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Table 4 Genes that were differentially expressed between ventricles from juvenile snapping turtles that had normal-sized or enlarged hearts relative to their body size

From: Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle

Locus # Gene name Gene symbol Log2 (enlarged/normal)
CS000003025 DnaJ heat shock protein family (Hsp40) member A2 DNAJA2 − 4.00011659
CS000005942 Mucin 2, oligomeric mucus/gel-forming MUC2 − 4
CS000020789    − 4
CS000020715    − 3.970542981
CS000000246    − 3.412275459
CS000000714 Interleukin 22 IL22 − 2.460702344
CS000008734 Mast cell proteinase-3   − 2.313632939
CS000006768 Capping protein, Arp2/3 and myosin-I linker protein 3-like − 2.266058389
CS000018994 Capping protein regulator and myosin 1 linker 3 CARMIL3 − 2.256232917
CS000008168 Glucagon GCG − 1.725877497
CS000002882 Short chain dehydrogenase (predicted)   − 1.68846675
CS000020555 Granzyme H GZMH − 1.641521247
CS000011467 T brachyury transcription factor TBXT − 1.62277543
CS000009580 Advillin AVIL − 1.59555768
CS000017383 G protein-coupled receptor 62 GPR62 − 1.591541521
CS000018663 Deleted in malignant brain tumors 1 protein-like   − 1.525993727
CS000008605 Contactin associated protein 1 CNTNAP1 − 1.459617958
CS000010544 C-type lectin-domain family 2 member D CLEC2D − 1.349128576
CS000014353 Aldo–keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) − 1.341939485
CS000008622 Sclerostin sost − 1.338528092
CS000013408 Solute carrier family 8 member A2 SLC8A2 − 1.333783678
CS000012528 Persephin PSPN − 1.322706586
CS000009180 CD69 molecule CD69 − 1.320171193
CS000019803    − 1.292382379
CS000000790 NFKB inhibitor like 1 NFKBIL1 − 1.268443921
CS000020022 Carcinoembryonic antigen related cell adhesion molecule 1 CEACAM1 − 1.249402634
CS000009788 Bone morphogenetic protein 10 BMP10 − 1.185425524
CS000012770 Nudix hydrolase 15 NUDT15 − 1.174821415
CS000002010 Nuclear receptor subfamily 1 group D member 2-like NR1D2 − 1.135755617
CS000012951 Zinc finger CW-type and PWWP domain containing 1 ZCWPW1 − 1.131146467
CS000015104 Rho GTPase activating protein 27 ARHGAP27 − 1.12138132
CS000009000 Cytochrome P450 family 8 subfamily B member 1 CYP8B1 − 1.119197734
CS000023981 Zinc finger protein 501-like   − 1.109988843
CS000019117    − 1.093528795
CS000004600    − 1.076659475
CS000020803    − 1.076581749
CS000024876 MHC class II DLA DRB1 beta chain   − 0.99585363
CS000003266 Synaptotagmin-15 SYT15 − 0.992965859
CS000013911    − 0.970276375
CS000022474 Dedicator of cytokinesis 2 DOCK2 − 0.970046644
CS000011784 C-type lectin-domain family 2, member e   − 0.947959012
CS000009177 Zinc finger protein 2 ZNF2 − 0.9470744
CS000017654 Junctophilin 4 JPH4 − 0.9449115
CS000017263 USH1 protein network component harmonin USH1C − 0.941279454
CS000012524 Synovial sarcoma, X breakpoint 2 interacting protein S homeolog ssx2ip.S − 0.939268547
CS000000565 Ras and Rab interactor-like protein RINL − 0.892810687
CS000023033 Calcitonin receptor CALCR − 0.88702029
CS000016033 Ring finger protein 25 rnf25 − 0.882108694
CS000021269 Neural EGFL like 1 NELL1 − 0.868462024
CS000012971 Neuron derived neurotrophic factor NDNF − 0.866800964
CS000020495 Kinase non-catalytic C-lobe domain containing 1 KNDC1 − 0.852740249
CS000002530 Collagen type XX alpha 1 chain COL20A1 − 0.843443212
CS000012304    − 0.799063985
CS000001767 Septin 5 SEPTIN5 − 0.795109503
CS000013081 PR/SET domain 8 PRDM8 − 0.778512974
CS000024963 Zinc finger protein 862 ZNF862 − 0.776513766
CS000002362 Acid sensing ion channel subunit 1 asic1 − 0.77548223
CS000006802 Sortilin related VPS10 domain containing receptor 1 SORCS1 − 0.774579369
CS000003991 Nuclear receptor subfamily 0 group B member 2-like NR0B2 − 0.752752113
CS000008630    − 0.742661864
CS000011782 C-type lectin-domain family 2 member D CLEC2D − 0.738112094
CS000020166 Tweety family member 1 TTYH1 − 0.727823227
CS000017666 Spectrin beta, non-erythrocytic 4 SPTBN4 − 0.727759339
CS000019541 Chromosome 21 orf 58 C21orf58 − 0.693870417
CS000014966 Ficolin 3 FCN3 − 0.683027443
CS000007237 Collectin subfamily member 10 COLEC10 − 0.67828483
CS000023359 Ral guanine nucleotide dissociation stimulator like 3 RGL3 − 0.676871711
CS000001261    − 0.673565294
CS000015636 Ecto-NOX disulfide-thiol exchanger 1 enox1 − 0.667186029
CS000018597 Neurexin 2 NRXN2 − 0.658378249
CS000004183 Kelch-like 42   − 0.645354432
CS000005642 Topoisomerase (DNA) III alpha TOP3A − 0.637881286
CS000012953 Immunoglobulin superfamily containing leucine-rich repeat ISLR − 0.636348281
CS000001835 Actin-binding Rho activating protein ABRA − 0.622678244
CS000006362 Nicotinamide riboside kinase 2 NMRK2 − 0.57894428
CS000000038 KH and NYN domain containing KHNYN − 0.560880734
CS000004606 Aryl hydrocarbon receptor nuclear translocator like ARNTL − 0.550619038
CS000008808 Alcohol dehydrogenase, iron containing 1 ADHFE1 − 0.546993977
CS000012473 Progestin and adipoQ receptor family member 6 PAQR6 − 0.540783679
CS000020112 Ral guanine nucleotide dissociation stimulator-like 2 RGL2 − 0.528180794
CS000024555 Stimulator of chondrogenesis 1 SCRG1 − 0.525168151
CS000003254 Tubulin tyrosine ligase like 3 TTLL3 − 0.517188122
CS000010967    − 0.516398171
CS000002912 Tripartite motif containing 21 TRIM21 − 0.514703
CS000016053 Sosondowah ankyrin repeat-domain family member C SOWAHC − 0.50414698
CS000007586 Proline and arginine rich end leucine rich repeat protein PRELP − 0.495350825
CS000019628 Predicted gene 4070   − 0.478962063
CS000000139 Galactosidase beta 1 like glb1l − 0.476795916
CS000009979 Cysteine rich transmembrane BMP regulator 1 CRIM1 − 0.465661576
CS000025399 Collagen type IV alpha 6 chain COL4A6 − 0.464490703
CS000014745 Cadherin EGF LAG seven-pass G-type receptor 3 celsr3 − 0.458822636
CS000002394 Neurotrimin NTM − 0.456792451
CS000024488 Endogenous retrovirus group MER34 member 1 ERVMER34-1 − 0.456570624
CS000002168 fibroblast growth factor receptor 3 FGFR3 − 0.45517114
CS000009429 Endogenous retrovirus group PABLB member 1 Env polyprotein ERVPABLB-1 − 0.454624962
CS000000163 DNA polymerase kappa POLK − 0.449829124
CS000000791 TNF receptor-associated factor 2-like   − 0.446715719
CS000013923    − 0.438881138
CS000010076 Tripartite motif containing 27 TRIM27 − 0.437359644
CS000012780 Potassium channel regulator KCNRG − 0.435061589
CS000020545 Nicotinamide N-methyltransferase-like   − 0.425412793
CS000018595 Signal-induced proliferation-associated 1 SIPA1 − 0.420335966
CS000017396 RNA-binding motif protein 5 RBM5 − 0.420294548
CS000015645 Regulator of cell cycle RGCC − 0.410119835
CS000008765 TBC1 domain containing kinase TBCK − 0.409881882
CS000010919 Solute carrier family 25 member 10 SLC25A10 − 0.402643235
CS000002886 Collagen type XV alpha 1 chain COL15A1 − 0.399950238
CS000013998 Patatin like phospholipase domain containing 7 PNPLA7 − 0.393493799
CS000009498 Glypican 3 GPC3 − 0.383165019
CS000025210 Wnt family member 11 WNT11 − 0.382187878
CS000013883 BCL tumor suppressor 7B BCL7B − 0.378585114
CS000023516 Hypoxia inducible factor 1 alpha subunit HIF1A − 0.377701984
CS000014058 Collagen, type XVIII, alpha 1 COL18A1 − 0.360702793
CS000017272 RNA-binding motif protein 10 RBM10 − 0.359302205
CS000001770 Neuroepithelial cell transforming 1 NET1 − 0.352443733
CS000004853 Collagen type III alpha 1 chain COL3A1 − 0.328008574
CS000024953    − 0.321005944
CS000005987 Tyrosine kinase 2 TYK2 − 0.298269494
CS000012361 FUS RNA-binding protein FUS − 0.29508553
CS000007770 Nucleolar protein 8 NOL8 − 0.294633032
CS000024095 Syntrophin beta 1 SNTB1 − 0.294318957
CS000003363 Programmed cell death 11 PDCD11 − 0.264560467
CS000018465 Family with sequence similarity 234 member A FAM234A − 0.255178537
CS000007341 Catenin delta 1 CTNND1 − 0.251866178
CS000012875 LOC400927-CSNK1E readthrough TPTEP2-CSNK1E − 0.230967711
CS000003886 PDZ domain containing ring finger 3 PDZRN3 0.22442223
CS000020331 Cyclin-dependent kinase 17 CDK17 0.241724877
CS000008574 2′,3′-Cyclic nucleotide 3′ phosphodiesterase CNP 0.266261699
CS000015509 Sodium voltage-gated channel alpha subunit 5 SCN5A 0.310625656
CS000009739 Tropomyosin 3 TPM3 0.312184844
CS000025418 Peptidylprolyl isomerase A PPIA 0.314495662
CS000023518 MNAT1, CDK activating kinase assembly factor MNAT1 0.323120508
CS000013900 N-Acetylglucosamine-1-phosphate transferase alpha and beta subunits GNPTAB 0.324699426
CS000008711 Synaptosome associated protein 29 SNAP29 0.325626966
CS000004194 Mitochondrial ribosomal protein S18C MRPS18C 0.327277429
CS000008823 Nuclear receptor coactivator 2 NCOA2 0.327760834
CS000002566 VAMP associated protein B and C VAPB 0.327878453
CS000023702 Prefoldin subunit 1 PFDN1 0.332371862
CS000008476 Growth factor receptor bound protein 10 GRB10 0.338931617
CS000004780 Amyloid beta precursor protein-binding family A member 1 APBA1 0.340118016
CS000006903 Family with sequence similarity 183, member A FAM183A 0.340987831
CS000001976 HAUS augmin like complex subunit 8 HAUS8 0.3445911
CS000012782 SPRY domain containing 7 SPRYD7 0.353656911
CS000011256 Sushi domain containing 3 SUSD3 0.362482561
CS000013749 Pitrilysin metallopeptidase 1 PITRM1 0.38762199
CS000007925 Family with sequence similarity 118 member B FAM118B 0.392163014
CS000020039 Mitochondrial intermediate peptidase MIPEP 0.394441129
CS000014649 Hematological and neurological expressed 1 HN1 0.40118652
CS000003093 Cadherin 13 CDH13 0.40428373
CS000008885 Neural precursor cell expressed, developmentally down-regulated 9 NEDD9 0.406086208
CS000009999 HAUS augmin like complex subunit 1 HAUS1 0.407190489
CS000012325 Receptor interacting serine/threonine kinase 2 RIPK2 0.407834454
CS000003646 Ubiquitin conjugating enzyme E2 B UBE2B 0.409403598
CS000015494 Limb development membrane protein 1 LMBR1 0.413015468
CS000014842 LARGE xylosyl- and glucuronyltransferase 1 LARGE1 0.418322361
CS000009751 Myosin light chain 7 MYL7 0.419170988
CS000003679 Mitogen-activated protein kinase 9 MAPK9 0.422947717
CS000000944 Troponin T2, cardiac type TNNT2 0.431038749
CS000002295 Family with sequence similarity 83 member H fam83h 0.431750631
CS000007019 Aquaporin 9 AQP9 0.436004498
CS000016136 Early endosome antigen 1 EEA1 0.443580231
CS000023302 Cdc42 guanine nucleotide exchange factor 9 ARHGEF9 0.459948169
CS000021606 Ependymin related 1 EPDR1 0.477676177
CS000011866 Ras homolog family member C RHOC 0.481673372
CS000019402 Heat shock protein family B (small) member 3 HSPB3 0.490224239
CS000013608 Transmembrane protein 51 TMEM51 0.490548583
CS000023885 Formin homology 2 domain containing 3 FHOD3 0.495382703
CS000018274 Cysteine and glycine rich protein 1 CSRP1 0.498739165
CS000003393 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 AGAP1 0.499342757
CS000002632 Cysteine and glycine rich protein 3 CSRP3 0.506402578
CS000023152 Mindbomb E3 ubiquitin protein ligase 1 MIB1 0.506464289
CS000005359 Synaptotagmin 11 SYT11 0.507330807
CS000000947 Pleckstrin homology-like domain family A member 3 PHLDA3 0.523937739
CS000000229 Potassium voltage-gated channel subfamily J member 11 KCNJ11 0.524801955
CS000020271 Myosin, light chain 12A, regulatory, non-sarcomeric MYL12A 0.529612298
CS000011198 Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 APPL1 0.535485261
CS000000757 Testis development related protein TDRP 0.552047882
CS000005687 G protein subunit alpha 12 GNA12 0.556060953
CS000000925 Nicotinamide riboside kinase 2-like   0.559479152
CS000020993 TYRO3 protein tyrosine kinase TYRO3 0.560184602
CS000009817 Rho related BTB domain containing 2 RHOBTB2 0.561224935
CS000011090 Secreted phosphoprotein 1 SPP1 0.562276569
CS000006432 Glutathione peroxidase 4 GPX4 0.570135795
CS000000499 Myopalladin MYPN 0.570884545
CS000007378 Heat shock protein family B (small) member 1 HSPB1 0.57397187
CS000012962 Protease, serine 12 PRSS12 0.583446299
CS000005505 SIVA1 apoptosis inducing factor SIVA1 0.584199204
CS000023280 Sorbin and SH3 domain containing 2 SORBS2 0.592192854
CS000008152 LY75-CD302 readthrough LY75-CD302 0.601643015
CS000006114 Chordin like 1 CHRDL1 0.606688517
CS000005009 Ring finger protein 207 RNF207 0.606887706
CS000004917 Bone morphogenetic protein receptor type 2 BMPR2 0.608134843
CS000008531 Digestive cysteine proteinase 2-like   0.608312906
CS000000963 Cardiac-enriched FHL2-interacting protein CUNH10orf71 0.619320903
CS000020738 Protein phosphatase, Mg2+/Mn2+-dependent 1H PPM1H 0.625433587
CS000001051 Monooxygenase DBH like 1 MOXD1 0.627515741
CS000019311 Protein kinase C alpha PRKCA 0.628980813
CS000010890 Family with sequence similarity 169 member A FAM169A 0.647101757
CS000023075 CD109 molecule CD109 0.649459241
CS000005076    0.653243213
CS000014425 B-Raf proto-oncogene, serine/threonine kinase BRAF 0.65486808
CS000004507 Cathepsin L ctsl 0.655047104
CS000012086 Actin, aortic smooth muscle-like ACTA2 0.670113468
CS000013316 KIAA0368 KIAA0368 0.692998191
CS000018070 Male germ cell associated kinase MAK 0.700509414
CS000012890 Sestrin 3 SESN3 0.706989256
CS000003989 Pleckstrin homology domain interacting protein PHIP 0.710494062
CS000017173 Solute carrier family 2 member 11 SLC2A11 0.732703259
CS000020613 Ribosomal protein S18-like   0.73789984
CS000009633 Activated leukocyte cell adhesion molecule ALCAM 0.742827537
CS000011644 DNA polymerase zeta catalytic subunit REV3L 0.770984303
CS000004444 RAB33A, member RAS oncogene family RAB33A 0.780890859
CS000014388 BICD cargo adaptor 1 BICD1 0.789743481
CS000019543    0.821651965
CS000009594 UDP glycosyltransferase 8-like UGT8L 0.823852981
CS000008337 Protein phosphatase, Mg2+/Mn2+-dependent 1L PPM1L 0.848557469
CS000009656 Collagen type VIII alpha 1 chain COL8A1 0.897700653
CS000006655 G protein-coupled receptor kinase 3 GRK3 0.898389538
CS000012858 Suppressor of cytokine signaling 2 SOCS2 0.945191217
CS000010981 ATP-binding cassette subfamily A member 5 ABCA5 0.957982052
CS000001795 Transmembrane protein 71 TMEM71 0.991430672
CS000023496 AHNAK nucleoprotein 2 AHNAK2 0.996386481
CS000003395 Ankyrin repeat and SOCS box containing 18 ASB18 1.000007423
CS000019856 TNF receptor associated factor 2 TRAF2 1.000486113
CS000004132 Low density lipoprotein receptor class A domain containing 4 LDLRAD4 1.016079793
CS000018434    1.023357895
CS000021605 Secreted frizzled related protein 4 SFRP4 1.024078897
CS000004537 Charged multivesicular body protein 4C CHMP4C 1.033646338
CS000009567 Keratin 18 KRT18 1.107725712
CS000018802 LanC like 3 LANCL3 1.116482677
CS000005377 Galectin 1 LGALS1 1.139460825
CS000014226 MOB kinase activator 1B MOB1B 1.171832671
CS000018642 Hyaluronan-binding protein 2 HABP2 1.185512417
CS000006855 Transforming acidic coiled-coil-containing protein 2 TACC2 1.237644425
CS000005131 Glutaredoxin GLRX 1.274526454
CS000022717 Fibrinogen C domain containing 1 FIBCD1 1.354378958
CS000024186 Leucine rich repeat containing 3B LRRC3B 1.366458011
CS000011960 Crystallin alpha B CRYAB 1.397658976
CS000013643 Heat shock protein 30C L homeolog   1.419468073
CS000018346 Abnormal spindle microtubule assembly ASPM 1.420184199
CS000014980 Complement factor B CFB 1.459428513
CS000011910 Heat shock protein 30C L homeolog   1.508403744
CS000008585 Heat shock protein, alpha-crystallin-related, b11   1.521530969
CS000005252 Myomesin 3 MYOM3 1.56777953
CS000012224 TNF receptor associated factor 3 TRAF3 1.605321051
CS000021043 Complement C1s C1S 1.630815717
CS000013370 Ectonucleoside triphosphate diphosphohydrolase 3 entpd3 1.743604465
CS000004501    1.793715013
CS000007782 Musculoskeletal, embryonic nuclear protein 1 mustn1 1.852375511
CS000022000 Mast cell proteinase-1 CPT1B 1.895535655
CS000016407 Fc fragment of IgG-binding protein FCGBP 1.955167136
CS000012089 CD59 Molecule (CD59 Blood Group)-like CD59 2.005971296
CS000001877 Glycoprotein nmb GPNMB 2.090003205
CS000025123 Mast cell proteinase-3   2.432617325
CS000000238 Tryptophan hydroxylase 1 TPH1 2.525652753
CS000006963 Secretogranin II SCG2 3.207453439
  1. The difference in expression in the last column is calculated as the log2 of the ratio of gene expression in enlarged hearts divided by gene expression in normal-sized hearts. Negative values indicate the gene was downregulated in enlarged hearts, while positive values indicate the gene was upregulated in enlarged hearts. The transcriptome was analyzed via RNA-Seq. Differences in gene expression were considered significant when results from DESeq2 and ANOVA were concordant