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Table 1 Roles of KDM1A in oncogenesis

From: KDM1A microenvironment, its oncogenic potential, and therapeutic significance

Type of cancer KDM1A interactions Functional role of KDM1A References
Prostate cancer Androgen receptor ↓E-cadherin, ↑VEGF-A [104, 105, 107]
Breast cancer Estrogen receptor (ERα), CAC2, β-catenin ↓p57Kip2, ↓LEFTY1, ↓BRCA1 [119, 120, 122,123,124]
Oral cancer E2F1 signaling pathway ↑Cell proliferation [130]
Colorectal cancer Wnt/β-catenin pathway ↓DKK1, ↑LGR5 [134, 135]
Neuroblastoma miR-137 ↑Poorly differentiated cells [111, 112]
Glioblastoma GSK3β ↓BMP2, ↓CDKN1A, ↓GATA6 [107, 114]
Acute myeloid leukemia MLL-AF9 ↑Activation of oncogenes [145]
T-cell acute lymphoid leukemia Notch signaling pathway, TAL1/SCL ↑Activation and ↓repression of Notch target genes [61, 62, 150]
  1. KDM1A interact with different signaling pathways and interacting partners. This interaction enables KDM1A to play role in development of different types of cancers. ↓ indicates the down regulation while ↑ denotes the upregulated expression of different genes and factors