Fig. 8
From: Differential usage of DNA modifications in neurons, astrocytes, and microglia
Differentially hydroxymethylated CG regions. Differentially hydroxymethylated CG regions (DhMCGRs) were determined between cell types. Distribution of hmCG differences A was plotted, along with overlap of hyper- B and hypo- C DhMCGRs between the three comparisons. Genomic distribution and magnitude of DhMCGRs for astrocytes vs neurons D, microglia vs neurons E, and astrocytes vs microglia F. Relative over- and under-representation in genic features for astrocytes vs neurons G, microglia vs neurons H, and astrocytes vs microglia I. Top enriched transcription factor binding motifs for astrocytes vs neurons J, microglia vs neurons K, and astrocytes vs microglia L. Genic regions containing no DhMCGRs were notated as “n.d.” (Woolf logit method for 95% confidence intervals, Fisher’s exact test for two-sided p-values; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)