Fig. 4
Histone O-GlcNAcylation as a key mechanism in DNA damage repair. ①Kinase ATM phosphorylates H2AX and MDC1; ② γH2AX recruits OGT and favors O-GlcNAcylation of H2AX on S139 and MDC1; ③ GlcNAc-H2AX restrains γH2AX expansion around the DNA-damaged site; ④ OGT O-GlcNAcylates H2A on S40 and H2B on S112; ⑤ GlcNAc-H2A favors accumulation of PRKDC and RAD51, while GlcNAc-H2B favors the accumulation of NBN. Adapted from Chen and Yu, Hayakawa et al. and Wang et al. [25, 26, 30]. Created with BioRender.com