Fig. 2

Heterooligomeric methyltransferase complex formation. a DNMT3A–DNMT3L or DNMT3B–DNMT3L heterotetramers are depicted with the positions of the outer FF interfaces and inner RD interfaces shown. These interfaces would be in the same locations for both types of homotetramers as well. b The PRMT1–PRMT6, PRMT1–PRMT2, and PRMT1–PRMT8 heterodimers are shown along with dashed lines to indicate additional interactions between PRMT2 and PRMT8, and PRMT1, PRMT2, and SAM68 (KH domain-containing, RNA-binding, signal transduction-associated protein 1). c The METTL3–METTL14 heterodimer is shown along with dashed lines indicating interactions with other members of the m6A methyltransferase complex. WTAP Wilms Tumor 1-Associating Protein, VIRMA Vir Like m6A Methyltransferase Associated, HAKAI E3 ubiquitin-protein ligase, RBM15 RNA binding motif protein 15, ZC3H13 Zinc Finger CCCH-Type Containing 13. d The METTL11A dimer is shown as a complex with METTL11B or METTL13 individually and in combination as one possible larger complex consisting of all three N-terminal methyltransferases. Created with BioRender.com