Fig. 1
From: Estimating genome-wide DNA methylation heterogeneity with methylation patterns
Illustrations of the DNA methylation patterns as a proxy for monitoring cellular development. A DNA methylation patterns are used to monitor cellular heterogeneity, possibly caused by cellular development, cell-type mixtures, differentiation, genetic changes, diseases, stresses. The black (white) dots represent methylated (unmethylated) cytosines. The different colours correspond to different subtypes of cells (Created with BioRender.com). B DNA methylation patterns formed by aligned methyl reads (by BS-seq or EM-seq) with colour-coded methylation statuses. A set of methylation haplotypes are circled to indicate the reads considered by certain scores covering a specific locus