Fig. 2

Differentiation-state-specific patterns of genome-wide DNA methylation are detected between lens epithelial and fiber cells. A Proportion of methylcytosines (mCs) that are mCG, mCHG, or mCHH found in lens epithelial and fiber cells. B mCG methylation levels at indicated genomic regions in lens epithelial and fiber cells. C Distribution of mCG differentially methylated regions (DMRs) at indicated genomic regions. D Percentage distribution of mCG DMRs at indicated genomic regions relative to random distribution across the genome. Positive values indicate that mCG DMRs cluster in the indicated genomic region are in excess of what is expected due to a random distribution while negative values indicate that mCG DMRs cluster in the indicated genomic region are less than what is expected due to a random distribution. E Number of hypo- and hyper-methylated regions at indicated genomic regions. Hypomethylated regions are demethylated in lens fiber cells compared to lens epithelial cells while hypermethylated regions are more methylated in lens fiber cells compared to lens epithelial cells