Epigenetics & Chromatin

Table 1 Loci showing differential DNA methylation between trisomic and control subjects

From: Extensive epigenetic reprogramming in human somatic tissues between fetus and adult

					Controls		Trisomies
Type	Tissue	Feature ID	Chromosome	FDR^a, %	Mean	SD	Mean	SD	Difference	GO^bterm
T18	Skin	HOXA9_E252_R	7	0	0.04	0.09	0.58	0.21	0.54	Developmental process
		ZNF264_P397_F	19	0	0.52	0.17	0.92	0.01	0.40	Biological regulation
		RYK_P493_F	3	0	0.17	0.08	0.56	0.12	0.39	Developmental process
		CASP10_P186_F	2	0	0.37	0.12	0.72	0.11	0.35	Developmental process
		IL1RN_P93_R	2	0	0.51	0.07	0.78	0.04	0.27	Immune response
		RBL2_P250_R	16	0	0.04	0.05	0.26	0.11	0.22	Biological regulation
		MAP2K6_P297_R	17	0	0.30	0.05	0.49	0.03	0.19	Metabolic process
		JAK3_P156_R	19	0	0.25	0.05	0.44	0.07	0.19	Developmental process
		MST1R_P392_F	3	0	0.15	0.05	0.32	0.05	0.17	Metabolic process
		RARA_P1076_R	17	2.08	0.19	0.08	0.52	0.19	0.33	Metabolic process
		CPA4_E20_F	7	2.08	0.37	0.07	0.61	0.13	0.24	Metabolic process
		CEACAM1_E57_R	19	2.08	0.27	0.05	0.46	0.09	0.19	Developmental process
		ARHGDIB_P148_R	12	3.38	0.74	0.10	0.92	0.02	0.19	Immune response
		SEPT9_P374_F	17	4.24	0.14	0.08	0.37	0.15	0.24	Immune response
		S100A4_E315_F	1	4.24	0.25	0.09	0.43	0.10	0.19	Developmental process
		RAD54B_P227_F	8	4.24	0.16	0.05	0.33	0.12	0.17	DNA repair
		CASP10_E139_F	2	4.24	0.74	0.10	0.92	0.01	0.17	Developmental process
T21	Skin	ZNF264_P397_F	19	0	0.52	0.17	0.85	0.06	0.33	Biological regulation
		WNT10B_P993_F	12	0	0.16	0.04	0.38	0.08	0.22	Developmental process
		DIO3_E230_R	14	0	0.45	0.11	0.65	0.05	0.19	Biological regulation
		TSC2_E140_F	16	0	0.61	0.06	0.79	0.08	0.18	Biological regulation
		IPF1_P750_F	13	3.89	0.33	0.12	0.56	0.12	0.23	Biological regulation
		DDB2_P407_F	11	3.89	0.12	0.09	0.35	0.16	0.23	DNA repair
		HLA-DRA_P77_R	6	3.89	0.70	0.10	0.87	0.05	0.17	Immune response
T21	Muscle	DDB2_P407_F	11	0	0.11	0.05	0.30	0.08	0.19	DNA repair

^aFalse discovery rate.
^bGene ontology.

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ISSN: 1756-8935

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