Table 1 Naturally available compounds inhibiting the TLR 7 pathway
From: Role of sex in immune response and epigenetic mechanisms
Compound | Class | Natural sources | Mechanism of action | References |
|---|---|---|---|---|
1,4-Naphthoquinone | Quinone | (i) English walnut (Juglans regia) (ii) American black walnut (Juglans nigra) | Inhibits IRAK 1 and it’s downstream molecules in in vitro human THP-1 macrophages | [52] |
Artemisinin derivative SM934 | Sesquiterpene lactone | Sweet wormwood (Artemisia annua) | Downregulates TLR 7 expression, suppressing B cell activation and Plasma cell formation | [98] |
Thiostrepton | Oligopeptide | Streptomycetes | Functions as TLR 7 antagonist | [43] |
Andrographolide | Diterpenoid | Green Chirata (Andrographis paniculata) | Promotes MyD88 degradation | [75] |
Azithromycin | Macrolide | Streptomycetes | Inhibited proteolytic processing of TLR 7 | [43] |