Figure 11
Early deletion of Brg1 compromise ocular morphogenesis in the conditional knockout (cKO) mutant embryos. Lens midsections were obtained from Brg1flox/floxand Brg1flox/flox; Le-Cre (mutant) mice from embryonic day 13.5 (A-C) and embryonic day 15.5 (D-F). The examined Brg1 mutant embryos still underwent lens induction but revealed disrupted lens specification as well as an abnormal neural retina during embryonic development. Scale bar, 100 μm.