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  1. Content type: Research

    Protein exchange kinetics correlate with the level of chromatin condensation and, in many cases, with the level of transcription. We used fluorescence recovery after photobleaching (FRAP) to analyse the kineti...

    Authors: Lenka Stixová, Eva Bártová, Pavel Matula, Ondřej Daněk, Soňa Legartová and Stanislav Kozubek

    Citation: Epigenetics & Chromatin 2011 4:5

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  2. Content type: Methodology

    Polycomb/Trithorax response elements (PREs) are cis-regulatory elements essential for the regulation of several hundred developmentally important genes. However, the precise sequence requirements for PRE function...

    Authors: Helena Okulski, Birgit Druck, Sheetal Bhalerao and Leonie Ringrose

    Citation: Epigenetics & Chromatin 2011 4:4

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  3. Content type: Research

    Unique structural characteristics of centromere chromatin enable it to support assembly of the kinetochore and its associated tensions. The histone H3 variant CENH3 (centromeric histone H3) is viewed as the ke...

    Authors: Jonathan I Gent, Kevin L Schneider, Christopher N Topp, Carmen Rodriguez, Gernot G Presting and R Kelly Dawe

    Citation: Epigenetics & Chromatin 2011 4:3

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  4. Content type: Research

    Methylation of histone H3 lysine 79 (H3K79) by Dot1 is highly conserved among species and has been associated with both gene repression and activation. To eliminate indirect effects and examine the direct cons...

    Authors: Iris JE Stulemeijer, Brietta L Pike, Alex W Faber, Kitty F Verzijlbergen, Tibor van Welsem, Floor Frederiks, Tineke L Lenstra, Frank CP Holstege, Susan M Gasser and Fred van Leeuwen

    Citation: Epigenetics & Chromatin 2011 4:2

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  5. Content type: Research

    Genes subject to genomic imprinting are mono-allelically expressed in a parent-of-origin dependent manner. Each imprinted locus has at least one differentially methylated region (DMR) which has allele specific...

    Authors: Kathryn Woodfine, Joanna E Huddleston and Adele Murrell

    Citation: Epigenetics & Chromatin 2011 4:1

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  6. Content type: Methodology

    Post-translational modifications (PTMs) on the N-terminal tails of histones and histone variants regulate distinct transcriptional states and nuclear events. Whereas the functional effects of specific PTMs are...

    Authors: Barry M Zee, Rebecca S Levin, Peter A DiMaggio and Benjamin A Garcia

    Citation: Epigenetics & Chromatin 2010 3:22

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  7. Content type: Research

    Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2β) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complex...

    Authors: Shuying He, Melinda K Pirity, Wei-Lin Wang, Louise Wolf, Bharesh K Chauhan, Kveta Cveklova, Ernst R Tamm, Ruth Ashery-Padan, Daniel Metzger, Akira Nakai, Pierre Chambon, Jiri Zavadil and Ales Cvekl

    Citation: Epigenetics & Chromatin 2010 3:21

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  8. Content type: Research

    Recent advances in the field of high-throughput genomics have rendered possible the performance of genome-scale studies to define the nucleosomal landscapes of eukaryote genomes. Such analyses are aimed toward...

    Authors: Christoforos Nikolaou, Sonja Althammer, Miguel Beato and Roderic Guigó

    Citation: Epigenetics & Chromatin 2010 3:20

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  9. Content type: Research

    CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription. CTCF may act ...

    Authors: Suzanne van de Nobelen, Manuel Rosa-Garrido, Joerg Leers, Helen Heath, Widia Soochit, Linda Joosen, Iris Jonkers, Jeroen Demmers, Michael van der Reijden, Verónica Torrano, Frank Grosveld, M Dolores Delgado, Rainer Renkawitz, Niels Galjart and Frank Sleutels

    Citation: Epigenetics & Chromatin 2010 3:19

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  10. Content type: Review

    Histone acetylation is one of the key regulatory mechanisms controlling transcriptional activity in eukaryotic cells. In higher eukaryotes, a number of nuclear histone acetyltransferase (HAT) enzymes have been...

    Authors: Krishanpal Anamika, Arnaud R Krebs, Julie Thompson, Olivier Poch, Didier Devys and Làszlò Tora

    Citation: Epigenetics & Chromatin 2010 3:18

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  11. Content type: Research

    Genomic methylation patterns are established during gametogenesis, and perpetuated in somatic cells by faithful maintenance methylation. There have been previous indications that genomic methylation patterns m...

    Authors: Steen KT Ooi, Daniel Wolf, Odelya Hartung, Suneet Agarwal, George Q Daley, Stephen P Goff and Timothy H Bestor

    Citation: Epigenetics & Chromatin 2010 3:17

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  12. Content type: Research

    Signal transducer and activator of transcription (STAT) activation of gene expression is both rapid and transient, and when properly executed it affects growth, differentiation, homeostasis and the immune resp...

    Authors: Lauren J Buro, Edmond Chipumuro and Melissa A Henriksen

    Citation: Epigenetics & Chromatin 2010 3:16

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  13. Content type: Research

    The processes through which the germline maintains its continuity across generations has long been the focus of biological research. Recent studies have suggested that germline continuity can involve epigeneti...

    Authors: Hirofumi Furuhashi, Teruaki Takasaki, Andreas Rechtsteiner, Tengguo Li, Hiroshi Kimura, Paula M Checchi, Susan Strome and William G Kelly

    Citation: Epigenetics & Chromatin 2010 3:15

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  14. Content type: Research

    Incorporation of histone variants into chromatin is one of the epigenetic mechanisms used for regulation of gene expression. Macro (m)H2A is a histone variant that has two different subtypes in vertebrates: mH...

    Authors: I Araya, G Nardocci, JP Morales, MI Vera, A Molina and M Alvarez

    Citation: Epigenetics & Chromatin 2010 3:14

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  15. Content type: Research

    The physiological function of eukaryotic DNA occurs in the context of nucleosomal arrays that can expose or obscure defined segments of the genome. Certain DNA sequences are capable of strongly positioning a n...

    Authors: Lia E Gracey, Zhi-Ying Chen, Jay M Maniar, Anton Valouev, Arend Sidow, Mark A Kay and Andrew Z Fire

    Citation: Epigenetics & Chromatin 2010 3:13

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  16. Content type: Research

    X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked genes in XX females relative to XY males, is triggered by chromosome-wide localisation of a cis-acting non-coding RNA, Xist....

    Authors: Y Amy Tang, Derek Huntley, Giovanni Montana, Andrea Cerase, Tatyana B Nesterova and Neil Brockdorff

    Citation: Epigenetics & Chromatin 2010 3:10

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  17. Content type: Research

    HP1 proteins are conserved components of eukaryotic constitutive heterochromatin. In mammals, there are three genes that encode HP1-like proteins, termed HP1α, HP1β and HP1γ, which have a high degree of homolo...

    Authors: Jeremy P Brown, Jörn Bullwinkel, Bettina Baron-Lühr, Mustafa Billur, Philipp Schneider, Heinz Winking and Prim B Singh

    Citation: Epigenetics & Chromatin 2010 3:9

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    The Erratum to this article has been published in Epigenetics & Chromatin 2012 5:18

  18. Content type: Research

    Vertebrate heterochromatin contains a non-allelic variant of the histone H2A called macroH2A1, which has the characteristic of being three times the size of the canonical H2A. The macroH2A1 C-terminal extensio...

    Authors: Mathieu Boulard, Sébastien Storck, Rong Cong, Rodrigo Pinto, Hélène Delage and Philippe Bouvet

    Citation: Epigenetics & Chromatin 2010 3:8

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  19. Content type: Research

    The linker histone H1 has a key role in establishing and maintaining higher order chromatin structure and in regulating gene expression. Mammals express up to 11 different H1 variants, with H1.2 and H1.4 being...

    Authors: Thomas Weiss, Sonja Hergeth, Ulrike Zeissler, Annalisa Izzo, Philipp Tropberger, Barry M Zee, Miroslav Dundr, Benjamin A Garcia, Sylvain Daujat and Robert Schneider

    Citation: Epigenetics & Chromatin 2010 3:7

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  20. Content type: Research

    Centromeres are responsible for the proper segregation of replicated chromatids during cell division. Neocentromeres are fully functional ectopic human centromeres that form on low-copy DNA sequences and permi...

    Authors: Alicia Alonso, Dan Hasson, Fanny Cheung and Peter E Warburton

    Citation: Epigenetics & Chromatin 2010 3:6

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  21. Content type: Research

    Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S protea...

    Authors: Olivia I Koues, Ninad T Mehta, Agnieszka D Truax, R Kyle Dudley, Jeanne K Brooks and Susanna F Greer

    Citation: Epigenetics & Chromatin 2010 3:5

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  22. Content type: Research

    When the nuclei of mammalian somatic cells are transplanted to amphibian oocytes in the first meiotic prophase, they are rapidly induced to begin transcribing several pluripotency genes, including Sox2 and Oct...

    Authors: Kazutaka Murata, Tony Kouzarides, Andrew J Bannister and John B Gurdon

    Citation: Epigenetics & Chromatin 2010 3:4

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  23. Content type: Research

    During early mouse development, two extra-embryonic lineages form alongside the future embryo: the trophectoderm (TE) and the primitive endoderm (PrE). Epigenetic changes known to take place during these early...

    Authors: Joana Santos, C Filipe Pereira, Aida Di-Gregorio, Thomas Spruce, Olivia Alder, Tristan Rodriguez, Véronique Azuara, Matthias Merkenschlager and Amanda G Fisher

    Citation: Epigenetics & Chromatin 2010 3:1

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  24. Content type: Research

    In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect. There is large variation in the level of t...

    Authors: Esther R Loney, Peter W Inglis, Sarah Sharp, Fiona E Pryde, Nicholas A Kent, Jane Mellor and Edward J Louis

    Citation: Epigenetics & Chromatin 2009 2:18

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  25. Content type: Research

    Acetylation of promoter nucleosomes is tightly correlated and mechanistically linked to gene activity. However, transcription is not necessary for promoter acetylation. It seems, therefore, that external and e...

    Authors: Ina Horst, Sascha Offermann, Bjoern Dreesen, Markus Niessen and Christoph Peterhansel

    Citation: Epigenetics & Chromatin 2009 2:17

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  26. Content type: Research

    The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. In this study, we investigated how higher-order chromatin structure modulates differential expression o...

    Authors: Sima Kheradmand Kia, Parham Solaimani Kartalaei, Elnaz Farahbakhshian, Farzin Pourfarzad, Marieke von Lindern and C Peter Verrijzer

    Citation: Epigenetics & Chromatin 2009 2:16

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  27. Content type: Research

    The archetypal epigenetic phenomenon of position effect variegation (PEV) in Drosophila occurs when a gene is brought abnormally close to heterochromatin, resulting in stochastic silencing of the affected gene in...

    Authors: Kyoko Hiragami-Hamada, Sheila Q Xie, Alexander Saveliev, Santiago Uribe-Lewis, Ana Pombo and Richard Festenstein

    Citation: Epigenetics & Chromatin 2009 2:14

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  28. Content type: Research

    Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells. Transcriptional regulators, such as Oct4, are critic...

    Authors: Leng-Siew Yeap, Katsuhiko Hayashi and M Azim Surani

    Citation: Epigenetics & Chromatin 2009 2:12

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  29. Content type: Research

    Dynamic changes to the chromatin structure play a critical role in transcriptional regulation. This is exemplified by the Spt6-mediated histone deposition on to histone-depleted promoters that results in displ...

    Authors: Ryosuke Ohsawa, Melissa Adkins and Jessica K Tyler

    Citation: Epigenetics & Chromatin 2009 2:11

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  30. Content type: Research

    Argonaute2 protein (Ago2) is a key component of RNA-induced gene silencing complex, which is crucial for microRNA-mediated repression of target genes. The function of Ago2 in the mouse oocyte and early embryon...

    Authors: Masahiro Kaneda, Fuchou Tang, Dónal O'Carroll, Kaiqin Lao and M Azim Surani

    Citation: Epigenetics & Chromatin 2009 2:9

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  31. Content type: Research

    Delimiting distinct chromatin domains is essential for temporal and spatial regulation of gene expression. Within the X-inactivation centre region (Xic), the Xist locus, which triggers X-inactivation, is juxtapos...

    Authors: Pablo Navarro, Sophie Chantalat, Mario Foglio, Corinne Chureau, Sébastien Vigneau, Philippe Clerc, Philip Avner and Claire Rougeulle

    Citation: Epigenetics & Chromatin 2009 2:8

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  32. Content type: Research

    DNA methylation is a major epigenetic modification important for regulating gene expression and suppressing spurious transcription. Most methods to scan the genome in different tissues for differentially methy...

    Authors: Cecilia De Bustos, Edward Ramos, Janet M Young, Robert K Tran, Uwe Menzel, Cordelia F Langford, Evan E Eichler, Li Hsu, Steve Henikoff, Jan P Dumanski and Barbara J Trask

    Citation: Epigenetics & Chromatin 2009 2:7

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  33. Content type: Research

    Histone methylation is thought to be central to the epigenetic mechanisms that maintain and confine cellular identity in multi-cellular organisms. To examine epigenetic roles in cellular homeostasis, we condit...

    Authors: Stefan Glaser, Sandra Lubitz, Kate L Loveland, Kazu Ohbo, Lorraine Robb, Frieder Schwenk, Jost Seibler, Daniela Roellig, Andrea Kranz, Konstantinos Anastassiadis and A Francis Stewart

    Citation: Epigenetics & Chromatin 2009 2:5

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  34. Content type: Research

    Genome-wide mappings of nucleosome occupancy in different species have shown presence of well-positioned nucleosomes. While the DNA sequences may help decide their locations, the observed positions in vivo are en...

    Authors: Vinesh Vinayachandran, Rama-Haritha Pusarla and Purnima Bhargava

    Citation: Epigenetics & Chromatin 2009 2:4

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    The Erratum to this article has been published in Epigenetics & Chromatin 2011 4:8

  35. Content type: Methodology

    DNA methylation plays a vital role in normal cellular function, with aberrant methylation signatures being implicated in a growing number of human pathologies and complex human traits. Methods based on the mod...

    Authors: Sophia J Docherty, Oliver SP Davis, Claire MA Haworth, Robert Plomin and Jonathan Mill

    Citation: Epigenetics & Chromatin 2009 2:3

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  36. Content type: Research

    Spinocerebellar ataxia (SCA) is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. Th...

    Authors: Kenneth K Lee, Selene K Swanson, Laurence Florens, Michael P Washburn and Jerry L Workman

    Citation: Epigenetics & Chromatin 2009 2:2

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  37. Content type: Research

    Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that sho...

    Authors: Maartje J Vogel, Ludo Pagie, Wendy Talhout, Marja Nieuwland, Ron M Kerkhoven and Bas van Steensel

    Citation: Epigenetics & Chromatin 2009 2:1

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  38. Content type: Methodology

    Direct visualization of chromatin has the potential to provide important insights into epigenetic processes. In particular, atomic force microscopy (AFM) can visualize single nucleosomes under physiological io...

    Authors: Hongda Wang, Yamini Dalal, Steven Henikoff and Stuart Lindsay

    Citation: Epigenetics & Chromatin 2008 1:10

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  39. Content type: Review

    The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks,...

    Authors: Christoffel Dinant, Adriaan B Houtsmuller and Wim Vermeulen

    Citation: Epigenetics & Chromatin 2008 1:9

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  40. Content type: Research

    In mammals the parental genomes are epigenetically reprogrammed after fertilization. This reprogramming includes a rapid demethylation of the paternal (sperm-derived) chromosomes prior to DNA replication in zy...

    Authors: Konstantin Lepikhov, Valeri Zakhartchenko, Ru Hao, Feikun Yang, Christine Wrenzycki, Heiner Niemann, Eckhard Wolf and Joern Walter

    Citation: Epigenetics & Chromatin 2008 1:8

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  41. Content type: Methodology

    Methylation-sensitive high resolution melting (MS-HRM) methodology is able to recognise heterogeneously methylated sequences by their characteristic melting profiles. To further analyse heterogeneously methyla...

    Authors: Ida LM Candiloro, Thomas Mikeska, Peter Hokland and Alexander Dobrovic

    Citation: Epigenetics & Chromatin 2008 1:7

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  42. Content type: Research

    Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. Th...

    Authors: Asako J Nakamura, Y Jeffrey Chiang, Karen S Hathcock, Izumi Horikawa, Olga A Sedelnikova, Richard J Hodes and William M Bonner

    Citation: Epigenetics & Chromatin 2008 1:6

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