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Table 2 Summary of differentially methylated loci between normal fetal and adult tissues

From: Extensive epigenetic reprogramming in human somatic tissues between fetus and adult

Tissue Number of hyperaloci Number of hypobloci Total number of aDMRsc Total number of associated genes GOdterms P FDRe, %
Brain 17 21 38 36 - - -
Kidney 10 27 37 33 Positive regulation of steroid metabolic process 0.00057 0.87
      Transport 0.0042 4.7
      Regulation of steroid metabolic process 0.0031 4.7
Lung 9 38 47 39 ATP binding 0.0013 1.6
      Positive regulation of steroid metabolic process 0.0013 2
      Positive regulation of lipid metabolic process 0.0015 2.3
      Adenyl ribonucleotide binding 0.0023 2.7
      Transport 0.0026 3
      Adenyl nucleotide binding 0.0028 3.3
      Nucleoside binding 0.003 3.5
      Purine nucleoside binding 0.003 3.5
      Nucleotide-binding 0.0035 4
All hypera,f 29 - 29 25 Embryonic morphogenesis 0.0019 2.8
All hypob,f - 60 60 50 NODg-like receptor signaling pathway 0.000017 0.018
  1. aHypermethylated.
  2. bHypermethylated.
  3. cAge-dependent differentially methylated regions.
  4. dGene ontology.
  5. eFalse discovery rate.
  6. fRedundant loci eliminated
  7. gNucleotide-binding oligomerization domain.