Fig. 4

Establishment of ERY and iMK AREs throughout hematopoiesis. a Heatmap comparing H3K27ac immunoprecipitation peaks in ERY and iMK samples. Calculations were performed using the R package DiffBind (v2.2.6). b Active regions are defined as the intersection of ATAC and H3K27ac peaks in ERY and iMK. c Establishment of open chromatin was defined as intersecting AREs from ERR or iMK with ATAC-Seq peaks in sequentially more primitive cell populations. d Significance of overlap was calculated by randomizing peak positions and calculating random versus expected overlap (500 iterations). Z-score of overlap between AREs and ATAC peaks. Hashed bars indicate p value > 0.05