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  1. Content type: Research

    During early mouse development, two extra-embryonic lineages form alongside the future embryo: the trophectoderm (TE) and the primitive endoderm (PrE). Epigenetic changes known to take place during these early...

    Authors: Joana Santos, C Filipe Pereira, Aida Di-Gregorio, Thomas Spruce, Olivia Alder, Tristan Rodriguez, Véronique Azuara, Matthias Merkenschlager and Amanda G Fisher

    Citation: Epigenetics & Chromatin 2010 3:1

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  2. Content type: Research

    In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect. There is large variation in the level of t...

    Authors: Esther R Loney, Peter W Inglis, Sarah Sharp, Fiona E Pryde, Nicholas A Kent, Jane Mellor and Edward J Louis

    Citation: Epigenetics & Chromatin 2009 2:18

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  3. Content type: Research

    Acetylation of promoter nucleosomes is tightly correlated and mechanistically linked to gene activity. However, transcription is not necessary for promoter acetylation. It seems, therefore, that external and e...

    Authors: Ina Horst, Sascha Offermann, Bjoern Dreesen, Markus Niessen and Christoph Peterhansel

    Citation: Epigenetics & Chromatin 2009 2:17

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  4. Content type: Research

    The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. In this study, we investigated how higher-order chromatin structure modulates differential expression o...

    Authors: Sima Kheradmand Kia, Parham Solaimani Kartalaei, Elnaz Farahbakhshian, Farzin Pourfarzad, Marieke von Lindern and C Peter Verrijzer

    Citation: Epigenetics & Chromatin 2009 2:16

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  5. Content type: Research

    The archetypal epigenetic phenomenon of position effect variegation (PEV) in Drosophila occurs when a gene is brought abnormally close to heterochromatin, resulting in stochastic silencing of the affected gene in...

    Authors: Kyoko Hiragami-Hamada, Sheila Q Xie, Alexander Saveliev, Santiago Uribe-Lewis, Ana Pombo and Richard Festenstein

    Citation: Epigenetics & Chromatin 2009 2:14

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  6. Content type: Research

    Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells. Transcriptional regulators, such as Oct4, are critic...

    Authors: Leng-Siew Yeap, Katsuhiko Hayashi and M Azim Surani

    Citation: Epigenetics & Chromatin 2009 2:12

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  7. Content type: Research

    Dynamic changes to the chromatin structure play a critical role in transcriptional regulation. This is exemplified by the Spt6-mediated histone deposition on to histone-depleted promoters that results in displ...

    Authors: Ryosuke Ohsawa, Melissa Adkins and Jessica K Tyler

    Citation: Epigenetics & Chromatin 2009 2:11

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  8. Content type: Research

    Argonaute2 protein (Ago2) is a key component of RNA-induced gene silencing complex, which is crucial for microRNA-mediated repression of target genes. The function of Ago2 in the mouse oocyte and early embryon...

    Authors: Masahiro Kaneda, Fuchou Tang, Dónal O'Carroll, Kaiqin Lao and M Azim Surani

    Citation: Epigenetics & Chromatin 2009 2:9

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  9. Content type: Research

    Delimiting distinct chromatin domains is essential for temporal and spatial regulation of gene expression. Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtapos...

    Authors: Pablo Navarro, Sophie Chantalat, Mario Foglio, Corinne Chureau, Sébastien Vigneau, Philippe Clerc, Philip Avner and Claire Rougeulle

    Citation: Epigenetics & Chromatin 2009 2:8

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  10. Content type: Research

    DNA methylation is a major epigenetic modification important for regulating gene expression and suppressing spurious transcription. Most methods to scan the genome in different tissues for differentially methy...

    Authors: Cecilia De Bustos, Edward Ramos, Janet M Young, Robert K Tran, Uwe Menzel, Cordelia F Langford, Evan E Eichler, Li Hsu, Steve Henikoff, Jan P Dumanski and Barbara J Trask

    Citation: Epigenetics & Chromatin 2009 2:7

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  11. Content type: Research

    Histone methylation is thought to be central to the epigenetic mechanisms that maintain and confine cellular identity in multi-cellular organisms. To examine epigenetic roles in cellular homeostasis, we condit...

    Authors: Stefan Glaser, Sandra Lubitz, Kate L Loveland, Kazu Ohbo, Lorraine Robb, Frieder Schwenk, Jost Seibler, Daniela Roellig, Andrea Kranz, Konstantinos Anastassiadis and A Francis Stewart

    Citation: Epigenetics & Chromatin 2009 2:5

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  12. Content type: Research

    Genome-wide mappings of nucleosome occupancy in different species have shown presence of well-positioned nucleosomes. While the DNA sequences may help decide their locations, the observed positions in vivo are en...

    Authors: Vinesh Vinayachandran, Rama-Haritha Pusarla and Purnima Bhargava

    Citation: Epigenetics & Chromatin 2009 2:4

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    The Erratum to this article has been published in Epigenetics & Chromatin 2011 4:8

  13. Content type: Methodology

    DNA methylation plays a vital role in normal cellular function, with aberrant methylation signatures being implicated in a growing number of human pathologies and complex human traits. Methods based on the mod...

    Authors: Sophia J Docherty, Oliver SP Davis, Claire MA Haworth, Robert Plomin and Jonathan Mill

    Citation: Epigenetics & Chromatin 2009 2:3

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  14. Content type: Research

    Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. Th...

    Authors: Kenneth K Lee, Selene K Swanson, Laurence Florens, Michael P Washburn and Jerry L Workman

    Citation: Epigenetics & Chromatin 2009 2:2

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  15. Content type: Research

    Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that sho...

    Authors: Maartje J Vogel, Ludo Pagie, Wendy Talhout, Marja Nieuwland, Ron M Kerkhoven and Bas van Steensel

    Citation: Epigenetics & Chromatin 2009 2:1

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  16. Content type: Methodology

    Direct visualization of chromatin has the potential to provide important insights into epigenetic processes. In particular, atomic force microscopy (AFM) can visualize single nucleosomes under physiological io...

    Authors: Hongda Wang, Yamini Dalal, Steven Henikoff and Stuart Lindsay

    Citation: Epigenetics & Chromatin 2008 1:10

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  17. Content type: Review

    The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks,...

    Authors: Christoffel Dinant, Adriaan B Houtsmuller and Wim Vermeulen

    Citation: Epigenetics & Chromatin 2008 1:9

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  18. Content type: Research

    In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zy...

    Authors: Konstantin Lepikhov, Valeri Zakhartchenko, Ru Hao, Feikun Yang, Christine Wrenzycki, Heiner Niemann, Eckhard Wolf and Joern Walter

    Citation: Epigenetics & Chromatin 2008 1:8

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  19. Content type: Methodology

    Methylation-sensitive high resolution melting (MS-HRM) methodology is able to recognise heterogeneously methylated sequences by their characteristic melting profiles. To further analyse heterogeneously methyla...

    Authors: Ida LM Candiloro, Thomas Mikeska, Peter Hokland and Alexander Dobrovic

    Citation: Epigenetics & Chromatin 2008 1:7

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  20. Content type: Research

    Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. Th...

    Authors: Asako J Nakamura, Y Jeffrey Chiang, Karen S Hathcock, Izumi Horikawa, Olga A Sedelnikova, Richard J Hodes and William M Bonner

    Citation: Epigenetics & Chromatin 2008 1:6

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  21. Content type: Research

    Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. We initiated a study of telomeric silencing in Neurospora crassa, a fungus that sports DNA methylation, ...

    Authors: Kristina M Smith, Gregory O Kothe, Cindy B Matsen, Tamir K Khlafallah, Keyur K Adhvaryu, Melissa Hemphill, Michael Freitag, Mohammad R Motamedi and Eric U Selker

    Citation: Epigenetics & Chromatin 2008 1:5

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  22. Content type: Research

    Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution th...

    Authors: Xueying Wang, Zvi Kam, Peter M Carlton, Lifeng Xu, John W Sedat and Elizabeth H Blackburn

    Citation: Epigenetics & Chromatin 2008 1:4

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  23. Content type: Research

    In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequence...

    Authors: Jan Postberg, Katharina Heyse, Marion Cremer, Thomas Cremer and Hans J Lipps

    Citation: Epigenetics & Chromatin 2008 1:3

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  24. Content type: Research

    X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-co...

    Authors: Tatyana B Nesterova, Bilyana C Popova, Bradley S Cobb, Sara Norton, Claire E Senner, Y Amy Tang, Thomas Spruce, Tristan A Rodriguez, Takashi Sado, Matthias Merkenschlager and Neil Brockdorff

    Citation: Epigenetics & Chromatin 2008 1:2

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