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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress

Fig. 4

Housing temperature alters bulk histone acetylation, but not methylation, in BAT and has no effect on bulk histone acetylation or methylation in liver. Percent (A) acetylated (1 + acetylation) and (B) methylated (1 + methylation) histones H3.2 and H4 isolated from liver and BAT. Number of (C) acetyl groups and (D) methyl groups (K4me2 = 2 methyl groups) per histones H3.2 and H4 isolated from liver and BAT. n = 3–5 per group. One-way ANOVA testing was conducted for all histone data from each tissue comparing TN, RT, and SC housing conditions, and p-values are indicated in each plot. TN: thermoneutral. RT: room temperature. SC: severe cold

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