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Table 1 GBAF subunits and their species-specific homologs in mammalian development and disease

From: GBAF, a small BAF sub-complex with big implications: a systematic review

Gene Saccharomyces cerevisiae Drosophila melanogaster Mammalian homolog Developmental roles Disease implications
ACTL6A Arp4, 7, 9 BAF55 BAF53a Hematopoietic development [72]; neuronal develoment [75]; mouse ESC survival [195]; regulation of ESC differentiation into primitive endoderm [196] Cancer [159,160,161, 163,164,165]
BICRAa    GLTSCR1 Mouse ESC survival [27] Cancer [27, 96,97,98,99,100, 103, 105,106,107]
BICRALa    GLTSCR1   Cancer [27]
BRD9a    BRD9 Naïve ESC pluripotency [55] Cancer [122, 123, 126,127,128, 130]
SMARCA4 Swi2/Snf2 BRM BRG1 Zygotic genome activation [59, 60]; loss is perimplantation lethal [60, 61]; ESC differentiation [64]; hematopoietic development [69,70,71]; neuronal development [75]; neural tube closure [197] Coffin–Siris syndrome [78, 82, 83]; cancer [60, 138, 140,141,142,143,144,145]
SMARCC1 Swi3/Snf12 BAP155/MOR BAF155 Nanog silencing [55]; ESC differentiation [64]; loss is perimplation lethal [64]; neural tube closure [197] Autism spectrum disorder [79]; Cancer [148,149,150,151,152, 156,157,158]
SMARCD1 Swp73/Snf12 BAP60 BAF60a   Neurodevelopmental disabilities [84]; Cancer [170, 172, 174, 175, 177]
SS18a    SS18 Knockdown and replacemet with CREST promotes neural developmental progression [76] Cancer [107, 182, 185,186,187,188, 190, 191]
  1. Not all subunits may have a defined homolog across species. References listed are from the prevailing literature and do not represent an exhaustive list for each category
  2. a Indicates a unique mammalian gene with no known homologs found in yeast or fly