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Table 3 Human polycomb phosphorylation sites

From: Talking to chromatin: post-translational modulation of polycomb group function

Complex Drosophila Name Alternative symbol Accession no. Total no. of amino acids Phosphosite Conservation in Mouse Refs
PRC2 E(z) EZH1   Q92800 747 - - -
   EZH2   Q15910 746 S21 S21 [52]
       T339 T339 [102]
       S362 S362 [103]
       S363 S363 [103]
       S366 S366 [102, 103]
       T367 T367 [102, 103]
       S380 S380 [104]
       T487 T487a [102, 103, 105110]
  Esc EED   O75530 441 S25 S25 [102]b
       S34 S34 [102]
       S43 S43 [102]b
       S46 S46 [102]b
       T50 T50 [102]b
       T55 T55 [102]
       T57 T57 [102]
  Su(z)12 SUZ12   Q15022 739 S37 S37 [102]
       T131 T133 [111]
       S139 S141 [111]
       S382 S384 [103]
       T418 NC [112]
       S541 S543 [102]
       S546 S548a [102, 103, 105, 107, 110]
       S583 S585a [103, 107]
PRC1 Pc CBX2 HPC1 Q14781 532 - - -
   CBX4 HPC2 O00257 558 Y205 Y207 [113]
       S347 S350 [102]b
       T349 T352 [102]b
       S413 S427 [110]
       T415 T412 [103]
       S430 S427 [107]
       T435 T432 [103]
       T495 NC [38]
   CBX6   O95503 412 S107 S107 [103]
       S301 S302 [107]
       S303 S304 [107]
   CBX7   O95931 251 - - -
   CBX8 HPC3 Q9HC52 389 S110 S110 [102, 108]c
       S130 NC [102]
       T234 T207 [102]b
       S256 S229a [102, 103]
       S265 S238a [102, 103, 108]c
       S311 S284a c
       S332 S305 [102, 107]
       S352 S325 [102]
       S354 S327 [102]b
  Ph PHC1 HPH1/EDR1 P78364 1,004 Y32 Y32 [113]
       S195 S195 c
       S645 S653 c
       S653 S661 [114]
       S657 S665 [114]
       S664 S672 [114]c
       S669 S677 [114]c
       S786 S794 c
       S895 S903 c
       T918 T926 [103]
       T922 T930 [103]c
   PHC2 HPH2 Q8IXK0 858 S591 S583 [102]
       T619 T611 [102]
       S621 S613 [103]
       S701 S693 [104]
       S704 S696 [104]
       S733 S725 [115]c
       S745 S737 [105]
   PHC3 HPH3/EDR3 Q8NDX5 983 S229 S227 [115]
       S263 S261 [105, 110]
       S315 S312 [102]c
       T609 T607a [102, 103, 105, 107, 109, 110]c
       T614 T612a [102, 107]b
       S616 S614a [102, 103, 105, 107, 109, 110]c
       S724 S722 [102]b
       S761 S759 [102]
       S762 S760 [102]
       S862 S860 c
  Sce/dRING RING1 RING1A/RNF1 Q06587 406 S38 S38 [102, 103, 107]c
       S187 S187 [102, 103]
       S188 S188 [102, 103]
       S190 S190 [102, 103]
       S229 S229 c
   RNF2 RING1B/RING2 Q99496 336 S41 S41 [69]
       S168 S168 [110]
  Psc BMI1 PCGF4 P35226 326 S251 S249a [110]
       S253 S251a [110]
       S255 S253a [110]
   PCGF2 RNF110/MEL18 P35227 344 Y197 Y197 [113]
       Y205 Y205 [113]
       Y206 Y206 [113]
       T344 gap [102]
PhoRC Pho YY1   P25490 414 S118 S120a [109]
       S184 S184 [104]
       S247 S247a [102, 103, 105, 108, 109]
       Y251 Y251 [102]
       T348 T348 [102, 116]
       T378 T378 [102, 103]
Other Psc PCGF1 NSPc1 Q9BSM1 259 - - -
   PCGF6 MBLR/RNF134 Q9BYE7 350 S30d S34 [44]
  Scm SCMH1   Q96GD3 660 S649 S653 [102, 114]
   SCML1   Q9UN30 208 S15 NA [102]b
       S17 NA [102]
       S117 NA [108]
   SCML2   Q9UQR0 700 S255 NA [102]b
       S256 NA [102]
       S258 NA [102]
       S267 NA [102]
       S299 NA [102]
       S300 NA [102]
       T305 NA [102]
       S495 NA [102]b
       S499 NA [102, 103, 105, 106]
       T503 NA [102]
       S511 NA [102, 103, 105, 106]
       S570 NA [115]
       S576 NA [102]
       T581 NA [102]b
       S583 NA [102]
       S590 NA [102, 103]
       S594 NA [102, 103]
       S606 NA [102]
   RYBP   Q8N488 228 S127 S127 [102]
       S130 S130 [102]
       S203 S203 [102]b
       T215 T215 [102]b
  1. a Sites that were detected as phosphorylation sites in mouse cells as well; b these putative phosphorylation sites do not reach a sufficiently high probability based on prediction algorithms used; c marks unpublished results (HN, JD, JWV); d site was referred to as S32 in original article.
  2. NA = not available; NC = non-conserved