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Reprogramming the chromain landscape at eukaryotic regulatory elements

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Eukaryotic transcription factors (TFs) regulate gene expression by interacting with chromatinized DNA response elements (REs). Access to these elements is dramatically restricted by chromatin organization, and modification of the nucleoprotein structure to allow factor binding is emerging as a key feature of cell selective gene regulation [14]. These processes are highly dynamic, often with oscillatory or cyclical components operating on multiple time scales. Furthermore, many regulatory elements are located at great distance from target genes; long range interactions must play a significant, possibly dominant, role in gene regulation [5, 6]. We will discuss an integrated dynamic model for regulatory element function on multiple scales.

References

  1. 1.

    Biddie : . Moecular Cell. 2011, 43: 145-155.

  2. 2.

    Siersbaek : . EMBO J. 2011, 30: 1459-1472. 10.1038/emboj.2011.65.

  3. 3.

    Voss : . Cell. 2011, 146: 544-554. 10.1016/j.cell.2011.07.006.

  4. 4.

    Grontved : . Epigenetics Chromatin. 2012, 5: 1-12. 10.1186/1756-8935-5-1.

  5. 5.

    Hakim : . Genome Res. 2011, 21: 697-706. 10.1101/gr.111153.110.

  6. 6.

    Hakim : . Genome Res. 2011, 23 (Jan 22).

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Correspondence to Gordon L Hager.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Gene Regulation
  • Long Range
  • Regulatory Element
  • Factor Binding
  • Response Element