GBAF, a small BAF sub-complex with big implications: a systematic review

Table 1 GBAF subunits and their species-specific homologs in mammalian development and disease

Gene	Saccharomyces cerevisiae	Drosophila melanogaster	Mammalian homolog	Developmental roles	Disease implications
ACTL6A	Arp4, 7, 9	BAF55	BAF53a	Hematopoietic development [72]; neuronal develoment [75]; mouse ESC survival [195]; regulation of ESC differentiation into primitive endoderm [196]	Cancer [159,160,161, 163,164,165]
BICRA^a			GLTSCR1	Mouse ESC survival [27]	Cancer [27, 96,97,98,99,100, 103, 105,106,107]
BICRAL^a			GLTSCR1		Cancer [27]
BRD9^a			BRD9	Naïve ESC pluripotency [55]	Cancer [122, 123, 126,127,128, 130]
SMARCA4	Swi2/Snf2	BRM	BRG1	Zygotic genome activation [59, 60]; loss is perimplantation lethal [60, 61]; ESC differentiation [64]; hematopoietic development [69,70,71]; neuronal development [75]; neural tube closure [197]	Coffin–Siris syndrome [78, 82, 83]; cancer [60, 138, 140,141,142,143,144,145]
SMARCC1	Swi3/Snf12	BAP155/MOR	BAF155	Nanog silencing [55]; ESC differentiation [64]; loss is perimplation lethal [64]; neural tube closure [197]	Autism spectrum disorder [79]; Cancer [148,149,150,151,152, 156,157,158]
SMARCD1	Swp73/Snf12	BAP60	BAF60a		Neurodevelopmental disabilities [84]; Cancer [170, 172, 174, 175, 177]
SS18^a			SS18	Knockdown and replacemet with CREST promotes neural developmental progression [76]	Cancer [107, 182, 185,186,187,188, 190, 191]

Not all subunits may have a defined homolog across species. References listed are from the prevailing literature and do not represent an exhaustive list for each category
^a Indicates a unique mammalian gene with no known homologs found in yeast or fly

ISSN: 1756-8935