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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Developmental programming of DNA methylation and gene expression patterns is associated with extreme cardiovascular tolerance to anoxia in the common snapping turtle

Fig. 6

CpG methylation levels around TSSs as a function of gene expression level in ventricles of juvenile snapping turtles. A Genes were divided into expression quintiles with the lowest expressed genes in the first quintile and the highest expressed genes in the fifth quintile. Methylation level for each quintile was plotted as a function of the distance from the TSS. Lines were produced via LOESS curve fitting. B Scatter plot showing methylation level for each CpG as a function distance from the TSS for genes in the fifth quintile. The blue line is the same LOESS smoothed curve as shown in the previous panel. C CpG methylation level around TSSs for genes that were differentially expressed in ventricles of 9-month-old snapping turtles that had been incubated in normoxic (N21) or hypoxic (H10) conditions as embryos. Methylation levels are shown for genes that were up-regulated (red line) or down-regulated (green line) in hypoxic turtles compared to normoxic turtles

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Epigenetics & Chromatin

ISSN: 1756-8935