Extensive epigenetic reprogramming in human somatic tissues between fetus and adult

Table 2 Summary of differentially methylated loci between normal fetal and adult tissues

Tissue	Number of hyper^aloci	Number of hypo^bloci	Total number of aDMRs^c	Total number of associated genes	GO^dterms	P	FDR^e, %
Brain	17	21	38	36	-	-	-
Kidney	10	27	37	33	Positive regulation of steroid metabolic process	0.00057	0.87
					Transport	0.0042	4.7
					Regulation of steroid metabolic process	0.0031	4.7
Lung	9	38	47	39	ATP binding	0.0013	1.6
					Positive regulation of steroid metabolic process	0.0013	2
					Positive regulation of lipid metabolic process	0.0015	2.3
					Adenyl ribonucleotide binding	0.0023	2.7
					Transport	0.0026	3
					Adenyl nucleotide binding	0.0028	3.3
					Nucleoside binding	0.003	3.5
					Purine nucleoside binding	0.003	3.5
					Nucleotide-binding	0.0035	4
All hyper^a,f	29	-	29	25	Embryonic morphogenesis	0.0019	2.8
All hypo^b,f	-	60	60	50	NOD^g-like receptor signaling pathway	0.000017	0.018

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