Chromatin balances cell redox and energy homeostasis

Table 1 List of histone chaperones and corresponding bound histones during nucleosome assembly

Histone chaperone	Histone	Functions	Refernces
HIRA (Xenopus and humans)	H3.3-H4	Deposition of H3.3-H4	[50, 51]
NAP1 (yeast and Human)	H2A-H2B	H2A-H2B nuclear import and deposition	[52,53,54]
NAP1 (yeast and Human)	H2A.Z-H2B,	Transfer of H2A.Z-H2B to SWR-C complex	[52,53,54]
Nap1 (yeast)	H3-H4, H2A-H2B	Nucleosome assembly	[52, 53, 152]
CAF-1 (humans)	H3.1-H4	Deposition of H3.1-H4	[51]
FACT (humans)	H2A-H2B, H2A.X-H2B, H3-H4	Deposition of H2A-H2B, H2A.X-H2B, H3-H4	[153]
Chz1 (yeast)	H2A.Z-H2B	Incorporation of H2A.Z-H2B	[154]
ASF1 (yeast, Drosophila, and humans)	H3-H4	Transfer of H3-H4 and H3.1-H4 to RTT106 and CAF-1	[152, 153]
ASF1 (humans)	H3.1-H4	Transfer of H3.1-H4 to CAF-1	[56, 152, 153]
ASF1 (humans)	H3.3-H4	Transfer of H3.3-H4 to HIRA	[56, 152, 153]
ANP32E (humans)	H2A.Z-H2B	Removal of H2A.Z-H2B	[152, 156]
RTT106 (yeast)	H3-H4	Formation of (H3-H4)₂	[157]

Examples of histone chaperones, each of which binds to a different histone or combination of histones. Xenopus and human HIRA (histone cell cycle regulation defective homolog A) deposits histone H.3.3-H4 [54, 55]; yeast and human NAP1 (nucleosome assembly protein 1) imports and deposits H2A-H2B or H2A.Z-H2B [56,57,58]; yeast Nap1 associates with H3-H4 and H2A-H2B [56, 57, 156]; human CAF-1 (chromatin assembly factor 1) deposits H3.1-H4 [55]; human FACT (facilitates chromatin transcription) deposits H2A-H2B, H2A.X-H2B, and H3-H4 [157]; yeast Chz1 incorporates H2A.Z-H2B [158]; yeast, D. melanogaster, and human ASF1 associates with H3-H4 [156, 159], H3.1-H4, and H3.3-H4 [60]; human ANP32E removes H2A.Z-H2B [156, 160]; and yeast Rtt106 forms (H3-H4)₂ tetramer [161]

ISSN: 1756-8935