Fig. 5

Impact of O-GlcNAcylation on Polycomb repressive complexes. a PRC1. O-GlcNAcylation on RING1B at T250/S251 and S278 controls PRC1 gene targeting, while O-GlcNAcylation on BMI1 at S255 increases its stability by limiting ubiquitin dependent proteasomal degradation; b PR-DUB. HCFC1 O-GlcNAcylation and OGT are indispensable for HCFC1 proteolytic maturation; BAP1 stabilizes OGT through limiting ubiquitin dependent proteasomal degradation; BAP1 is O-GlcNAcylated with no evidence of its impact. ASXL1 O-GlcNAcylation at S199 increases its stability; c PRC2. O-GlcNAcylation on EZH2 at S73, S76, S87 and T313 increases its stability while O-GlcNAcylation at S729 promotes its di- and trimethyltransferase activity. Created with BioRender.com