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  1. In marsupials, growth and development of the young occur postnatally, regulated by milk that changes in composition throughout the long lactation. To initiate lactation in mammals, there is an absolute require...

    Authors: Jessica M Stringer, Shunsuke Suzuki, Andrew J Pask, Geoff Shaw and Marilyn B Renfree

    Citation: Epigenetics & Chromatin 2012 5:14

    Content type: Research

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  2. In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the nucleus. Recent genome-wide st...

    Authors: Tanja Prenzel, Frank Kramer, Upasana Bedi, Sankari Nagarajan, Tim Beissbarth and Steven A Johnsen

    Citation: Epigenetics & Chromatin 2012 5:13

    Content type: Research

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  3. Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic modulation during...

    Authors: Peggy Prickaerts, Hanneke EC Niessen, Emmanuèle Mouchel-Vielh, Vivian EH Dahlmans, Guus GH van den Akker, Claudia Geijselaers, Michiel E Adriaens, Frank Spaapen, Yoshihiro Takihara, Ulf R Rapp, Frédérique Peronnet and Jan Willem Voncken

    Citation: Epigenetics & Chromatin 2012 5:12

    Content type: Research

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  4. Clear cause-and-effect relationships are commonly established between genotype and the inherited risk of acquiring human and plant diseases and aberrant phenotypes. By contrast, few such cause-and-effect relat...

    Authors: Richard B Meagher and Kristofer J Müssar

    Citation: Epigenetics & Chromatin 2012 5:11

    Content type: Review

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  5. The challenge in extracting genome-wide chromatin features from limiting clinical samples poses a significant hurdle in identification of regulatory marks that impact the physiological or pathological state. C...

    Authors: Lars Grøntved, Russell Bandle, Sam John, Songjoon Baek, Hye-Jung Chung, Ying Liu, Greti Aguilera, Carl Oberholtzer, Gordon L Hager and David Levens

    Citation: Epigenetics & Chromatin 2012 5:10

    Content type: Methodology

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  6. Non-small cell lung carcinoma (NSCLC) is a complex malignancy that owing to its heterogeneity and poor prognosis poses many challenges to diagnosis, prognosis and patient treatment. DNA methylation is an impor...

    Authors: Rejane Hughes Carvalho, Vanja Haberle, Jun Hou, Teus van Gent, Supat Thongjuea, Wilfred van IJcken, Christel Kockx, Rutger Brouwer, Erikjan Rijkers, Anieta Sieuwerts, John Foekens, Mirjam van Vroonhoven, Joachim Aerts, Frank Grosveld, Boris Lenhard and Sjaak Philipsen

    Citation: Epigenetics & Chromatin 2012 5:9

    Content type: Research

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  7. CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and epigen...

    Authors: Frank Sleutels, Widia Soochit, Marek Bartkuhn, Helen Heath, Sven Dienstbach, Philipp Bergmaier, Vedran Franke, Manuel Rosa-Garrido, Suzanne van de Nobelen, Lisa Caesar, Michael van der Reijden, Jan Christian Bryne, Wilfred van IJcken, J Anton Grootegoed, M Dolores Delgado, Boris Lenhard…

    Citation: Epigenetics & Chromatin 2012 5:8

    Content type: Research

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  8. Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conven...

    Authors: Paul B Talbert, Kami Ahmad, Geneviève Almouzni, Juan Ausió, Frederic Berger, Prem L Bhalla, William M Bonner, W Zacheus Cande, Brian P Chadwick, Simon W L Chan, George A M Cross, Liwang Cui, Stefan I Dimitrov, Detlef Doenecke, José M Eirin-López, Martin A Gorovsky…

    Citation: Epigenetics & Chromatin 2012 5:7

    Content type: Review

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  9. Chromatin structure at a given site can differ between chromosome copies in a cell, and such imbalances in chromatin structure have been shown to be important in understanding the molecular mechanisms controll...

    Authors: James G D Prendergast, Pin Tong, David C Hay, Susan M Farrington and Colin A M Semple

    Citation: Epigenetics & Chromatin 2012 5:6

    Content type: Research

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  10. The protein anti-silencing function 1 (Asf1) chaperones histones H3/H4 for assembly into nucleosomes every cell cycle as well as during DNA transcription and repair. Asf1 interacts directly with H4 through the...

    Authors: Myrriah S Chavez, Jean K Scorgie, Briana K Dennehey, Seth Noone, Jessica K Tyler and Mair EA Churchill

    Citation: Epigenetics & Chromatin 2012 5:5

    Content type: Research

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  11. The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks. DNA damage interferes with v...

    Authors: Hannes Lans, Jurgen A Marteijn and Wim Vermeulen

    Citation: Epigenetics & Chromatin 2012 5:4

    Content type: Review

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  12. DNA methylation, histone modifications and nucleosome occupancy act in concert for regulation of gene expression patterns in mammalian cells. Recently, G9a, a H3K9 methyltransferase, has been shown to play a r...

    Authors: Shikhar Sharma, Daniel S Gerke, Han F Han, Shinwu Jeong, Michael R Stallcup, Peter A Jones and Gangning Liang

    Citation: Epigenetics & Chromatin 2012 5:3

    Content type: Research

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  13. The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effec...

    Authors: Lauren B Auriemma, Shaili Shah, Lara M Linden and Melissa A Henriksen

    Citation: Epigenetics & Chromatin 2012 5:2

    Content type: Research

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  14. Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share speci...

    Authors: Petros Kolovos, Tobias A Knoch, Frank G Grosveld, Peter R Cook and Argyris Papantonis

    Citation: Epigenetics & Chromatin 2012 5:1

    Content type: Review

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  15. Gene regulation in eukaryotes is a complex process entailing the establishment of transcriptionally silent chromatin domains interspersed with regions of active transcription. Imprinted domains consist of clus...

    Authors: Lisa Korostowski, Anjali Raval, Gillian Breuer and Nora Engel

    Citation: Epigenetics & Chromatin 2011 4:21

    Content type: Research

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  16. A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important op...

    Authors: Natalia Varlakhanova, Rebecca Cotterman, Keith Bradnam, Ian Korf and Paul S Knoepfler

    Citation: Epigenetics & Chromatin 2011 4:20

    Content type: Research

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  17. Signaling via protein lysine methylation has been proposed to play a central role in the regulation of many physiologic and pathologic programs. In contrast to other post-translational modifications such as ph...

    Authors: Dan Levy, Chih Long Liu, Ze Yang, Aaron M Newman, Ash A Alizadeh, Paul J Utz and Or Gozani

    Citation: Epigenetics & Chromatin 2011 4:19

    Content type: Methodology

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  18. Histone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histo...

    Authors: Zhihui Liang, Marc Diamond, Johanna A Smith, Matthias Schnell and René Daniel

    Citation: Epigenetics & Chromatin 2011 4:18

    Content type: Research

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  19. Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcript...

    Authors: Tatyana B Nesterova, Claire E Senner, Janina Schneider, Tilly Alcayna-Stevens, Anna Tattermusch, Myriam Hemberger and Neil Brockdorff

    Citation: Epigenetics & Chromatin 2011 4:17

    Content type: Research

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  20. Polycomb group (PcG) genes code for chromatin multiprotein complexes that are responsible for maintaining gene silencing of transcriptional programs during differentiation and in adult tissues. Despite the lar...

    Authors: Lovorka Stojic, Zuzana Jasencakova, Carolina Prezioso, Alexandra Stützer, Beatrice Bodega, Diego Pasini, Rebecca Klingberg, Chiara Mozzetta, Raphael Margueron, Pier Lorenzo Puri, Dirk Schwarzer, Kristian Helin, Wolfgang Fischle and Valerio Orlando

    Citation: Epigenetics & Chromatin 2011 4:16

    Content type: Research

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  21. Histone H1 is an important constituent of chromatin, and is involved in regulation of its structure. During the cell cycle, chromatin becomes locally decondensed in S phase, highly condensed during metaphase, ...

    Authors: Anna Gréen, Bettina Sarg, Henrik Gréen, Anita Lönn, Herbert H Lindner and Ingemar Rundquist

    Citation: Epigenetics & Chromatin 2011 4:15

    Content type: Research

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  22. Random monoallelic expression contributes to phenotypic variation of cells and organisms. However, the epigenetic mechanisms by which individual alleles are randomly selected for expression are not known. Taki...

    Authors: Brandon J Thomas, Eric D Rubio, Niklas Krumm, Pilib Ó Broin, Karol Bomsztyk, Piri Welcsh, John M Greally, Aaron A Golden and Anton Krumm

    Citation: Epigenetics & Chromatin 2011 4:14

    Content type: Research

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  23. Transcription initiation RNAs (tiRNAs) are nuclear localized 18 nucleotide RNAs derived from sequences immediately downstream of RNA polymerase II (RNAPII) transcription start sites. Previous reports have show...

    Authors: Ryan J Taft, Peter G Hawkins, John S Mattick and Kevin V Morris

    Citation: Epigenetics & Chromatin 2011 4:13

    Content type: Research

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  24. Endogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-depo...

    Authors: Irina A Maksakova, Preeti Goyal, Jörn Bullwinkel, Jeremy P Brown, Misha Bilenky, Dixie L Mager, Prim B Singh and Matthew C Lorincz

    Citation: Epigenetics & Chromatin 2011 4:12

    Content type: Research

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  25. Covalent histone modifications are central to all DNA-dependent processes. Modifications of histones H3 and H4 are becoming well characterised, but knowledge of how H2A modifications regulate chromatin dynamic...

    Authors: Tanja Waldmann, Annalisa Izzo, Kinga Kamieniarz, Florian Richter, Christine Vogler, Bettina Sarg, Herbert Lindner, Nicolas L Young, Gerhard Mittler, Benjamin A Garcia and Robert Schneider

    Citation: Epigenetics & Chromatin 2011 4:11

    Content type: Research

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  26. Genomic imprinting is an important epigenetic process involved in regulating placental and foetal growth. Imprinted genes are typically associated with differentially methylated regions (DMRs) whereby one of t...

    Authors: Ryan KC Yuen, Ruby Jiang, Maria S Peñaherrera, Deborah E McFadden and Wendy P Robinson

    Citation: Epigenetics & Chromatin 2011 4:10

    Content type: Methodology

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  27. In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, impl...

    Authors: Marco De Gobbi, David Garrick, Magnus Lynch, Douglas Vernimmen, Jim R Hughes, Nicolas Goardon, Sidinh Luc, Karen M Lower, Jacqueline A Sloane-Stanley, Cristina Pina, Shamit Soneji, Raffaele Renella, Tariq Enver, Stephen Taylor, Sten Eirik W Jacobsen, Paresh Vyas…

    Citation: Epigenetics & Chromatin 2011 4:9

    Content type: Research

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  28. Development of human tissue is influenced by a combination of intrinsic biological signals and extrinsic environmental stimuli, both of which are mediated by epigenetic regulation, including DNA methylation. H...

    Authors: Ryan KC Yuen, Sarah MA Neumann, Alexandra K Fok, Maria S Peñaherrera, Deborah E McFadden, Wendy P Robinson and Michael S Kobor

    Citation: Epigenetics & Chromatin 2011 4:7

    Content type: Research

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  29. The male-specific lethal (MSL) complex of Drosophila remodels the chromatin of the X chromosome in males to enhance the level of transcription of most X-linked genes, and thereby achieve dosage compensation. The ...

    Authors: Rosa Morra, Ruth Yokoyama, Huiping Ling and John C Lucchesi

    Citation: Epigenetics & Chromatin 2011 4:6

    Content type: Research

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  30. Protein exchange kinetics correlate with the level of chromatin condensation and, in many cases, with the level of transcription. We used fluorescence recovery after photobleaching (FRAP) to analyse the kineti...

    Authors: Lenka Stixová, Eva Bártová, Pavel Matula, Ondřej Daněk, Soňa Legartová and Stanislav Kozubek

    Citation: Epigenetics & Chromatin 2011 4:5

    Content type: Research

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  31. Polycomb/Trithorax response elements (PREs) are cis-regulatory elements essential for the regulation of several hundred developmentally important genes. However, the precise sequence requirements for PRE function...

    Authors: Helena Okulski, Birgit Druck, Sheetal Bhalerao and Leonie Ringrose

    Citation: Epigenetics & Chromatin 2011 4:4

    Content type: Methodology

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  32. Unique structural characteristics of centromere chromatin enable it to support assembly of the kinetochore and its associated tensions. The histone H3 variant CENH3 (centromeric histone H3) is viewed as the ke...

    Authors: Jonathan I Gent, Kevin L Schneider, Christopher N Topp, Carmen Rodriguez, Gernot G Presting and R Kelly Dawe

    Citation: Epigenetics & Chromatin 2011 4:3

    Content type: Research

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  33. Methylation of histone H3 lysine 79 (H3K79) by Dot1 is highly conserved among species and has been associated with both gene repression and activation. To eliminate indirect effects and examine the direct cons...

    Authors: Iris JE Stulemeijer, Brietta L Pike, Alex W Faber, Kitty F Verzijlbergen, Tibor van Welsem, Floor Frederiks, Tineke L Lenstra, Frank CP Holstege, Susan M Gasser and Fred van Leeuwen

    Citation: Epigenetics & Chromatin 2011 4:2

    Content type: Research

    Published on:

  34. Genes subject to genomic imprinting are mono-allelically expressed in a parent-of-origin dependent manner. Each imprinted locus has at least one differentially methylated region (DMR) which has allele specific...

    Authors: Kathryn Woodfine, Joanna E Huddleston and Adele Murrell

    Citation: Epigenetics & Chromatin 2011 4:1

    Content type: Research

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  35. Post-translational modifications (PTMs) on the N-terminal tails of histones and histone variants regulate distinct transcriptional states and nuclear events. Whereas the functional effects of specific PTMs are...

    Authors: Barry M Zee, Rebecca S Levin, Peter A DiMaggio and Benjamin A Garcia

    Citation: Epigenetics & Chromatin 2010 3:22

    Content type: Methodology

    Published on:

  36. Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2β) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complex...

    Authors: Shuying He, Melinda K Pirity, Wei-Lin Wang, Louise Wolf, Bharesh K Chauhan, Kveta Cveklova, Ernst R Tamm, Ruth Ashery-Padan, Daniel Metzger, Akira Nakai, Pierre Chambon, Jiri Zavadil and Ales Cvekl

    Citation: Epigenetics & Chromatin 2010 3:21

    Content type: Research

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  37. Recent advances in the field of high-throughput genomics have rendered possible the performance of genome-scale studies to define the nucleosomal landscapes of eukaryote genomes. Such analyses are aimed toward...

    Authors: Christoforos Nikolaou, Sonja Althammer, Miguel Beato and Roderic Guigó

    Citation: Epigenetics & Chromatin 2010 3:20

    Content type: Research

    Published on:

  38. CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription. CTCF may act ...

    Authors: Suzanne van de Nobelen, Manuel Rosa-Garrido, Joerg Leers, Helen Heath, Widia Soochit, Linda Joosen, Iris Jonkers, Jeroen Demmers, Michael van der Reijden, Verónica Torrano, Frank Grosveld, M Dolores Delgado, Rainer Renkawitz, Niels Galjart and Frank Sleutels

    Citation: Epigenetics & Chromatin 2010 3:19

    Content type: Research

    Published on:

  39. Histone acetylation is one of the key regulatory mechanisms controlling transcriptional activity in eukaryotic cells. In higher eukaryotes, a number of nuclear histone acetyltransferase (HAT) enzymes have been...

    Authors: Krishanpal Anamika, Arnaud R Krebs, Julie Thompson, Olivier Poch, Didier Devys and Làszlò Tora

    Citation: Epigenetics & Chromatin 2010 3:18

    Content type: Review

    Published on:

  40. Genomic methylation patterns are established during gametogenesis, and perpetuated in somatic cells by faithful maintenance methylation. There have been previous indications that genomic methylation patterns m...

    Authors: Steen KT Ooi, Daniel Wolf, Odelya Hartung, Suneet Agarwal, George Q Daley, Stephen P Goff and Timothy H Bestor

    Citation: Epigenetics & Chromatin 2010 3:17

    Content type: Research

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  41. Signal transducer and activator of transcription (STAT) activation of gene expression is both rapid and transient, and when properly executed it affects growth, differentiation, homeostasis and the immune resp...

    Authors: Lauren J Buro, Edmond Chipumuro and Melissa A Henriksen

    Citation: Epigenetics & Chromatin 2010 3:16

    Content type: Research

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  42. The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have suggested that germline continuity can involve epigeneti...

    Authors: Hirofumi Furuhashi, Teruaki Takasaki, Andreas Rechtsteiner, Tengguo Li, Hiroshi Kimura, Paula M Checchi, Susan Strome and William G Kelly

    Citation: Epigenetics & Chromatin 2010 3:15

    Content type: Research

    Published on:

  43. Incorporation of histone variants into chromatin is one of the epigenetic mechanisms used for regulation of gene expression. Macro (m)H2A is a histone variant that has two different subtypes in vertebrates: mH...

    Authors: I Araya, G Nardocci, JP Morales, MI Vera, A Molina and M Alvarez

    Citation: Epigenetics & Chromatin 2010 3:14

    Content type: Research

    Published on:

  44. The physiological function of eukaryotic DNA occurs in the context of nucleosomal arrays that can expose or obscure defined segments of the genome. Certain DNA sequences are capable of strongly positioning a n...

    Authors: Lia E Gracey, Zhi-Ying Chen, Jay M Maniar, Anton Valouev, Arend Sidow, Mark A Kay and Andrew Z Fire

    Citation: Epigenetics & Chromatin 2010 3:13

    Content type: Research

    Published on:

  45. X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist....

    Authors: Y Amy Tang, Derek Huntley, Giovanni Montana, Andrea Cerase, Tatyana B Nesterova and Neil Brockdorff

    Citation: Epigenetics & Chromatin 2010 3:10

    Content type: Research

    Published on:

  46. HP1 proteins are conserved components of eukaryotic constitutive heterochromatin. In mammals, there are three genes that encode HP1-like proteins, termed HP1α, HP1β and HP1γ, which have a high degree of homolo...

    Authors: Jeremy P Brown, Jörn Bullwinkel, Bettina Baron-Lühr, Mustafa Billur, Philipp Schneider, Heinz Winking and Prim B Singh

    Citation: Epigenetics & Chromatin 2010 3:9

    Content type: Research

    Published on:

    The Erratum to this article has been published in Epigenetics & Chromatin 2012 5:18

  47. Vertebrate heterochromatin contains a non-allelic variant of the histone H2A called macroH2A1, which has the characteristic of being three times the size of the canonical H2A. The macroH2A1 C-terminal extensio...

    Authors: Mathieu Boulard, Sébastien Storck, Rong Cong, Rodrigo Pinto, Hélène Delage and Philippe Bouvet

    Citation: Epigenetics & Chromatin 2010 3:8

    Content type: Research

    Published on:

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