Fig. 2
Adapted from Brimble et al., Tan et al., and Dehennaut et al. Created with BioRender.com
O-GlcNAcylation is involved in the regulation of gene expression through different mechanisms. O-GlcNAcylation regulates stability (a), transcriptional activity (b), localization (c) and DNA binding (d) of transcription factors; impacts directly or indirectly histone modification (e); modulates DNA methylation (f); regulates RNA polymerase II (g); controls PRC (h); contributes to the intro retention process (i) and determines translational regulation of N6-methyladenosine (m6A) modified-mRNAs (j). PRC1, PRC2: Polycomb repressive complex 1, 2; CARM1: coactivator-associated arginine methyltransferase 1; DNMT1: DNA methyltransferase 1; TET: ten-eleven translocation; SP1: transcription factor SP1; PDX1: Pancreas/duodenum homeobox protein 1; CTNNB1: catenin beta-1; NEUROD1: transcription factor NEUROD1; FOXO1: forkhead box protein O1; YTHDF: YTH m6A-RNA-binding proteins.