KDM1A microenvironment, its oncogenic potential, and therapeutic significance

Table 1 Roles of KDM1A in oncogenesis

Type of cancer	KDM1A interactions	Functional role of KDM1A	References
Prostate cancer	Androgen receptor	↓E-cadherin, ↑VEGF-A	[104, 105, 107]
Breast cancer	Estrogen receptor (ERα), CAC2, β-catenin	↓p57Kip2, ↓LEFTY1, ↓BRCA1	[119, 120, 122,123,124]
Oral cancer	E2F1 signaling pathway	↑Cell proliferation	[130]
Colorectal cancer	Wnt/β-catenin pathway	↓DKK1, ↑LGR5	[134, 135]
Neuroblastoma	miR-137	↑Poorly differentiated cells	[111, 112]
Glioblastoma	GSK3β	↓BMP2, ↓CDKN1A, ↓GATA6	[107, 114]
Acute myeloid leukemia	MLL-AF9	↑Activation of oncogenes	[145]
T-cell acute lymphoid leukemia	Notch signaling pathway, TAL1/SCL	↑Activation and ↓repression of Notch target genes	[61, 62, 150]

KDM1A interact with different signaling pathways and interacting partners. This interaction enables KDM1A to play role in development of different types of cancers. ↓ indicates the down regulation while ↑ denotes the upregulated expression of different genes and factors

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