Generation and initial evaluation of the dnBrg1 transgenic mice. (A) Schematic of the transgenic construct. αA-crystallin promoter fragment (-366 to + 46, Cryaa; blue arrow) was used to express mutated Brg1 (K798R) with a C-terminal FLAG tag (green triangle). ATPase domain (yellow) and bromodomain (blue) are shown. (B) Two-month-old wild-type (WT) and transgenic mice. Note the cataract formation in the transgenic mouse and in isolated lens.