Fig. 1

O-GlcNAcylation consists in the addition of a GlcNAc moiety on proteins which are involved in many if not all cellular processes. OGA exists in two isoforms: long OGA (lOGA) has a histone-like acetyltransferase domain (HAT-like), while short OGA (sOGA) does not. Both isoforms contain a catalytic domain and an OGT-binding domain (OGT). The C-terminal of sOGA contains a specific sequence of 15 amino acids (15). Created with BioRender.com