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  1. Epithelial mesenchymal transition (EMT) is tightly regulated by a network of transcription factors (EMT-TFs). Among them is the nuclear factor ZEB2, a member of the zinc-finger E-box binding homeobox family. Z...

    Authors: Nicolas Skrypek, Kenneth Bruneel, Cindy Vandewalle, Eva De Smedt, Bieke Soen, Nele Loret, Joachim Taminau, Steven Goossens, Niels Vandamme and Geert Berx
    Citation: Epigenetics & Chromatin 2018 11:70
    Content type: Research Published on:

  2. Nickel is an occupational and environmental toxicant associated with a number of diseases in humans including pulmonary fibrosis, bronchitis and lung and nasal cancers. Our earlier studies showed that the nick...

    Authors: Cynthia C. Jose, Zhenjia Wang, Vinay Singh Tanwar, Xiaoru Zhang, Chongzhi Zang and Suresh Cuddapah
    Citation: Epigenetics & Chromatin 2019 12:75
    Content type: Research Published on:

  3. The histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native CENP-A is often found overexpressed in human cancer cells and a range of human tumors. Co...

    Authors: Rajbir K Athwal, Marcin P Walkiewicz, Songjoon Baek, Song Fu, Minh Bui, Jordi Camps, Thomas Ried, Myong-Hee Sung and Yamini Dalal
    Citation: Epigenetics & Chromatin 2015 8:2
    Content type: Research Published on:

  4. DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent sex determination (TSD) epitomizes phenotypic plasticity where environmental ...

    Authors: Srihari Radhakrishnan, Robert Literman, Beatriz Mizoguchi and Nicole Valenzuela
    Citation: Epigenetics & Chromatin 2017 10:28
    Content type: Research Published on:

  5. Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to an...

    Authors: Stefan Wallner, Christopher Schröder, Elsa Leitão, Tea Berulava, Claudia Haak, Daniela Beißer, Sven Rahmann, Andreas S. Richter, Thomas Manke, Ulrike Bönisch, Laura Arrigoni, Sebastian Fröhler, Filippos Klironomos, Wei Chen, Nikolaus Rajewsky, Fabian Müller…
    Citation: Epigenetics & Chromatin 2016 9:33
    Content type: Research Published on:

  6. Infection by the human malaria parasite leads to important changes in mosquito phenotypic traits related to vector competence. However, we still lack a clear understanding of the underlying mechanisms and, in ...

    Authors: José L. Ruiz, Rakiswendé S. Yerbanga, Thierry Lefèvre, Jean B. Ouedraogo, Victor G. Corces and Elena Gómez-Díaz
    Citation: Epigenetics & Chromatin 2019 12:5
    Content type: Research Published on:

  7. Contact domains of chromatin serve as a fundamental unit to regulate action of enhancers for target genes. Looping between a pair of CCCTC-binding factor (CTCF)-binding sites in convergent orientations underli...

    Authors: Taro Tsujimura, Osamu Takase, Masahiro Yoshikawa, Etsuko Sano, Matsuhiko Hayashi, Tsuyoshi Takato, Atsushi Toyoda, Hideyuki Okano and Keiichi Hishikawa
    Citation: Epigenetics & Chromatin 2018 11:51
    Content type: Research Published on:

  8. The main chromatin unit, the nucleosome, can be modulated by the incorporation of histone variants that, in combination with posttranslational histones modifications, determine epigenetics properties of chroma...

    Authors: Viacheslav M. Morozov, Serena Giovinazzi and Alexander M. Ishov
    Citation: Epigenetics & Chromatin 2017 10:63
    Content type: Research Published on:

  10. During meiosis, the X and Y chromosomes are transcriptionally silenced. The persistence of repressive chromatin marks on the sex chromatin after meiosis initially led to the assumption that XY gene silencing ...

    Authors: Charlotte Moretti, Daniel Vaiman, Frederic Tores and Julie Cocquet
    Citation: Epigenetics & Chromatin 2016 9:47
    Content type: Research Published on:

  11. Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycl...

    Authors: Kyohei Oyama, Danny El-Nachef, Chen Fang, Hidemi Kajimoto, Jeremy P. Brown, Prim B. Singh and W. Robb MacLellan
    Citation: Epigenetics & Chromatin 2018 11:18
    Content type: Research Published on:

  12. Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding tran...

    Authors: Yilin Zhao, Deyou Zheng and Ales Cvekl
    Citation: Epigenetics & Chromatin 2019 12:27
    Content type: Research Published on:

  13. Environmental toxicants such as DDT have been shown to induce the epigenetic transgenerational inheritance of disease (e.g., obesity) through the germline. The current study was designed to investigate the DDT...

    Authors: Michael K. Skinner, Millissia Ben Maamar, Ingrid Sadler-Riggleman, Daniel Beck, Eric Nilsson, Margaux McBirney, Rachel Klukovich, Yeming Xie, Chong Tang and Wei Yan
    Citation: Epigenetics & Chromatin 2018 11:8
    Content type: Research Published on:

  14. Epigenetic inheritance plays a crucial role in many biological processes, such as gene expression in early embryo development, imprinting and the silencing of transposons. It has recently been established that...

    Authors: Kostas A. Triantaphyllopoulos, Ioannis Ikonomopoulos and Andrew J. Bannister
    Citation: Epigenetics & Chromatin 2016 9:31
    Content type: Review Published on:

  15. Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes ...

    Authors: Eriko Oya, Mickaël Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli and Karl Ekwall
    Citation: Epigenetics & Chromatin 2019 12:45
    Content type: Research Published on:

  16. Genomic imprinting is governed by allele-specific DNA methylation at imprinting control regions (ICRs), and the mechanism controlling its differential methylation establishment during gametogenesis has been a ...

    Authors: Hitomi Matsuzaki, Eiichi Okamura, Daichi Kuramochi, Aki Ushiki, Katsuhiko Hirakawa, Akiyoshi Fukamizu and Keiji Tanimoto
    Citation: Epigenetics & Chromatin 2018 11:36
    Content type: Research Published on:

  17. CHD1 and CHD2 chromatin remodeling enzymes play important roles in development, cancer and differentiation. At a molecular level, the mechanisms are not fully understood but include transcriptional regulation,...

    Authors: Lee Siggens, Lina Cordeddu, Michelle Rönnerblad, Andreas Lennartsson and Karl Ekwall
    Citation: Epigenetics & Chromatin 2015 8:4
    Content type: Research Published on:

  19. Genomic imprinting leads to maternal expression of IGF2R in both mouse and opossum. In mouse, the antisense long noncoding (lnc) RNA Airn, which is paternally expressed from the differentially methylated region (...

    Authors: Shunsuke Suzuki, Geoffrey Shaw and Marilyn B. Renfree
    Citation: Epigenetics & Chromatin 2018 11:55
    Content type: Research Published on:

  20. Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, He...

    Authors: Jian-Jun Jiang, Le-Hua Cheng, Huan Wu, Yong-Han He and Qing-Peng Kong
    Citation: Epigenetics & Chromatin 2016 9:51
    Content type: Research Published on:

  21. Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases...

    Authors: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang and Ting Zhang
    Citation: Epigenetics & Chromatin 2019 12:69
    Content type: Research Published on:

  22. Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 vari...

    Authors: Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian and Yamini Dalal
    Citation: Epigenetics & Chromatin 2017 10:17
    Content type: Research Published on:

  23. Disease risk and incidence between males and females reveal differences, and sex is an important component of any investigation of the determinants of phenotypes or disease etiology. Further striking differenc...

    Authors: Paula Singmann, Doron Shem-Tov, Simone Wahl, Harald Grallert, Giovanni Fiorito, So-Youn Shin, Katharina Schramm, Petra Wolf, Sonja Kunze, Yael Baran, Simonetta Guarrera, Paolo Vineis, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Anja Kretschmer…
    Citation: Epigenetics & Chromatin 2015 8:43
    Content type: Research Published on:

  25. There is growing evidence that DNA methylation alterations contribute to carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the proportion of tissue-specific versus tissue-indepe...

    Authors: Yuting Chen, Charles E. Breeze, Shao Zhen, Stephan Beck and Andrew E. Teschendorff
    Citation: Epigenetics & Chromatin 2016 9:10
    Content type: Research Published on:

  26. Localized functional domains within chromosomes, known as topologically associating domains (TADs), have been recently highlighted. In Drosophila, TADs are biochemically defined by epigenetic marks, this suggesti...

    Authors: Antony Lesage, Vincent Dahirel, Jean-Marc Victor and Maria Barbi
    Citation: Epigenetics & Chromatin 2019 12:28
    Content type: Research Published on:

  27. Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that v...

    Authors: Kevin T. Ebata, Kathryn Mesh, Shichong Liu, Misha Bilenky, Alexander Fekete, Michael G. Acker, Martin Hirst, Benjamin A. Garcia and Miguel Ramalho-Santos
    Citation: Epigenetics & Chromatin 2017 10:36
    Content type: Research Published on:

  28. The timing of the first cell divisions may predict the developmental potential of an embryo, including its ability to establish pregnancy. Besides differences related to metabolism, stress, and survival, embr...

    Authors: Jessica Ispada, Camila Bruna de Lima, Marc-André Sirard, Patrícia Kubo Fontes, Marcelo Fábio Gouveia Nogueira, Kelly Annes and Marcella Pecora Milazzotto
    Citation: Epigenetics & Chromatin 2018 11:1
    Content type: Research Published on:

  29. Lentiviral vectors (LV) are widely used for various gene transfer or gene therapy applications. The effects of LV on target cells are expected to be limited to gene delivery. Yet, human hematopoietic CD34+ cel...

    Authors: Tamas Aranyi, Daniel Stockholm, Roseline Yao, Catherine Poinsignon, Thibaut Wiart, Guillaume Corre, Nizar Touleimat, Jörg Tost, Anne Galy and Andràs Paldi
    Citation: Epigenetics & Chromatin 2016 9:29
    Content type: Research Published on:

  30. Cell type-specific use of cis-acting regulatory elements is mediated by the combinatorial activity of transcription factors involved in lineage determination and maintenance of cell identity. In macrophages, spec...

    Authors: Federica Ferri, Vanessa Petit, Vilma Barroca and Paul-Henri Romeo
    Citation: Epigenetics & Chromatin 2019 12:46
    Content type: Research Published on:

  32. The identification and characterisation of differentially methylated regions (DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We present a novel method, DMRcate, that fits replic...

    Authors: Timothy J Peters, Michael J Buckley, Aaron L Statham, Ruth Pidsley, Katherine Samaras, Reginald V Lord, Susan J Clark and Peter L Molloy
    Citation: Epigenetics & Chromatin 2015 8:6
    Content type: Methodology Published on:

  33. The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis. The centromere position is...

    Authors: Jing Zhu, Kevin Chi Lok Cheng and Karen Wing Yee Yuen
    Citation: Epigenetics & Chromatin 2018 11:16
    Content type: Research Published on:

  34. MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates wit...

    Authors: Yonghwan Shin, Nikhil B. Ghate, Byoungsan Moon, Kyungpyo Park, Wange Lu and Woojin An
    Citation: Epigenetics & Chromatin 2019 12:25
    Content type: Research Published on:

  35. Comparisons of Hi–C data sets between cell types and conditions have revealed differences in topologically associated domains (TADs) and A/B compartmentalization, which are correlated with differences in gene ...

    Authors: Lila Rieber and Shaun Mahony
    Citation: Epigenetics & Chromatin 2019 12:61
    Content type: Methodology Published on:

  37. Placental inflammation, often presenting as acute chorioamnionitis (aCA), is commonly associated with preterm birth. Preterm birth can have both immediate and long-term adverse effects on the health of the bab...

    Authors: Chaini Konwar, E. Magda Price, Li Qing Wang, Samantha L. Wilson, Jefferson Terry and Wendy P. Robinson
    Citation: Epigenetics & Chromatin 2018 11:63
    Content type: Research Published on:

  38. DNA methylation is one of the main epigenetic mechanisms for the regulation of gene expression in eukaryotes. In the standard model, methylation in gene promoters has received the most attention since it is ge...

    Authors: Dafni Anastasiadi, Anna Esteve-Codina and Francesc Piferrer
    Citation: Epigenetics & Chromatin 2018 11:37
    Content type: Research Published on:

  39. Intrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of...

    Authors: Zac Chatterton, Brigham J. Hartley, Man-Ho Seok, Natalia Mendelev, Sean Chen, Maria Milekic, Gorazd Rosoklija, Aleksandar Stankov, Iskra Trencevsja-Ivanovska, Kristen Brennand, Yongchao Ge, Andrew J. Dwork and Fatemeh Haghighi
    Citation: Epigenetics & Chromatin 2017 10:4
    Content type: Research Published on:

  40. DNA methylation plays important roles in many regulatory processes in plants. It is economically infeasible to profile genome-wide DNA methylation at a single-base resolution in maize, given its genome size o...

    Authors: Fei-Man Hsu, Ming-Ren Yen, Chi-Ting Wang, Chien-Yu Lin, Chung-Ju Rachel Wang and Pao-Yang Chen
    Citation: Epigenetics & Chromatin 2017 10:42
    Content type: Methodology Published on:

  41. Meiotic recombination hotspots control the frequency and distribution of Spo11 (Rec12)-initiated recombination in the genome. Recombination occurs within and is regulated in part by chromatin structure, but re...

    Authors: Aaron J. Storey, Hsin-Ping Wang, Reine U. Protacio, Mari K. Davidson, Alan J. Tackett and Wayne P. Wahls
    Citation: Epigenetics & Chromatin 2018 11:64
    Content type: Research Published on:

  43. The role of epigenetic modifications such as DNA methylation during vertebrate sexual development is far from being clear. Using the zebrafish model, we tested the effects of one of the most common DNA methylt...

    Authors: Laia Ribas, Konstantinos Vanezis, Marco Antonio Imués and Francesc Piferrer
    Citation: Epigenetics & Chromatin 2017 10:59
    Content type: Research Published on:

  44. Epithelial to mesenchymal transition (EMT) plays a crucial role in cancer propagation. It can be orchestrated by the activation of multiple signaling pathways, which have been found to be highly coordinated wi...

    Authors: Congcong Lu, Simone Sidoli, Katarzyna Kulej, Karen Ross, Cathy H. Wu and Benjamin A. Garcia
    Citation: Epigenetics & Chromatin 2019 12:11
    Content type: Research Published on:

  45. CREB-binding protein (CBP, also known as nejire) is a transcriptional co-activator that is conserved in metazoans. CBP plays an important role in embryonic development and cell differentiation and mutations in CB...

    Authors: Philge Philip, Ann Boija, Roshan Vaid, Allison M. Churcher, David J. Meyers, Philip A. Cole, Mattias Mannervik and Per Stenberg
    Citation: Epigenetics & Chromatin 2015 8:48
    Content type: Research Published on:

    The Erratum to this article has been published in Epigenetics & Chromatin 2016 9:38

  46. The brain, spinal cord, and neural retina comprise the central nervous system (CNS) of vertebrates. Understanding the regulatory mechanisms that underlie the enormous cell-type diversity of the CNS is a signif...

    Authors: Matthew S Wilken, Joseph A Brzezinski, Anna La Torre, Kyle Siebenthall, Robert Thurman, Peter Sabo, Richard S Sandstrom, Jeff Vierstra, Theresa K Canfield, R Scott Hansen, Michael A Bender, John Stamatoyannopoulos and Thomas A Reh
    Citation: Epigenetics & Chromatin 2015 8:8
    Content type: Research Published on:

  47. Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer agents for particular malignancies. However, clinical use is often confounded by toxicity, perhaps due to indiscriminate hyp...

    Authors: Christopher L. Frank, Dinesh Manandhar, Raluca Gordân and Gregory E. Crawford
    Citation: Epigenetics & Chromatin 2016 9:15
    Content type: Research Published on:

  48. Chlordecone (CD) is an insecticide that was used in the French West Indies for several years to control the banana root borer pest. Given its nonsignificant degradation, it persists in the environment. CD is a...

    Authors: Louis Legoff, Ouzna Dali, Shereen Cynthia D’Cruz, Antonio Suglia, Aurore Gely-Pernot, Chloé Hémery, Pierre-Yves Kernanec, Abbassia Demmouche, Christine Kervarrec, Sergei Tevosian, Luc Multigner and Fatima Smagulova
    Citation: Epigenetics & Chromatin 2019 12:29
    Content type: Research Published on:

  49. Epigenetics allows for the inheritance of information in cellular lineages during differentiation, independent of changes to the underlying genetic sequence. This raises the question of whether epigenetic mech...

    Authors: Michael A. Christopher, Stephanie M. Kyle and David J. Katz
    Citation: Epigenetics & Chromatin 2017 10:47
    Content type: Review Published on:

  50. It is well recognized that the interphase chromatin of higher eukaryotes folds into non-random configurations forming territories within the nucleus. Chromosome territories have biologically significant proper...

    Authors: Nicholas Allen Kinney, Igor V. Sharakhov and Alexey V. Onufriev
    Citation: Epigenetics & Chromatin 2018 11:3
    Content type: Research Published on:
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ISSN: 1756-8935