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Table 2 Expression of acetyl-CoA generating enzymes, one-carbon metabolic genes, epigenetic modifiers, and alternative splicing factors is altered in response to chronic thermogenic activation as measured by RNA-Seq

From: Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress

Gene

SC vs TN

SC vs RT

RT vs TN

Category

Log2FC

Padj

Log2FC

Padj

Log2FC

Padj

Acly

3.69

5.10E−11

1.03

1.19E−02

2.62

2.92E−05

Acetyl-CoA generation

Acss2

2.52

2.64E−33

− 0.08

0.77

2.56

1.36E−28

Acetyl-CoA generation

Crat

1.14

1.15E−35

0.27

9.10E−05

0.82

6.26E−16

Acetyl-CoA generation

Crot

0.43

6.96E−04

0.09

0.44

0.30

1.82E−02

Acetyl-CoA generation

Slc25a32

1.47

3.61E−13

0.72

7.85E−03

0.71

1.54E−02

One-carbon metabolism

Sfxn1

1.14

5.20E−18

− 0.07

0.59

1.17

1.37E−19

One-carbon metabolism

Mthfd2l

0.95

4.60E−15

− 0.05

0.72

0.96

1.00E−15

One-carbon metabolism

Aldh1l1

0.91

1.88E−10

− 0.12

0.59

0.99

2.07E−07

One-carbon metabolism

Tcn2

0.72

1.82E−16

0.06

0.63

0.61

1.32E−09

One-carbon metabolism

Mthfd2

0.68

1.64E−03

1.31

5.77E−12

− 0.67

1.24E−02

One-carbon metabolism

Sardh

0.64

5.69E−10

0.00

0.99

0.60

5.28E−04

One-carbon metabolism

Chdh

0.60

4.24E−06

0.12

0.31

0.44

1.76E−03

One-carbon metabolism

Pemt

0.54

2.33E−03

− 0.32

0.13

0.82

4.06E−05

One-carbon metabolism

Slc19a1

0.52

7.30E−04

− 0.24

0.26

0.72

1.50E−04

One-carbon metabolism

Ahcyl1

0.46

2.56E−03

0.12

0.24

0.30

0.07

One-carbon metabolism

Fpgs

− 0.30

0.07

0.24

0.22

− 0.58

2.12E−03

One-carbon metabolism

Shmt2

− 0.31

4.47E−03

− 0.13

0.23

− 0.22

0.08

One-carbon metabolism

Sfxn3

− 0.52

2.24E−02

0.40

3.60E−02

− 0.96

3.48E−05

One-carbon metabolism

Mat2a

− 0.68

5.56E−08

− 0.08

0.75

− 0.64

1.58E−03

One-carbon metabolism

Mtr

− 0.86

7.19E−24

− 0.30

8.94E−03

− 0.61

2.98E−09

One-carbon metabolism

Shmt1

− 1.01

1.80E−14

− 0.71

3.35E−09

− 0.34

2.32E−02

One-carbon metabolism

Aldh1l2

− 1.36

9.27E−06

−

−

− 1.18

1.31E−04

One-carbon metabolism

Dnmt1

− 0.40

7.02E−03

0.28

8.49E−02

− 0.73

1.33E−06

DNA methyltransferase

Dnmt3a

− 0.38

1.53E−03

0.04

0.77

− 0.47

1.16E−04

DNA methyltransferase

Dnmt3b

− 1.30

2.18E−06

−

−

− 0.75

6.45E−03

DNA methyltransferase

Smyd4

1.32

3.28E−16

1.06

6.11E−13

0.21

0.32

Histone modification

Fcor

1.23

3.40E−25

− 0.79

2.18E−15

1.98

3.80E−98

Histone modification

Sirt5

0.94

4.31E−09

0.00

0.98

0.91

1.59E−06

Histone modification

Kdm5c

0.65

1.12E−12

0.24

5.52E−03

0.36

1.02E−04

Histone modification

N6amt1

0.62

5.38E−07

0.05

0.75

0.52

8.27E−05

Histone modification

H1f0

0.51

1.15E−04

0.16

0.27

0.31

1.68E−02

Histone modification

Setd7

0.50

2.28E−03

0.50

3.85E−04

− 0.03

0.90

Histone modification

Kdm3a

0.50

8.89E−03

0.55

1.69E−02

− 0.09

0.69

Histone modification

Kdm8

0.50

1.06E−02

0.20

0.54

0.27

0.42

Histone modification

Hdac2

0.46

4.84E−06

0.12

0.35

0.30

2.12E−02

Histone modification

Kat8

0.45

1.23E−04

0.06

0.74

0.36

8.18E−03

Histone modification

Setd3

0.41

1.23E−06

− 0.05

0.68

0.42

2.77E−05

Histone modification

Kat2b

0.37

4.19E−03

0.15

0.28

0.18

0.20

Histone modification

Prmt7

0.24

2.90E−02

0.16

0.16

0.03

0.84

Histone modification

Kdm2b

0.13

0.43

0.54

5.61E−03

− 0.45

3.21E−02

Histone modification

Hdac5

− 0.07

0.50

− 0.30

2.30E−04

0.19

2.87E−02

Histone modification

Hdac3

− 0.16

0.08

− 0.47

3.87E−10

0.27

1.68E−03

Histone modification

Hdac10

− 0.24

4.81E−02

− 0.28

3.87E−02

0.00

1.00

Histone modification

Kdm5b

− 0.33

1.26E−02

− 0.31

1.74E−02

− 0.06

0.68

Histone modification

Hat1

− 0.38

1.32E−03

− 0.26

3.02E−02

− 0.16

0.22

Histone modification

Chaf1a

− 0.53

3.24E−02

−

−

− 1.07

1.34E−04

Histone modification

Smyd3

− 0.56

3.30E−03

− 0.48

1.85E−02

− 0.12

0.52

Histone modification

Hdac7

− 0.64

9.63E−11

− 0.09

0.54

− 0.60

1.62E−07

Histone modification

Suv39h1

− 1.08

3.18E−08

− 0.35

0.16

− 0.77

3.52E−04

Histone modification

Hdac9

− 1.20

1.16E−06

−

−

− 0.94

2.93E−05

Histone modification

Igf2bp2

0.79

3.92E−03

0.93

3.03E−07

− 0.20

0.60

Alternative splicing

Elavl1

0.44

1.02E−04

0.23

1.37E−02

0.17

0.15

Alternative splicing

Ybx3

0.11

0.37

− 0.19

0.10

0.25

3.62E−02

Alternative splicing

Ybx1

− 0.08

0.34

− 0.39

3.03E−05

0.27

6.71E−03

Alternative splicing

Ctcf

− 0.13

0.12

0.01

0.90

− 0.19

4.19E−02

Alternative splicing

Srsf1

− 0.33

6.75E−04

− 0.32

3.91E−03

− 0.05

0.68

Alternative splicing

Srsf2

− 0.33

4.43E−04

− 0.20

0.15

− 0.18

0.18

Alternative splicing

Srsf11

− 0.40

5.36E−04

− 0.52

9.59E−10

0.08

0.49

Alternative splicing

Rbm4

− 0.45

0.14

− 0.58

3.30E−02

0.10

0.76

Alternative splicing

Srsf5

− 0.59

1.70E−06

− 0.48

3.81E−04

− 0.16

0.10

Alternative splicing

Srsf3

− 0.62

2.17E−07

− 0.27

6.08E−02

− 0.39

4.10E−03

Alternative splicing

Srsf7

− 0.66

4.31E−11

− 0.09

0.50

− 0.61

3.03E−06

Alternative splicing

Nova2

− 0.78

2.15E−05

0.04

0.87

− 0.86

1.46E−06

Alternative splicing

Pspc1

− 0.80

8.13E−04

− 0.52

3.80E−02

− 0.32

0.30

Alternative splicing

  1. n = 4 per group. Log2FC: log2 fold change. TN: thermoneutral. RT: room temperature. SC: severe cold
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Epigenetics & Chromatin

ISSN: 1756-8935