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  1. The specific deposition of histone variants into chromatin is an important epigenetic mechanism that contributes to gene regulation through chromatin architectural changes. The histone variant H2A.Z is essenti...

    Authors: Nicolas Guillermo Simonet, Mauricio Reyes, Gino Nardocci, Alfredo Molina and Marco Alvarez
    Citation: Epigenetics & Chromatin 2013 6:22
    Content type: Research Published on:

  2. Previous elegant studies performed in the fission yeast Schizosaccharomyces pombe have identified a requirement for heterochromatin protein 1 (HP1) for spindle pole formation and appropriate cell division. In mam...

    Authors: Adrienne Grzenda, Phoebe Leonard, Seungmae Seo, Angela J Mathison, Guillermo Urrutia, Ezequiel Calvo, Juan Iovanna, Raul Urrutia and Gwen Lomberk
    Citation: Epigenetics & Chromatin 2013 6:21
    Content type: Research Published on:

  3. An integral component of cancer biology is the understanding of molecular properties uniquely distinguishing one cancer type from another. One class of such properties is histone post-translational modificatio...

    Authors: Gary LeRoy, Peter A DiMaggio, Eric Y Chan, Barry M Zee, M Andres Blanco, Barbara Bryant, Ian Z Flaniken, Sherry Liu, Yibin Kang, Patrick Trojer and Benjamin A Garcia
    Citation: Epigenetics & Chromatin 2013 6:20
    Content type: Methodology Published on:

  4. Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not al...

    Authors: Arne W Mould, Zhenyi Pang, Miha Pakusch, Ian D Tonks, Mitchell Stark, Dianne Carrie, Pamela Mukhopadhyay, Annica Seidel, Jonathan J Ellis, Janine Deakin, Matthew J Wakefield, Lutz Krause, Marnie E Blewitt and Graham F Kay
    Citation: Epigenetics & Chromatin 2013 6:19
    Content type: Research Published on:

  6. Growing evidence suggests that DNA methylation plays a role in tissue-specific differentiation. Current approaches to methylome analysis using enrichment with the methyl-binding domain protein (MBD) are restri...

    Authors: Verity F Oliver, Jun Wan, Saurabh Agarwal, Donald J Zack, Jiang Qian and Shannath L Merbs
    Citation: Epigenetics & Chromatin 2013 6:17
    Content type: Methodology Published on:

  7. The packaging of eukaryotic DNA into nucleosomal arrays permits cells to tightly regulate and fine-tune gene expression. The ordered disassembly and reassembly of these nucleosomes allows RNA polymerase II (RN...

    Authors: Swaminathan Venkatesh, Jerry L Workman and Michaela Smolle
    Citation: Epigenetics & Chromatin 2013 6:16
    Content type: Review Published on:

  8. In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTas...

    Authors: Irina A Maksakova, Peter J Thompson, Preeti Goyal, Steven JM Jones, Prim B Singh, Mohammad M Karimi and Matthew C Lorincz
    Citation: Epigenetics & Chromatin 2013 6:15
    Content type: Research Published on:

  12. DNA methylation and repressive histone modifications cooperate to silence promoters. One mechanism by which regions of methylated DNA could acquire repressive histone modifications is via methyl DNA-binding tr...

    Authors: Adam Blattler, Lijing Yao, Yao Wang, Zhenqing Ye, Victor X Jin and Peggy J Farnham
    Citation: Epigenetics & Chromatin 2013 6:13
    Content type: Research Published on:

  13. Recognition of histone modifications by specialized protein domains is a key step in the regulation of DNA-mediated processes like gene transcription. The structural basis of these interactions is usually stud...

    Authors: Rick van Nuland, Frederik MA van Schaik, Marieke Simonis, Sebastiaan van Heesch, Edwin Cuppen, Rolf Boelens, HT Marc Timmers and Hugo van Ingen
    Citation: Epigenetics & Chromatin 2013 6:12
    Content type: Research Published on:

  14. Histone deacetylase inhibitors (HDACi) cause histone hyperacetylation and H3K4 hypermethylation in various cell types. They find clinical application as anti-epileptics and chemotherapeutic agents, but the pat...

    Authors: Elsa Boudadi, Hannah Stower, John A Halsall, Charlotte E Rutledge, Martin Leeb, Anton Wutz, Laura P O’Neill, Karl P Nightingale and Bryan M Turner
    Citation: Epigenetics & Chromatin 2013 6:11
    Content type: Research Published on:

  16. DNA methylation is one of the most phylogenetically widespread epigenetic modifications of genomic DNA. In particular, DNA methylation of transcription units (‘gene bodies’) is highly conserved across diverse ...

    Authors: Iksoo Huh, Jia Zeng, Taesung Park and Soojin V Yi
    Citation: Epigenetics & Chromatin 2013 6:9
    Content type: Research Published on:

    The Erratum to this article has been published in Epigenetics & Chromatin 2014 7:13

  17. Hox genes impart segment identity to body structures along the anterior-posterior axis and are crucial for the proper development of all organisms. Multiple regulatory elements, best defined in Drosophila melanog...

    Authors: Surabhi Srivastava, Deepika Puri, Hita Sony Garapati, Jyotsna Dhawan and Rakesh K Mishra
    Citation: Epigenetics & Chromatin 2013 6:8
    Content type: Research Published on:

  18. The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. ...

    Authors: Kelly M Bush, Benjamin TK Yuen, Bonnie L Barrilleaux, John W Riggs, Henriette O’Geen, Rebecca F Cotterman and Paul S Knoepfler
    Citation: Epigenetics & Chromatin 2013 6:7
    Content type: Research Published on:

  20. Authors: Ignacio Mazon, Sharon Squazzo, Jan Hendrickx, Géraldine Goens, Catherine D’andrea, Geoffrey Berguet, Celine Sabatel, Miklos Laczik and Dominique Poncelet
    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P133
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  37. Authors: Hisato Kobayashi, Takayuki Sakurai, Fumihito Miura, Misaki Imai, Kentaro Mochiduki, Eikichi Yanagisawa, Akihiko Sakashita, Takuya Wakai, Yutaka Suzuki, Takashi lto, Yasuhisa Matsui and Tomohiro Kono
    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P116
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  48. Authors: Matias Alvarez-Saavedra, Pamela Lagali, Keqin Yan, Emile Hashem, Alan Mears, Yves De Repentigny, Valerie A Wallace, Rashmi Kothary, Tomas Stopka, Arthur I Skoultchi and David J Picketts
    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P105
    Content type: Poster presentation Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  49. Mitosis is accompanied by dramatic changes in chromatin organization and nuclear architecture. Transcription halts globally and most sequence-specific transcription factors and co-factors are ejected from mito...

    Authors: Stephan Kadauke and Gerd A Blobel
    Citation: Epigenetics & Chromatin 2013 6:6
    Content type: Review Published on:
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