Figure 2From: Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleationGeneration and initial evaluation of the dnBrg1 transgenic mice. (A) Schematic of the transgenic construct. αA-crystallin promoter fragment (-366 to + 46, Cryaa; blue arrow) was used to express mutated Brg1 (K798R) with a C-terminal FLAG tag (green triangle). ATPase domain (yellow) and bromodomain (blue) are shown. (B) Two-month-old wild-type (WT) and transgenic mice. Note the cataract formation in the transgenic mouse and in isolated lens.Back to article page