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  1. Content type: Poster presentation

    Authors: Relja Popovic, Eva Martinez-Garcia, Quanwei Zhang, Teresa Ezponda, Mrinal Y Shah, Yupeng Zhang, Yanwen Jiang, Christine M Will, Eliza C Small, Marinka Bulic, Olivier Elemento, Neil Kelleher, William Kath, Ji-Ping Wang and Jonathan D Licht

    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P66

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    This article is part of a Supplement: Volume 6 Supplement 1

  2. Content type: Poster presentation

    Authors: Juan J Carmona, Benedetta Izzi, Allan C Just, Jitendra Barupal, Alexandra M Binder, John Hutchinson, Oliver Hofmann, Joel Schwartz, Andrea Baccarelli and Karin B Michels

    Citation: Epigenetics & Chromatin 2013 6(Suppl 1):P36

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    This article is part of a Supplement: Volume 6 Supplement 1

  3. Content type: Research

    DNA methylation and demethylation are important epigenetic regulatory mechanisms in eukaryotic cells and, so far, only partially understood. We exploit the minimalistic biological ciliate system to understand ...

    Authors: Aneta Bulic, Jan Postberg, Andreas Fischer, Franziska Jönsson, Günter Reuter and Hans J Lipps

    Citation: Epigenetics & Chromatin 2013 6:5

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  4. Content type: Research

    Measurement of genome-wide DNA methylation (DNAm) has become an important avenue for investigating potential physiologically-relevant epigenetic changes. Illumina Infinium (Illumina, San Diego, CA, USA) is a c...

    Authors: E Magda Price, Allison M Cotton, Lucia L Lam, Pau Farré, Eldon Emberly, Carolyn J Brown, Wendy P Robinson and Michael S Kobor

    Citation: Epigenetics & Chromatin 2013 6:4

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  5. Content type: Research

    Histone methyltransferase enhancer of zeste homologue 2 (EZH2) forms an obligate repressive complex with suppressor of zeste 12 and embryonic ectoderm development, which is thought, along with EZH1, to be prim...

    Authors: Adrienne Grzenda, Gwen Lomberk, Phyllis Svingen, Angela Mathison, Ezequiel Calvo, Juan Iovanna, Yuning Xiong, William Faubion and Raul Urrutia

    Citation: Epigenetics & Chromatin 2013 6:3

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  6. Content type: Editorial

    On 11 to 13 March 2013, BioMed Central will be hosting its inaugural conference, Epigenetics & Chromatin: Interactions and Processes, at Harvard Medical School, Boston, MA, USA. Epigenetics & Chromatin has now la...

    Authors: Steven Henikoff and Frank Grosveld

    Citation: Epigenetics & Chromatin 2013 6:2

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  7. Content type: Research

    Different histone post-translational modifications (PTMs) fine-tune and integrate different cellular signaling pathways at the chromatin level. ADP-ribose modification of histones by cellular ADP-ribosyltransf...

    Authors: Ingrid Kassner, Marc Barandun, Monika Fey, Florian Rosenthal and Michael O Hottiger

    Citation: Epigenetics & Chromatin 2013 6:1

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  8. Content type: Methodology

    A plastic chromatin structure has emerged as fundamental to the self-renewal and pluripotent capacity of embryonic stem (ES) cells. Direct measurement of chromatin dynamics in vivo is, however, challenging as hig...

    Authors: Elizabeth Hinde, Francesco Cardarelli, Aaron Chen, Michelle Khine and Enrico Gratton

    Citation: Epigenetics & Chromatin 2012 5:20

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  9. Content type: Research

    In fission yeast, centromeric heterochromatin is necessary for the fidelity of chromosome segregation. Propagation of heterochromatin in dividing cells requires RNA interference (RNAi) and transcription of cen...

    Authors: Michael Thorsen, Heidi Hansen, Michela Venturi, Steen Holmberg and Genevieve Thon

    Citation: Epigenetics & Chromatin 2012 5:19

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  10. Content type: Research

    Nuclear reprogramming is potentially important as a route to cell replacement and drug discovery, but little is known about its mechanism. Nuclear transfer to eggs and oocytes attempts to identify the mechanis...

    Authors: Jerome Jullien, Carolina Astrand, Emmanuelle Szenker, Nigel Garrett, Genevieve Almouzni and John B Gurdon

    Citation: Epigenetics & Chromatin 2012 5:17

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  11. Content type: Research

    The β-globin gene domains of vertebrate animals constitute popular models for studying the regulation of eukaryotic gene transcription. It has previously been shown that in the mouse the developmental switchin...

    Authors: Sergey V Ulianov, Alexey A Gavrilov and Sergey V Razin

    Citation: Epigenetics & Chromatin 2012 5:16

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  12. Content type: Research

    Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. The proliferative arrest i...

    Authors: Kévin Contrepois, Jean-Yves Thuret, Régis Courbeyrette, François Fenaille and Carl Mann

    Citation: Epigenetics & Chromatin 2012 5:15

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  13. Content type: Research

    In marsupials, growth and development of the young occur postnatally, regulated by milk that changes in composition throughout the long lactation. To initiate lactation in mammals, there is an absolute require...

    Authors: Jessica M Stringer, Shunsuke Suzuki, Andrew J Pask, Geoff Shaw and Marilyn B Renfree

    Citation: Epigenetics & Chromatin 2012 5:14

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  14. Content type: Research

    In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the nucleus. Recent genome-wide st...

    Authors: Tanja Prenzel, Frank Kramer, Upasana Bedi, Sankari Nagarajan, Tim Beissbarth and Steven A Johnsen

    Citation: Epigenetics & Chromatin 2012 5:13

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  15. Content type: Research

    Gene-environment interactions are mediated by epigenetic mechanisms. Polycomb Group proteins constitute part of an epigenetic cellular transcriptional memory system that is subject to dynamic modulation during...

    Authors: Peggy Prickaerts, Hanneke EC Niessen, Emmanuèle Mouchel-Vielh, Vivian EH Dahlmans, Guus GH van den Akker, Claudia Geijselaers, Michiel E Adriaens, Frank Spaapen, Yoshihiro Takihara, Ulf R Rapp, Frédérique Peronnet and Jan Willem Voncken

    Citation: Epigenetics & Chromatin 2012 5:12

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  16. Content type: Review

    Clear cause-and-effect relationships are commonly established between genotype and the inherited risk of acquiring human and plant diseases and aberrant phenotypes. By contrast, few such cause-and-effect relat...

    Authors: Richard B Meagher and Kristofer J Müssar

    Citation: Epigenetics & Chromatin 2012 5:11

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  17. Content type: Methodology

    The challenge in extracting genome-wide chromatin features from limiting clinical samples poses a significant hurdle in identification of regulatory marks that impact the physiological or pathological state. C...

    Authors: Lars Grøntved, Russell Bandle, Sam John, Songjoon Baek, Hye-Jung Chung, Ying Liu, Greti Aguilera, Carl Oberholtzer, Gordon L Hager and David Levens

    Citation: Epigenetics & Chromatin 2012 5:10

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  18. Content type: Research

    Non-small cell lung carcinoma (NSCLC) is a complex malignancy that owing to its heterogeneity and poor prognosis poses many challenges to diagnosis, prognosis and patient treatment. DNA methylation is an impor...

    Authors: Rejane Hughes Carvalho, Vanja Haberle, Jun Hou, Teus van Gent, Supat Thongjuea, Wilfred van IJcken, Christel Kockx, Rutger Brouwer, Erikjan Rijkers, Anieta Sieuwerts, John Foekens, Mirjam van Vroonhoven, Joachim Aerts, Frank Grosveld, Boris Lenhard and Sjaak Philipsen

    Citation: Epigenetics & Chromatin 2012 5:9

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  19. Content type: Research

    CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and epigen...

    Authors: Frank Sleutels, Widia Soochit, Marek Bartkuhn, Helen Heath, Sven Dienstbach, Philipp Bergmaier, Vedran Franke, Manuel Rosa-Garrido, Suzanne van de Nobelen, Lisa Caesar, Michael van der Reijden, Jan Christian Bryne, Wilfred van IJcken, J Anton Grootegoed, M Dolores Delgado, Boris Lenhard…

    Citation: Epigenetics & Chromatin 2012 5:8

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  20. Content type: Review

    Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conven...

    Authors: Paul B Talbert, Kami Ahmad, Geneviève Almouzni, Juan Ausió, Frederic Berger, Prem L Bhalla, William M Bonner, W Zacheus Cande, Brian P Chadwick, Simon W L Chan, George A M Cross, Liwang Cui, Stefan I Dimitrov, Detlef Doenecke, José M Eirin-López, Martin A Gorovsky…

    Citation: Epigenetics & Chromatin 2012 5:7

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  21. Content type: Research

    Chromatin structure at a given site can differ between chromosome copies in a cell, and such imbalances in chromatin structure have been shown to be important in understanding the molecular mechanisms controll...

    Authors: James G D Prendergast, Pin Tong, David C Hay, Susan M Farrington and Colin A M Semple

    Citation: Epigenetics & Chromatin 2012 5:6

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  22. Content type: Research

    The protein anti-silencing function 1 (Asf1) chaperones histones H3/H4 for assembly into nucleosomes every cell cycle as well as during DNA transcription and repair. Asf1 interacts directly with H4 through the...

    Authors: Myrriah S Chavez, Jean K Scorgie, Briana K Dennehey, Seth Noone, Jessica K Tyler and Mair EA Churchill

    Citation: Epigenetics & Chromatin 2012 5:5

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  23. Content type: Review

    The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks. DNA damage interferes with v...

    Authors: Hannes Lans, Jurgen A Marteijn and Wim Vermeulen

    Citation: Epigenetics & Chromatin 2012 5:4

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  24. Content type: Research

    DNA methylation, histone modifications and nucleosome occupancy act in concert for regulation of gene expression patterns in mammalian cells. Recently, G9a, a H3K9 methyltransferase, has been shown to play a r...

    Authors: Shikhar Sharma, Daniel S Gerke, Han F Han, Shinwu Jeong, Michael R Stallcup, Peter A Jones and Gangning Liang

    Citation: Epigenetics & Chromatin 2012 5:3

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  25. Content type: Research

    The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effec...

    Authors: Lauren B Auriemma, Shaili Shah, Lara M Linden and Melissa A Henriksen

    Citation: Epigenetics & Chromatin 2012 5:2

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  26. Content type: Review

    Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share speci...

    Authors: Petros Kolovos, Tobias A Knoch, Frank G Grosveld, Peter R Cook and Argyris Papantonis

    Citation: Epigenetics & Chromatin 2012 5:1

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  27. Content type: Research

    Gene regulation in eukaryotes is a complex process entailing the establishment of transcriptionally silent chromatin domains interspersed with regions of active transcription. Imprinted domains consist of clus...

    Authors: Lisa Korostowski, Anjali Raval, Gillian Breuer and Nora Engel

    Citation: Epigenetics & Chromatin 2011 4:21

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  28. Content type: Research

    A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important op...

    Authors: Natalia Varlakhanova, Rebecca Cotterman, Keith Bradnam, Ian Korf and Paul S Knoepfler

    Citation: Epigenetics & Chromatin 2011 4:20

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  29. Content type: Methodology

    Signaling via protein lysine methylation has been proposed to play a central role in the regulation of many physiologic and pathologic programs. In contrast to other post-translational modifications such as ph...

    Authors: Dan Levy, Chih Long Liu, Ze Yang, Aaron M Newman, Ash A Alizadeh, Paul J Utz and Or Gozani

    Citation: Epigenetics & Chromatin 2011 4:19

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  30. Content type: Research

    Histone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histo...

    Authors: Zhihui Liang, Marc Diamond, Johanna A Smith, Matthias Schnell and René Daniel

    Citation: Epigenetics & Chromatin 2011 4:18

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  31. Content type: Research

    Expression of Xist, the master regulator of X chromosome inactivation, is extinguished in pluripotent cells, a process that has been linked to programmed X chromosome reactivation. The key pluripotency transcript...

    Authors: Tatyana B Nesterova, Claire E Senner, Janina Schneider, Tilly Alcayna-Stevens, Anna Tattermusch, Myriam Hemberger and Neil Brockdorff

    Citation: Epigenetics & Chromatin 2011 4:17

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  32. Content type: Research

    Polycomb group (PcG) genes code for chromatin multiprotein complexes that are responsible for maintaining gene silencing of transcriptional programs during differentiation and in adult tissues. Despite the lar...

    Authors: Lovorka Stojic, Zuzana Jasencakova, Carolina Prezioso, Alexandra Stützer, Beatrice Bodega, Diego Pasini, Rebecca Klingberg, Chiara Mozzetta, Raphael Margueron, Pier Lorenzo Puri, Dirk Schwarzer, Kristian Helin, Wolfgang Fischle and Valerio Orlando

    Citation: Epigenetics & Chromatin 2011 4:16

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  33. Content type: Research

    Histone H1 is an important constituent of chromatin, and is involved in regulation of its structure. During the cell cycle, chromatin becomes locally decondensed in S phase, highly condensed during metaphase, ...

    Authors: Anna Gréen, Bettina Sarg, Henrik Gréen, Anita Lönn, Herbert H Lindner and Ingemar Rundquist

    Citation: Epigenetics & Chromatin 2011 4:15

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  34. Content type: Research

    Random monoallelic expression contributes to phenotypic variation of cells and organisms. However, the epigenetic mechanisms by which individual alleles are randomly selected for expression are not known. Taki...

    Authors: Brandon J Thomas, Eric D Rubio, Niklas Krumm, Pilib Ó Broin, Karol Bomsztyk, Piri Welcsh, John M Greally, Aaron A Golden and Anton Krumm

    Citation: Epigenetics & Chromatin 2011 4:14

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  35. Content type: Research

    Transcription initiation RNAs (tiRNAs) are nuclear localized 18 nucleotide RNAs derived from sequences immediately downstream of RNA polymerase II (RNAPII) transcription start sites. Previous reports have show...

    Authors: Ryan J Taft, Peter G Hawkins, John S Mattick and Kevin V Morris

    Citation: Epigenetics & Chromatin 2011 4:13

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  36. Content type: Research

    Endogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-depo...

    Authors: Irina A Maksakova, Preeti Goyal, Jörn Bullwinkel, Jeremy P Brown, Misha Bilenky, Dixie L Mager, Prim B Singh and Matthew C Lorincz

    Citation: Epigenetics & Chromatin 2011 4:12

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  37. Content type: Research

    Covalent histone modifications are central to all DNA-dependent processes. Modifications of histones H3 and H4 are becoming well characterised, but knowledge of how H2A modifications regulate chromatin dynamic...

    Authors: Tanja Waldmann, Annalisa Izzo, Kinga Kamieniarz, Florian Richter, Christine Vogler, Bettina Sarg, Herbert Lindner, Nicolas L Young, Gerhard Mittler, Benjamin A Garcia and Robert Schneider

    Citation: Epigenetics & Chromatin 2011 4:11

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  38. Content type: Methodology

    Genomic imprinting is an important epigenetic process involved in regulating placental and foetal growth. Imprinted genes are typically associated with differentially methylated regions (DMRs) whereby one of t...

    Authors: Ryan KC Yuen, Ruby Jiang, Maria S Peñaherrera, Deborah E McFadden and Wendy P Robinson

    Citation: Epigenetics & Chromatin 2011 4:10

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  39. Content type: Research

    In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, impl...

    Authors: Marco De Gobbi, David Garrick, Magnus Lynch, Douglas Vernimmen, Jim R Hughes, Nicolas Goardon, Sidinh Luc, Karen M Lower, Jacqueline A Sloane-Stanley, Cristina Pina, Shamit Soneji, Raffaele Renella, Tariq Enver, Stephen Taylor, Sten Eirik W Jacobsen, Paresh Vyas…

    Citation: Epigenetics & Chromatin 2011 4:9

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  40. Content type: Research

    Development of human tissue is influenced by a combination of intrinsic biological signals and extrinsic environmental stimuli, both of which are mediated by epigenetic regulation, including DNA methylation. H...

    Authors: Ryan KC Yuen, Sarah MA Neumann, Alexandra K Fok, Maria S Peñaherrera, Deborah E McFadden, Wendy P Robinson and Michael S Kobor

    Citation: Epigenetics & Chromatin 2011 4:7

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  41. Content type: Research

    The male-specific lethal (MSL) complex of Drosophila remodels the chromatin of the X chromosome in males to enhance the level of transcription of most X-linked genes, and thereby achieve dosage compensation. The ...

    Authors: Rosa Morra, Ruth Yokoyama, Huiping Ling and John C Lucchesi

    Citation: Epigenetics & Chromatin 2011 4:6

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