Skip to main content
Fig. 9 | Epigenetics & Chromatin

Fig. 9

From: Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers

Fig. 9

Immunofluorescence analysis of CTCF in developing mouse lens. (a) E14.5 mouse lens labeled for CTCF and nuclear stain Hoechst showing lens epithelium (LE) and primary lens fiber (LF) elongation and secondary LF formation at the transition zone (TZ). (b) Magnification of lens epithelium nuclei showing localization of CTCF in both nucleoplasm and nucleoli. (c) Early primary lens fiber cells also show localization of CTCF in nucleoli, but more diffusion in the nucleoplasm. (d) P0.5 lens showing mature structure of the lens and formation of the organelle-free zone (OFZ) as primary lens fiber cells are already denucleated. (e) Lens epithelial cells show strong CTCF signal in nucleoli and staining across the nucleoplasm. (f) Primary and secondary fiber cells show translocation of CTCF to the lens nucleoplasm prior their denucleation

Back to article page

Epigenetics & Chromatin

ISSN: 1756-8935