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Table 1 Loci showing differential DNA methylation between trisomic and control subjects

From: Extensive epigenetic reprogramming in human somatic tissues between fetus and adult

      Controls Trisomies   
Type Tissue Feature ID Chromosome FDRa, % Mean SD Mean SD Difference GObterm
T18 Skin HOXA9_E252_R 7 0 0.04 0.09 0.58 0.21 0.54 Developmental process
   ZNF264_P397_F 19 0 0.52 0.17 0.92 0.01 0.40 Biological regulation
   RYK_P493_F 3 0 0.17 0.08 0.56 0.12 0.39 Developmental process
   CASP10_P186_F 2 0 0.37 0.12 0.72 0.11 0.35 Developmental process
   IL1RN_P93_R 2 0 0.51 0.07 0.78 0.04 0.27 Immune response
   RBL2_P250_R 16 0 0.04 0.05 0.26 0.11 0.22 Biological regulation
   MAP2K6_P297_R 17 0 0.30 0.05 0.49 0.03 0.19 Metabolic process
   JAK3_P156_R 19 0 0.25 0.05 0.44 0.07 0.19 Developmental process
   MST1R_P392_F 3 0 0.15 0.05 0.32 0.05 0.17 Metabolic process
   RARA_P1076_R 17 2.08 0.19 0.08 0.52 0.19 0.33 Metabolic process
   CPA4_E20_F 7 2.08 0.37 0.07 0.61 0.13 0.24 Metabolic process
   CEACAM1_E57_R 19 2.08 0.27 0.05 0.46 0.09 0.19 Developmental process
   ARHGDIB_P148_R 12 3.38 0.74 0.10 0.92 0.02 0.19 Immune response
   SEPT9_P374_F 17 4.24 0.14 0.08 0.37 0.15 0.24 Immune response
   S100A4_E315_F 1 4.24 0.25 0.09 0.43 0.10 0.19 Developmental process
   RAD54B_P227_F 8 4.24 0.16 0.05 0.33 0.12 0.17 DNA repair
   CASP10_E139_F 2 4.24 0.74 0.10 0.92 0.01 0.17 Developmental process
T21 Skin ZNF264_P397_F 19 0 0.52 0.17 0.85 0.06 0.33 Biological regulation
   WNT10B_P993_F 12 0 0.16 0.04 0.38 0.08 0.22 Developmental process
   DIO3_E230_R 14 0 0.45 0.11 0.65 0.05 0.19 Biological regulation
   TSC2_E140_F 16 0 0.61 0.06 0.79 0.08 0.18 Biological regulation
   IPF1_P750_F 13 3.89 0.33 0.12 0.56 0.12 0.23 Biological regulation
   DDB2_P407_F 11 3.89 0.12 0.09 0.35 0.16 0.23 DNA repair
   HLA-DRA_P77_R 6 3.89 0.70 0.10 0.87 0.05 0.17 Immune response
T21 Muscle DDB2_P407_F 11 0 0.11 0.05 0.30 0.08 0.19 DNA repair
  1. aFalse discovery rate.
  2. bGene ontology.