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Fig. 9 | Epigenetics & Chromatin

Fig. 9

From: Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters

Fig. 9

The exclusivity of H3K36me3 and H3K27me3 localisations. (A) clustering the H3K36me3 localisations and quantifying the % of overlap of H3K27me3, and (B) clustering the H3K27me3 localisations and quantifying the overlap of H3K36me3 localisations. (C) mark connection function (magenta) vs. randomly simulated data (cyan) was performed on H3K27me3 and H3K36me3 localisations along the Y loops to give confidence to the results with a more untargeted analysis. Values around zero show the chance of overlap between H3K27me3 and H3K36me3 localisations is random, those above zero show an attraction rule and those below zero show a repulsion rule. A strong repulsion between H3K27me3 and H3K36me3 is shown at distances below 200 nm

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Epigenetics & Chromatin

ISSN: 1756-8935