Fig. 5From: The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and diseaseThe role of SETDB1 in tumors by methylating nonhistones. SETDB1 trimethylates AKT at K64, K140 or K142 to increase the phosphorylation and activity of AKT, which accelerates non-small cell lung cancer and colorectal cancer or skin tumorigenesis, respectively. In liver cancer, SETDB1 dimethylates gain-of-function (GOF) mutant P53 at K370 to prevent its degradation by ubiquitination, and then promotes liver cancer cell growthBack to article page