci, Alfredo Molina and Marco Alvarez
    Citation: Epigenetics & Chromatin 2013 6:22
  9. Previous elegant studies performed in the fission yeast Schizosaccharomyces pombe have identified a requirement for heterochromatin protein 1 (HP1) for spindle pole formation and appropriate cell division. In mam...

    Authors: Adrienne Grzenda, Phoebe Leonard, Seungmae Seo, Angela J Mathison, Guillermo Urrutia, Ezequiel Calvo, Juan Iovanna, Raul Urrutia and Gwen Lomberk
    Citation: Epigenetics & Chromatin 2013 6:21
  10. An integral component of cancer biology is the understanding of molecular properties uniquely distinguishing one cancer type from another. One class of such properties is histone post-translational modificatio...

    Authors: Gary LeRoy, Peter A DiMaggio, Eric Y Chan, Barry M Zee, M Andres Blanco, Barbara Bryant, Ian Z Flaniken, Sherry Liu, Yibin Kang, Patrick Trojer and Benjamin A Garcia
    Citation: Epigenetics & Chromatin 2013 6:20
  11. Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not al...

    Authors: Arne W Mould, Zhenyi Pang, Miha Pakusch, Ian D Tonks, Mitchell Stark, Dianne Carrie, Pamela Mukhopadhyay, Annica Seidel, Jonathan J Ellis, Janine Deakin, Matthew J Wakefield, Lutz Krause, Marnie E Blewitt and Graham F Kay
    Citation: Epigenetics & Chromatin 2013 6:19
  12. Growing evidence suggests that DNA methylation plays a role in tissue-specific differentiation. Current approaches to methylome analysis using enrichment with the methyl-binding domain protein (MBD) are restri...

    Authors: Verity F Oliver, Jun Wan, Saurabh Agarwal, Donald J Zack, Jiang Qian and Shannath L Merbs
    Citation: Epigenetics & Chromatin 2013 6:17
  13. The packaging of eukaryotic DNA into nucleosomal arrays permits cells to tightly regulate and fine-tune gene expression. The ordered disassembly and reassembly of these nucleosomes allows RNA polymerase II (RN...

    Authors: Swaminathan Venkatesh, Jerry L Workman and Michaela Smolle
    Citation: Epigenetics & Chromatin 2013 6:16
  14. In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTas...

    Authors: Irina A Maksakova, Peter J Thompson, Preeti Goyal, Steven JM Jones, Prim B Singh, Mohammad M Karimi and Matthew C Lorincz
    Citation: Epigenetics & Chromatin 2013 6:15
  15. DNA methylation and repressive histone modifications cooperate to silence promoters. One mechanism by which regions of methylated DNA could acquire repressive histone modifications is via methyl DNA-binding tr...

    Authors: Adam Blattler, Lijing Yao, Yao Wang, Zhenqing Ye, Victor X Jin and Peggy J Farnham
    Citation: Epigenetics & Chromatin 2013 6:13
  16. Recognition of histone modifications by specialized protein domains is a key step in the regulation of DNA-mediated processes like gene transcription. The structural basis of these interactions is usually stud...

    Authors: Rick van Nuland, Frederik MA van Schaik, Marieke Simonis, Sebastiaan van Heesch, Edwin Cuppen, Rolf Boelens, HT Marc Timmers and Hugo van Ingen
    Citation: Epigenetics & Chromatin 2013 6:12
  17. Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics and chemotherapeutic agents, but the pat...

    Authors: Elsa Boudadi, Hannah Stower, John A Halsall, Charlotte E Rutledge, Martin Leeb, Anton Wutz, Laura P O’Neill, Karl P Nightingale and Bryan M Turner
    Citation: Epigenetics & Chromatin 2013 6:11
  18. DNA methylation is one of the most phylogenetically widespread epigenetic modifications of genomic DNA. In particular, DNA methylation of transcription units (‘gene bodies’) is highly conserved across diverse ...

    Authors: Iksoo Huh, Jia Zeng, Taesung Park and Soojin V Yi
    Citation: Epigenetics & Chromatin 2013 6:9

    The Erratum to this article has been published in Epigenetics & Chromatin 2014 7:13

  19. Hox genes impart segment identity to body structures along the anterior-posterior axis and are crucial for the proper development of all organisms. Multiple regulatory elements, best defined in Drosophila melanog...

    Authors: Surabhi Srivastava, Deepika Puri, Hita Sony Garapati, Jyotsna Dhawan and Rakesh K Mishra
    Citation: Epigenetics & Chromatin 2013 6:8
  20. The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. ...

    Authors: Kelly M Bush, Benjamin TK Yuen, Bonnie L Barrilleaux, John W Riggs, Henriette O’Geen, Rebecca F Cotterman and Paul S Knoepfler
    Citation: Epigenetics & Chromatin 2013 6:7
  21. Authors: Ignacio Mazon, Sharon Squazzo, Jan Hendrickx, Géraldine Goens, Catherine D’andrea, Geoffrey Berguet, Celine Sabatel, Miklos Laczik and Dominique Poncelet
    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P133

    This article is part of a Supplement: Volume 6 Supplement 1

  22. Authors: Matias Alvarez-Saavedra, Pamela Lagali, Keqin Yan, Emile Hashem, Alan Mears, Yves De Repentigny, Valerie A Wallace, Rashmi Kothary, Tomas Stopka, Arthur I Skoultchi and David J Picketts
    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P105

    This article is part of a Supplement: Volume 6 Supplement 1

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  • Epigenetics & Chromatin is affiliated with the International Society for Molecular and Clinical Epigenetics (isMOCLEP). isMOCLEP is open to all those interested in the wide spectrum of epigenetic research, from molecular to clinical aspects. isMOCLEP community welcomes academic researchers, early career scientists, companies, policy makers, and beyond.

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